Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase

Liver International

Volumn 28, Issue 1, 2008, Pages 54-60

  Souza Dos Santos, Rosane M ^a   De Bem, Andreza F ^a   Colpo, Elisângela ^a   Bertoncello, Iara ^a   Nogueira, Cristina W ^a   Rocha, João B T ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Aminotransferases; Antioxidants; HepatitisC; Oxidative stress; Vitamin C

Indexed keywords

ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE PEROXIDASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; FEMALE; HEPATITIS C; HUMAN; MALE; OXIDATIVE STRESS; STATISTICAL ANALYSIS; VITAMIN BLOOD LEVEL;

EID: 84984584169     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2007.01599.x     Document Type: Article

References (35)

1. Ikeda K, Saitoh S, Suzuki Y, et al. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol 1998; 28: 930-8.
2. Harrison TR. Chronic Hepatitis. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 1994; 1478-83.
3. Mathurin P, Moussalli J, Cadranel JF, et al. Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity. Hepatology 1998; 27: 868-72.
4. Davis GL, Esteban-Mur R, Rustgi V, et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group. N Engl J Med 1998; 339: 1493-9.
5. Alter HJ. Clinical, virological and epidemiological basis for the treatment of chronic non-A, non-B hepatitis. J Hepatol 1990; 11: S19-25.
6. Koziel MJ. Immunology of viral hepatitis. Am J Med 1996; 100: 98-109.
7. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004; 266: 37-56.
8. Cadenas E. Basic mechanisms of antioxidant activity. Biofactors 1997; 6: 391-7.
9. De Haan JB, Wolvetang EJ, Cristiano F, et al. Reactive oxygen species and their contribution to pathology in Down Syndrome. Adv Pharmacol 1997; 38: 379-402.
10. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994; 15: 7-10.
11. Matés JM, Péres-Gómes C, Castro IN. Antioxidant enzymes and human diseases. Clin Biochem 1999; 32: 595-603.
12. Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997; 113: 1069-73.
13. Beloqui O, Prieto J, Suarez M, et al. N -acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: A pilot study. J Interferon Res 1993; 13: 279-82.
14. Ideo G, Bellobuono A, Tempini S, et al. Antioxidant drugs combined with alpha-interferon on chronic hepatitis C not responsive to alpha-interferon alone: A randomized multicenter study. Eur J Gastroenterol Hepatol 1999; 11: 1203-7.
15. Yadav D, Hertan HI, Schweitzer P, Norkus EP, Pitchumoni CS. Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C. Am J Gastroenterol 2002; 97: 2634-9.
16. Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys 1959; 82: 70-7.
17. Ohkawa H, Ohishi H, Yagi K. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-8.
18. Jacques-Silva MC, Nogueira CW, Broch LC, Flores EMM, Rocha JBT. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacol Toxicol 2001; 88: 119-25.
19. Pagalia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
20. Aebi H. Catalase in vitro. Methods Enzymol 1974; 105: 121-6.
21. Karmen A, Wroblewski F, Ladue JS. Transaminase activity in human blood. J Clin Invest 1955; 34: 126-33.
22. Vendemiale G, Grattagliano I, Portincasa P, et al. Oxidative stress in symptom-free HCV carriers: Relation with ALT flare-up. Eur J Clin Invest 2001; 31: 54-63.
23. Paradis V, Mathurin P, Kollinger M, et al. In situ detection of lipid peroxidation in chronic hepatitis C: Correlation with pathological features. J Clin Pathol 1997; 50: 401-6.
24. De Maria N, Colantoni A, Fagiuoli S, et al. Association between reactive oxygen species and disease activity in chronic hepatitis C. Free Radic Biol Med 1996; 21: 291-5.
25. Hezode C, Cazeneuve C, Coue O, et al. Liver iron accumulation in patients with chronic active hepatitis C: Prevalence and role of haemochromatosis gene mutations and relationship with hepatic histological lesions. J Hepatol 1999; 31: 979-84.
26. Pietrangelo A. Iron, oxidative stress and liver fibrogenesis. J Hepatol 1998; 28 (Suppl. 1): 8-13.
27. Barbaro G, Di Lorenzo G, Ribersani M, et al. Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype. J Hepatol 1999; 30: 774-82.
28. Jain SK, Pemberton PW, Smith A, et al. Oxidative stress in chronic hepatitis C: Not just a feature of late stage disease. J Hepatol 2002; 36: 805-11.
29. Frei B, England L, Ames B. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Nat Acad Sci USA 1989; 86: 6377-81.
30. Bandara P, George J, Mccaughan G, et al. Antioxidant levels in peripheral blood, disease activity and fibrotic stage in chronic hepatitis C. Liver Int 2005; 25: 518-26.
31. Sakagishi Y. Alanine aminotransferase (ALT). Nippon Rinsho 1995; 53: 1146-50.
32. Haber MM, West AB, Haber AD, Reuben A. Relationship of aminotranferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 1995; 90: 1250-7.
33. Shaib YH, Vega KJ, Jamal MM. Approach to patients with hepatitis C and persistently normal alanine transferase levels. Clin Perspect Gastroenterol 2000; 252-8.
34. Proteggente AR, Rehman A, Halliwell B, Rice-Evans C. Potential problems of ascorbate and iron supplementation: Pro-oxidant effect in vivo? Biochem Biophys Res Commun 2000; 277: 535-40.
35. Lutsenko EA, Cárcamo JM, Golde DW. Vitamin C prevents DNA mutation induced by oxidative stress. J Biol Chem 2002; 277: 16895-9.