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Volumn 67, Issue , 2016, Pages 11-20

A study-level meta-analysis of efficacy data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer

Author keywords

Bevacizumab; Cetuximab; Meta analysis; Panitumumab; Progression free survival; Survival

Indexed keywords

BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PANITUMUMAB; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; MAGNESIUM; MONOCLONAL ANTIBODY; RAS PROTEIN;

EID: 84984848472     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2016.07.019     Document Type: Article
Times cited : (51)

References (35)
  • 2
    • 84867122727 scopus 로고    scopus 로고
    • ESMO consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
    • [2] Schmoll, H.J., Van Cutsem, E., Stein, A., Valentini, V., Glimelius, B., Haustermans, K., et al. ESMO consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Ann Oncol 23 (2012), 2479–2516.
    • (2012) Ann Oncol , vol.23 , pp. 2479-2516
    • Schmoll, H.J.1    Van Cutsem, E.2    Stein, A.3    Valentini, V.4    Glimelius, B.5    Haustermans, K.6
  • 3
    • 84908540607 scopus 로고    scopus 로고
    • Targeted therapies in metastatic colorectal cancer: a systematic review and assessment of currently available data
    • [3] Kirstein, M.M., Lange, A., Prenzler, A., Manns, M.P., Kubicka, S., Vogel, A., Targeted therapies in metastatic colorectal cancer: a systematic review and assessment of currently available data. Oncologist 19 (2014), 1156–1168.
    • (2014) Oncologist , vol.19 , pp. 1156-1168
    • Kirstein, M.M.1    Lange, A.2    Prenzler, A.3    Manns, M.P.4    Kubicka, S.5    Vogel, A.6
  • 4
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study
    • [4] Tournigand, C., André, T., Achille, E., Lledo, G., Flesh, M., Mery-Mignard, D., et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22 (2004), 229–237.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    André, T.2    Achille, E.3    Lledo, G.4    Flesh, M.5    Mery-Mignard, D.6
  • 5
    • 84984800478 scopus 로고    scopus 로고
    • MAVERICC, a phase 2 study of mFOLFOX6-bevacizumab (BV) vs FOLFIRI-BV with biomarker stratification as first-line (1L) chemotherapy (CT) in patients (pts) with metastatic colorectal cancer (mCRC)
    • Abstract 493
    • [5] Lenz, H.J., Lee, F.C., Yau, L., Koh, H.A., Knost, J.A., Mitchell, E.P., et al. MAVERICC, a phase 2 study of mFOLFOX6-bevacizumab (BV) vs FOLFIRI-BV with biomarker stratification as first-line (1L) chemotherapy (CT) in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol, 34(Suppl. 4S), 2016 Abstract 493.
    • (2016) J Clin Oncol , vol.34
    • Lenz, H.J.1    Lee, F.C.2    Yau, L.3    Koh, H.A.4    Knost, J.A.5    Mitchell, E.P.6
  • 6
    • 84975169279 scopus 로고    scopus 로고
    • Phase II trial of panitumumab plus FOLFOX4 or FOLFIRI in subjects with KRAS wild-type colorectal cancer and liver-limited disease: the PLANET study
    • Abstract 3560
    • [6] Abad, A., Massuti, B., Grávalos, C., Escudero, P., Guillén-Ponce, C., Manzano, J.L., et al. Phase II trial of panitumumab plus FOLFOX4 or FOLFIRI in subjects with KRAS wild-type colorectal cancer and liver-limited disease: the PLANET study. J Clin Oncol, 32(Suppl.), 2014 Abstract 3560.
    • (2014) J Clin Oncol , vol.32
    • Abad, A.1    Massuti, B.2    Grávalos, C.3    Escudero, P.4    Guillén-Ponce, C.5    Manzano, J.L.6
  • 7
    • 84920436690 scopus 로고    scopus 로고
    • A randomized phase III trial of mFOLFOX6 plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment for metastatic colorectal cancer: West Japan Oncology Group study 4407G (WJOG4407G)
    • Abstract 3534
    • [7] Yamazaki, K., Nagase, M., Tamagawa, H., Ueda, S., Tamura, T., Murata, K., et al. A randomized phase III trial of mFOLFOX6 plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment for metastatic colorectal cancer: West Japan Oncology Group study 4407G (WJOG4407G). J Clin Oncol, 32(Suppl. 5S), 2014 Abstract 3534.
