The Heart Failure Overweight/Obesity Survival Paradox: The Missing Sex Link

JACC: Heart Failure

Volumn 3, Issue 11, 2015, Pages 917-926

  Vest, Amanda R ^a   Wu, Yuping ^b   Hachamovitch, Rory ^a   Young, James B ^a   Cho, Leslie ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

Author keywords

female; gender; heart failure; obesity; overweight

Indexed keywords

ADULT; AGED; BODY MASS; COMPARATIVE STUDY; COMPLICATION; EXERCISE TEST; FEMALE; FOLLOW UP; HEART FAILURE, SYSTOLIC; HEART STROKE VOLUME; HUMAN; MALE; MIDDLE AGED; MORTALITY; OBESITY; PATHOPHYSIOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SEX RATIO; SURVIVAL ANALYSIS;

ADULT; AGED; BODY MASS INDEX; EXERCISE TEST; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE, SYSTOLIC; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEX DISTRIBUTION; STROKE VOLUME; SURVIVAL ANALYSIS;

EID: 84984844786     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2015.06.009     Document Type: Article

References (33)

1. Loehr, L.R., Rosamond, W.D., Poole, C., et al. Association of multiple anthropometrics of overweight and obesity with incident heart failure. Circ Heart Fail 2 (2009), 18–24.
2. Djoussé, L., Bartz, T.M., Ix, J.H., et al. Adiposity and incident heart failure in older adults: the cardiovascular health study. Obesity (Silver Spring) 20 (2011), 1936–1941.
3. Hu, G., Jousilahti, P., Antikainen, R., Katzmarzyk, P.T., Tuomilehto, J., Joint effects of physical activity, body mass index, waist circumference, and waist-to-hip ratio on the risk of heart failure. Circulation 121 (2010), 237–244.
4. Horwich, T.B., Fonarow, G.C., Hamilton, M.A., MacLellan, W.R., Woo, M.A., Tillisch, J.H., The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol 38 (2001), 789–795.
5. Curtis, J.P., Selter, J.G., Wang, Y., et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 165 (2005), 55–61.
6. Fonarow, G.C., Srikanthan, P., Costanzo, M.R., Cintron, G.B., Lopatin, M., An obesity paradox in acute heart failure: analysis of body mass index and inhospital mortality for 108,927 patients in the Acute Decompensated Heart Failure National Registry. Am Heart J 153 (2007), 74–81.
7. Futter, J.E., Cleland, J.G.F., Clark, A.L., Body mass indices and outcome in patients with chronic heart failure. Eur J Heart Fail 13 (2011), 207–213.
8. Horwich, T.B., Broderick, S., Chen, L., et al. Relation among body mass index, exercise training, and outcomes in chronic systolic heart failure. Am J Cardiol 108 (2011), 1754–1759.
9. Lavie, C.J., Alpert, M.A., Arena, R., Mehra, M.R., Milani, R.V., Ventura, H.O., Impact Of obesity and the obesity paradox on prevalence and prognosis in heart failure. J Am Coll Cardiol HF 1 (2013), 93–102.
10. Clark, A.L., Fonarow, G.C., Horwich, T.B., Obesity and the obesity paradox in heart failure. Prog Cardiovasc Dis 56 (2014), 409–414.
11. Ghali, J.K., Krause-Steinrauf, H.J., Adams, K.F., et al. Gender differences in advanced heart failure: insights from the BEST Study. J Am Coll Cardiol 42 (2003), 2128–2134.
12. Gustafsson, F., Torp-Pedersen, C., Burchardt, H., et al. Female sex is associated with a better long-term survival in patients hospitalized with congestive heart failure. Eur Heart J 25 (2004), 129–135.
13. O'Meara, E., Clayton, T., McEntegart, M.B., et al. Sex differences in clinical characteristics and prognosis in a broad spectrum of patients with heart failure: results of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) Program. Circulation 115 (2007), 3111–3120.
