The association between vitamin D and cardiometabolic risk factors in children: A systematic review

Clinical Pediatrics

Volumn 52, Issue 3, 2013, Pages 210-223

  Dolinsky, Diana H ^a   Armstrong, Sarah ^a   Mangarelli, Caren ^a   Kemper, Alex R ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

blood pressure; cholesterol; diabetes mellitus; insulin resistance; vascular stiffness

Indexed keywords

25 HYDROXYVITAMIN D; GLUCOSE; INSULIN;

ARTERIAL STIFFNESS; CARDIOMETABOLIC RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; GLUCOSE METABOLISM; HUMAN; INSULIN METABOLISM; LOW DRUG DOSE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; VITAMIN SUPPLEMENTATION;

ADOLESCENT; BLOOD PRESSURE; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; GLUCOSE; HUMANS; INSULIN RESISTANCE; LIPIDS; OBESITY; RISK; VASCULAR STIFFNESS; VITAMIN D;

EID: 84874099178     PISSN: 00099228     EISSN: 19382707     Source Type: Journal    
DOI: 10.1177/0009922812470742     Document Type: Review

References (48)

1. Looker AC, Johnson CL, Lacher DA, Pfeiffer CM, Schleicher RL, Sempos CT. Vitamin D status: United States, 2001-2006. NCHS Data Brief. 2011 ; (59). 1-8
2. RossACACTaylorCLCLYaktineALALDel ValleHBHB, eds. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press; 2011. http://www.ncbi.nlm.nih.gov/pubmed/21796828. Accessed December 3, 2012.
3. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am J Clin Nutr. 2011 ; 94: 225-233
4. Grandi NC, Breitling LP, Brenner H. Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies. Prev Med. 2010 ; 51 (3-4). 228-233
5. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas. 2010 ; 65: 225-236
6. Pittas AG, Chung M, Trikalinos T, et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 2010 ; 152: 307-314
7. Johnson WD, Kroon JJM, Greenway FL, Bouchard C, Ryan D, Katzmarzyk PT. Prevalence of risk factors for metabolic syndrome in adolescents: National Health and Nutrition Examination Survey (NHANES), 2001-2006. Arch Pediatr Adolesc Med. 2009 ; 163: 371-377
8. Zhou S, LeBoff MS, Glowacki J. Vitamin D metabolism and action in human bone marrow stromal cells. Endocrinology. 2010 ; 151: 14-22
9. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008 ; 4: 80-90
10. Hewison M, Burke F, Evans KN, et al. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007 ; 103 (3-5). 316-321
11. Manson JE, Bassuk SS, Lee I-M, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials. 2012 ; 33: 159-171
12. Arnberg K, Østergård M, Madsen AL, Krarup H, Michaelsen KF, Mølgaard C. Associations between vitamin D status in infants and blood lipids, body mass index and waist circumference. Acta Paediatr. 2011 ; 100: 1244-1248
13. Brenner DR, Arora P, Garcia-Bailo B, et al. Plasma vitamin D levels and risk of metabolic syndrome in Canadians. Clin Invest Med. 2011 ; 34: E377
14. Ashraf AP, Alvarez JA, Gower BA, Saenz KH, McCormick KL. Associations of serum 25-hydroxyvitamin D and components of the metabolic syndrome in obese adolescent females. Obesity (Silver Spring). 2011 ; 19: 2214-2221
15. Williams DM, Fraser A, Lawlor DA. Associations of vitamin D, parathyroid hormone and calcium with cardiovascular risk factors in US adolescents. Heart. 2011 ; 97: 315-320
16. Ford ES, Zhao G, Tsai J, Li C. Associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c among adolescents in the United States. Diabetes Care. 2011 ; 34: 646-648
17. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004. Pediatrics. 2009 ; 124: e362 - e370
18. Reis JP, von Mühlen D, Miller ER, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009 ; 124: e371 - e379
19. National Center for Health Statistics. Revised analytic note for NHANES 2000-2006 and NHANES III (1988-1994) 25-hydroxyvitamin D analysis. http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source= web&cd=1&cad=rja&ved=0CC8QFjAA&url=http%3A%2F%2Fwww.cdc. gov%2Fnchs%2Fdata%2Fnhanes%2Fnhanes3%2FVitaminD-analyticnote.pdf&ei= c0S8UIDoD8LrrQfGroHIBA&usg=AFQjCNESN-Utr6OYNnT5SN-eH53BI-oR3Q. Accessed December 3, 2012.
20. Dong Y, Stallmann-Jorgensen IS, Pollock NK, et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab. 2010 ; 95: 4584-4591
