Impact of Gender on the Myocardial Metabolic Response to Obesity

JACC: Cardiovascular Imaging

Volumn 1, Issue 4, 2008, Pages 424-433

  Peterson, Linda R ^a,b   Soto, Pablo F ^a,b   Herrero, Pilar ^b   Mohammed, B Selma ^a   Avidan, Michael S ^a   Schechtman, Kenneth B ^a   Dence, Carmen ^b   Gropler, Robert J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

gender; myocardial blood flow; myocardial efficiency; myocardial metabolism; obesity; positron emission tomography

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LIPID; TRIACYLGLYCEROL;

ADULT; AGE DISTRIBUTION; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HEART DISEASE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART VENTRICLE REMODELING; HEART WORK; HUMAN; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL;

ADAPTATION, PHYSIOLOGICAL; ADULT; CORONARY CIRCULATION; ECHOCARDIOGRAPHY, DOPPLER; ENERGY METABOLISM; FATTY ACIDS; FEMALE; GLUCOSE; HEART FAILURE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; MYOCARDIUM; OBESITY; OXYGEN CONSUMPTION; POSITRON-EMISSION TOMOGRAPHY; PROSPECTIVE STUDIES; SEX FACTORS; VENTRICULAR FUNCTION, LEFT; YOUNG ADULT;

EID: 47349115249     PISSN: 1936878X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcmg.2008.05.004     Document Type: Article

References (27)

1. Kenchaiah S., Evans J.C., Levy D., et al. Obesity and the risk of heart failure. N Engl J Med 347 (2002) 305-313
2. Alpert M.A. Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. Am J Med Sci 321 (2001) 225-236
3. Peterson L.R., Waggoner A.D., Schechtman K.B., et al. Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 43 (2004) 1399-1404
4. Zhou Y.T., Grayburn P., Karim A., et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A 97 (2000) 1784-1789
5. Peterson L.R., Herrero P., Schechtman K.B., et al. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109 (2004) 2191-2196
6. Knuuti J., Takala T.O., Nagren K., et al. Myocardial fatty acid oxidation in patients with impaired glucose tolerance. Diabetologia 44 (2001) 184-187
7. Turpeinen A.K., Kuikka J.T., Vanninen E., and Uusitupa M.I. Abnormal myocardial kinetics of 123I-heptadecanoic acid in subjects with impaired glucose tolerance. Diabetologia 40 (1997) 541-549
8. Tarnopolsky L.J., MacDougall J.D., Atkinson S.A., Tarnopolsky M.A., and Sutton J.R. Gender differences in substrate for endurance exercise. J Appl Physiol 68 (1990) 302-308
9. Mittendorfer B., Patterson B.W., Klein S., and Sidossis L.S. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of gender and obesity. Am J Physiol Endocrinol Metab 284 (2003) E708-E715
10. Peterson L.R., Soto P.F., Herrero P., Schechtman K.B., Dence C., and Gropler R.J. Gender differences in myocardial oxygen and glucose metabolism. J Nucl Cardiol 14 (2007) 573-581
11. Bergmann S.R., Herrero P., Markham J., Weinheimer C.J., and Walsh M.N. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol 14 (1989) 639-652
12. Buck A., Wolpers H.G., Hutchins G.D., et al. Effect of carbon-11-acetate recirculation on estimates of myocardial oxygen consumption by PET. J Nucl Med 32 (1991) 1950-1957
13. Herrero P., Weinheimer C.J., Dence C., Oellerich W.F., and Gropler R.J. Quantification of myocardial glucose utilization by PET and 1-carbon-11-glucose. J Nucl Cardiol 9 (2002) 5-14
14. Bergmann S.R., Weinheimer C.J., Markham J., and Herrero P. Quantitation of myocardial fatty acid metabolism using positron emission tomography. J Nucl Med 37 (1996) 1723-1730
15. Kates A.M., Herrero P., Dence C., et al. Impact of aging on substrate metabolism by the human heart. J Am Coll Cardiol 41 (2003) 293-299
16. Sundell J., Laine H., Luotolahti M., et al. Obesity affects myocardial vasoreactivity and coronary flow response to insulin. Obes Res 10 (2002) 617-624
17. Kunnas T.A., Lehtimaki T., Karhunen P.J., et al. Estrogen receptor genotype modulates myocardial perfusion in young men. J Mol Med 82 (2004) 821-825
18. Collins P., Rosano G.M., Sarrel P.M., et al. 17 beta-Estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease. Circulation 92 (1995) 24-30
19. Murray A.J., Anderson R.E., Watson G.C., Radda G.K., and Clarke K. Uncoupling proteins in human heart. Lancet 364 (2004) 1786-1788
20. Pedersen S.B., Bruun J.M., Kristensen K., and Richelsen B. Regulation of UCP1, UCP2, and UCP3 mRNA expression in brown adipose tissue, white adipose tissue, and skeletal muscle in rats by estrogen. Biochem Biophys Res Commun 288 (2001) 191-197
21. Hatta H., Atomi Y., Shinohara S., Yamamoto Y., and Yamada S. The effects of ovarian hormones on glucose and fatty acid oxidation during exercise in female ovariectomized rats. Horm Metab Res 20 (1988) 609-611
22. Mittendorfer B. Gender dimorphism in human lipid metabolism. J Nutr 135 (2005) 681-686
23. Lei B., Matsuo K., Labinskyy V., et al. Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo. Proc Natl Acad Sci U S A 102 (2005) 6966-6971
24. Turpeinen A.K., Takala T.O., Nuutila P., et al. Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid. Diabetes 48 (1999) 1245-1250
25. Ellis G.S., Lanza-Jacoby S., Gow A., and Kendrick Z.V. Effects of estradiol on lipoprotein lipase activity and lipid availability in exercised male rats. J Appl Physiol 77 (1994) 209-215
26. Campbell S.E., and Febbraio M.A. Effect of ovarian hormones on mitochondrial enzyme activity in the fat oxidation pathway of skeletal muscle. Am J Physiol Endocrinol Metab 281 (2001) E803-E808
27. Aasum E., Hafstad A.D., Severson D.L., and Larsen T.S. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52 (2003) 434-441