Quality of care is improved by rapid short incubation MALDI-ToF identification from blood cultures as measured by reduced length of stay and patient outcomes as part of a multi-disciplinary approach to bacteremia in pediatric patients

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Delport, Johannes A ^a,b   Strikwerda, Arend ^b   Armstrong, Amanda ^a   Schaus, David ^a   John, Michael ^a,b  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b WESTERN UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ARTICLE; BACTEREMIA; BLOOD CULTURE; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; INCUBATION TIME; INFANT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PATIENT CARE; PROCESS OPTIMIZATION; RETROSPECTIVE STUDY; RISK FACTOR; SEX RATIO; TREND STUDY; BACTERIUM; CLASSIFICATION; HEALTH CARE QUALITY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MICROBIOLOGY; PRESCHOOL CHILD; SEPSIS; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; BACTERIA; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; QUALITY OF HEALTH CARE; RETROSPECTIVE STUDIES; SEPSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TREATMENT OUTCOME;

EID: 84983479541     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160618     Document Type: Article

References (11)

1. Verroken A, Defourny L, Lechgar L, Magnette A, Delmée M, Glupczynski Y. Reducing time to identification of positive blood cultures with MALDI-TOF MS analysis after a 5-h subculture. Eur J Clin Microbiol Infect Dis. 2015 Feb; 34(2): 405-13. doi: 10.1007/s10096-014-2242-4 PMID: 25252627
2. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013; 41: 580-637. doi: 10.1097/CCM.0b013e31827e83af PMID: 23353941
3. Bryan CS, Reynolds KL, Brenner ER. Analysis of 1,186 episodes of gram-negative bacteremia in nonuniversity hospitals: the effects of antimicrobial therapy. Rev Infect Dis. 1983; 5(4): 629-638. PMID: 6353525
4. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet. 1991; 338 (8769): 732-736. PMID: 1679876
5. Watson RS, Linde-Zwirble WT, Lidicker J, Carcillo JA, Angus DC. The increasing burden of severe sepsis in U.S. children. Crit Care Med. 2002; 29: A8.
6. Odetola FO, Gebremariam A, Freed GL. Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics. 2007 Mar; 119(3): 487-494. PMID: 17332201
7. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001; 345(19): 1368-1377. PMID: 11794169
8. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock: pathogenesis. Lancet. 1991; 338 (8769): 732-736. PMID: 1679876
9. Biondi E, Evans R, Mischler M, Bendel-Stenzel M, Horstmann S, Lee V, et al. Epidemiology of bacteremia in febrile infants in the United States. Pediatrics. 2013 Dec. 132(6): 990-996. doi: 10.1542/peds. 2013-1759 PMID: 24218461
10. Perez K, Randall J, Olsen RJ, Musick WL, Cernoch PL, Davis JR, et al. Integrating Rapid Pathogen Identification and Antimicrobial Stewardship Significantly Decreases Hospital Costs. Arch Pathol Lab Med. 2013; 137: 1247-1254; doi: 10.5858/arpa.2012-0651-OA PMID: 23216247
11. Kohlmann R, Hoffmann A, Geisb G, Gatermann G. MALDI-TOF mass spectrometry following short incubation on a solid medium is a valuable tool for rapid pathogen identification from positive blood cultures. Int J Med Microbiol. 2015; 305(4-5): 469-479; doi: 10.1016/j.ijmm.2015.04.004 PMID: 25953498