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1
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84991246758
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Role of the vagus nerve in the development and treatment of diet-induced obesity
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1 de Lartigue, G., Role of the vagus nerve in the development and treatment of diet-induced obesity. J Physiol, 2016.
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(2016)
J Physiol
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de Lartigue, G.1
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2
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84917743584
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Plasticity of gastro-intestinal vagal afferent endings
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2 Kentish, S.J., Page, A.J., Plasticity of gastro-intestinal vagal afferent endings. Physiol Behav 136 (2014), 170–178.
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Physiol Behav
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Kentish, S.J.1
Page, A.J.2
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3
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84938340373
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Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: impact of age and sex
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3 Li, H., Frisby, C.L., O'Donnell, T.A., Kentish, S.J., Wittert, G.A., Page, A.J., Neuropeptide W modulation of gastric vagal afferent mechanosensitivity: impact of age and sex. Peptides 71 (2015), 141–148.
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Peptides
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Li, H.1
Frisby, C.L.2
O'Donnell, T.A.3
Kentish, S.J.4
Wittert, G.A.5
Page, A.J.6
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4
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84905219892
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Diet-dependent modulation of gastro-oesphageal vagal afferent mechanosensitivity by endogenous nitric oxide
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4 Kentish, S.J., O'Donnell, T.A., Wittert, G.A., Page, A.J., Diet-dependent modulation of gastro-oesphageal vagal afferent mechanosensitivity by endogenous nitric oxide. J Physiol 592 (2014), 3287–3301.
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Kentish, S.J.1
O'Donnell, T.A.2
Wittert, G.A.3
Page, A.J.4
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5
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84961263003
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High-fat diet-induced obesity ablates gastric vagal afferent circadian rhythms
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Evidence that rhythmicity of vagal afferent neurons is abolished in response of a high fat diet, providing a novel putative mechanism by which gut–brain signaling may increase food intake in obesity.
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5• Kentish, S.J., Vincent, A.D., Kennaway, D.J., Wittert, G.A., Page, A.J., High-fat diet-induced obesity ablates gastric vagal afferent circadian rhythms. J Neurosci 36 (2016), 3199–3207 Evidence that rhythmicity of vagal afferent neurons is abolished in response of a high fat diet, providing a novel putative mechanism by which gut–brain signaling may increase food intake in obesity.
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(2016)
J Neurosci
, vol.36
, pp. 3199-3207
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Kentish, S.J.1
Vincent, A.D.2
Kennaway, D.J.3
Wittert, G.A.4
Page, A.J.5
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6
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84899960125
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Altered gastric vagal mechanosensitivity in diet-induced obesity persists on return to normal chow and is accompanied by increased food intake
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6 Kentish, S.J., O'Donnell, T.A., Frisby, C.L., Li, H., Wittert, G.A., Page, A.J., Altered gastric vagal mechanosensitivity in diet-induced obesity persists on return to normal chow and is accompanied by increased food intake. Int J Obes (Lond) 38 (2014), 636–642.
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Int J Obes (Lond)
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Kentish, S.J.1
O'Donnell, T.A.2
Frisby, C.L.3
Li, H.4
Wittert, G.A.5
Page, A.J.6
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7
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84969988922
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Sensory neurons that detect stretch and nutrients in the digestive system
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Technical tour de force identifying genetic markers for vagal afferent neurons innervating the gastrointestinal tract. Optogenetics and calcium imaging was used in vagal afferent neurons in vivo to determine response to gastrointestinal signals and function of two subpopulations of vagal afferent neurons. Identification of unsuspected role of GLP1R encoded VANs in mechanosensitivity.
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7•• Williams, E.K., Chang, R.B., Strochlic, D.E., Umans, B.D., Lowell, B.B., Liberles, S.D., Sensory neurons that detect stretch and nutrients in the digestive system. Cell, 2016 Technical tour de force identifying genetic markers for vagal afferent neurons innervating the gastrointestinal tract. Optogenetics and calcium imaging was used in vagal afferent neurons in vivo to determine response to gastrointestinal signals and function of two subpopulations of vagal afferent neurons. Identification of unsuspected role of GLP1R encoded VANs in mechanosensitivity.
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(2016)
Cell
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Williams, E.K.1
Chang, R.B.2
Strochlic, D.E.3
Umans, B.D.4
Lowell, B.B.5
Liberles, S.D.6
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8
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84904255671
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Ability of GLP-1 to decrease food intake is dependent on nutritional status
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8 Ronveaux, C.C., de Lartigue, G., Raybould, H.E., Ability of GLP-1 to decrease food intake is dependent on nutritional status. Physiol Behav 135 (2014), 222–229.