    • (2014) J Clin Oncol , vol.32
    • Yamazaki, K.1    Nagase, M.2    Tamagawa, H.3    Ueda, S.4    Tamura, T.5    Murata, K.6
  • 8
    • 84975237335 scopus 로고    scopus 로고
    • ® (panitumumab) summary of product characteristics
    • ® (panitumumab) summary of product characteristics. 2015.
    • (2015)
    • European Medicines Agency1
  • 9
    • 79951853372 scopus 로고    scopus 로고
    • ® (cetuximab) summary of product characteristics
    • ® (cetuximab) summary of product characteristics. 2015.
    • (2015)
    • European Medicines Agency1
  • 10
    • 84925340214 scopus 로고    scopus 로고
    • Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer
    • [10] Price, T.J., Bruhn, M.A., Lee, C.K., Hardingham, J.E., Townsend, A.R., Mann, K.P., et al. Correlation of extended RAS and PIK3CA gene mutation status with outcomes from the phase III AGITG MAX STUDY involving capecitabine alone or in combination with bevacizumab plus or minus mitomycin C in advanced colorectal cancer. Br J Cancer 112 (2015), 963–970.
    • (2015) Br J Cancer , vol.112 , pp. 963-970
    • Price, T.J.1    Bruhn, M.A.2    Lee, C.K.3    Hardingham, J.E.4    Townsend, A.R.5    Mann, K.P.6
  • 11
    • 84921784091 scopus 로고    scopus 로고
    • Significance of KRAS mutation in patients receiving mFOLFOX6 with or without bevacizumab for metastatic colorectal cancer
    • [11] Koike, J., Ushigome, M., Funahashi, K., Shiokawa, H., Kaneko, T., Arai, K., et al. Significance of KRAS mutation in patients receiving mFOLFOX6 with or without bevacizumab for metastatic colorectal cancer. Hepatogastroenterology 61 (2014), 2222–2226.
    • (2014) Hepatogastroenterology , vol.61 , pp. 2222-2226
    • Koike, J.1    Ushigome, M.2    Funahashi, K.3    Shiokawa, H.4    Kaneko, T.5    Arai, K.6
  • 12
    • 84975237335 scopus 로고    scopus 로고
    • ® (bevacizumab) summary of product characteristics
    • ® (bevacizumab) summary of product characteristics. 2015.
    • (2015)
    • European Medicines Agency1
  • 13
    • 84907027361 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the rectum or colon (MCRC)
    • Abstract LBA3
    • [13] Venook, A.P., Niedzwiecki, D., Lenz, H.J., Innocenti, F., Mahoney, M.R., O'Neil, B.H., et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the rectum or colon (MCRC). J Clin Oncol, 32(Suppl. 5S), 2014 Abstract LBA3.
    • (2014) J Clin Oncol , vol.32
    • Venook, A.P.1    Niedzwiecki, D.2    Lenz, H.J.3    Innocenti, F.4    Mahoney, M.R.5    O'Neil, B.H.6
  • 14
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial
    • [14] Heinemann, V., von Weikersthal, L.F., Decker, T., Kiani, A., Vehling-Kaiser, U., Al-Batran, S.E., et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 15 (2014), 1065–1075.
    • (2014) Lancet Oncol , vol.15 , pp. 1065-1075
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3    Kiani, A.4    Vehling-Kaiser, U.5    Al-Batran, S.E.6
  • 15
    • 84937204003 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC)
    • Abstract 501O
    • [15] Lenz, H., Niedzwiecki, D., Innocenti, F., Blanke, C., Mahoney, M.R., O'Neil, B.H., et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with expanded ras analyses untreated metastatic adenocarcinoma of the colon or rectum (mCRC). Ann Oncol, 25(Suppl. 4), 2014 Abstract 501O.
