A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris

Journal of the European Academy of Dermatology and Venereology

Volumn 30, Issue 6, 2016, Pages 966-973

  Schaller, M ^a   Sebastian, M ^b   Ress, C ^c   Seidel, D ^c   Hennig, M ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Mahlow   (Germany)

^c GLAXOSMITHKLINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AZELAIC ACID; BENZOYL PEROXIDE PLUS CLINDAMYCIN;

ACNE VULGARIS; ADOLESCENT; ADULT; APPLICATION SITE REACTION; ARTICLE; BRUCELLOSIS; CHILD; CONTROLLED STUDY; CREAM; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ERYTHEMA; EYELID EDEMA; FEMALE; GASTROENTERITIS; GERMANY; HEMATOMA; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN; PARALLEL DESIGN; PHASE 4 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; STRESS; TOPICAL TREATMENT; TREATMENT DURATION; URINE RETENTION;

EID: 84983349042     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/jdv.13541     Document Type: Article

References (16)

1. Hanna S, Sharma J, Klotz J. Acne vulgaris: more than skin deep. Dermatol Online J 2003; 9: 8.
2. Ghodsi SZ, Orawa H, Zouboulis CC. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 2009; 129: 2136–2141.
3. Nast A, Dreno B, Bettoli V et al. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 2012; 26(Suppl. 1): 1–29.
4. ® once daily 10 mg/g + 30 mg/g gel: summary of product characteristics. [WWW document] 2015. URL https://www.medicines.org.uk/emc/medicine/28007/SPC/Duac+Once+Daily+10+mg+g+%2B+30+mg+g+Gel/ (last accessed: 6 May 2015).
5. Eichenfield LF, Alio Saenz AB. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol 2011; 10: 1382–1396.
6. Langner A, Chu A, Goulden V, Ambroziak M. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris. Br J Dermatol 2008; 158: 122–129.
7. ® 20% cream: summary of product characteristics. [WWW document] 2015. URL https://www.medicines.org.uk/emc/medicine/19239/SPC/Skinoren+Cream/ (last accessed: 8 May 2015).
8. Gollnick HP, Graupe K, Zaumseil RP. [Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies]. J Dtsch Dermatol Ges 2004; 2: 841–847.
9. Stinco G, Bragadin G, Trotter D, Pillon B, Patrone P. Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. J Eur Acad Venereol Dermatol 2007; 21: 320–325.
10. Mallon E, Newton JN, Klassen A, Stewart-Brown SL, Ryan TJ, Finlay AY. The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol 1999; 140: 672–676.
11. Lewis-Jones MS, Finlay AY. The Children's Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol 1995; 132: 942–949.
12. Katsambas AD. Why and when the treatment of acne fails. What to do. Dermatology 1998; 196: 158–161.
13. Koo J. How do you foster medication adherence for better acne vulgaris management? Skinmed 2003; 2: 229–233.
14. Zaghloul SS, Goodfield MJ. Objective assessment of compliance with psoriasis treatment. Arch Dermatol 2004; 140: 408–414.
15. Zouboulis CC, Fischer TC, Wohlrab J, Barnard J, Alio AB. Study of the efficacy, tolerability, and safety of 2 fixed-dose combination gels in the management of acne vulgaris. Cutis 2009; 84: 223–229.
16. Langner A, Sheehan-Dare R, Layton A. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris. J Eur Acad Venereol Dermatol 2007; 21: 311–319.