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Ronveaux, C.C.1
de Lartigue, G.2
Raybould, H.E.3
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9
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84962144025
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Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia
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Impressive study selectively knocking down GLP1R in vagal afferent neurons. Conclusively demonstrates that GLP1 mediates satiation, inhibition of gastric emptying, and glycemic control at least in part by activating GLP1R on vagal afferent neurons.
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9•• Krieger, J.P., Arnold, M., Pettersen, K.G., Lossel, P., Langhans, W., Lee, S.J., Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia. Diabetes 65 (2016), 34–43 Impressive study selectively knocking down GLP1R in vagal afferent neurons. Conclusively demonstrates that GLP1 mediates satiation, inhibition of gastric emptying, and glycemic control at least in part by activating GLP1R on vagal afferent neurons.
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(2016)
Diabetes
, vol.65
, pp. 34-43
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Krieger, J.P.1
Arnold, M.2
Pettersen, K.G.3
Lossel, P.4
Langhans, W.5
Lee, S.J.6
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10
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84877341342
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The long chain fatty acid oleate activates mouse intestinal afferent nerves in vitro
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10 Webster, W.A., Beyak, M.J., The long chain fatty acid oleate activates mouse intestinal afferent nerves in vitro. Can J Physiol Pharmacol 91 (2013), 375–379.
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Webster, W.A.1
Beyak, M.J.2
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11
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84940490991
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KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin
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11 Grabauskas, G., Wu, X., Lu, Y., Heldsinger, A., Song, I., Zhou, S.Y., Owyang, C., KATP channels in the nodose ganglia mediate the orexigenic actions of ghrelin. J Physiol 593 (2015), 3973–3989.
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Grabauskas, G.1
Wu, X.2
Lu, Y.3
Heldsinger, A.4
Song, I.5
Zhou, S.Y.6
Owyang, C.7
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12
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84935052674
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Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
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12 Naznin, F., Toshinai, K., Waise, T.M., NamKoong, C., Md Moin, A.S., Sakoda, H., Nakazato, M., Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation. J Endocrinol 226 (2015), 81–92.
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Naznin, F.1
Toshinai, K.2
Waise, T.M.3
NamKoong, C.4
Md Moin, A.S.5
Sakoda, H.6
Nakazato, M.7
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13
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84940460124
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One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
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13 Waise, T.M., Toshinai, K., Naznin, F., NamKoong, C., Md Moin, A.S., Sakoda, H., Nakazato, M., One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice. Biochem Biophys Res Commun 464 (2015), 1157–1162.
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Biochem Biophys Res Commun
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Waise, T.M.1
Toshinai, K.2
Naznin, F.3
NamKoong, C.4
Md Moin, A.S.5
Sakoda, H.6
Nakazato, M.7
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14
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84903598127
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Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors
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14 Darling, R.A., Zhao, H., Kinch, D., Li, A.J., Simasko, S.M., Ritter, S., Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. Am J Physiol Regul Integr Comp Physiol 307 (2014), R35–R43.
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Darling, R.A.1
Zhao, H.2
Kinch, D.3
Li, A.J.4
Simasko, S.M.5
Ritter, S.6
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15
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84897566360
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PPARgamma in vagal neurons regulates high-fat diet induced thermogenesis
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15 Liu, C., Bookout, A.L., Lee, S., Sun, K., Jia, L., Lee, C., Udit, S., Deng, Y., Scherer, P.E., Mangelsdorf, D.J., et al. PPARgamma in vagal neurons regulates high-fat diet induced thermogenesis. Cell Metab 19 (2014), 722–730.
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Liu, C.1
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Lee, S.3
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Lee, C.6
Udit, S.7
Deng, Y.8
Scherer, P.E.9
Mangelsdorf, D.J.10
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16
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84984598083
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Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors
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16 Li, A.J., Wang, Q., Dinh, T.T., Simasko, S.M., Ritter, S., Mercaptoacetate blocks fatty acid-induced GLP-1 secretion in male rats by directly antagonizing GPR40 fatty acid receptors. Am J Physiol Regul Integr Comp Physiol 310 (2016), R724–R732.
