Monitoring of anti-hepatitis E virus antibody seroconversion in asymptomatically infected blood donors: Systematic comparison of nine commercial anti-HEV IgM and IgG assays

Viruses

Volumn 8, Issue 8, 2016, Pages

  Vollmer, Tanja ^a   Diekmann, Juergen ^a   Eberhardt, Matthias ^b   Knabbe, Cornelius ^a   Dreier, Jens ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b TMD Gesellschaft fur transfusionsmedizinische Dienste mbH   (Germany)

Author keywords

Hepatitis E virus; IgG; IgM; Sensitivity; Seroconversion; Serology

Indexed keywords

HEPATITIS E ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS RNA; VIRUS ANTIBODY;

ADULT; ARTICLE; BLOOD DONOR; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS E; HEPATITIS E VIRUS; HUMAN; IMMUNOASSAY; MALE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SEROCONVERSION; SEROLOGY; SEROPREVALENCE; BLOOD; EVALUATION STUDY; IMMUNOLOGY; PROCEDURES;

ANTIBODIES, VIRAL; BLOOD DONORS; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; SENSITIVITY AND SPECIFICITY; SEROCONVERSION;

EID: 84983402731     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v8080232     Document Type: Article

References (44)

1. Kamar, N.; Bendall, R.; Legrand-Abravanel, F.; Xia, N.S.; Ijaz, S.; Izopet, J.; Dalton, H.R. Hepatitis E. Lancet 2012, 379, 2477-2488. [CrossRef]
2. Borgen, K.; Herremans, T.; Duizer, E.; Vennema, H.; Rutjes, S.; Bosman, A.; de Roda Husman, A.M.; Koopmans, M. Non-travel related Hepatitis E virus genotype 3 infections in the Netherlands; a case series 2004-2006. BMC Infect. Dis. 2008, 8, 61. [CrossRef] [PubMed]
3. Dalton, H.R.; Kamar, N.; Izopet, J. Hepatitis E in developed countries: Current status and future perspectives. Future Microbiol. 2014, 9, 1361-1372. [CrossRef] [PubMed]
4. Pischke, S.; Behrendt, P.; Bock, C.T.; Jilg, W.; Manns, M.P.; Wedemeyer, H. Hepatitis E in Germany—An under-reported infectious disease. Dtsch. Arzteblatt Int. 2014, 111, 577-583.
5. Peron, J.M.; Bureau, C.; Poirson, H.; Mansuy, J.M.; Alric, L.; Selves, J.; Dupuis, E.; Izopet, J.; Vinel, J.P. Fulminant liver failure from acute autochthonous hepatitis E in France: Description of seven patients with acute hepatitis E and encephalopathy. J. Viral Hepat. 2007, 14, 298-303. [CrossRef] [PubMed]
6. Worm, H.C.; van der Poel, W.H.; Brandstatter, G. Hepatitis E: An overview. Microbes Infect. 2002, 4, 657-666. [CrossRef]
7. Boccia, D.; Guthmann, J.P.; Klovstad, H.; Hamid, N.; Tatay, M.; Ciglenecki, I.; Nizou, J.Y.; Nicand, E.; Guerin, P.J. High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan. Clin. Infect. Dis. 2006, 42, 1679-1684. [CrossRef] [PubMed]
8. Christensen, P.B.; Engle, R.E.; Hjort, C.; Homburg, K.M.; Vach, W.; Georgsen, J.; Purcell, R.H. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: A potential zoonosis in Denmark. Clin. Infect. Dis. 2008, 47, 1026-1031. [CrossRef] [PubMed]
