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Volumn 311, Issue 2, 2016, Pages E396-E404

Elevated expression of the sertoli cell androgen receptor disrupts male fertility

Author keywords

Androgen; Sertoli cell; Spermatogenesis; Testis; Transgenic mouse

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANEDIOL; ANDROSTANOLONE; BENZAMIDE DERIVATIVE; EPPIN PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; LEUKOCYTE ELASTASE INHIBITOR; N-PHENYL-N-(1-(PIPERIDINE-1-CARBONYL)CYCLOHEXYL)BENZAMIDE; PIPERIDINE DERIVATIVE; PROTEIN; RHOX5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

EID: 84983732372     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00159.2016     Document Type: Article
Times cited : (12)

References (37)
  • 1
    • 1642546562 scopus 로고    scopus 로고
    • Complete Sertoli cell proliferation induced by follicle- stimulating hormone (FSH) independently of luteinizing hormone activity: Evidence from genetic models of isolated FSH action
    • Allan CM, Garcia A, Spaliviero J, Zhang FP, Jimenez M, Huhtaniemi I, Handelsman DJ. Complete Sertoli cell proliferation induced by follicle- stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action. Endocrinology 145: 1587–1593, 2004.
    • (2004) Endocrinology , vol.145 , pp. 1587-1593
    • Allan, C.M.1    Garcia, A.2    Spaliviero, J.3    Zhang, F.P.4    Jimenez, M.5    Huhtaniemi, I.6    Handelsman, D.J.7
  • 2
    • 0022447799 scopus 로고
    • The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium
    • Bartlett JM, Kerr JB, Sharpe RM. The effect of selective destruction and regeneration of rat Leydig cells on the intratesticular distribution of testosterone and morphology of the seminiferous epithelium. J Androl 7: 240–253, 1986.
    • (1986) J Androl , vol.7 , pp. 240-253
    • Bartlett, J.M.1    Kerr, J.B.2    Sharpe, R.M.3
  • 3
    • 0028103854 scopus 로고
    • Immunohistochemical localization of androgen receptors in the rat testis: Evidence for stage-dependent expression and regulation by androgens
    • Bremner WJ, Millar MR, Sharpe RM, Saunders PT. Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Endocrinology 135: 1227–1234, 1994.
    • (1994) Endocrinology , vol.135 , pp. 1227-1234
    • Bremner, W.J.1    Millar, M.R.2    Sharpe, R.M.3    Saunders, P.T.4
  • 4
    • 2342595087 scopus 로고    scopus 로고
    • Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
    • Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H, Yeh S. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci USA 101: 6876–6881, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6876-6881
    • Chang, C.1    Chen, Y.T.2    Yeh, S.D.3    Xu, Q.4    Wang, R.S.5    Guillou, F.6    Lardy, H.7    Yeh, S.8
  • 5
    • 0020183803 scopus 로고
    • Luteinizing hormone and testosterone secretion in young and old male mice
    • Coquelin A, Desjardins C. Luteinizing hormone and testosterone secretion in young and old male mice. Am J Physiol Endocrinol Metab 243: E257–E263, 1982.
    • (1982) Am J Physiol Endocrinol Metab , vol.243 , pp. E257-E263
    • Coquelin, A.1    Desjardins, C.2
  • 9
    • 0037318477 scopus 로고    scopus 로고
    • Sertoli and germ cell development in hypogonadal (Hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone
    • Haywood M, Spaliviero J, Jimemez M, King NJ, Handelsman DJ, Allan CM. Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology 144: 509–517, 2003.
    • (2003) Endocrinology , vol.144 , pp. 509-517
    • Haywood, M.1    Spaliviero, J.2    Jimemez, M.3    King, N.J.4    Handelsman, D.J.5    Allan, C.M.6
  • 11
    • 84883168515 scopus 로고    scopus 로고
    • Sertoli cell androgen receptor expression regulates temporal fetal and adult Leydig cell differentiation, function, and population size