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Li, A.J.1
Wang, Q.2
Dinh, T.T.3
Simasko, S.M.4
Ritter, S.5
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17
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84933056415
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Loss of the liver X receptor LXRalpha/beta in peripheral sensory neurons modifies energy expenditure
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17 Mansuy-Aubert, V., Gautron, L., Lee, S., Bookout, A.L., Kusminski, C., Sun, K., Zhang, Y., Scherer, P.E., Mangelsdorf, D.J., Elmquist, J.K., Loss of the liver X receptor LXRalpha/beta in peripheral sensory neurons modifies energy expenditure. Elife, 2015, 4.
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Mansuy-Aubert, V.1
Gautron, L.2
Lee, S.3
Bookout, A.L.4
Kusminski, C.5
Sun, K.6
Zhang, Y.7
Scherer, P.E.8
Mangelsdorf, D.J.9
Elmquist, J.K.10
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18
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84984675430
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Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats
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18 Shen, L., Haas, M., Wang, D.Q., May, A., Lo, C.C., Obici, S., Tso, P., Woods, S.C., Liu, M., Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats. Physiol Rep, 2015, 3.
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Shen, L.1
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Lo, C.C.5
Obici, S.6
Tso, P.7
Woods, S.C.8
Liu, M.9
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19
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84866286932
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Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons
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19 Babic, T., Troy, A.E., Fortna, S.R., Browning, K.N., Glucose-dependent trafficking of 5-HT3 receptors in rat gastrointestinal vagal afferent neurons. Neurogastroenterol Motil 24 (2012), e476–e488.
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Babic, T.1
Troy, A.E.2
Fortna, S.R.3
Browning, K.N.4
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20
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84952832034
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High fat diet attenuates glucose-dependent facilitation of 5-HT3-mediated responses in rat gastric vagal afferents
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20 Troy, A.E., Simmonds, S.S., Stocker, S.D., Browning, K.N., High fat diet attenuates glucose-dependent facilitation of 5-HT3-mediated responses in rat gastric vagal afferents. J Physiol 594 (2016), 99–114.
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Troy, A.E.1
Simmonds, S.S.2
Stocker, S.D.3
Browning, K.N.4
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21
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84920151868
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L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats
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21 Konishi, Y., Koosaka, Y., Maruyama, R., Imanishi, K., Kasahara, K., Matsuda, A., Akiduki, S., Hishida, Y., Kurata, Y., Shibamoto, T., et al. L-Ornithine intake affects sympathetic nerve outflows and reduces body weight and food intake in rats. Brain Res Bull 111 (2015), 48–52.
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Konishi, Y.1
Koosaka, Y.2
Maruyama, R.3
Imanishi, K.4
Kasahara, K.5
Matsuda, A.6
Akiduki, S.7
Hishida, Y.8
Kurata, Y.9
Shibamoto, T.10
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22
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84917730302
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Putative roles of neuropeptides in vagal afferent signaling
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22 de Lartigue, G., Putative roles of neuropeptides in vagal afferent signaling. Physiol Behav 136 (2014), 155–169.
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de Lartigue, G.1
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23
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84907143444
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Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist
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23 Campos, C.A., Shiina, H., Ritter, R.C., Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist. J Neurosci 34 (2014), 12636–12645.
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Campos, C.A.1
Shiina, H.2
Ritter, R.C.3
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24
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84920263206
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NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation
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24 Campos, C.A., Ritter, R.C., NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Am J Physiol Regul Integr Comp Physiol 308 (2015), R1–R9.
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Campos, C.A.1
Ritter, R.C.2
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25
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84898053043
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Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses
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25 Fenwick, A.J., Wu, S.W., Peters, J.H., Isolation of TRPV1 independent mechanisms of spontaneous and asynchronous glutamate release at primary afferent to NTS synapses. Front Neurosci, 8, 2014, 6.
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Fenwick, A.J.1
Wu, S.W.2
Peters, J.H.3
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26
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84942465808
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TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice
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26 Kentish, S.J., Frisby, C.L., Kritas, S., Li, H., Hatzinikolas, G., O'Donnell, T.A., Wittert, G.A., Page, A.J., TRPV1 channels and gastric vagal afferent signalling in lean and high fat diet induced obese mice. PLOS ONE, 10, 2015, e0135892.
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PLOS ONE
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Kentish, S.J.1
Frisby, C.L.2
Kritas, S.3
Li, H.4
Hatzinikolas, G.5
O'Donnell, T.A.6
Wittert, G.A.7
Page, A.J.8
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27
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Vagal plasticity the key to obesity
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27 de Lartigue, G., Ronveaux, C.C., Raybould, H.E., Vagal plasticity the key to obesity. Mol Metab 3 (2014), 855–856.
