Early lipid changes in acute kidney injury using SWATH lipidomics coupled with MALDI tissue imaging

American Journal of Physiology - Renal Physiology

Volumn 310, Issue 10, 2016, Pages F1136-F1147

  Rao, Sangeetha ^a   Walters, Kelly B ^b,c   Wilson, Landon ^d   Chen, Bo ^b   Bolisetty, Subhashini ^b   Graves, David ^b   Barnes, Stephen ^d   Agarwal, Anupam ^b   Kabarowski, Janusz H ^c  

^a Children's Hospital Alabama   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

Acute kidney injury; AKI; IR; Ischemia reperfusion; Lipidomics; MALDI IMS; Matrix assisted laser desorption ionization imaging mass spectrometry; Sequential window acquisition of all theoretical spectra mass spectrometry; SWATH MS

Indexed keywords

CHOLINE; CREATININE; ETHER PHOSPHOLIPID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DESORPTION; IMMUNOFLUORESCENCE; INJURY SEVERITY; IONIZATION; KIDNEY PROXIMAL TUBULE; KIDNEY STRUCTURE; KIDNEY TUBULE NECROSIS; LIPID ANALYSIS; LIPID OXIDATION; LIPIDOMICS; MALE; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; SEQUENTIAL WINDOW ACQUISITION OF ALL THEORETICAL SPECTRA; ACUTE KIDNEY INJURY; ANIMAL; C57BL MOUSE; LIPID METABOLISM; METABOLISM; METABOLOMICS; PROCEDURES;

ACUTE KIDNEY INJURY; ANIMALS; LIPID METABOLISM; MALE; METABOLOMICS; MICE, INBRED C57BL; REPERFUSION INJURY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84984633367     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00100.2016     Document Type: Article

References (47)

1. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69: 89-95, 2001
2. Black LL, Srivastava R, Schoeb TR, Moore RD, Barnes S, Kabarowski JH. Cholesterol-independent suppression of lymphocyte activation, autoimmunity, and glomerulonephritis by apolipoprotein A-I in normocholesterolemic lupus-prone mice. J Immunol 195: 4685-4698, 2015
3. Braverman NE, Moser AB. Functions of plasmalogen lipids in health and disease. Biochim Biophys Acta 1822: 1442-1452, 2012
4. Clermont G, Acker CG, Angus DC, Sirio CA, Pinsky MR, Johnson JP. Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney Int 62: 986-996, 2002
5. Devarajan P. Emerging biomarkers of acute kidney injury. Contrib Nephrol 156: 203-212, 2007
6. Devarajan P. Proteomics for biomarker discovery in acute kidney injury. Semin Nephrol 27: 637-651, 2007
7. Druml W. Long term prognosis of patients with acute renal failure: is intensive care worth it? Intensive Care Med 31: 1145-1147, 2005
8. Edelstein CL, Ling H, Schrier RW. The nature of renal cell injury. Kidney Int 51: 1341-1351, 1997
9. Ferreira MA, Barcelos LS, Teixeira MM, Bakhle YS, Andrade SP. Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). Life Sci 81: 210-217, 2007
10. Gorgas K, Teigler A, Komljenovic D, Just WW. The ether lipiddeficient mouse: tracking down plasmalogen functions. Biochim Biophys Acta 1763: 1511-1526, 2006
11. Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. J Lipid Res 55: 1375-1385, 2014
12. Hull TD, Kamal AI, Boddu R, Bolisetty S, Guo L, Tisher CC, Rangarajan S, Chen B, Curtis LM, George JF, Agarwal A. Heme oxygenase-1 regulates myeloid cell trafficking in AKI. J Am Soc Nephrol 26: 2139-2151, 2015
13. Johnson AC, Stahl A, Zager RA. Triglyceride accumulation in injured renal tubular cells: alterations in both synthetic and catabolic pathways. Kidney Int 67: 2196-2209, 2005
14. Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmele T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17: R25, 2013
15. Kribben A, Wieder ED, Wetzels JF, Yu L, Gengaro PE, Burke TJ, Schrier RW. Evidence for role of cytosolic free calcium in hypoxiainduced proximal tubule injury. J Clin Invest 93: 1922-1929, 1994
16. Kulah E, Tascilar O, Acikgoz S, Tekin IO, Karadeniz G, Can M, Gun B, Barut F, Comert M. Oxidized LDL accumulation in experimental renal ischemia reperfusion injury model. Ren Fail 29: 409-415, 2007
17. Ling XB, Mellins ED, Sylvester KG, Cohen HJ. Urine peptidomics for clinical biomarker discovery. Adv Clin Chem 51: 181-213, 2010
18. Liu Y, Yan S, Ji C, Dai W, Hu W, Zhang W, Mei C. Metabolomic changes and protective effect of (L)-carnitine in rat kidney ischemia/ reperfusion injury. Kidney Blood Press Res 35: 373-381, 2012
19. Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab 21: 51-64, 2015
20. Magnusson CD, Haraldsson GG. Ether lipids. Chem Phys Lipids 164: 315-340, 2011
21. Makris K, Kafkas N. Neutrophil gelatinase-associated lipocalin in acute kidney injury. Adv Clin Chem 58: 141-191, 2012
22. Mehta RL, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Chertow GM, and Program to Improve Care in Acute Renal Disease. Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66: 1613-1621, 2004
23. Metnitz PG, Krenn CG, Steltzer H, Lang T, Ploder J, Lenz K, Le Gall JR, Druml W. Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 30: 2051-2058, 2002
24. Molitoris BA, Simon FR. Renal cortical brush-border and basolateral membranes: cholesterol and phospholipid composition and relative turnover. J Membr Biol 83: 207-215, 1985
25. Naito M, Bomsztyk K, Zager RA. Renal ischemia-induced cholesterol loading: transcription factor recruitment and chromatin remodeling along the HMG CoA reductase gene. Am J Pathol 174: 54-62, 2009
26. Pallone TL, Silldorff EP, Turner MR. Intrarenal blood flow: microvascular anatomy and the regulation of medullary perfusion. Clin Exp Pharmacol Physiol 25: 383-392, 1998
27. Portilla D. Role of fatty acid beta-oxidation and calcium-independent phospholipase A2 in ischemic acute renal failure. Curr Opin Nephrol Hypertens 8: 473-477, 1999
28. Portilla D, Creer MH. Plasmalogen phospholipid hydrolysis during hypoxic injury of rabbit proximal tubules. Kidney Int 47: 1087-1094, 1995
29. Portilla D, Schnackenberg L, Beger RD. Metabolomics as an extension of proteomic analysis: study of acute kidney injury. Semin Nephrol 27: 609-620, 2007
30. Portilla D, Shah SV, Lehman PA, Creer MH. Role of cytosolic calcium-independent plasmalogen-selective phospholipase A2 in hypoxic injury to rabbit proximal tubules. J Clin Invest 93: 1609-1615, 1994
31. Reis A, Rudnitskaya A, Chariyavilaskul P, Dhaun N, Melville V, Goddard J, Webb DJ, Pitt AR, Spickett CM. Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease. J Lipid Res 56: 413-422, 2015
32. Reiss D, Beyer K, Engelmann B. Delayed oxidative degradation of polyunsaturated diacyl phospholipids in the presence of plasmalogen phospholipids in vitro. Biochem J 323: 807-814, 1997
33. Rodemer C, Thai TP, Brugger B, Kaercher T, Werner H, Nave KA, Wieland F, Gorgas K, Just WW. Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum Mol Genet 12: 1881-1895, 2003
34. Sigdel TK, Klassen RB, Sarwal MM. Interpreting the proteome and peptidome in transplantation. Adv Clin Chem 47: 139-169, 2009
35. Simons B, Kauhanen D, Sylvanne T, Tarasov K, Duchoslav E, Ekroos K. Shotgun lipidomics by sequential precursor ion fragmentation on a hybrid quadrupole time-of-flight mass spectrometer. Metabolites 2: 195-213, 2012
36. Subramaniam S, Fahy E, Gupta S, Sud M, Byrnes RW, Cotter D, Dinasarapu AR, Maurya MR. Bioinformatics and systems biology of the lipidome. Chem Rev 111: 6452-6490, 2011
37. Sun L, He Z, Ke J, Li S, Wu X, Lian L, He X, He X, Hu J, Zou Y, Wu X, Lan P. PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer. Int J Clin Exp Pathol 8: 432-440, 2015
38. Thai TP, Rodemer C, Jauch A, Hunziker A, Moser A, Gorgas K, Just WW. Impaired membrane traffic in defective ether lipid biosynthesis. Hum Mol Genet 10: 127-136, 2001
39. Thongboonkerd V. Proteomic analysis of renal diseases: unraveling the pathophysiology and biomarker discovery. Expert Rev Proteomics 2: 349-366, 2005
40. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C,. Beginning, and ending supportive therapy for the kidney. I. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294: 813-818, 2005
41. Uehara T, Horinouchi A, Morikawa Y, Tonomura Y, Minami K, Ono A, Yamate J, Yamada H, Ohno Y, Urushidani T. Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats. J Appl Toxicol 34: 1087-1095, 2014
42. Waddington EI, Croft KD, Sienuarine K, Latham B, Puddey IB. Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. Atherosclerosis 167: 111-120, 2003
43. Wei Q, Xiao X, Fogle P, Dong Z. Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion. PLoS One 9: e106647, 2014
44. Whitehouse T, Stotz M, Taylor V, Stidwill R, Singer M. Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion. Am J Physiol Renal Physiol 291: F647-F653, 2006
45. Yang F, Zhang L, Wu H, Zou H, Du Y. Clinical analysis of cause, treatment and prognosis in acute kidney injury patients. PLoS One 9: e85214, 2014
46. Zager RA, Andoh T, Bennett WM. Renal cholesterol accumulation: a durable response after acute and subacute renal insults. Am J Pathol 159: 743-752, 2001
47. Zhao YY, Vaziri ND, Lin RC. Lipidomics: new insight into kidney disease. Adv Clin Chem 68: 153-175, 2015