Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: A multi-centered, prospective, cohort study

Annals of Oncology

Volumn 26, Issue 7, 2015, Pages 1446-1451

  Cheung, Y T ^a,b   Ng, T ^a,b   Shwe, M ^a   K Ho, H ^a   Foo, K M ^c   Cham, M T ^c   Lee, J A ^c   Fan, G ^b   Tan, Y P ^b   Yong, W S ^b   Madhukumar, P ^b   Loo, S K ^b   Ang, S F ^b   Wong, M ^b   Chay, W Y ^b   Ooi, W S ^b   Dent, R A ^b,d   Yap, Y S ^b   Ng, R ^b,d   Chan, Alexandre ^a,b,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Breast cancer; Chemobrain; Cognitive disturbance; Cognitive impairment; Cytokines; Fact cog

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR MARKER; TUMOR NECROSIS FACTOR ALPHA; AUTACOID;

ADULT; ARTICLE; BREAST CANCER; CANCER STAGING; CHINESE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HUMAN; OUTCOME ASSESSMENT; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PSYCHOLOGIC ASSESSMENT; SINGAPORE; TREATMENT RESPONSE; BLOOD; BREAST NEOPLASMS; CHEMICALLY INDUCED; COGNITION DISORDERS; COMPLICATION; FOLLOW UP; IMMUNOASSAY; MIDDLE AGED; MULTICENTER STUDY; PROGNOSIS; PSYCHOLOGY;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOMARKERS, TUMOR; BREAST NEOPLASMS; COGNITION DISORDERS; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOASSAY; INFLAMMATION MEDIATORS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 84984586020     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdv206     Document Type: Article

References (25)

1. Cheung YT, Lim SR, Ho HK, Chan A. Cytokines as mediators of chemotherapyassociated cognitive changes: current evidence, limitations and directions for future research. PLoS One 2013; 8: e81234.
2. Ganz PA, Bower JE, Kwan L et al. Does tumor necrosis factor-alpha (TNF-α) play a role in post-chemotherapy cerebral dysfunction? Brain Behav Immun 2013; 30:S99-S108.
3. Kesler S, Janelsins M, Koovakkattu D et al. Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors. Brain Behav Immun 2013; 30 (suppl): S109-S116.
4. Janelsins MC, Mustian KM, Palesh OG et al. Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Support Care Cancer 2012; 20: 831-839.
5. Jacobson NS, Truax P. Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol 1991; 59:12-19.
6. Vardy J, Rourke S, Tannock IF. Evaluation of cognitive function associated with chemotherapy: a review of published studies and recommendations for future research. J Clin Oncol 2007; 25: 2455-2463.
7. Vardy J, Wefel JS, Ahles T et al. Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Ann Oncol 2008; 19: 623-629.
8. Wefel JS, Vardy J, Ahles T, Schagen SB. International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol 2011; 12: 703-708.
9. Cheung YT, Foo YL, Shwe M et al. Minimal clinically important difference (MCID) for the functional assessment of cancer therapy: cognitive function (FACT-Cog) in breast cancer patients. J Clin Epidemiol 2014; 67: 811-820.
10. Cheung YT, Shwe M, Chui WK et al. Effects of chemotherapy and psychosocial distress on perceived cognitive disturbances in asian breast cancer patients. Ann Pharmacother 2012; 46: 1645-1655.
11. Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 2007; 7: 192-201.
12. Ahles TA, Saykin AJ, McDonald BC et al. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol 2010; 28: 4434-4440.
13. Vardy J. Cognitive function in breast cancer survivors. Cancer Treat Res 2009; 151: 387-419.
14. Forlenza OV, Diniz BS, Talib LL et al. Increased serum IL-1β level in Alzheimer's disease and mild cognitive impairment. Dement Geriatr Cogn Disord 2009; 28:507-512.
15. Ng TP, Leong T, Chiam PC, Kua EH. Ethnic variations in dementia: the contributions of cardiovascular, psychosocial and neuropsychological factors. Dement Geriatr Cogn Disord 2010; 29: 131-138.
16. Myers JS. The possible role of cytokines in chemotherapy-induced cognitive deficits. Adv Exp Med Biol 2010; 678: 119-123.
17. Gadani SP, Cronk JC, Norris GT, Kipnis J. IL-4 in the brain: a cytokine to remember. J Immunol 2012; 189: 4213-4219.
18. Maher FO, Nolan Y, Lynch MA. Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiol Aging 2005; 26: 717-728.
19. Gan HK, Bernstein LJ, Brown J et al. Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011; 81: 126-134.
20. Booth C, Vardy J, Crawley A et al. Cognitive impairment associated with chemotherapy for breast cancer: an exploratory case-control study. J Clin Oncol (Meeting Abstracts) 2006; 24: abstr 8501.
21. Konsman JP, Vigues S, Mackerlova L et al. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J Comp Neurol 2004; 472: 113-129.
22. Anthony DC, Bolton SJ, Fearn S, Perry VH. Age-related effects of interleukin-1 beta on polymorphonuclear neutrophil-dependent increases in blood-brain barrier permeability in rats. Brain 1997; 120(Pt 3): 435-444.
23. Das S, Basu A. Inflammation: a new candidate in modulating adult neurogenesis. J Neurosci Res 2008; 86: 1199-1208.
24. Wilson CJ, Finch CE, Cohen HJ. Cytokines and cognition-the case for a head-totoe inflammatory paradigm. J Am Geriatr Soc 2002; 50: 2041-2056.
25. Gibertini M. Cytokines and cognitive behavior. Neuroimmunomodulation 1998; 5:160-165.