9. Kamar, N.; Selves, J.; Mansuy, J.M.; Ouezzani, L.; Peron, J.M.; Guitard, J.; Cointault, O.; Esposito, L.; Abravanel, F.; Danjoux, M.; et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N. Engl. J. Med. 2008, 358, 811-817. [CrossRef] [PubMed]
10. Legrand-Abravanel, F.; Kamar, N.; Sandres-Saune, K.; Garrouste, C.; Dubois, M.; Mansuy, J.M.; Muscari, F.; Sallusto, F.; Rostaing, L.; Izopet, J. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J. Infect. Dis. 2010, 202, 835-844. [CrossRef] [PubMed]
11. Engle, R.E.; Yu, C.; Emerson, S.U.; Meng, X.J.; Purcell, R.H. Hepatitis E virus (HEV) capsid antigens derived from viruses of human and swine origin are equally efficient for detecting anti-HEV by enzyme immunoassay. J. Clin. Microbiol. 2002, 40, 4576-4580. [CrossRef] [PubMed]
12. Mansuy, J.M.; Peron, J.M.; Bureau, C.; Alric, L.; Vinel, J.P.; Izopet, J. Immunologically silent autochthonous acute hepatitis E virus infection in France. J. Clin. Microbiol. 2004, 42, 912-913. [CrossRef] [PubMed]
13. Nicand, E.; Grandadam, M.; Teyssou, R.; Rey, J.L.; Buisson, Y. Viraemia and faecal shedding of HEV in symptom-free carriers. Lancet 2001, 357, 68-69. [CrossRef]
14. Ferguson, M.; Walker, D.; Mast, E.; Fields, H. Report of a collaborative study to assess the suitability of a reference reagent for antibodies to hepatitis E virus. Biol. J. Int. Assoc. Biol. Stand. 2002, 30, 43-48. [CrossRef] [PubMed]
15. Yu, C.; Engle, R.E.; Bryan, J.P.; Emerson, S.U.; Purcell, R.H. Detection of immunoglobulin M antibodies to hepatitis E virus by class capture enzyme immunoassay. Clin. Diagn. Lab. Immunol. 2003, 10, 579-586. [CrossRef] [PubMed]
16. Abravanel, F.; Chapuy-Regaud, S.; Lhomme, S.; Miedouge, M.; Peron, J.M.; Alric, L.; Rostaing, L.; Kamar, N.; Izopet, J. Performance of anti-HEV assays for diagnosing acute hepatitis E in immunocompromised patients. J. Clin.Virol. 2013, 58, 624-628. [CrossRef] [PubMed]
17. Bendall, R.; Ellis, V.; Ijaz, S.; Ali, R.; Dalton, H. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J. Med. Virol. 2010, 82, 799-805. [CrossRef] [PubMed]
18. Drobeniuc, J.; Meng, J.; Reuter, G.; Greene-Montfort, T.; Khudyakova, N.; Dimitrova, Z.; Kamili, S.; Teo, C.G. Serologic assays specific to immunoglobulinMantibodies against hepatitis E virus: Pangenotypic evaluation of performances. Clin. Infect. Dis. 2010, 51, e24-e27. [CrossRef] [PubMed]
19. Legrand-Abravanel, F.; Thevenet, I.; Mansuy, J.M.; Saune, K.; Vischi, F.; Peron, J.M.; Kamar, N.; Rostaing, L.; Izopet, J. Good performance of immunoglobulin M assays in diagnosing genotype 3 hepatitis E virus infections. Clin. Vaccine Immunol. CVI 2009, 16, 772-774. [CrossRef] [PubMed]
20. Mansuy, J.M.; Bendall, R.; Legrand-Abravanel, F.; Saune, K.; Miedouge, M.; Ellis, V.; Rech, H.; Destruel, F.; Kamar, N.; Dalton, H.R.; et al. Hepatitis E virus antibodies in blood donors, France. Emerg. Infect. Dis. 2011, 17, 2309-2312. [CrossRef] [PubMed]