    • (2014) Ann Oncol , vol.25
    • Lenz, H.1    Niedzwiecki, D.2    Innocenti, F.3    Blanke, C.4    Mahoney, M.R.5    O'Neil, B.H.6
  • 16
    • 84911460699 scopus 로고    scopus 로고
    • Independent radiological evaluation of objective response, early tumour shrinkage, and depth of response in FIRE-3 (AIO KRK-0306)
    • Abstract O-0030
    • [16] Heinemann, V., Modest, D.P., Fischer von Weikersthal, L., Decker, T., Kiani, A., Vehling-Kaiser, U., et al. Independent radiological evaluation of objective response, early tumour shrinkage, and depth of response in FIRE-3 (AIO KRK-0306). Ann Oncol, 25(Suppl. 4), 2014 Abstract O-0030.
    • (2014) Ann Oncol , vol.25
    • Heinemann, V.1    Modest, D.P.2    Fischer von Weikersthal, L.3    Decker, T.4    Kiani, A.5    Vehling-Kaiser, U.6
  • 17
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
    • [17] Schwartzberg, L.S., Rivera, F., Karthaus, M., Fasola, G., Canon, J.L., Hecht, J.R., et al. PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOLFOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol 32 (2014), 2240–2247.
    • (2014) J Clin Oncol , vol.32 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3    Fasola, G.4    Canon, J.L.5    Hecht, J.R.6
  • 18
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • [18] DerSimonian, R., Laird, N., Meta-analysis in clinical trials. Control Clin Trials 7 (1986), 177–188.
    • (1986) Control Clin Trials , vol.7 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 19
    • 84907022526 scopus 로고    scopus 로고
    • Mutations within the EGFR signaling pathway: influences on efficacy in FIRE-3-A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients
    • Abstract 445
    • [19] Stintzing, S., Jung, A., Rossius, L., Modest, D.P., Fischer von Weikersthal, L., Decker, T., et al. Mutations within the EGFR signaling pathway: influences on efficacy in FIRE-3-A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients. J Clin Oncol, 32(Suppl. 3), 2014 Abstract 445.
    • (2014) J Clin Oncol , vol.32
    • Stintzing, S.1    Jung, A.2    Rossius, L.3    Modest, D.P.4    Fischer von Weikersthal, L.5    Decker, T.6
  • 20
    • 84984799080 scopus 로고    scopus 로고
    • Final analysis of the PEAK trial: overall survival (OS) and tumour responses during first-line treatment with mFOLFOX6 + either panitumumab (pmab) or bevacizumab (bev) in patients (pts) with metastatic colorectal cancer (mCRC)
    • Abstract 2014
    • [20] Rivera, F., Karthaus, M., Hecht, J.R., Fasola, G., Canon, J.L., Guan, X., et al. Final analysis of the PEAK trial: overall survival (OS) and tumour responses during first-line treatment with mFOLFOX6 + either panitumumab (pmab) or bevacizumab (bev) in patients (pts) with metastatic colorectal cancer (mCRC). Eur J Cancer, 51(Suppl), 2015 Abstract 2014.
    • (2015) Eur J Cancer , vol.51
    • Rivera, F.1    Karthaus, M.2    Hecht, J.R.3    Fasola, G.4    Canon, J.L.5    Guan, X.6
  • 21
    • 84947436561 scopus 로고    scopus 로고
    • Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial: first-line therapy with FOLFIRI plus cetuximab or bevacizumab in patients with KRAS wild-type tumors in metastatic colorectal cancer
    • [21] Modest, D.P., Stintzing, S., von Weikersthal, L.F., Decker, T., Kiani, A., Vehling-Kaiser, U., et al. Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial: first-line therapy with FOLFIRI plus cetuximab or bevacizumab in patients with KRAS wild-type tumors in metastatic colorectal cancer. J Clin Oncol 33 (2015), 3718–3726.
    • (2015) J Clin Oncol , vol.33 , pp. 3718-3726
    • Modest, D.P.1    Stintzing, S.2    von Weikersthal, L.F.3    Decker, T.4    Kiani, A.5    Vehling-Kaiser, U.6
  • 22
    • 84929141867 scopus 로고    scopus 로고
    • Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials
    • [22] Sorich, M.J., Wiese, M.D., Rowland, A., Kichenadasse, G., McKinnon, R.A., Karapetis, C.S., Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials. Ann Oncol 26 (2015), 13–21.
