메뉴 건너뛰기




Volumn 59, Issue 12, 2016, Pages 2579-2587

Effects of linagliptin on renal endothelial function in patients with type 2 diabetes: a randomised clinical trial

Author keywords

DPP 4 inhibitor; Endothelial function; Nitric oxide; Renal; Type 2 diabetes

Indexed keywords

ALBUMIN; ARGININE; CREATININE; GLUCOSE; HEMOGLOBIN A1C; LINAGLIPTIN; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

EID: 84984791882     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4083-4     Document Type: Article
Times cited : (23)

References (41)
  • 1
    • 33845234269 scopus 로고    scopus 로고
    • Urinary albumin excretion and glomerular filtration rate across the spectrum of glucose abnormalities in essential hypertension
    • COI: 1:CAS:528:DC%2BD28XhtlCntLrO
    • Redon J, Morales-Olivas F, Galgo A et al (2006) Urinary albumin excretion and glomerular filtration rate across the spectrum of glucose abnormalities in essential hypertension. J Am Soc Nephrol 17:S236–S245
    • (2006) J Am Soc Nephrol , vol.17 , pp. S236-S245
    • Redon, J.1    Morales-Olivas, F.2    Galgo, A.3
  • 2
    • 77954170602 scopus 로고    scopus 로고
    • Prevention of microalbuminuria in patients with type 2 diabetes: what do we know?
    • Ruilope L, Izzo J, Haller H et al (2010) Prevention of microalbuminuria in patients with type 2 diabetes: what do we know? J Clin Hypertens 12:422–430
    • (2010) J Clin Hypertens , vol.12 , pp. 422-430
    • Ruilope, L.1    Izzo, J.2    Haller, H.3
  • 3
    • 79551582074 scopus 로고    scopus 로고
    • Reduction in basal nitric oxide activity causes albuminuria
    • COI: 1:CAS:528:DC%2BC3MXisVOmu70%3D
    • Ott C, Schneider MP, Delles C, Schlaich MP, Schmieder RE (2011) Reduction in basal nitric oxide activity causes albuminuria. Diabetes 60:572–576
    • (2011) Diabetes , vol.60 , pp. 572-576
    • Ott, C.1    Schneider, M.P.2    Delles, C.3    Schlaich, M.P.4    Schmieder, R.E.5
  • 4
    • 38349120435 scopus 로고    scopus 로고
    • Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia
    • COI: 1:CAS:528:DC%2BD1cXhsVCju70%3D
    • Ott C, Schlaich MP, Schmidt BM, Titze SI, Schaufele T, Schmieder RE (2008) Rosuvastatin improves basal nitric oxide activity of the renal vasculature in patients with hypercholesterolemia. Atherosclerosis 196:704–711
    • (2008) Atherosclerosis , vol.196 , pp. 704-711
    • Ott, C.1    Schlaich, M.P.2    Schmidt, B.M.3    Titze, S.I.4    Schaufele, T.5    Schmieder, R.E.6
  • 5
    • 58249108732 scopus 로고    scopus 로고
    • Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BD1MXivVWgsbo%3D
    • Ritt M, Ott C, Raff U et al (2009) Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis 53:281–289
    • (2009) Am J Kidney Dis , vol.53 , pp. 281-289
    • Ritt, M.1    Ott, C.2    Raff, U.3
  • 6
    • 0033982133 scopus 로고    scopus 로고
    • Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD3cXks1OgsA%3D%3D
    • Veelken R, Hilgers KF, Hartner A, Haas A, Bohmer KP, Sterzel RB (2000) Nitric oxide synthase isoforms and glomerular hyperfiltration in early diabetic nephropathy. J Am Soc Nephrol 11:71–79
    • (2000) J Am Soc Nephrol , vol.11 , pp. 71-79
    • Veelken, R.1    Hilgers, K.F.2    Hartner, A.3    Haas, A.4    Bohmer, K.P.5    Sterzel, R.B.6
  • 7
    • 37349073089 scopus 로고    scopus 로고
    • Basal nitric oxide synthase activity is a major determinant of glomerular haemodynamics in humans
    • COI: 1:CAS:528:DC%2BD2sXhsVCjsrjJ
    • Schlaich MP, Schmitt D, Ott C, Schmidt BM, Schmieder RE (2008) Basal nitric oxide synthase activity is a major determinant of glomerular haemodynamics in humans. J Hypertens 26:110–116
    • (2008) J Hypertens , vol.26 , pp. 110-116
    • Schlaich, M.P.1    Schmitt, D.2    Ott, C.3    Schmidt, B.M.4    Schmieder, R.E.5
  • 8
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • COI: 1:STN:280:DC%2BD2M7pvFyhsw%3D%3D
    • Holst JJ, Deacon CF (2005) Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 48:612–615
    • (2005) Diabetologia , vol.48 , pp. 612-615
