High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods

ADMET and DMPK

Volumn 2, Issue 2, 2014, Pages 98-106

  Cabot, Joan Marc ^a   Subirats, Xavier ^a   Fuguet, Elisabet ^a   Rosés, Martí ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acidity constants; CHI; Chromatographic hydrophobicity index; Drug discovery; Internal standard; Lipophilicity

Indexed keywords

EID: 84983470072     PISSN: None     EISSN: 18487718     Source Type: Journal    
DOI: 10.5599/admet.2.2.44     Document Type: Article

References (16)

1. K. Valkó, P. Slégel, J. Chromatogr. A 631 (1993) 49-61.
2. K. Valkó, C. Bevan, D. Reynolds, Anal. Chem. 69 (1997) 2022-2029.
3. K. Valkó, C.M. Du, C. Bevan, D.P. Reynolds, M.H. Abraham, Curr. Med. Chem. 8 (2001) 1137-1146.
4. S.F. Donovan, M.C. Pescatore, J. Chromatogr. A 952 (2002) 47-61.
5. E. Fuguet, C. Ràfols, E. Bosch, M. Rosés, J. Chromatogr. A 1216 (2009) 3646-3651.
6. J.M. Cabot, E. Fuguet, C. Ràfols, M. Rosés, J. Chromatogr. A 1217 (2010) 8340-8345.
7. E. Fuguet, C. Ràfols, M. Rosés, J. Chromatogr. A 1218 (2011) 3928-3934.
8. J.M. Cabot, E. Fuguet, C. Ràfols, M. Rosés, J. Chromatogr. A 1279 (2013) 108-116.
9. E. Fuguet, C. Ràfols, E. Bosch, M. Rosés, J. Chromatogr. A 1173 (2007) 110-119.
10. E. Fuguet, C. Ràfols, E. Bosch, M. Rosés, J. Chromatogr. A 1216 (2009) 7798-7805.
11. K. Valkó, C.M. Du, C.D. Bevan, D.P. Reynolds, M.H. Abraham, J. Pharm. Sci. 89 (2000) 1085-1096.
12. Bio-Loom, BioByte Corp. (Claremont, CA, USA), Version 1.5.
13. A. Andrés, M. Rosés, C. Ràfols, E. Bosch, S. Espinosa, V. Segarra, J.M. Huerta, Manuscript in preparation.
14. A. Avdeef, Absorption and drug development: solutility, permeability, and charge state, Wiley, Hoboken, NJ, USA, 2003.
15. ACD/Labs, Advanced Chemistry Development, Inc. (Toronto, Canada), build 2203 (29-Jan-2013).
16. C. Horváth, W. Melander, I. Molnár, Anal. Chem. 49 (1977) 142-154.