Low Vitamin D is associated with hypertension in paediatric obesity

Journal of Paediatrics and Child Health

Volumn 51, Issue 12, 2015, Pages 1207-1213

  Kao, Kung Ting ^a,b,c   Abidi, Nobia ^d   Ranasinha, Sanjeeva ^d   Brown, Justin ^d,e   Rodda, Christine ^c,d,f   McCallum, Zoe ^a,c   Zacharin, Margaret ^a,b,c   Simm, Peter J ^a,b,e   Magnussen, Costan G ^g,h   Sabin, Matthew A ^a,b,c,d  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e MONASH CHILDREN S HOSPITAL   (Australia)

^f SUNSHINE HOSPITAL   (Australia)

^g UNIVERSITY OF TASMANIA   (Australia)

^h UNIVERSITY OF TURKU   (Finland)

Author keywords

children; hypertension; metabolic syndrome; obesity; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; PHOSPHATE; TRIACYLGLYCEROL; 25-HYDROXYVITAMIN D; VITAMIN D;

ADOLESCENT; ADULT; ANTHROPOMETRY; ARTICLE; AUSTRALIA; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS; CALCIUM BLOOD LEVEL; CARDIOMETABOLIC RISK; CHILD; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ELEVATED BLOOD PRESSURE; FAT MASS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; OBESITY; PHOSPHATE BLOOD LEVEL; PREVALENCE; PRIORITY JOURNAL; PUBERTY; RETROSPECTIVE STUDY; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; BLOOD; PEDIATRIC OBESITY; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; AUSTRALIA; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; HYPERTENSION; MALE; PEDIATRIC OBESITY; RETROSPECTIVE STUDIES; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84983119696     PISSN: 10344810     EISSN: 14401754     Source Type: Journal    
DOI: 10.1111/jpc.12935     Document Type: Article

References (41)

