Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts

Journal of Natural Products

Volumn 79, Issue 8, 2016, Pages 1962-1970

  Aguda, Adeleke H ^a,b   Lavallee, Vincent ^b   Cheng, Ping ^a   Bott, Tina M ^a   Meimetis, Labros G ^a   Law, Simon ^a   Nguyen, Nham T ^a   Williams, David E ^b   Kaleta, Jadwiga ^a   Villanueva, Ivan ^c   Davies, Julian ^c   Andersen, Raymond J ^a   Brayer, Gary D ^b   Brömme, Dieter ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Faculty of Science   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPAIN; ANTIPAIN DERIVATIVE; CATHEPSIN K INHIBITOR; LEUPEPTIN; LICHOSTATINAL; NATURAL PRODUCT; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CATHEPSIN K; PEPTIDE;

ACTINOBACTERIA; AFFINITY CHROMATOGRAPHY; ARTICLE; BACTERIAL STRAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STRUCTURE; HYDROGEN BOND; NONHUMAN; NUCLEOTIDE SEQUENCE; SYNTHESIS; ANTAGONISTS AND INHIBITORS; BRITISH COLUMBIA; CHEMICAL STRUCTURE; CHEMISTRY; ISOLATION AND PURIFICATION; LICHEN (ORGANISM); NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ANTIPAIN; BIOLOGICAL PRODUCTS; BRITISH COLUMBIA; CATHEPSIN K; CRYSTALLOGRAPHY, X-RAY; LICHENS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES;

EID: 84984848098     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.6b00215     Document Type: Article

References (28)