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Mol Metab
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de Lartigue, G.1
Ronveaux, C.C.2
Raybould, H.E.3
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28
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84906253378
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Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
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This landmark paper provides the first direct evidence that vagal afferent neurons are involved in the longterm control of body weight. It demonstrates that disruption of vagal afferent signaling is sufficient for the onset of hyperphagia and obesity using the most selective and complete knockdown of a gene in vagal afferent neurons to date.
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28•• de Lartigue, G., Ronveaux, C.C., Raybould, H.E., Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab 3 (2014), 595–607 This landmark paper provides the first direct evidence that vagal afferent neurons are involved in the longterm control of body weight. It demonstrates that disruption of vagal afferent signaling is sufficient for the onset of hyperphagia and obesity using the most selective and complete knockdown of a gene in vagal afferent neurons to date.
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(2014)
Mol Metab
, vol.3
, pp. 595-607
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de Lartigue, G.1
Ronveaux, C.C.2
Raybould, H.E.3
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29
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84911488130
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Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons
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This study provides evidence that chronic low doses of microbial product, lipopolysaccharide, disrupts leptin signaling in vagal afferent neurons of chow fed animals and promotes hyperphagia. This finding is the first to identify a microbiota–gut–brain pathway as a mechanism for the onset of obesity.
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29• de La Serre, C.B., de Lartigue, G., Raybould, H.E., Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. Physiol Behav 139 (2015), 188–194 This study provides evidence that chronic low doses of microbial product, lipopolysaccharide, disrupts leptin signaling in vagal afferent neurons of chow fed animals and promotes hyperphagia. This finding is the first to identify a microbiota–gut–brain pathway as a mechanism for the onset of obesity.
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Physiol Behav
, vol.139
, pp. 188-194
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de La Serre, C.B.1
de Lartigue, G.2
Raybould, H.E.3
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30
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84863233973
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Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats
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30 de Lartigue, G., Barbier de la Serre, C., Espero, E., Lee, J., Raybould, H.E., Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS One, 7, 2012, e32967.
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de Lartigue, G.1
Barbier de la Serre, C.2
Espero, E.3
Lee, J.4
Raybould, H.E.5
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31
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84983784787
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Linking gut microbiota and inflammation to obesity and insulin resistance
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31 Saad, M.J., Santos, A., Prada, P.O., Linking gut microbiota and inflammation to obesity and insulin resistance. Physiology (Bethesda) 31 (2016), 283–293.
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Saad, M.J.1
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32
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79959608810
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Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons
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32 de Lartigue, G., Barbier de la Serre, C., Espero, E., Lee, J., Raybould, H.E., Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. Am J Physiol Endocrinol Metab 301 (2011), E187–E195.
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de Lartigue, G.1
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Espero, E.3
Lee, J.4
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33
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84923872937
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Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity
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Oxytocin activates cultured vagal afferent neurons, and one time intraperitoneal injection ablation of vagal signaling prevents oxytocin induced hypophagia and weight loss in lean animals. In db/db mice, oxytocin activates neurons that are unresponsive to leptin acutely and subchronic intraperitoneal administration for 12 days reduces food intake and promotes weight loss in these genetically obese mice.
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33• Iwasaki, Y., Maejima, Y., Suyama, S., Yoshida, M., Arai, T., Katsurada, K., Kumari, P., Nakabayashi, H., Kakei, M., Yada, T., Peripheral oxytocin activates vagal afferent neurons to suppress feeding in normal and leptin-resistant mice: a route for ameliorating hyperphagia and obesity. Am J Physiol Regul Integr Comp Physiol 308 (2015), R360–R369 Oxytocin activates cultured vagal afferent neurons, and one time intraperitoneal injection ablation of vagal signaling prevents oxytocin induced hypophagia and weight loss in lean animals. In db/db mice, oxytocin activates neurons that are unresponsive to leptin acutely and subchronic intraperitoneal administration for 12 days reduces food intake and promotes weight loss in these genetically obese mice.
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Am J Physiol Regul Integr Comp Physiol
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Iwasaki, Y.1
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Nakabayashi, H.8
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34
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Recent advances in metabolic and bariatric surgery
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34 Albaugh, V.L., Flynn, C.R., Tamboli, R.A., Abumrad, N.N., Recent advances in metabolic and bariatric surgery. F1000Research, 2016, 5.