21. Myint, K.S.; Endy, T.P.; Gibbons, R.V.; Laras, K.; Mammen, M.P., Jr.; Sedyaningsih, E.R.; Seriwatana, J.; Glass, J.S.; Narupiti, S.; Corwin, A.L. Evaluation of diagnostic assays for hepatitis E virus in outbreak settings. J. Clin. Microbiol. 2006, 44, 1581-1583. [CrossRef] [PubMed]
22. Pas, S.D.; Streefkerk, R.H.; Pronk, M.; de Man, R.A.; Beersma, M.F.; Osterhaus, A.D.; van der Eijk, A.A. Diagnostic performance of selected commercial HEV IgM and IgG ELISAs for immunocompromised and immunocompetent patients. J. Clin. Virol. 2013, 58, 629-634. [CrossRef] [PubMed]
23. Schnegg, A.; Burgisser, P.; Andre, C.; Kenfak-Foguena, A.; Canellini, G.; Moradpour, D.; Abravanel, F.; Izopet, J.; Cavassini, M.; Darling, K.E. An analysis of the benefit of using HEV genotype 3 antigens in detecting anti-HEV IgG in a European population. PLoS ONE 2013, 8, e62980. [CrossRef] [PubMed]
24. Wenzel, J.J.; Preiss, J.; Schemmerer, M.; Huber, B.; Jilg, W. Test Performance Characteristics of Anti-HEV IgG Assays Strongly Influence Hepatitis E Seroprevalence Estimates. J. Infect. Dis. 2013, 207, 497-500. [CrossRef] [PubMed]
25. Blood Advisory Committee, Topic I: Hepatitis E Virus (HEV) and Blood Transfusion Safety. Available online: http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/bloodvaccinesandotherbiologics/bloodproductsadvisorycommittee/ucm319542.pdf (accessed on 17 August 2016).
26. Avellon, A.; Morago, L.; Garcia-Galera, M.; Munoz, M.; Echevarria, J.M. Comparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection. J. Med. Virol. 2015, 87, 1934-1939. [CrossRef] [PubMed]
27. Vollmer, T.; Diekmann, J.; Eberhardt M.; Knabbe C.; Dreier J. Hepatitis E in blood donors: Investigation of the natural course of asymptomatic infection. Eurosurveillance 2016, in press.
28. Vollmer, T.; Diekmann, J.; Johne, R.; Eberhardt M.; Knabbe C.; Dreier J. Novel approach for the detection of Hepatitis E virus infection in German blood donors. J. Clin. Microbiol. 2012, 50, 2708-2713. [CrossRef] [PubMed]
29. Dreier J.; Juhl, D. Autochthonous Hepatitis E Virus Infections: A New Transfusion-Associated Risk? Transfus. Med. Hemother. 2014, 41, 29-39. [CrossRef] [PubMed]
30. Li, R.C.; Ge, S.X.; Li, Y.P.; Zheng, Y.J.; Nong, Y.; Guo, Q.S.; Zhang, J.; Ng, M.H.; Xia, N.S. Seroprevalence of hepatitis E virus infection, rural southern People’s Republic of China. Emerg. Infect. Dis. 2006, 12, 1682-1688. [CrossRef] [PubMed]
31. Seriwatana, J.; Shrestha, M.P.; Scott, R.M.; Tsarev, S.A.; Vaughn, D.W.; Myint, K.S.; Innis, B.L. Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M. Clin. Diagn. Lab. Immunol. 2002, 9, 1072-1078. [CrossRef] [PubMed]
32. Mansuy, J.M.; Legrand-Abravanel, F.; Calot, J.P.; Peron, J.M.; Alric, L.; Agudo, S.; Rech, H.; Destruel, F.; Izopet, J. High prevalence of anti-hepatitis E virus antibodies in blood donors from South West France. J. Med. Virol. 2008, 80, 289-293. [CrossRef] [PubMed]
