Long-term follow-up of hepatitis B carrier children treated with interferon and prednisolone

Journal of Medical Virology

Volumn 78, Issue 7, 2006, Pages 888-895

  Boxall, Elizabeth H ^a,b   Sira, Jaswant ^a   Ballard, Anna L ^b   Davies, Paul ^a   Kelly, Deirdre A ^a  

^a BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

HBeAg seroconversion; HBV DNA response; Hepatitis B children infected perinatally

Indexed keywords

ALPHA2B INTERFERON; AMINOTRANSFERASE; HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; LIVER ENZYME; PREDNISOLONE;

ADOLESCENT; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FOLLOW UP; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOMODULATION; KAPLAN MEIER METHOD; MALE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; REVIEW; SEROCONVERSION; TIME; UNITED KINGDOM; VIRUS CARRIER; VIRUS SHEDDING;

ADOLESCENT; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; ASPARTATE AMINOTRANSFERASES; CARRIER STATE; CHILD; CHILD, PRESCHOOL; DISEASE TRANSMISSION, VERTICAL; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; GREAT BRITAIN; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; INFANT, NEWBORN; INTERFERON ALFA-2B; PREDNISOLONE; PREGNANCY;

EID: 33744963090     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.20637     Document Type: Review

References (32)

1. Barbera C, Bortolotti F, Crivellaro C, Coscia A, Zancan L, Cadrobbi P, Nebbia G, Pilla MN, Lepore L, Parrella T, Dastoli G, Brunetto M, Bonino F. 1994. Recombinant interferon a 2a hastens the rate of HBeAg clearance in children with chronic hepatitis B. Hepatology 20:287-290.
2. Beasley RP. Hepatitis B virus. 1988. The major etiology of hepatocellular carcinoma. Cancer 6:1942-1945.
3. Bortolotti F, Jara P, Barbera C, Gregorio GV, Vegnente A, Zancan L, Hierro L, Crivellaro C, Vergani GM, Iorio R, Pace M, Con P, Gatta A. 2000. Long term effect of alpha interferon in children with chronic hepatitis B. Gut 46:715-718.
4. Boxall E, Sira J, Standish RA, Sleight E, Adeodu O, Dhillon AP, Scheuer PJ, Kelly D. 2004. The natural history of hepatitis B in perinatally infected carriers. Arch Dis Child Fetal Neonatal Ed 89: F456-F460.
5. Chan HL, Hui AY, Wong VW, Chim AM, Wong ML, Sung JJ. 2005. Long-term follow-up of peginterferon and lamivudine combination treatment in HBeAg-positive chronic hepatitis B. Hepatology 41:1357-1364.
6. Erhardt A, Blondin D, Hauck K, Sagir A, Kohnle T, Heintges T, Haussinger D. 2005. Response to interferon alfa is hepatitis B virus genotype dependent: Genotype A is more sensitive to interferon than genotype D. Gut 54:1009-1013.
7. Gregorio M, Jara P, Hierro L, Diaz C, DeLa Vega A, Vengnente A, Iorio R, Bortolotti F, Crivellardo C, Zancan L, Daniels H, Portman B, Mieli-Vergani G. 1996. Lymphobastoid interferon alpha with or without steroid pre-treatment in children with chronic hepatitis B: A multicentre controlled trial. Hepatology 23:700-707.
8. Jara P, Bortolotti F. 1999. Interferon-α treatment of chronic hepatitis B in childhood: A consensus advice based on experience in European children. J Paediatr Gastroenterology Nutr 29:163-170.
9. Jonas M, Kelly D, Mizerski J, Mizarski J, Badia IB, Areias JA, Schwarz KB, Little NR, Greensmith MJ, Gardner SD, Bell MS, Sokal EM. 2002. Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med 346:1706-1713.
10. Kane MA, Clements J, Hu D. 1993. Hepatitis B. In: Jamison DT, Moseley WH, Measham AR, Bobadilla J. Disease control priorities in developing countries. New York: Oxford University Press, p 321-330.
11. Koziel MJ. 1999. What once was lost, now is found: Restoration of hepatitis B-specific immunity after treatment of chronic hepatitis B. Hepatology 4:1331-1333.
12. Krogsgaard K, Marcellin P, Trepo C, Berthelot P, Sanchez-Tapias JM, Bassendine M, Tran A, Ouzan D, Ring-Larsen H, Lindberg J, Enriquez J, Benhamou JP, Bindslev N. 1996. Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B. INTERPRED Trial Group. J Hepatol 25:803-881.
