Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

Psychopharmacology

Volumn 233, Issue 21-22, 2016, Pages 3797-3802

  Ota, Miho ^a   Matsuo, Junko ^a   Ishida, Ikki ^a   Hattori, Kotaro ^a   Teraishi, Toshiya ^a   Tonouchi, Hidekazu ^b   Ashida, Kinya ^b   Takahashi, Takeshi ^b   Kunugi, Hiroshi ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b MEIJI DAIRIES CORPORATION   (Japan)

Author keywords

Cognition; Elderly; Ketogenic meal; Medium chain triglycerides; hydroxybutyrate

Indexed keywords

3 HYDROXYBUTYRIC ACID; KETONE; MEDIUM CHAIN TRIACYLGLYCEROL; GLUCOSE; KETONE BODY; TRIACYLGLYCEROL;

3 HYDROXYBUTYRIC ACID BLOOD LEVEL; AGED; ARTICLE; BLOOD LEVEL; BODY HEIGHT; BODY MASS; BODY WEIGHT; COGNITION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EXECUTIVE FUNCTION; FEMALE; HUMAN; INFORMED CONSENT; JAPANESE (PEOPLE); KETOGENIC DIET; KETONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ATTENTION; BLOOD; BRAIN; METABOLISM; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; SHORT TERM MEMORY;

3-HYDROXYBUTYRIC ACID; AGED; ATTENTION; BRAIN; COGNITION; DIET, KETOGENIC; FEMALE; GLUCOSE; HUMANS; KETONE BODIES; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; TRIGLYCERIDES;

EID: 84983802988     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-016-4414-7     Document Type: Article

References (25)

1. Auestad N, Korsak RA, Morrow JW, Edmond J (1991) Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J Neurochem 56:1376–1386
2. Ebert D, Haller RG, Walton ME (2003) Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy. J Neurosci 23:5928–5935
3. Gasior M, Rogawski MA, Hartman AL (2006) Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol 17:431–439
4. Hasselbalch SG, Knudsen GM, Jakobsen J, Hageman LP, Holm S, Paulson OB (1994) Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14:125–131
5. Hasselbalch SG, Madsen PL, Hageman LP, Olsen KS, Justesen N, Holm S, Paulson OB (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am J Phys 270:E746–E751
6. Hayashi A, Kumada T, Nozaki F, Hiejima I, Miyajima T, Fujii T (2013) Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula. No To Hattatsu 45:288–293
7. Henderson ST, Poirier J (2011) Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study. BMC Med Genet 12:137
8. Henderson ST, Vogel JL, Barr LJ, Garvin F, Jones JJ, Costantini LC (2009) Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond) 6:31
9. Izumi Y, Ishii K, Katsuki H, Benz AM, Zorumski CF (1998) Beta-hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. J Clin Invest 101:1121–1132
10. Kashiwaya Y, Bergman C, Lee JH, Wan R, King MT, Mughal MR, Okun E, Clarke K, Mattson MP, Veech RL (2013) A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 34:1530–1539
11. Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ (2012) Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging 425:e19–e27
12. Lezak MD, Howieson DB, Loring DW (2004) Neuropsychological assessment. Oxford University Press, NY
13. Otsubo T, Tanaka K, Koda R, et al. (2005) Reliability and validity of Japanese version of the mini-international neuropsychiatric interview. Psychiatry Clin Neurosci 59:517–526
14. Page KA, Williamson A, Yu N, McNay EC, Dzuira J, McCrimmon RJ, Sherwin RS (2009) Medium-chain fatty acids improve cognitive function in intensively treated type 1 diabetic patients and support in vitro synaptic transmission during acute hypoglycemia. Diabetes 58:1237–1244
15. Reger MA, Henderson ST, Hale C, Cholerton B, Baker LD, Watson GS, Hyde K, Chapman D, Craft S (2004) Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiol Aging 25:311–314
16. Sheehan DV, Lecrubier Y, Sheehan KH, et al. (1998) The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22–57
17. Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM (2008) Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Res 1226:209–217
18. Thevenet J, De Marchi U, Domingo, JS, Christinat N, Bultot L, Lefebvre G, Sakamoto K, Descombes P, Masoodi M, Wiederkehr A (2016) Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems. FASEB J 30:1913–1926
19. Tominaga D (2005) The standardization of the Ryudai’s trail making test (RTMT): from attentional function and working memory’s viewpoint. University of the Ryukyus Repository 67:243–252
20. Traul KA, Driedger A, Ingle DL, Nakhasi D (2000) Review of the toxicologic properties of medium-chain triglycerides. Food Chem Toxicol 38:79–98
21. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J (1994) Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43:1311–1317
22. Wechsler D (1987) Wechsler memory scale-revised. Psychological Corporation, San Antonio
23. Wechsler D (1997) Wechsler Adult Intelligence Scale (3rd edn.). Psychological Corporation, San Antonio
24. Wing RR, Vazquez JA, Ryan CM (1995) Cognitive effects of ketogenic weight-reducing diets. Int J Obes Relat Metab Disord 19:811–816
25. Yoshizawa H, Gazes Y, Stern Y, Miyata Y, Uchiyama S (2014) Characterizing the normative profile of 18F-FDG PET brain imaging: sex difference, aging effect, and cognitive reserve. Psychiatry Res 221:78–85