    • (2015) Ann Oncol , vol.26 , pp. 13-21
    • Sorich, M.J.1    Wiese, M.D.2    Rowland, A.3    Kichenadasse, G.4    McKinnon, R.A.5    Karapetis, C.S.6
  • 23
    • 84929519878 scopus 로고    scopus 로고
    • Role of first-line anti-epidermal growth factor receptor therapy compared with anti-vascular endothelial growth factor therapy in advanced colorectal cancer: a meta-analysis of randomized clinical trials
    • [23] Khattak, M.A., Martin, H., Davidson, A., Phillips, M., Role of first-line anti-epidermal growth factor receptor therapy compared with anti-vascular endothelial growth factor therapy in advanced colorectal cancer: a meta-analysis of randomized clinical trials. Clin Colorectal Cancer 14 (2015), 81–90.
    • (2015) Clin Colorectal Cancer , vol.14 , pp. 81-90
    • Khattak, M.A.1    Martin, H.2    Davidson, A.3    Phillips, M.4
  • 24
    • 84878178425 scopus 로고    scopus 로고
    • Early tumor shrinkage in metastatic colorectal cancer: retrospective analysis from an irinotecan-based randomized first-line trial
    • [24] Giessen, C., Laubender, R.P., Fischer von, W.L., Schalhorn, A., Modest, D.P., Stintzing, S., et al. Early tumor shrinkage in metastatic colorectal cancer: retrospective analysis from an irinotecan-based randomized first-line trial. Cancer Sci 104 (2013), 718–724.
    • (2013) Cancer Sci , vol.104 , pp. 718-724
    • Giessen, C.1    Laubender, R.P.2    Fischer von, W.L.3    Schalhorn, A.4    Modest, D.P.5    Stintzing, S.6
  • 25
    • 84930636475 scopus 로고    scopus 로고
    • Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer
    • [25] Douillard, J.Y., Siena, S., Peeters, M., Koukakis, R., Terwey, J.H., Tabernero, J., Impact of early tumour shrinkage and resection on outcomes in patients with wild-type RAS metastatic colorectal cancer. Eur J Cancer 51 (2015), 1231–1242.
    • (2015) Eur J Cancer , vol.51 , pp. 1231-1242
    • Douillard, J.Y.1    Siena, S.2    Peeters, M.3    Koukakis, R.4    Terwey, J.H.5    Tabernero, J.6
  • 26
    • 84938086499 scopus 로고    scopus 로고
    • Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord Ovest
    • [26] Cremolini, C., Loupakis, F., Antoniotti, C., Lonardi, S., Masi, G., Salvatore, L., et al. Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord Ovest. Ann Oncol 26 (2015), 1188–1194.
    • (2015) Ann Oncol , vol.26 , pp. 1188-1194
    • Cremolini, C.1    Loupakis, F.2    Antoniotti, C.3    Lonardi, S.4    Masi, G.5    Salvatore, L.6
  • 27
    • 84939475603 scopus 로고    scopus 로고
    • Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC)
    • [27] Heinemann, V., Stintzing, S., Modest, D.P., Giessen-Jung, C., Michl, M., Mansmann, U.R., Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC). Eur J Cancer 51 (2015), 1927–1936.
    • (2015) Eur J Cancer , vol.51 , pp. 1927-1936
    • Heinemann, V.1    Stintzing, S.2    Modest, D.P.3    Giessen-Jung, C.4    Michl, M.5    Mansmann, U.R.6
  • 28
    • 84927513911 scopus 로고    scopus 로고
    • Early tumour shrinkage as a prognostic factor and surrogate end-point in colorectal cancer: a systematic review and pooled-analysis
    • [28] Petrelli, F., Pietrantonio, F., Cremolini, C., Di Bartolomeo, M., Coinu, A., Lonati, V., et al. Early tumour shrinkage as a prognostic factor and surrogate end-point in colorectal cancer: a systematic review and pooled-analysis. Eur J Cancer 51 (2015), 800–807.