1. McChesney, J. D.; Venkataraman, S. K.; Henri, J. T. Phytochemistry 2007, 68, 2015 10.1016/j.phytochem.2007.04.032
2. Atanasov, A. G.; Waltenberger, B.; Pferschy-Wenzig, E. M.; Linder, T.; Wawrosch, C.; Uhrin, P.; Temml, V.; Wang, L.; Schwaiger, S.; Heiss, E. H.; Rollinger, J. M.; Schuster, D.; Breuss, J. M.; Bochkov, V.; Mihovilovic, M. D.; Kopp, B.; Bauer, R.; Dirsch, V. M.; Stuppner, H. Biotechnol. Adv. 2015, 33, 1582 10.1016/j.biotechadv.2015.08.001
3. Reen, F. J.; Romano, S.; Dobson, A. D.; O'Gara, F. Mar. Drugs 2015, 13, 4754 10.3390/md13084754
4. Costa, A. G.; Cusano, N. E.; Silva, B. C.; Cremers, S.; Bilezikian, J. P. Nat. Rev. Rheumatol. 2011, 7, 447 10.1038/nrrheum.2011.77
5. Hwang, K. S.; Kim, H. U.; Charusanti, P.; Palsson, B. O.; Lee, S. Y. Biotechnol. Adv. 2014, 32, 255 10.1016/j.biotechadv.2013.10.008
6. Maeda, K.; Kawamura, K.; Kondo, S.; Aoyagi, T.; Takeuchi, T. J. Antibiot. 1971, 24, 402 10.7164/antibiotics.24.402
7. Umezawa, S.; Tatsuta, K.; Fujimoto, K.; Tsuchiya, T.; Umezawa, H. J. Antibiot. 1972, 25, 267 10.7164/antibiotics.25.267
8. Albright, A. L.; White, J. M. Methods Mol. Biol. 2013, 1055, 149 10.1007/978-1-62703-577-4-11
9. Patel, D.; Bauman, J. D.; Arnold, E. Prog. Biophys. Mol. Biol. 2014, 116, 92 10.1016/j.pbiomolbio.2014.08.004
10. Joseph-McCarthy, D.; Campbell, A. J.; Kern, G.; Moustakas, D. J. Chem. Inf. Model. 2014, 54, 693 10.1021/ci400731w
11. Inokuma, Y.; Yoshioka, S.; Ariyoshi, J.; Arai, T.; Hitora, Y.; Takada, K.; Matsunaga, S.; Rissanen, K.; Fujita, M. Nature 2013, 495, 461 10.1038/nature11990
12. Yoshioka, S.; Inokuma, Y.; Hoshino, M.; H, S.; Fujita, M. Chem. Sci. 2015, 6, 3765 10.1039/C5SC01681A
13. Zhao, B.; Janson, C. A.; Amegadzie, B. Y.; D'Alessio, K.; Griffin, C.; Kurdyla, J.; McQueney, M.; Qiu, X.; Smith, W. W.; Abdel-Meguid, S. S. Nat. Struct. Biol. 1997, 4, 109 10.1038/nsb0297-109
14. Li, Z.; Kienetz, M.; Cherney, M. M.; James, M. N.; Bromme, D. J. Mol. Biol. 2008, 383, 78 10.1016/j.jmb.2008.07.038
15. McGrath, M. E.; Klaus, J. L.; Barnes, M. G.; Bromme, D. Nat. Struct. Biol. 1997, 4, 105 10.1038/nsb0297-105
16. Schroder, E.; Phillips, C.; Garman, E.; Harlos, K.; Crawford, C. FEBS Lett. 1993, 315, 38 10.1016/0014-5793(93)81128-M
17. Lecaille, F.; Choe, Y.; Brandt, W.; Li, Z.; Craik, C. S.; Bromme, D. Biochemistry 2002, 41, 8447 10.1021/bi025638x
18. Sharma, V.; Panwar, P.; O'Donoghue, A. J.; Cui, H.; Guido, R. V.; Craik, C. S.; Bromme, D. Biochem. J. 2015, 465, 163 10.1042/BJ20140809
19. Lee, A. Y.; Smitka, T. A.; Bonjouklian, R.; Clardy, J. Chem. Biol. 1994, 1, 113 10.1016/1074-5521(94)90049-3
20. Williams, L. K.; Zhang, X.; Caner, S.; Tysoe, C.; Nguyen, N. T.; Wicki, J.; Williams, D. E.; Coleman, J.; McNeill, J. H.; Yuen, V.; Andersen, R. J.; Withers, S. G.; Brayer, G. D. Nat. Chem. Biol. 2015, 11, 691 10.1038/nchembio.1865
21. Henderson, P. J. Biochem. J. 1972, 127, 321 10.1042/bj1270321
22. McPhillips, T. M.; McPhillips, S. E.; Chiu, H. J.; Cohen, A. E.; Deacon, A. M.; Ellis, P. J.; Garman, E.; Gonzalez, A.; Sauter, N. K.; Phizackerley, R. P.; Soltis, S. M.; Kuhn, P. J. Synchrotron Radiat. 2002, 9, 401 10.1107/S0909049502015170
23. Soltis, S. M.; Cohen, A. E.; Deacon, A.; Eriksson, T.; Gonzalez, A.; McPhillips, S.; Chui, H.; Dunten, P.; Hollenbeck, M.; Mathews, I.; Miller, M.; Moorhead, P.; Phizackerley, R. P.; Smith, C.; Song, J.; van dem Bedem, H.; Ellis, P.; Kuhn, P.; McPhillips, T.; Sauter, N.; Sharp, K.; Tsyba, I.; Wolf, G. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2008, 64, 1210 10.1107/S0907444908030564
24. Cohen, A. E.; Ellis, P. J.; Miller, M. D.; Deacon, A. M.; Phizackerley, R. P. J. Appl. Crystallogr. 2002, 35, 720 10.1107/S0021889802016709
25. Leslie, A. Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography 01; 1992, No. 26.
26. Collaborative Computational Project, N Acta Crystallogr., Sect. D: Biol. Crystallogr. 1994, 50, 760 10.1107/S0907444994003112
27. McCoy, A. J.; Grosse-Kunstleve, R. W.; Adams, P. D.; Winn, M. D.; Storoni, L. C.; Read, R. J. J. Appl. Crystallogr. 2007, 40, 658 10.1107/S0021889807021206
28. Emsley, P.; Cowtan, K. Acta Crystallogr., Sect. D: Biol. Crystallogr. 2004, 60, 2126 10.1107/S0907444904019158