Perioperative diagnosis and treatment of serotonin syndrome following administration of methylene blue

American Journal of Case Reports

Volumn 17, Issue , 2016, Pages 347-351

  Francescangeli, James ^a   Vaida, Sonia ^a   Bonavia, Anthony S ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Drug Related Side Effects and Adverse Reactions; Methylene Blue; Serotonin Syndrome

Indexed keywords

DULOXETINE; FENTANYL; GLYCOPYRRONIUM; HYDROMORPHONE; LIDOCAINE; METHYLENE BLUE; MIDAZOLAM; NALOXONE; NEOSTIGMINE; PARACETAMOL; PROPOFOL; ROCURONIUM; SEVOFLURANE; TRAMADOL; TRAZODONE; COLORING AGENT;

AGED; AGITATION; ANXIETY DISORDER; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CAUCASIAN; COLON RESECTION; DEPRESSION; DIAPHORESIS; DISCECTOMY; ENDOTRACHEAL INTUBATION; EXTUBATION; FACIAL EXPRESSION; FEVER; GENERAL ANESTHESIA; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOT FLUSH; HUMAN; HYPERTENSION; ILEORECTAL ANASTOMOSIS; INTENSIVE CARE UNIT; INTRAOPERATIVE PERIOD; KIDNEY CARCINOMA; LAPAROSCOPY; MALE; NECK PAIN; NEUROMUSCULAR BLOCKING; PARTIAL NEPHRECTOMY; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RECOVERY ROOM; SEROTONIN SYNDROME; TACHYCARDIA; CHEMICALLY INDUCED; PEROPERATIVE COMPLICATION;

AGED; ANESTHESIA, GENERAL; COLORING AGENTS; HUMANS; INTRAOPERATIVE COMPLICATIONS; MALE; METHYLENE BLUE; SEROTONIN SYNDROME;

EID: 84984999008     PISSN: None     EISSN: 19415923     Source Type: Journal    
DOI: 10.12659/AJCR.897671     Document Type: Article

References (20)

1. Mason PJ, Morris VA, Balcezak TJ: Serotonin syndrome. Presentation of 2 cases and review of the literature. Medicine, 2000; 79(4): 201-9
2. Stanford SC, Stanford BJ, Gillman PK: Risk of severe serotonin toxicity following co-administration of methylene blue and serotonin reuptake inhibitors: An update on a case report of postoperative delirium. J Psychopharmacol, 2010; 24: 1433-38
3. Isbister GK, Buckley NA, Whyte IM: Serotonin toxicity: A practical approach to diagnosis and treatment. Med J Aust, 2007; 187(6): 361-65
4. Dunkley EJC, Isbister GK, Sibbritt D et al: The Hunter Serotonin Toxicity Criteria: Aimple and accurate diagnostic decision rules for serotonin toxicity. Q J Med, 2003; 96: 635-42
5. Hidaka BH: Depression as a disease of modernity: explanations for increasing prevalence. J Affect Disord, 2012; 140(3): 205-14
6. Boyer EW, Shannon M: The serotonin syndrome. N Engl J Med, 2005; 352(11): 1112-20
7. Top WM, Gillman PK, de Langen CJ, Kooy A: Fatal methylene blue associated serotonin toxicity. Neth J Med, 2014; 72: 179-81
8. Shakoor MT, Ayub S, Ahad A, Ayub Z: Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor. Am J Case Rep, 2014; 15: 562-64
9. Yee AH, Wijdicks EF: A perfect storm in the emergency department. Neurocrit Care, 2010; 12(2): 258-60
10. Locke A: Methylene blue and the risk of serotonin toxicity. APSF Newsletter, 2015; 30(1): 1-7
11. Levin RL, Degrange MA, Bruno GF et al: Methylene blue reduces mortality and morbidity in vasoplegic patients after cardiac surgery. Ann Thorac Surg, 2005; 28(5): 705-10
12. FDA Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications. U.S. Food and Drug Administration website. http://www.fda.gov/Drugs/ DrugSafety/ucm263190.htm. Created October 20, 2011. Accessed February 2, 2016
13. Smith CJ, Wang D, Sgambelluri A et al: Serotonin syndrome following methylene blue administration during cardiothoracic surgery. J Pharm Pract, 2015; 28(2): 207-11
14. Grubb KJ, Kennedy JL, Bergin JD et al: The role of methylene blue in serotonin syndrome following cardiac transplantation: A case report and review of the literature. J Thorac Cardiovasc Surg, 2012; 144(5): e113-16
15. Hanna ER, Clark JA: Serotonin syndrome after cardiopulmonary bypass: a case demonstrating the interaction between methylene blue and selective serotonin reuptake inhibitors. A A Case Rep, 2014; 2(9): 113-14
16. Martino EAM, Winterton D, Nardelli P et al: The blue coma: The role of methylene blue in unexplained coma after cardiac surgery: A case series. J Cardiothorac Vasc Anesth, 2015 [Epub ahead of print]
17. Bradley KW, Andrew JD: The role of methylene blue in serotonin syndrome: A systematic review. Psychosomatics, 2010; 51(3): 194-200
18. Gillman PK: CNS toxicity involving methylene blue: The exemplar for understanding and predicting drug interactions that precipitate serotonin toxicity. J Psychopharmacol, 2011; 25: 429-36
19. Ng BK, Cameron AJ, Liang R, Rahman H: Serotonin syndrome following methylene blue infusion during parathyroidectomy: A case report and literature review. Can J Anaesth, 2008; 55: 36-41
20. Indigo Carmine Injection. American Society of Health-System Pharmacists website. http://www.ashp.org/menu/DrugShortages/CurrentShortages/Bulletin.aspx?id=861. Created December 22, 2015. Accessed February 9, 2016