    • Holst, J.J.1    Deacon, C.F.2
  • 9
    • 22144437777 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats
    • Ozyazgan S, Kutluata N, Afsar S, Ozdas SB, Akkan AG (2005) Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats. Pharmacology 74:119–126
    • (2005) Pharmacology , vol.74 , pp. 119-126
    • Ozyazgan, S.1    Kutluata, N.2    Afsar, S.3    Ozdas, S.B.4    Akkan, A.G.5
  • 10
    • 80051752340 scopus 로고    scopus 로고
    • Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways
    • COI: 1:CAS:528:DC%2BC3MXhtVKmurvK
    • Shah Z, Pineda C, Kampfrath T et al (2011) Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways. Vasc Pharmacol 55:2–9
    • (2011) Vasc Pharmacol , vol.55 , pp. 2-9
    • Shah, Z.1    Pineda, C.2    Kampfrath, T.3
  • 11
    • 84906957817 scopus 로고    scopus 로고
    • Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats
    • COI: 1:CAS:528:DC%2BC2cXhsV2lsLrL
    • Takai S, Sakonjo H, Jin D (2014) Significance of vascular dipeptidyl peptidase-4 inhibition on vascular protection in Zucker diabetic fatty rats. J Pharmacol Sci 125:386–393
    • (2014) J Pharmacol Sci , vol.125 , pp. 386-393
    • Takai, S.1    Sakonjo, H.2    Jin, D.3
  • 12
    • 84964314896 scopus 로고    scopus 로고
    • DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure
    • Koibuchi N, Hasegawa Y, Katayama T et al (2014) DPP-4 inhibitor linagliptin ameliorates cardiovascular injury in salt-sensitive hypertensive rats independently of blood glucose and blood pressure. Cardiovasc Diabetol 13:157
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 157
    • Koibuchi, N.1    Hasegawa, Y.2    Katayama, T.3
  • 13
    • 84929469873 scopus 로고    scopus 로고
    • Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis
    • COI: 1:CAS:528:DC%2BC2cXhvVekur%2FI
    • Nakashima S, Matsui T, Takeuchi M, Yamagishi SI (2014) Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis. Horm Metab Res 46:717–721
    • (2014) Horm Metab Res , vol.46 , pp. 717-721
    • Nakashima, S.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.I.4
  • 14
    • 0028576415 scopus 로고
    • Renal hemodynamic response to stress is influenced by ACE-inhibitors
    • COI: 1:CAS:528:DyaK2MXjsF2ltro%3D
    • Schmieder RE, Gatzka C, Schobel H, Schachinger H, Weihprecht H (1994) Renal hemodynamic response to stress is influenced by ACE-inhibitors. Clin Nephrol 42:381–388
    • (1994) Clin Nephrol , vol.42 , pp. 381-388
    • Schmieder, R.E.1    Gatzka, C.2    Schobel, H.3    Schachinger, H.4    Weihprecht, H.5
  • 16
    • 0001459424 scopus 로고
    • The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man
    • COI: 1:CAS:528:DyaH2MXitl2itA%3D%3D
    • Smith HW, Finkelstein N, Aliminosa L, Crawford B, Graber M (1945) The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J Clin Invest 24:388–404
    • (1945) J Clin Invest , vol.24 , pp. 388-404
    • Smith, H.W.1    Finkelstein, N.2    Aliminosa, L.3    Crawford, B.4    Graber, M.5
  • 17
    • 0001704334 scopus 로고
    • Evaluation of renal resistances, with special reference to changes in essential hypertension
    • COI: 1:STN:280:DyaG38%2FhvVyjsA%3D%3D
    • Gomez DM (1951) Evaluation of renal resistances, with special reference to changes in essential hypertension. J Clin Invest 30:1143–1155
    • (1951) J Clin Invest , vol.30 , pp. 1143-1155
    • Gomez, D.M.1
  • 18
    • 0035109563 scopus 로고    scopus 로고
    • Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy
    • COI: 1:STN:280:DC%2BD3M3hsVSlsw%3D%3D
    • Guidi E, Cozzi MG, Minetti EE, Civati G, Busnach G, Brando B (2001) Effect of familial hypertension on glomerular hemodynamics and tubulo-glomerular feedback after uninephrectomy. Am J Hypertens 14:121–128
    • (2001) Am J Hypertens , vol.14 , pp. 121-128
    • Guidi, E.1    Cozzi, M.G.2    Minetti, E.E.3    Civati, G.4    Busnach, G.5    Brando, B.6
  • 19
    • 70649089013 scopus 로고    scopus 로고
    • Rosuvastatin does not affect intrarenal hemodynamics in patients with hypercholesterolemia
    • COI: 1:CAS:528:DC%2BD1MXhs1Wiu7vF