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35
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84959509832
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Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice
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35 Hao, Z., Mumphrey, M.B., Townsend, R.L., Morrison, C.D., Munzberg, H., Ye, J., Berthoud, H.R., Reprogramming of defended body weight after Roux-En-Y gastric bypass surgery in diet-induced obese mice. Obesity (Silver Spring) 24 (2016), 654–660.
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Hao, Z.1
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Ye, J.6
Berthoud, H.R.7
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36
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An investigation of the neural mechanisms underlying the efficacy of the adjustable gastric band
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36 Aneta Stefanidis, P.D., Forrest, N., Brown, W.A., Dixon, J.B., O'Brien, P.B., Juliane, K.B.J.O., An investigation of the neural mechanisms underlying the efficacy of the adjustable gastric band. Surg Obes Relat Dis, 2015.
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37
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A critical re-evaluation of the specificity of action of perivagal capsaicin
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37 Browning, K.N., Babic, T., Holmes, G.M., Swartz, E., Travagli, R.A., A critical re-evaluation of the specificity of action of perivagal capsaicin. J Physiol 591 (2013), 1563–1580.
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38
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Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse
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38 Gautron, L., Zechner, J.F., Aguirre, V., Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse. Int J Obes (Lond) 37 (2013), 1603–1607.
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39 Bueter, M., Lowenstein, C., Ashrafian, H., Hillebrand, J., Bloom, S.R., Olbers, T., Lutz, T., le Roux, C.W., Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obes Surg 20 (2010), 616–622.
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40
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Transection versus preservation of the neurovascular bundle of the lesser omentum in primary Roux-en-Y gastric bypass surgery
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40 van Wezenbeek, M.R., van Oudheusden, T.R., Smulders, J.F., Nienhuijs, S.W., Luyer, M.D., Transection versus preservation of the neurovascular bundle of the lesser omentum in primary Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis 12 (2016), 283–289.
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41
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Vagal innervation of intestine contributes to weight loss after Roux-en-Y gastric bypass surgery in rats
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41 Hao, Z., Townsend, R.L., Mumphrey, M.B., Patterson, L.M., Ye, J., Berthoud, H.R., Vagal innervation of intestine contributes to weight loss after Roux-en-Y gastric bypass surgery in rats. Obes Surg 24 (2014), 2145–2151.
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42
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42 Shin, A.C., Zheng, H., Berthoud, H.R., Vagal innervation of the hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Ann Surg 255 (2012), 294–301.
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43
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43 Qiu, N.C., Zhang, Q., Song, X., Liu, M.E., Li, X.K., Shan, C.X., Qiu, M., Impact of the hepatic branch of the vagus and Roux-en-Y gastric bypass on the hypoglycemic effect and glucagon-like peptide-1 in rats with type 2 diabetes mellitus. J Surg Res 191 (2014), 123–129.
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44
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This study identifies exaggerated activation of anorexigenic brainstem circuits, downstream of the vagus nerve, in a mouse model of Roux-en-Y gastric bypass.
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44• Mumphrey, M.B., Hao, Z., Townsend, R.L., Patterson, L.M., Munzberg, H., Morrison, C.D., Ye, J., Berthoud, H.R., Eating in mice with gastric bypass surgery causes exaggerated activation of brainstem anorexia circuit. Int J Obes (Lond), 2016 This study identifies exaggerated activation of anorexigenic brainstem circuits, downstream of the vagus nerve, in a mouse model of Roux-en-Y gastric bypass.
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Mumphrey, M.B.1
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45
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84924145555
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This study delineates the histological damage to vagal gut–brain of two different bariatric surgeries in lean rats. They report marked differences between RYGB and VSG in the number of vagal afferent neurons innervating the stomach, central vagal afferent fibers density, and active microglia in the NTS, suggesting that the metabolic benefits provided by these surgeries may be mediated by two different vagal afferent mechanisms.
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45•• Ballsmider, L.A., Vaughn, A.C., David, M., Hajnal, A., Di Lorenzo, P.M., Czaja, K., Sleeve gastrectomy and Roux-en-Y gastric bypass alter the gut–brain communication. Neural Plast, 2015, 2015, 601985 This study delineates the histological damage to vagal gut–brain of two different bariatric surgeries in lean rats. They report marked differences between RYGB and VSG in the number of vagal afferent neurons innervating the stomach, central vagal afferent fibers density, and active microglia in the NTS, suggesting that the metabolic benefits provided by these surgeries may be mediated by two different vagal afferent mechanisms.