33. Zhou, H.; Jiang, C.W.; Li, L.P.; Zhao, C.Y.;Wang, Y.C.; Xu, Y.W.; Chen, X.F. Comparison of the reliability of two ELISA kits for detecting IgM antibody against hepatitis E virus. Zhonghua Yu Fang Yi Xue Za Zhi/Chin. J. Prev. Med. 2008, 42, 667-671.
34. Wu, W.C.; Su, C.W.; Yang, J.Y.; Lin, S.F.; Chen, J.Y.; Wu, J.C. Application of serologic assays for diagnosing acute hepatitis E in national surveillance of a nonendemic area. J. Med. Virol. 2014, 86, 720-728. [CrossRef] [PubMed]
35. Norder, H.; Karlsson, M.; Mellgren, A.; Konar, J.; Sandberg, E.; Lasson, A.; Castedal, M.; Magnius, L.; Lagging, M. Diagnostic Performance of Five Assays for Anti-Hepatitis E Virus IgG and IgM in a Large Cohort Study. J. Clin. Microbiol. 2016, 54, 549-555. [CrossRef] [PubMed]
36. Abravanel, F.; Lhomme, S.; Chapuy-Regaud, S.; Peron, J.M.; Alric, L.; Rostaing, L.; Kamar, N.; Izopet, J. Performance of a new rapid test for detecting anti-hepatitis E virus immunoglobulinMin immunocompetent and immunocompromised patients. J. Clin. Virol. 2015, 70, 101-104. [CrossRef] [PubMed]
37. Chen, H.Y.; Lu, Y.; Howard, T.; Anderson, D.; Fong, P.Y.; Hu, W.P.; Chia, C.P.; Guan, M. Comparison of a new immunochromatographic test to enzyme-linked immunosorbent assay for rapid detection of immunoglobulin m antibodies to hepatitis e virus in human sera. Clin. Diagn. Lab. Immunol. 2005, 12, 593-598. [CrossRef] [PubMed]
38. Baylis, S.A.; Blümel, J.; Mizusawa, S.; Matsubayashi, K.; Sakata, H.; Okada, Y. World Health Organization International Standard to harmonize assays for detection of hepatitis E virus RNA. Emerg. Infect. Dis. 2013, 19. [CrossRef] [PubMed]
39. Rossi-Tamisier, M.; Moal, V.; Gerolami, R.; Colson, P. Discrepancy between anti-hepatitis E virus immunoglobulin G prevalence assessed by two assays in kidney and liver transplant recipients. J. Clin. Virol. 2013, 56, 62-64. [CrossRef] [PubMed]
40. Biomex, HEV Serokonversion Panel. Available online: http://www.biomex.de/produkteservice/produkte/validierung/seroconversion-panels/ (accessed on 17 August 2016).
41. Bendall, R.; Ellis, V.; Ijaz, S.; Thurairajah, P.; Dalton, H.R. Serological response to hepatitis E virus genotype 3 infection: IgG quantitation, avidity, and IgM response. J. Med. Virol. 2008, 80, 95-101. [CrossRef] [PubMed]
42. Bryan, J.P.; Tsarev, S.A.; Iqbal, M.; Ticehurst, J.; Emerson, S.; Ahmed, A.; Duncan, J.; Rafiqui, A.R.; Malik, I.A.; Purcell, R.H.; et al. Epidemic hepatitis E in Pakistan: Patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. J. Infect. Dis. 1994, 170, 517-521. [CrossRef] [PubMed]
43. Khuroo, M.S.; Kamili, S.; Dar, M.Y.; Moecklii, R.; Jameel, S. Hepatitis E and long-term antibody status. Lancet 1993, 341, 1355. [PubMed]
44. Kmush, B.L.; Labrique, A.B.; Dalton, H.R.; Ahmed, Z.B.; Ticehurst, J.R.; Heaney, C.D.; Nelson, K.E.; Zaman, K. Two Generations of “Gold Standards”: The Impact of a Decade in Hepatitis E Virus Testing Innovation onPopulation Seroprevalence. Am. J. Trop. Med. Hyg. 2015, 93, 714-717. [CrossRef] [PubMed]