14. Peterson, L.R., Soto, P.F., Herrero, P., et al. Impact of gender on the myocardial metabolic response to obesity. J Am Coll Cardiol Img 1 (2008), 424–433.
15. Robbins, M., Francis, G., Pashkow, F.J., et al. Ventilatory and heart rate responses to exercise: better predictors of heart failure mortality than peak oxygen consumption. Circulation 100 (1999), 2411–2417.
16. Boer, P., Estimated lean body mass as an index for normalization of body fluid volumes in humans. Am J Physiol 247 (1984), F632–F636.
17. Osman, A.F., Mehra, M.R., Lavie, C.J., Nunez, E., Milani, R.V., The incremental prognostic importance of body fat adjusted peak oxygen consumption in chronic heart failure. J Am Coll Cardiol 36 (2000), 2126–2131.
18. Herrero, P., Soto, P.F., Dence, C.S., et al. Impact of hormone replacement on myocardial fatty acid metabolism: potential role of estrogen. J Nucl Cardiol 12 (2005), 574–581.
19. Mittendorfer, B., Sexual dimorphism in human lipid metabolism. J Nutr 135 (2005), 681–686.
20. Hsich, E., Chadalavada, S., Krishnaswamy, G., et al. Long-term prognostic value of peak oxygen consumption in women versus men with heart failure and severely impaired left ventricular systolic function. Am J Cardiol 100 (2007), 291–295.
21. Menzaghi, C., Xu, M., Salvemini, L., et al. Circulating adiponectin and cardiovascular mortality in patients with type 2 diabetes mellitus: evidence of sexual dimorphism. Cardiovasc Diabetol, 13, 2014, 130.
22. Lavie, C.J., Osman, A.F., Milani, R.V., Mehra, M.R., Body composition and prognosis in chronic systolic heart failure: the obesity paradox. Am J Cardiol 91 (2003), 891–894.
23. Clark, A.L., Chyu, J., Horwich, T.B., The obesity paradox in men versus women with systolic heart failure. Am J Cardiol 110 (2012), 77–82.
24. Shah, R., Gayat, E., Januzzi, J.L., et al. Body mass index and mortality in acutely decompensated heart failure across the world: a global obesity paradox. J Am Coll Cardiol 63 (2014), 778–785.
25. Güder, G., Frantz, S., Bauersachs, J., et al. Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors. Circ Heart Fail 2 (2009), 563–571.
26. Lavie, C.J., Cahalin, L.P., Chase, P., et al. Impact of cardiorespiratory fitness on the obesity paradox in patients with heart failure. Mayo Clin Proc 88 (2013), 251–258.
27. Lavie, C.J., McAuley, P.A., Church, T.S., Milani, R.V., Blair, S.N., Obesity and cardiovascular diseases—implications regarding fitness, fatness and severity in the obesity paradox. J Am Coll Cardiol 63 (2014), 1345–1354.
28. Barry, V.W., Baruth, M., Beets, M.W., Durstine, J.L., Liu, J., Blair, S.N., Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis 56 (2014), 382–390.
29. Clark, A.L., Fonarow, G.C., Horwich, T.B., Impact of cardiorespiratory fitness on the obesity paradox in patients with systolic heart failure. Am J Cardiol 115 (2015), 209–213.
30. McAuley, P.A., Beavers, K.M., Contribution of cardiorespiratory fitness to the obesity paradox. Prog Cardiovasc Dis 56 (2014), 434–440.
31. Prentice, A.M., Jebb, S.A., Beyond body mass index. Obes Rev 2 (2001), 141–147.
32. Crespo, J., Lavie, C.J., Milani, R.V., Gilliland, Y.E., Patel, H.M., Ventura, H.O., Metabolic parameters derived from cardiopulmonary stress testing for prediction of prognosis in patients with heart failure: the Ochsner experience. Ochsner J 9 (2009), 46–53.
33. De Schutter, A., Lavie, C.J., Kachur, S., Patel, D.A., Milani, R.V., Body composition and mortality in a large cohort with preserved ejection fraction: untangling the obesity paradox. Mayo Clin Proc 89 (2014), 1072–1079.