An outbreak of clostridium difficile ribotype 027 associated with length of stay in the intensive care unit and use of selective decontamination of the digestive tract: A case control study

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Van Beurden, Yvette H ^a   Dekkers, Olaf M ^b   Bomers, Marije K ^a   Kaiser, Annie M ^a   Van Houdt, Robin ^a   Knetsch, Cornelis W ^b   Girbes, Armand R J ^a   Mulder, Chris J J ^a   Vandenbroucke Grauls, Christina M J E ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; CARBAPENEM; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; MACROLIDE; METRONIDAZOLE; PENICILLIN DERIVATIVE; PROTON PUMP INHIBITOR; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

ADULT; AGED; ARTICLE; BACTERIAL STRAIN; CASE CONTROL STUDY; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; EPIDEMIC; FEMALE; GENE SEQUENCE; GENOTYPE; HOSPITAL ADMISSION; HUMAN; INFECTION; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; RIBOTYPING; SANITATION; SELECTIVE DECONTAMINATION OF THE DIGESTIVE TRACT; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE NUCLEOTIDE VARIANT; WHOLE GENOME SEQUENCING; CLASSIFICATION; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DECONTAMINATION; GASTROINTESTINAL TRACT; GENETICS; INCIDENCE; MICROBIOLOGY; MIDDLE AGED; MORTALITY; NETHERLANDS; PEPTOCLOSTRIDIUM DIFFICILE; PROCEDURES; RISK FACTOR; UNIVERSITY HOSPITAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DECONTAMINATION; DISEASE OUTBREAKS; FEMALE; GASTROINTESTINAL TRACT; HOSPITALS, UNIVERSITY; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; NETHERLANDS; RIBOTYPING; RISK FACTORS;

EID: 84984820131     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160778     Document Type: Article

References (23)

1. Ghose C. Clostridium difficile infection in the twenty-first century. Emerg Microbes Infect 2013 Sep; 2(9):e62. doi: 10.1038/emi.2013.62 PMID: 26038491
2. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, et al. A predominantly clonal multiinstitutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005 Dec. 8;353(23):2442-9. PMID: 16322602
3. Miller M, Gravel D, Mulvey M, Taylor G, Boyd D, Simor A, et al. Health care-associated Clostridium difficile infection in Canada: patient age and infecting strain type are highly predictive of severe outcome and mortality. Clin Infect Dis 2010 Jan 15;50(2):194-201. doi: 10.1086/649213 PMID: 20025526
4. Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med 2015 Apr. 16;372(16):1539-48. doi: 10.1056/NEJMra1403772 PMID: 25875259
5. Ananthakrishnan AN. Clostridium difficile infection: epidemiology, riskfactors and management. Nat Rev Gastroenterol Hepatol 2011 Jan; 8(1):17-26. doi: 10.1038/nrgastro.2010.190 PMID: 21119612
6. Stevens VW, Khader K, Nelson RE, Jones M, Rubin MA, Brown KA, et al. Excess Length of Stay Attributable to Clostridium difficile Infection (CDI) in the Acute Care Setting: A Multistate Model. Infect Control Hosp Epidemiol 2015 Sep; 36(9):1024-30. doi: 10.1017/ice.2015.132 PMID: 26006153
7. van Prehn J, Vandenbroucke-Grauls C, van Beurden Y, van Houdt R, Vainio S, Ang C. Diagnostic yield of repeat sampling with immunoassay, real-time PCR, and toxigenic culture for the detection of toxigenic Clostridium difficile in an epidemic and a non-epidemic setting. Eur J Clin Microbiol Infect Dis 2015 Sep. 16.
8. Bruijnesteijn van Coppenraet LES, Savelkoul PHM, Buffing N, van der Bijl MW, Woudenberg J, Lindeboom JA, et al. Amplified fragment length polymorphism analysis of human clinical isolates of Mycobacterium haemophilum from different continents. Clin Microbiol Infect 2009 Oct; 15(10):924-30. doi: 10. 1111/j.1469-0691.2009.02798.x PMID: 19659689
9. Bentley DR, Balasubramanian S, Swerdlow HP, Smith GP, Milton J, Brown CG, et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 2008 Nov. 6;456(7218):53-9. doi: 10.1038/nature07517 PMID: 18987734
10. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40(5):373-83. PMID: 3558716
11. Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients. Crit Care Med 2006 May; 34(5):1297-310. PMID: 16540951
12. Knetsch CW, Connor TR, Mutreja A, van Dorp SM, Sanders IM, Browne HP, et al. Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011. Euro Surveill 2014;19(45):20954. PMID: 25411691
13. Oostdijk EAN, Kesecioglu J, Schultz MJ, Visser CE, de Jonge E, van Essen EHR, et al. Effects of decontamination of the oropharynx and intestinal tract on antibiotic resistance in ICUs: a randomized clinical trial. JAMA 2014 Oct. 8;312(14):1429-37. doi: 10.1001/jama.2014.7247 PMID: 25271544
14. Janarthanan S, Ditah I, Adler DG, Ehrinpreis MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol 2012 Jul; 107(7):1001-10. doi: 10.1038/ajg.2012.179 PMID: 22710578
15. Hensgens MPM, Goorhuis A, van Kinschot CMJ, Crobach MJT, Harmanus C, Kuijper EJ. Clostridium difficile infection in an endemic setting in the Netherlands. Eur J Clin Microbiol Infect Dis 2011 Apr; 30(4):587-93. doi: 10.1007/s10096-010-1127-4 PMID: 21194003
16. Lofgren ET, Cole SR, Weber DJ, Anderson DJ, Moehring RW. Hospital-acquired Clostridium difficile infections: estimating all-cause mortality and length of stay. Epidemiology 2014 Jul; 25(4):n570-5. doi: 10.1097/EDE.0000000000000119 PMID: 24815305
17. Jernberg C, Lofmark S, Edlund C, Jansson JK. Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology 2010 Nov; 156(Pt 11):3216-23. doi: 10.1099/mic.0.040618-0 PMID: 20705661
18. Dethlefsen L, Huse S, Sogin ML, Relman DA. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoSBiol 2008 Nov. 18;6(11):e280. doi: 10. 1371/journal.pbio.0060280 PMID: 19018661
19. Hensgens MPM, Goorhuis A, Dekkers OM, Kuijper EJ. Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics. J Antimicrob Chemother 2012 Mar; 67(3):742-8. doi: 10. 1093/jac/dkr508 PMID: 22146873
20. Stevens V, Dumyati G, Fine LS, Fisher SG, van Wijngaarden E. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin Infect Dis 2011 Jul. 1;53(1):42-8. doi: 10.1093/cid/cir301 PMID: 21653301
21. Daneman N, Sarwar S, Fowler RA, Cuthbertson BH. Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis 2013 Apr; 13(4):328-41. doi: 10.1016/S1473-3099 (12) 70322-5 PMID: 23352693
22. Archibald LK, Banerjee SN, Jarvis WR. Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001. J Infect Dis 2004 May 1;189(9):1585-9. PMID: 15116293
23. Lawrence SJ, Puzniak LA, Shadel BN, Gillespie KN, Kollef MH, Mundy LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 2007 Feb; 28(2):123-30. PMID: 17265392