Interferon-γ Release Assay vs. Tuberculin Skin Test for Tuberculosis Screening in Exposed Healthcare Workers: A Longitudinal Multicenter Comparative Study

Infection Control and Hospital Epidemiology

Volumn 36, Issue 5, 2015, Pages 569-574

  Lucet, Jean Christophe ^a,b   Abiteboul, Dominique ^a   Estellat, Candice ^a,c   Roy, Carine ^a,c   Chollet Martin, Sylvie ^a,c   Tubach, Florence ^a,c,d   Carcelain, Guislaine ^b,c,e  

^a BICHAT HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

^d Assistance publique Hôpitaux de Paris   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BCG VACCINATION; FOLLOW UP; HEALTH CARE PERSONNEL; HUMAN; INCIDENCE; INTERFERON GAMMA RELEASE ASSAY; INTERMETHOD COMPARISON; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MYCOBACTERIUM TUBERCULOSIS TEST KIT; OCCUPATIONAL EXPOSURE; PROSPECTIVE STUDY; SCREENING; TUBERCULIN TEST; TUBERCULOSIS; UNIVERSITY HOSPITAL; CLINICAL TRIAL; COMPARATIVE STUDY; CROSS INFECTION; DISEASE TRANSMISSION; HOSPITAL PERSONNEL; MALE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; TUBERCULOSIS, PULMONARY;

ADULT; CROSS INFECTION; HUMANS; INCIDENCE; INFECTIOUS DISEASE TRANSMISSION, PATIENT-TO-PROFESSIONAL; INTERFERON-GAMMA RELEASE TESTS; LONGITUDINAL STUDIES; MALE; OCCUPATIONAL EXPOSURE; PERSONNEL, HOSPITAL; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; TUBERCULIN TEST; TUBERCULOSIS, PULMONARY;

EID: 84984917575     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1017/ice.2015.19     Document Type: Article

References (23)

1. Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 2008;149:177-184.
2. Antoine D, Belghiti F, Guthmann J, Campese C, Lévy-Bruhl D, Che D. Les cas de tuberculose déclarés en France en 2012. BEH 2014:352-359.
3. Zwerling A, Benedetti A, Cojocariu M, et al. Repeat IGRA testing in Canadian health workers: conversions or unexplained variability PloS One 2013;8:e54748.
4. Dorman SE, Belknap R, Graviss EA, et al. Interferon-release assays and tuberculin skin testing for diagnosis of latent tuberculosis infection in healthcare workers in the United States. Am J Respir Crit Care Med 2014;189:77-87.
5. Pai M, Denkinger CM, Kik SV, et al. interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev 2014;27:3-20.
6. Targeted tuberculin testing and treatment of latent tuberculosis infection. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. This is a Joint Statement of the American Thoracic Society (ATS) and the Centers for Disease Control and Prevention (CDC). This statement was endorsed by the Council of the Infectious Diseases Society of America. (IDSA), September 1999, and the sections of this statement. Am J Respir Crit Care Med 2000;161:S221-S247.
7. Ringshausen FC, Schablon A, Nienhaus A. Interferon-release assays for the tuberculosis serial testing of health care workers: a systematic review. J Occup Med Toxicol Lond Engl 2012;7:6.
8. Zwerling A, Hof S, van den, Scholten J, Cobelens F, Menzies D, Pai M. Interferon-release assays for tuberculosis screening of healthcare workers: a systematic review. Thorax 2012;67:62-70.
9. Drobniewski F, Balabanova Y, Zakamova E, Nikolayevskyy V, Fedorin I. Rates of latent tuberculosis in health care staff in Russia. PLoS Med 2007;4:e55.
10. Girardi E, Angeletti C, Puro V, et al. Estimating diagnostic accuracy of tests for latent tuberculosis infection without a gold standard among healthcare workers. Euro Surveill Bull 2009:14.
11. Harada N, Nakajima Y, Higuchi K, Sekiya Y, Rothel J, Mori T. Screening for tuberculosis infection using whole-blood interferon-and Mantoux testing among Japanese healthcare workers. Infect Control Hosp Epidemiol 2006;27:442-448.
12. Lien LT, Hang NTL, Kobayashi N, et al. Prevalence and risk factors for tuberculosis infection among hospital workers in Hanoi, Viet Nam. PloS One 2009;4:e6798.
13. Campo MT, del, Fouad H, Solís-Bravo MM, Sánchez-Uriz MA, Mahíllo-Fernández I, Esteban J. Cost-effectiveness of different screening strategies (single or dual) for the diagnosis of tuberculosis infection in healthcare workers. Infect Control Hosp Epidemiol 2012;33:1226-1234.
14. Demkow U, Broniarek-Samson B, Filewska M, et al. Prevalence of latent tuberculosis infection in health care workers in Poland assessed by interferon-whole blood and tuberculin skin tests. J Physiol Pharmacol 2008;59(Suppl 6):209-217.
15. Torres Costa J, Sá R, Cardoso MJ, et al. Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-release assay. Eur Respir J 2009;34: 1423-1428.
16. Hotta K, Ogura T, Nishii K, et al. Whole blood interferon-assay for baseline tuberculosis screening among Japanese healthcare students. PloS One 2007;2:e803.
17. Topi RZ, Dodig S, Zorici-Letoja I. Interferon-and immunoglobulins in latent tuberculosis infection. Arch Med Res 2009; 40:103-108.
18. Vinton P,Mihrshahi S, Johnson P, Jenkin GA, Jolley D, Biggs B-A. Comparison of QuantiFERON-TB Gold In-Tube Test and tuberculin skin test for identification of latent Mycobacterium tuberculosis infection in healthcare staff and association between positive test results and known risk factors for infection. Infect Control Hosp Epidemiol 2009;30:215-221.
19. Larsen NM, Biddle CL, SotirMJ, WhiteN, Parrott P, Blumberg HM. Risk of tuberculin skin test conversion among health care workers: occupational versus community exposure and infection. Clin Infect Dis 2002;35:796-801.
20. Fong KS, Tomford JW, Teixeira L, et al. Challenges of interferon-release assay conversions in serial testing of health-care workers in a TB control program. Chest 2012;142:55-62.
21. Gandra S, ScottWS, Somaraju V,Wang H, Wilton S, Feigenbaum M. Questionable effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a screening tool in healthcare workers. Infect Control Hosp Epidemiol 2010;31:1279-1285.
22. Pai M, Joshi R, Dogra S, et al. Serial testing of health care workers for tuberculosis using interferon-assay. Am J Respir Crit Care Med 2006;174:349-355.
23. Ringshausen FC, Nienhaus A, Schablon A, Schlösser S, Schultze-Werninghaus G, Rohde G. Predictors of persistently positive Mycobacterium-tuberculosis-specific interferon-responses in the serial testing of health care workers. BMC Infect Dis 2010;10:220.