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Ballsmider, L.A.1
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46
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Intermittent vagal nerve block for improvements in obesity, cardiovascular risk factors, and glycemic control in patients with type 2 diabetes mellitus: 2-year results of the VBLOC DM2 study
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46 Shikora, S.A., Toouli, J., Herrera, M.F., Kulseng, B., Brancatisano, R., Kow, L., Pantoja, J.P., Johnsen, G., Brancatisano, A., Tweden, K.S., et al. Intermittent vagal nerve block for improvements in obesity, cardiovascular risk factors, and glycemic control in patients with type 2 diabetes mellitus: 2-year results of the VBLOC DM2 study. Obes Surg 26 (2016), 1021–1028.
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47
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Two year follow up of a clinical study demonstrating that blocking vagal afferent signaling from the abdominal organs can lead to significant weight loss and improvement in glycemic control compared to sham controls in obese and obese/diabetic patients.
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47• Camilleri, M., Toouli, J., Herrera, M.F., Kulseng, B., Kow, L., Pantoja, J.P., Marvik, R., Johnsen, G., Billington, C.J., Moody, F.G., et al. Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device. Surgery 143 (2008), 723–731 Two year follow up of a clinical study demonstrating that blocking vagal afferent signaling from the abdominal organs can lead to significant weight loss and improvement in glycemic control compared to sham controls in obese and obese/diabetic patients.
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48
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48 Han, L., Jian-Bin, Z., Chen, X., Qing-Qing, T., Wei-Xing, S., Jing-Zhu, Z., Jian-De, C., Yin-Ping, W., Effects and mechanisms of auricular vagus nerve stimulation on high-fat-diet-induced obese rats. Nutrition 31 (2015), 1416–1422.
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49
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49 Kentish, S.J., Frisby, C.L., Kennaway, D.J., Wittert, G.A., Page, A.J., Circadian variation in gastric vagal afferent mechanosensitivity. J Neurosci 33 (2013), 19238–19242.
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50
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50 Blouet, C., Schwartz, G.J., Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats. PLoS One, 7, 2012, e51898.
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51 Zukerman, S., Ackroff, K., Sclafani, A., Rapid post-oral stimulation of intake and flavor conditioning by glucose and fat in the mouse. Am J Physiol Regul Integr Comp Physiol 301 (2011), R1635–R1647.
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52 de Araujo, I.E., Ferreira, J.G., Tellez, L.A., Ren, X., Yeckel, C.W., The gut–brain dopamine axis: a regulatory system for caloric intake. Physiol Behav 106 (2012), 394–399.
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53
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A gut lipid messenger links excess dietary fat to dopamine deficiency
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This study identifies a novel role for the vagus nerve in lipid-conditioned reward. Self-administered gastric infusions of lipid in response to licking of dry spouts results in dopamine efflux in the dorsal striatum, and this is abolished by both capsaicin and vagotomy.
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53• Tellez, L.A., Medina, S., Han, W., Ferreira, J.G., Licona-Limon, P., Ren, X., Lam, T.T., Schwartz, G.J., de Araujo, I.E., A gut lipid messenger links excess dietary fat to dopamine deficiency. Science 341 (2013), 800–802 This study identifies a novel role for the vagus nerve in lipid-conditioned reward. Self-administered gastric infusions of lipid in response to licking of dry spouts results in dopamine efflux in the dorsal striatum, and this is abolished by both capsaicin and vagotomy.
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Science
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54
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Separate circuitries encode the hedonic and nutritional values of sugar
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54 Tellez, L.A., Han, W., Zhang, X., Ferreira, T.L., Perez, I.O., Shammah-Lagnado, S.J., van den Pol, A.N., de Araujo, I.E., Separate circuitries encode the hedonic and nutritional values of sugar. Nat Neurosci 19 (2016), 465–470.
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55
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Striatal dopamine links gastrointestinal rerouting to altered sweet appetite
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55 Han, W., Tellez, L.A., Niu, J., Medina, S., Ferreira, T.L., Zhang, X., Su, J., Tong, J., Schwartz, G.J., van den Pol, A., et al. Striatal dopamine links gastrointestinal rerouting to altered sweet appetite. Cell Metab 23 (2016), 103–112.
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56
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Gut vagal afferents differentially modulate innate anxiety and learned fear
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56 Klarer, M., Arnold, M., Gunther, L., Winter, C., Langhans, W., Meyer, U., Gut vagal afferents differentially modulate innate anxiety and learned fear. J Neurosci 34 (2014), 7067–7076.
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