Investigation of cerebral iron deposition in aged patients with ischemic cerebrovascular disease using susceptibility-weighted imaging

Therapeutics and Clinical Risk Management

Volumn 12, Issue , 2016, Pages 1239-1247

  Liu, Yin ^a   Liu, Jun ^a   Liu, Huanghui ^a   Liao, Yunjie ^a   Cao, Lu ^a   Ye, Bin ^a   Wang, Wei ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cerebral microbleed; Iron; Ischemia; Lenticular nucleus; Susceptibility weighted imaging

Indexed keywords

IRON;

AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN LEVEL; BRAIN REGION; CAUDATE NUCLEUS; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE SEVERITY; FEMALE; FRONTAL WHITE MATTER; HUMAN; LACUNAR STROKE; LENTICULAR NUCLEUS; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MULTIPLE LINEAR REGRESSION ANALYSIS; NERVOUS SYSTEM PARAMETERS; OCCIPITAL WHITE MATTER; RETROSPECTIVE STUDY; SUSCEPTIBILITY WEIGHTED IMAGING; THALAMUS; TRANSIENT ISCHEMIC ATTACK; WHITE MATTER; WHITE MATTER HYPERINTENSITY;

EID: 84983320475     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S107783     Document Type: Article

References (34)

1. Scharf J, Bräuherr E, Forsting M, Sartor K. Significance of haemorrhagic lacunes on MRI in patients with hypertensive cerebrovascular disease and intracerebral haemorrhage. Neuroradiology. 1994;36(7):504–508.
2. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain. 2007;130(pt 8):1988–2003.
3. Charidimou A, Kakar P, Fox Z, Werring DJ. Cerebral microbleeds and the risk of intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2013;84(3):277–280.
4. Dichgans M, Holtmannspötter M, Herzog J, Peters N, Bergmann M, Yousry TA. Cerebral microbleeds in CADASIL: a gradient-echo magnetic resonance imaging and autopsy study. Stroke. 2002;33(1):67–71.
5. Dichgans M, Mayer M, Uttner I, et al. The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol. 1998;44(5):731–739.
6. Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20(4):637–642.
7. Schrag M, McAuley G, Pomakian J, et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol. 2010;119(3):291–302.
8. Iancu TC. Ultrastructural aspects of iron storage, transport and metabolism. J Neural Transm (Vienna). 2011;118(3):329–335.
9. McAuley G, Schrag M, Barnes S, Obenaus A, Dickson A, Kirsch W. In vivo iron quantification in collagenase-induced microbleeds in rat brain. Magn Reson Med. 2012;67(3):711–717.
10. Janaway B, Simpson JE, Hoggard N, et al; MRC Cognitive Function and Ageing Neuropathology Study. Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds. Neuropathol Appl Neurobiol. 2014;40(3):258–269.
11. Mittal S, Wu Z, Neelavalli J, Haacke EM. Susceptibility-weighted imaging: technical aspects and clinical applications, part 2. AJNR Am J Neuroradiol. 2009;30(2):232–252.
12. Haacke EM, Cheng NY, House MJ, et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging. 2005;23(1):1–25.
13. Wang Y, Butros SR, Shuai X, et al. Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging. AJNR Am J Neuroradiol. 2012;33(2):266–273.
14. Wang D, Li WB, Wei XE, Li YH, Dai YM. An investigation of age-related iron deposition using susceptibility weighted imaging. PLoS One. 2012;7(11):e50706.
15. Yakushiji Y, Noguchi T, Hara M, et al. Distributional impact of brain microbleeds on global cognitive function in adults without neurological disorder. Stroke. 2012;43(7):1800–1805.
16. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol. 1987;149(2):351–356.
17. Braffman BH, Zimmerman RA, Trojanowski JQ, Gonatas NK, Hickey WF, Schlaepfer WW. Brain MR: pathologic correlation with gross and histopathology. 1. Lacunar infarction and Virchow-Robin spaces. AJR Am J Roentgenol. 1988;9(4):621–628.
18. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci. 2004;5(11):863–873.
19. Selim MH, Ratan RR. The role of iron neurotoxicity in ischemic stroke. Ageing Res Rev. 2004;3(3):345–353.
20. Dávalos A, Fernandez-Real JM, Ricart W, et al. Iron-related damage in acute ischemic stroke. Stroke. 1994;25(8):1543–1546.
21. Bishop GM, Robinson SR. Quantitative analysis of cell death and ferritin expression in response to cortical iron: implications for hypoxia-ischemia and stroke. Brain Res. 2001;907(1):175–187.
22. Dietrich R, Bradley WG Jr. Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. Radiology. 1988;168(1):203–206.
23. Bartzokis G, Tishler TA. MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer’s and Huntington’s disease. Cell Mol Biol (Noisy-le-grand). 2000;46(4):821–833.
24. Bartzokis G, Sultzer D, Cummings J, et al. In vivo evaluation of brain iron in Alzheimer disease using magnetic resonance imaging. Arch Gen Psychiatry. 2000;57(1):47–53.
25. Drayer B, Burger P, Hurwitz B, Dawson D, Cain J. Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content? AJR Am J Roentgenol. 1987;149(2):357–363.
26. Hayflick S, Hartman M, Coryell J, Gitschier J, Rowley H. Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations. AJNR Am J Neuroradiol. 2006;27(6):1230–1233.
27. Akhlaghpoor S, Ghahari A, Morteza A, Khalilzadeh O, Shakourirad A, Alinaghizadeh MR. Quantitative T2* magnetic resonance imaging for evaluation of iron deposition in the brain of β-thalassemia patients. Clin Neuroradiol. 2012;22(3):211–217.
28. Aquino D, Bizzi A, Grisoli M, et al. Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects 1. Radiology. 2009;252(1):165–172.
29. Urich H. Malformations of the nervous system, perinatal damage and related conditions in early life. In: Blackwood W, Corsellis JAN, eds. Greenfield’s Neuropathology. London: Edward Arnold; 1976:434.
30. Akoudad S, Ikram MA, Koudstaal PJ, et al. Cerebral microbleeds are associated with the progression of ischemic vascular lesions. Cerebrovasc Dis. 2014;37(5):382–388.
31. Werring D, Coward LJ, Losseff NA, Jäger HR, Brown MM. Cerebral microbleeds are common in ischemic stroke but rare in TIA. Neurology. 2005;65(12):1914–1918.
32. Vernooij MW, Ikram MA, Wielopolski PA, Krestin GP, Breteler MM, van der Lugt A. Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection 1. Radiology. 2008;248(1):272–277.
33. Bartzokis G, Tishler TA, Lu PH, et al. Brain ferritin iron may influence age- and gender-related risks of neurodegeneration. Neurobiol Aging. 2007;28(3):414–423.
34. Xu X, Wang Q, Zhang M. Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. Neuroimage. 2008;40(1):35–42.