    • Ott C, Ritt M, Titze SI, Schaufele T, Schmieder RE (2009) Rosuvastatin does not affect intrarenal hemodynamics in patients with hypercholesterolemia. J Nephrol 22:675–681
    • (2009) J Nephrol , vol.22 , pp. 675-681
    • Ott, C.1    Ritt, M.2    Titze, S.I.3    Schaufele, T.4    Schmieder, R.E.5
  • 20
    • 84871164251 scopus 로고    scopus 로고
    • Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension
    • COI: 1:CAS:528:DC%2BC38XhvVGmsbnK
    • Ott C, Schneider MP, Raff U et al (2013) Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension. Br J Clin Pharmacol 75:129–135
    • (2013) Br J Clin Pharmacol , vol.75 , pp. 129-135
    • Ott, C.1    Schneider, M.P.2    Raff, U.3
  • 21
    • 34249869003 scopus 로고    scopus 로고
    • Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXntlWksLs%3D
    • Schmieder RE, Delles C, Mimran A, Fauvel JP, Ruilope LM (2007) Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care 30:1351–1356
    • (2007) Diabetes Care , vol.30 , pp. 1351-1356
    • Schmieder, R.E.1    Delles, C.2    Mimran, A.3    Fauvel, J.P.4    Ruilope, L.M.5
  • 22
    • 0027311108 scopus 로고
    • Role of EDRF (nitric oxide) in diabetic renal hyperfiltration
    • COI: 1:STN:280:DyaK3szgt1amtw%3D%3D
    • Bank N, Aynedjian HS (1993) Role of EDRF (nitric oxide) in diabetic renal hyperfiltration. Kidney Int 43:1306–1312
    • (1993) Kidney Int , vol.43 , pp. 1306-1312
    • Bank, N.1    Aynedjian, H.S.2
  • 23
    • 0033946110 scopus 로고    scopus 로고
    • Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration
    • COI: 1:CAS:528:DC%2BD3cXkslOqtL4%3D
    • Chiarelli F, Cipollone F, Romano F et al (2000) Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration. Diabetes 49:1258–1263
    • (2000) Diabetes , vol.49 , pp. 1258-1263
    • Chiarelli, F.1    Cipollone, F.2    Romano, F.3
  • 24
    • 45849154964 scopus 로고    scopus 로고
    • Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats
    • COI: 1:CAS:528:DyaK2sXmt1CqtLw%3D
    • Choi KC, Kim NH, An MR, Kang DG, Kim SW, Lee J (1997) Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats. Kidney Int Suppl 60:S23–S27
    • (1997) Kidney Int Suppl , vol.60 , pp. S23-S27
    • Choi, K.C.1    Kim, N.H.2    An, M.R.3    Kang, D.G.4    Kim, S.W.5    Lee, J.6
  • 26
    • 21044436751 scopus 로고    scopus 로고
    • NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy
    • COI: 1:CAS:528:DC%2BD2MXlsVymtro%3D
    • Satoh M, Fujimoto S, Haruna Y et al (2005) NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy. Am J Physiol Renal Physiol 288:F1144–F1152
    • (2005) Am J Physiol Renal Physiol , vol.288 , pp. F1144-F1152
    • Satoh, M.1    Fujimoto, S.2    Haruna, Y.3
  • 27
    • 84891851622 scopus 로고    scopus 로고
    • Poor glycemic control is related to increased nitric oxide activity within the renal circulation of patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFaksLjI
    • Schneider MP, Ott C, Schmidt S, Kistner I, Friedrich S, Schmieder RE (2013) Poor glycemic control is related to increased nitric oxide activity within the renal circulation of patients with type 2 diabetes. Diabetes Care 36:4071–4075
    • (2013) Diabetes Care , vol.36 , pp. 4071-4075
    • Schneider, M.P.1    Ott, C.2    Schmidt, S.3    Kistner, I.4    Friedrich, S.5    Schmieder, R.E.6
  • 29
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • COI: 1:CAS:528:DyaK28Xhtlajur4%3D
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA (1996) Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97:22–28
    • (1996) J Clin Invest , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 30
    • 33645745733 scopus 로고    scopus 로고
    • Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28XjsVequ7k%3D
    • Monnier L, Mas E, Ginet C et al (2006) Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295:1681–1687
    • (2006) JAMA , vol.295 , pp. 1681-1687
    • Monnier, L.1    Mas, E.2    Ginet, C.3
  • 31
    • 84866645242 scopus 로고    scopus 로고
    • Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition
    • COI: 1:CAS:528:DC%2BC38Xhs1Gks7%2FK
    • Rizzo MR, Barbieri M, Marfella R, Paolisso G (2012) Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition. Diabetes Care 35:2076–2082
    • (2012) Diabetes Care , vol.35 , pp. 2076-2082
    • Rizzo, M.R.1    Barbieri, M.2    Marfella, R.3    Paolisso, G.4
  • 32
    • 33845479510 scopus 로고    scopus 로고
    • Serum and urinary nitrites and nitrates and Doppler sonography in children with diabetes
    • Savino A, Pelliccia P, Schiavone C et al (2006) Serum and urinary nitrites and nitrates and Doppler sonography in children with diabetes. Diabetes Care 29:2676–2681
    • (2006) Diabetes Care , vol.29 , pp. 2676-2681
    • Savino, A.1    Pelliccia, P.2    Schiavone, C.3
  • 34
    • 48149097894 scopus 로고    scopus 로고
    • Autonomic renal denervation ameliorates experimental glomerulonephritis
    • COI: 1:CAS:528:DC%2BD1cXovFeks7k%3D
    • Veelken R, Vogel EM, Hilgers K et al (2008) Autonomic renal denervation ameliorates experimental glomerulonephritis. J Am Soc Nephrol 19:1371–1378
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1371-1378
    • Veelken, R.1    Vogel, E.M.2    Hilgers, K.3
  • 35
    • 0031773118 scopus 로고    scopus 로고
    • Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy
    • COI: 1:CAS:528:DyaK1cXnvVaiurg%3D
    • Sugimoto H, Shikata K, Matsuda M et al (1998) Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy. Diabetologia 41:1426–1434
    • (1998) Diabetologia , vol.41 , pp. 1426-1434
    • Sugimoto, H.1    Shikata, K.2    Matsuda, M.3
  • 36
    • 84868686759 scopus 로고    scopus 로고
    • Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA)
    • COI: 1:CAS:528:DC%2BC38XpvFGgtro%3D
    • Peralta CA, Katz R, Bonventre JV et al (2012) Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 60:904–911
    • (2012) Am J Kidney Dis , vol.60 , pp. 904-911
    • Peralta, C.A.1    Katz, R.2    Bonventre, J.V.3
  • 37
    • 84898886016 scopus 로고    scopus 로고
    • Kidney injury molecule (KIM)-1 is associated with insulin resistance: results from two community-based studies of elderly individuals
    • COI: 1:CAS:528:DC%2BC2cXmtlCnsr0%3D
    • Carlsson AC, Calamia M, Riserus U et al (2014) Kidney injury molecule (KIM)-1 is associated with insulin resistance: results from two community-based studies of elderly individuals. Diabetes Res Clin Pract 103:516–521
    • (2014) Diabetes Res Clin Pract , vol.103 , pp. 516-521
    • Carlsson, A.C.1    Calamia, M.2    Riserus, U.3
  • 38
    • 84908075907 scopus 로고    scopus 로고
    • Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes
    • COI: 1:CAS:528:DC%2BC2cXhvFGjt7bO
    • Sabbisetti VS, Waikar SS, Antoine DJ et al (2014) Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol 25:2177–2186
    • (2014) J Am Soc Nephrol , vol.25 , pp. 2177-2186
    • Sabbisetti, V.S.1    Waikar, S.S.2    Antoine, D.J.3
  • 39
    • 84901453059 scopus 로고    scopus 로고
    • Prevention of obesity-induced renal injury in male mice by DPP4 inhibition
    • Nistala R, Habibi J, Lastra G et al (2014) Prevention of obesity-induced renal injury in male mice by DPP4 inhibition. Endocrinology 155:2266–2276
    • (2014) Endocrinology , vol.155 , pp. 2266-2276
    • Nistala, R.1    Habibi, J.2    Lastra, G.3
  • 40
    • 84876780409 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes
    • COI: 1:CAS:528:DC%2BC3sXotFykurs%3D
    • Matsubara J, Sugiyama S, Akiyama E et al (2013) Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes. Circ J 77:1337–1344
    • (2013) Circ J , vol.77 , pp. 1337-1344
    • Matsubara, J.1    Sugiyama, S.2    Akiyama, E.3
  • 41
    • 84876776496 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors--emerging player for vascular protection
    • COI: 1:CAS:528:DC%2BC3sXotFyktbw%3D
    • Satoh K (2013) Dipeptidyl peptidase-4 inhibitors--emerging player for vascular protection. Circ J 77:1156–1157
    • (2013) Circ J , vol.77 , pp. 1156-1157
    • Satoh, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.