    • (2015) Eur J Cancer , vol.51 , pp. 800-807
    • Petrelli, F.1    Pietrantonio, F.2    Cremolini, C.3    Di Bartolomeo, M.4    Coinu, A.5    Lonati, V.6
  • 29
    • 84923199426 scopus 로고    scopus 로고
    • Independent radiological evaluation of objective response, early tumor shrinkage, and depth of response in FIRE-3 (AIO KRK-0306) in the final RAS evaluable population
    • Abstract LBA11
    • [29] Stintzing, S., Modest, D.P., Fischer von Weikersthal, L., Decker, T., Kiani, A., Vehling-Kaiser, U., et al. Independent radiological evaluation of objective response, early tumor shrinkage, and depth of response in FIRE-3 (AIO KRK-0306) in the final RAS evaluable population. Ann Oncol, 25(Suppl 4), 2014 Abstract LBA11.
    • (2014) Ann Oncol , vol.25
    • Stintzing, S.1    Modest, D.P.2    Fischer von Weikersthal, L.3    Decker, T.4    Kiani, A.5    Vehling-Kaiser, U.6
  • 30
    • 84929691348 scopus 로고    scopus 로고
    • First-line treatment with modified FOLFOX6 (mFOLFOX6) + panitumumab (pmab) or bevacizumab (bev) in wild-type (WT) RAS metastatic colorectal carcinoma (mCRC): tumor response outcomes beyond RECIST
    • Abstract 660
    • [30] Rivera, F., Karthaus, M., Hecht, J.R., Fasola, G., Canon, J.L., Koukakis, R., et al. First-line treatment with modified FOLFOX6 (mFOLFOX6) + panitumumab (pmab) or bevacizumab (bev) in wild-type (WT) RAS metastatic colorectal carcinoma (mCRC): tumor response outcomes beyond RECIST. J Clin Oncol, 33(Suppl 3), 2015 Abstract 660.
    • (2015) J Clin Oncol , vol.33
    • Rivera, F.1    Karthaus, M.2    Hecht, J.R.3    Fasola, G.4    Canon, J.L.5    Koukakis, R.6
  • 32
    • 84925324704 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer
    • [32] Van Cutsem, E., Lenz, H.J., Köhne, C.H., Heinemann, V., Tejpar, S., Melezinek, I., et al. Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol 33 (2015), 692–700.
    • (2015) J Clin Oncol , vol.33 , pp. 692-700
    • Van Cutsem, E.1    Lenz, H.J.2    Köhne, C.H.3    Heinemann, V.4    Tejpar, S.5    Melezinek, I.6
  • 33
    • 84979929813 scopus 로고    scopus 로고
    • PARADIGM study: a multicenter, randomized, phase III study of 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab or bevacizumab as first-line treatment in patients with RAS(KRAS/NRAS) wild-type metastatic colorectal cancer
    • Abstract TPS776
    • [33] Yoshino, T., Uetake, H., Tsuchihara, K., Shitara, K., Yamazaki, K., Oki, E., et al. PARADIGM study: a multicenter, randomized, phase III study of 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus panitumumab or bevacizumab as first-line treatment in patients with RAS(KRAS/NRAS) wild-type metastatic colorectal cancer. J Clin Oncol, 34(Suppl 4S), 2016 Abstract TPS776.
    • (2016) J Clin Oncol , vol.34
    • Yoshino, T.1    Uetake, H.2    Tsuchihara, K.3    Shitara, K.4    Yamazaki, K.5    Oki, E.6
  • 34
    • 84936935306 scopus 로고    scopus 로고
    • The importance of optimal drug sequencing in metastatic colorectal cancer: biological rationales for the observed survival benefit conferred by first-line treatment with EGFR inhibitors
    • [34] Wainberg, Z.A., Drakaki, A., The importance of optimal drug sequencing in metastatic colorectal cancer: biological rationales for the observed survival benefit conferred by first-line treatment with EGFR inhibitors. Expert Opin Biol Ther 15 (2015), 1205–1220.
    • (2015) Expert Opin Biol Ther , vol.15 , pp. 1205-1220
    • Wainberg, Z.A.1    Drakaki, A.2
  • 35
    • 84899981129 scopus 로고    scopus 로고
    • Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study
    • [35] Price, T.J., Peeters, M., Kim, T.W., Li, J., Cascinu, S., Ruff, P., et al. Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study. Lancet Oncol 15 (2014), 569–579.
    • (2014) Lancet Oncol , vol.15 , pp. 569-579
    • Price, T.J.1    Peeters, M.2    Kim, T.W.3    Li, J.4    Cascinu, S.5    Ruff, P.6


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