13. Lai CL, Lin HJ, Lau JYN, Lok ASF, Wu PC, Chung HT, Wong LSK, Leung MP, Yeung CY. 1989. Use of recombinant alpha-2 interferon with or without steroids in Chinese HBsAg carrier children: A prospective double blind controlled trial. Gastroenterology 96: A618.
14. Lai CL, Lin HJ, Lau JN, Flok AS, Wu PC, Chung HT, Leung MP, Yeung CY. 1991. Effect of recombinant alpha 2 Interferon alone with or without Prednisolone in Chinese HBsAg carrier children. Q J Med 78:155-163.
15. Lau DT, Everhart J, Klainer DE, Park Y, Vergalla J, Schmid P, Hoofnagle JH. 1997. Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa. Gastroenterology 113:1660-1667.
16. Liaw Y, Tsai S, Chien R, Yeh CT, Chu CM. 2000. Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B. Hepatology 32:604-609.23.
17. Lin SM, Sheen IS, Chien RN, Sheen IS, Chu CM, Liaw YF. 1999. Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection. Hepatology 29:971-975.
18. Lok ASF, Lai CL, Wu PC, Leung EK. 1988. Long term follow-up in a randomised controlled trial of recombinant alpha interferon in Chinese patients with chronic hepatitis B infection. Lancet ii:298-302.
19. McMahon BJ, Alward WL, Hall DB, Heyward WL, Bender TR, Francis DP, Maynard JE. 1985. Acute hepatitis B infection: Relation of age to the clinical expression of disease and subsequent development of the carrier state. J Infect Dis 151:599-603.
20. Mellerup MT, Krogsgaard K, Mathurin P, Gluud C, Poynard T. 2002. Sequential combination of glucocorticosteroids and alfa interferon versus alfa Interferon alone for HBeAg-positive chronic hepatitis B. Cochrane Database of Systematic Reviews (2):CD000345.
21. Mosmann TR, Sad S. 1996. The expanding universe of T-cell subsets:Th1, Th2 and more. Immunol Today 17:13.8-146.
22. Niederau C, Heintges T, Lange S, Goldman G, Niederau CM, Mohr L, Haussinger D. 1996. Long-term follow-up of HBeAg positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med 334:1422-1427.
23. Ruiz Moreno M, Rua JJ, Molina J, Moraleda G, Moreno A, Garcia-Aguado J, Carreno V. 1991. Prospective, randomised controlled trial of Interferon alone alpha in children with chronic hepatitis B. Hepatology 13:1035-1039.
24. Sokal EM, Conjeevaram H, Roberts EA, Alvarez F, Bern EM, Goyens P, Rosenthal P, Lachaux A, Shelton M, Sarles J, Hoofnagle J. 1998. Interferon alpha for treatment of paediatric chronic hepatitis B: A randomised controlled multicenter trial. Gastroenterology 114:988-995.
25. Torre D, Tambini R. 1996. Interferon-alpha therapy for chronic hepatitis B in children: A meta- analysis. Clin Infect Dis 23:131-137.
26. Utili R, Sagnelli E, Gaeta G, Galanti B, Nardiel-Lo S, Felaco FM, Pasquale G. 1994. Treatment of chronic hepatitis B in children with prednisone followed by alfa-interferon: A controlled randomised study. J Hepatol 20:163-167.
27. Wheeley SM, Boxall EH, Tarlow MJ. 1989. Chronic hepatitis B infection in male and female children of HBsAg carrier mothers. J Hepatol 8:226-231.
28. Wheeley SM, Boxall EH, Tarlow MJ, Gatrad AR, Anderson J, Bissenden J, Chin KC, Mayne A. 1990. Hepatitis B vaccine in the prevention of perinatally transmitted hepatitis B virus infection: Final report on a West Midlands pilot study. J Med Virol 30:113-116.
29. Wheeley SM, Jackson PT, Boxall EH, Tarlow MJ, Gatrad AR, Anderson J, Bissenden J. 1991. Prevention of perinatal transmission of hepatitis B virus (HBV): A comparison of two prophylactic schedules. J Med Virol 35:212-215.
30. Yuen MF, Tanaka Y, Lai CL. 2003. Hepatitis B genotypes in chronic hepatitis B and lamivudine therapy. Intervirology 46:373-376.
31. Yuen MF, Fung SK, Tanaka Y, Kato T, Mizokami M, Yuen JC, Wong DK, Yuan HJ, Sum SM, Chan AO, Wong BC, Lai CL. 2004. Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C. J Clin Microbiol 42:5036-5040.
32. Zollner B, Petersen J, Puchhammer-Stockl E, Kletzmayr J, Sterneck M, Fischer L, Schroter M, Laufs R, Feucht HH. 2004. Viral features of lamivudine resistant hepatitis genotypes A and D. Hepatology 39:42-50.