1. Holick MF,. Vitamin D deficiency. N. Engl. J. Med. 2007; 357: 266-281.
2. Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr. Rev. 2012; 33: 456-492.
3. Hossein-nezhad A, Holick MF,. Vitamin D for health: a global perspective. Mayo Clinic Proc. 2013; 88: 720-755.
4. Shi H, Norman AW, Okamura WH, Sen A, Zemel MB,. 1alpha,25-Dihydroxyvitamin D3 modulates human adipocyte metabolism via nongenomic action. FASEB J. 2001; 15: 2751-2753.
5. Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE,. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr. Rev. 2013; 34: 33-83.
6. Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care 2010; 33: 1379-1381.
7. Kajikawa M, Ishida H, Fujimoto S, et al. An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction. Endocrinology 1999; 140: 4706-4712.
8. The Lancet Diabetes & Endocrinology. Vitamin D: chasing a myth? Lancet Diabetes Endocrinol. 2014; 2: 1.
9. Turer CB, Lin H, Flores G,. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics 2013; 131: e152-161.
10. Ganji V, Zhang X, Shaikh N, Tangpricha V,. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am. J. Clin. Nutr. 2011; 94: 225-233.
11. Belenchia AM, Tosh AK, Hillman LS, Peterson CA,. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am. J. Clin. Nutr. 2013; 97: 774-781.
12. Dolinsky DH, Armstrong S, Mangarelli C, Kemper AR,. The association between vitamin D and cardiometabolic risk factors in children: a systematic review. Clin. Pediatr. (Phila) 2013; 52: 210-223.
13. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114 (2 Suppl. 4th Report): 555-576.
14. McCarthy HD, Ashwell M,. A study of central fatness using waist-to-height ratios in UK children and adolescents over two decades supports the simple message -'keep your waist circumference to less than half your height'. Int. J. Obes. (Lond) 2006; 30: 988-992.
15. McCarthy HD, Cole TJ, Fry T, Jebb SA, Prentice AM,. Body fat reference curves for children. Int. J. Obes. (Lond) 2006; 30: 598-602.
16. Paxton GA, Teale GR, Nowson CA, et al. Vitamin D and health in pregnancy, infants, children and adolescents in Australia and New Zealand: a position statement. Med. J. Aust. 2013; 198: 142-143.
17. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 2002; 109: 45-60.
18. Brown RJ, Yanovski JA,. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr. Diabetes 2014; 15: 151-161.
19. Viner RM, White B, Barrett T, et al. Assessment of childhood obesity in secondary care: OSCA consensus statement. Arch. Dis. Child. Educ Pract. Ed. 2012; 97: 98-105.
20. Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH,. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch. Paediatr. Adolesc. Med. 2003; 157: 821-827.
21. Fernandez JR, Redden DT, Pietrobelli A, Allison DB,. Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J. Pediatr. 2004; 145: 439-444.
22. Kaelber DC, Pickett F,. Simple table to identify children and adolescents needing further evaluation of blood pressure. Pediatrics 2009; 123: e972-974.
23. Aatola H, Magnussen CG, Koivistoinen T, et al. Simplified definitions of elevated paediatric blood pressure and high adult arterial stiffness. Pediatrics 2013; 132: e70-76.
24. Poomthavorn P, Saowan S, Mahachoklertwattana P, Chailurkit L, Khlairit P,. Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics. Int. J. Obes. (Lond) 2012; 36: 491-495.
25. Xiang W, Kong J, Chen S, et al. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am. J. Physiol. Endocrinol. Metab. 2005; 288: E125-132.
26. Merke J, Hofmann W, Goldschmidt D, Ritz E,. Demonstration of 1,25(OH)2 vitamin D3 receptors and actions in vascular smooth muscle cells in vitro. Calcif. Tissue Int. 1987; 41: 112-114.
27. Kota SK, Kota SK, Jammula S, et al. Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study. Indian J. Endocrinol. Metab. 2011; 15 (Suppl. 4): S395-401.
28. Sulistyoningrum DC, Gasevic D, Green TJ, Lear SA, Devlin AM,. Adiposity and the relationship between vitamin D and blood pressure. Metabolism 2013; 62: 1795-1802.
29. Sun X, Zemel MB,. Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression. Obesity. 2007; 15: 340-348.
30. Brambilla P, Antolini L, Street ME, et al. Adiponectin and hypertension in normal-weight and obese children. Am. J. Hypertens. 2013; 26: 257-264.
31. Ishizaka N, Ishizaka Y, Toda E, Hashimoto H, Nagai R, Yamakado M,. Hypertension is the most common component of metabolic syndrome and the greatest contributor to carotid arteriosclerosis in apparently healthy Japanese individuals. Hypertens. Res. 2005; 28: 27-34.
32. Zaliunas R, Slapikas R, Babarskiene R, et al. The prevalence of the metabolic syndrome components and their combinations in men and women with acute ischemic syndromes. Medicina 2008; 44: 521-528.
33. Tamez H, Kalim S, Thadhani RI,. Does vitamin D modulate blood pressure? Curr. Opin. Nephrol. Hypertens. 2013; 22: 204-209.
34. Vimaleswaran KS, Cavadino A, Berry DJ, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014; 2: 719-729.
35. Krause R, Buhring M, Hopfenmuller W, Holick MF, Sharma AM,. Ultraviolet B and blood pressure. Lancet 1998; 352: 709-710.
36. Ashraf AP, Alvarez JA, Gower BA, Saenz KH, McCormick KL,. Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity. 2011; 19: 2214-2221.
37. Witham MD, Nadir MA, Struthers AD,. Effect of vitamin D on blood pressure: a systematic review and meta-analysis. J. Hypertens. 2009; 27: 1948-1954.
38. Pittas AG, Chung M, Trikalinos T, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann. Intern. Med. 2010; 152: 307-314.
39. Alemzadeh R, Kichler J, Babar G, Calhoun M,. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008; 57: 183-191.
40. Geldenhuys S, Hart PH, Endersby R, et al. Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet. Diabetes 2014; 63: 3759-3769.
41. Miersch A, Vogel M, Gausche R, et al. Influence of seasonal variation on blood pressure measurements in children, adolescents and young adults. Pediatr. Nephrol. 2013; 28: 2343-2349.