    • Hazra R, Jimenez M, Desai R, Handelsman DJ, Allan CM. Sertoli cell androgen receptor expression regulates temporal fetal and adult Leydig cell differentiation, function, and population size. Endocrinology 154: 3410–3422, 2013.
    • (2013) Endocrinology , vol.154 , pp. 3410-3422
    • Hazra, R.1    Jimenez, M.2    Desai, R.3    Handelsman, D.J.4    Allan, C.M.5
  • 13
    • 0842301556 scopus 로고    scopus 로고
    • Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids
    • Holdcraft RW, Braun RE. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 131: 459–467, 2004.
    • (2004) Development , vol.131 , pp. 459-467
    • Holdcraft, R.W.1    Braun, R.E.2
  • 14
    • 57649178303 scopus 로고    scopus 로고
    • KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3
    • Huang X, Li X, Guo B. KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. J Biol Chem 283: 29795–29801, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 29795-29801
    • Huang, X.1    Li, X.2    Guo, B.3
  • 15
  • 16
    • 0035000459 scopus 로고    scopus 로고
    • Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation
    • Johnston DS, Russell LD, Friel PJ, Griswold MD. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142: 2405–2408, 2001.
    • (2001) Endocrinology , vol.142 , pp. 2405-2408
    • Johnston, D.S.1    Russell, L.D.2    Friel, P.J.3    Griswold, M.D.4
  • 17
    • 79957834530 scopus 로고    scopus 로고
    • Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats
    • Kostic TS, Stojkov NJ, Bjelic MM, Mihajlovic AI, Janjic MM, Andric SA. Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. Toxicol Sci 121: 397–407, 2011.
    • (2011) Toxicol Sci , vol.121 , pp. 397-407
    • Kostic, T.S.1    Stojkov, N.J.2    Bjelic, M.M.3    Mihajlovic, A.I.4    Janjic, M.M.5    Ric, S.A.6
  • 18
    • 40949116757 scopus 로고    scopus 로고
    • The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis
    • Li D, Yin X, Zmuda EJ, Wolford CC, Dong X, White MF, Hai T. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes 57: 635–644, 2008.
    • (2008) Diabetes , vol.57 , pp. 635-644
    • Li, D.1    Yin, X.2    Zmuda, E.J.3    Wolford, C.C.4    Dong, X.5    White, M.F.6    Hai, T.7
  • 20
    • 0016767238 scopus 로고
    • Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis
    • Lyon MF, Glenister PH, Lamoreux ML. Normal spermatozoa from androgen-resistant germ cells of chimaeric mice and the role of androgen in spermatogenesis. Nature 258: 620–622, 1975.
    • (1975) Nature , vol.258 , pp. 620-622
    • Lyon, M.F.1    Glenister, P.H.2    Lamoreux, M.L.3
  • 21
    • 0034888531 scopus 로고    scopus 로고
    • Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis
    • Mashima T, Udagawa S, Tsuruo T. Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J Cell Physiol 188: 352–358, 2001.
    • (2001) J Cell Physiol , vol.188 , pp. 352-358
    • Mashima, T.1    Udagawa, S.2    Tsuruo, T.3
  • 22
    • 84884694539 scopus 로고    scopus 로고
    • Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene
    • McGee SR, Narayan P. Precocious puberty and Leydig cell hyperplasia in male mice with a gain of function mutation in the LH receptor gene. Endocrinology 154: 3900–3913, 2013.
    • (2013) Endocrinology , vol.154 , pp. 3900-3913
    • McGee, S.R.1    Narayan, P.2
  • 24
    • 3343019124 scopus 로고    scopus 로고
    • Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation
    • Nunlist EH, Dozmorov I, Tang Y, Cowan R, Centola M, Lin HK. Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation. J Steroid Biochem Mol Biol 91: 157–170, 2004.
    • (2004) J Steroid Biochem Mol Biol , vol.91 , pp. 157-170
    • Nunlist, E.H.1    Dozmorov, I.2    Tang, Y.3    Cowan, R.4    Centola, M.5    Lin, H.K.6
  • 26
    • 0017618998 scopus 로고
    • Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats
    • Russell LD, Clermont Y. Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats. Anat Rec 187: 347–366, 1977.
    • (1977) Anat Rec , vol.187 , pp. 347-366
    • Russell, L.D.1    Clermont, Y.2
  • 27
    • 0025650618 scopus 로고
    • Immunohistochemical localization of the androgen receptor in rat and human tissues
    • Sar M, Lubahn DB, French FS, Wilson EM. Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinology 127: 3180–3186, 1990.
    • (1990) Endocrinology , vol.127 , pp. 3180-3186
    • Sar, M.1    Lubahn, D.B.2    French, F.S.3    Wilson, E.M.4
  • 28
    • 0028876068 scopus 로고
    • Induction of spermatogenesis by androgens in gonadotropin-deficient (Hpg) mice
    • Singh J, O’Neill C, Handelsman DJ. Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice. Endocrinology 136: 5311–5321, 1995.
    • (1995) Endocrinology , vol.136 , pp. 5311-5321
    • Singh, J.1    O’Neill, C.2    Handelsman, D.J.3
  • 29
    • 84901637163 scopus 로고    scopus 로고
    • The regulation of spermatogenesis by androgens
    • Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Semin Cell Dev Biol 30: 2–13, 2014.
    • (2014) Semin Cell Dev Biol , vol.30 , pp. 2-13
    • Smith, L.B.1    Walker, W.H.2
  • 30
    • 0035845558 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
    • Stanbrough M, Leav I, Kwan PW, Bubley GJ, Balk SP. Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc Natl Acad Sci USA 98: 10823–10828, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10823-10828
    • Stanbrough, M.1    Leav, I.2    Kwan, P.W.3    Bubley, G.J.4    Balk, S.P.5
  • 32
    • 34948871606 scopus 로고    scopus 로고
    • Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells
    • Tsai MY, Yeh SD, Wang RS, Yeh S, Zhang C, Lin HY, Tzeng CR, Chang C. Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells. Proc Natl Acad Sci USA 103: 18975–18980, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18975-18980
    • Tsai, M.Y.1    Yeh, S.D.2    Wang, R.S.3    Yeh, S.4    Zhang, C.5    Lin, H.Y.6    Tzeng, C.R.7    Chang, C.8
  • 33
    • 65249154823 scopus 로고    scopus 로고
    • Androgen receptor roles in spermatogenesis and fertility: Lessons from testicular cell-specific androgen receptor knockout mice
    • Wang RS, Yeh S, Tzeng CR, Chang C. Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev 30: 119–132, 2009.
    • (2009) Endocr Rev , vol.30 , pp. 119-132
    • Wang, R.S.1    Yeh, S.2    Tzeng, C.R.3    Chang, C.4
  • 34
    • 72749101744 scopus 로고    scopus 로고
    • Androgen action via testicular peritubular myoid cells is essential for male fertility
    • Welsh M, Saunders PT, Atanassova N, Sharpe RM, Smith LB. Androgen action via testicular peritubular myoid cells is essential for male fertility. FASEB J 23: 4218–4230, 2009.
    • (2009) FASEB J , vol.23 , pp. 4218-4230
    • Welsh, M.1    Saunders, P.T.2    Atanassova, N.3    Sharpe, R.M.4    Smith, L.B.5
  • 35
    • 50249118153 scopus 로고    scopus 로고
    • 5alpha-androstane- 3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: Implication of androgen-independent prostate cancer progression
    • Yang Q, Titus MA, Fung KM, Lin HK. 5alpha-androstane- 3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression. J Cell Biochem 104: 1612–1624, 2008.
    • (2008) J Cell Biochem , vol.104 , pp. 1612-1624
    • Yang, Q.1    Titus, M.A.2    Fung, K.M.3    Lin, H.K.4
  • 36
  • 37
    • 80053032377 scopus 로고    scopus 로고
    • Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate
    • Zhu C, Luong R, Zhuo M, Johnson DT, McKenney JK, Cunha GR, Sun Z. Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate. J Biol Chem 286: 33478–33488, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 33478-33488
    • Zhu, C.1    Luong, R.2    Zhuo, M.3    Johnson, D.T.4    McKenney, J.K.5    Cunha, G.R.6    Sun, Z.7


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