21. Pacifico L, Anania C, Osborn JF, et al. Low 25(OH)D3 levels are associated with total adiposity, metabolic syndrome, and hypertension in Caucasian children and adolescents. Eur J Endocrinol. 2011 ; 165: 603-611
22. Al-Daghri NM, Al-Attas OS, Alokail MS, et al. Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Central Eur J Med. 2010 ; 5: 752-757
23. Hirschler V, Maccallinni G, Gilligan T, et al. Association of vitamin D with insulin resistance in Argentine boys: a pilot study. J Pediatr Biochem. 2012 ; 2: 91-99
24. Nsiah-Kumi PA, Erickson JM, Beals JL, et al. Vitamin D insufficiency is associated with diabetes risk in Native American children. Clin Pediatr (Phila). 2012 ; 51: 146-153
25. Olson ML, Maalouf NM, Oden JD, White PC, Hutchison MR. Vitamin D deficiency in obese children and its relationship to glucose homeostasis. J Clin Endocrinol Metab. 2012 ; 97: 279-285
26. PirgonOCekmezFBilginHErenEDundarB. Low 25-hydroxyvitamin D level is associated with insulin sensitivity in obese adolescents with non-alcoholic fatty liver disease. Obes Res Clin Pract. http://linkinghub.elsevier.com/ retrieve/pii/S1871403X12000099. Accessed September 26, 2012.
27. Sharma M, Sharma VK, Jain RK, Jain P. Vitamin D and the metabolic syndrome in Indian sub-population. J Clin Diagn Res. 2012 ; 6: 89-91
28. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten S. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab. 2007 ; 20: 817-823
29. Zhou P, Schechter C, Cai Z, Markowitz M. Determinants of 25(OH)D sufficiency in obese minority children: selecting outcome measures and analytic approaches. J Pediatr. 2011 ; 158: 930-934.e1
30. Ashraf A, Alvarez J, Saenz K, Gower B, McCormick K, Franklin F. Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African-American adolescents. J Clin Endocrinol Metab. 2009 ; 94: 3200-3206
31. Boucher-Berry C, Speiser PW, Carey DE, et al. Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children. J Bone Miner Res. 2012 ; 27: 283-293
32. Delvin EE, Lambert M, Levy E, et al. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr. 2010 ; 140: 987-991
33. Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S. Relationships between 25-hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients. J Pediatr. 2010 ; 156: 444-449
34. Rajakumar K, de las Heras J, Chen TC, Lee S, Holick MF, Arslanian SA. Vitamin D status, adiposity, and lipids in black American and Caucasian children. J Clin Endocrinol Metab. 2011 ; 96: 1560-1567
35. Rodríguez-Rodríguez E, Ortega RM, González- Rodríguez LG, López-Sobaler AM. Vitamin D deficiency is an independent predictor of elevated triglycerides in Spanish school children. Eur J Nutr. 2011 ; 50: 373-378
36. Sacheck J, Goodman E, Chui K, Chomitz V, Must A, Economos C. Vitamin D deficiency, adiposity, and cardiometabolic risk in urban schoolchildren. J Pediatr. 2011 ; 159: 945-950
37. Tonstad S, Aksnes L. Fat-soluble vitamin levels in familial hypercholesterolemia. J Pediatr. 1997 ; 130: 274-280
38. Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metab Clin Exp. 2008 ; 57: 183-191
39. Buyukinan M, Ozen S, Kokkun S, Saz EU. The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab. 2012 ; 25 (1-2). 83-87
40. Kelly A, Brooks LJ, Dougherty S, Carlow DC, Zemel BS. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child. 2011 ; 96: 447-452
41. Nunlee-Bland G, Gambhir K, Abrams C, Abdul M, Vahedi M, Odonkor W. Vitamin D deficiency and insulin resistance in obese African-American adolescents. J Pediatr Endocrinol Metab. 2011 ; 24 (1-2). 29-33
42. Poomthavorn P, Saowan S, Mahachoklertwattana P, Chailurkit L, Khlairit P. Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics. Int J Obes (Lond). 2012 ; 36: 491-495
43. Rajakumar K, de las Heras J, Lee S, Holick MF, Arslanian SA. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care. 2012 ; 35: 627-633
44. Reinehr T, de Sousa G, Alexy U, Kersting M, Andler W. Vitamin D status and parathyroid hormone in obese children before and after weight loss. Eur J Endocrinol. 2007 ; 157: 225-232
45. Forsythe LK, Livingstone MBE, Barnes MS, et al. Effect of adiposity on vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older Irish adults. Br J Nutr. 2012 ; 107: 126-134
46. Harel Z, Flanagan P, Forcier M, Harel D. Low vitamin D status among obese adolescents: prevalence and response to treatment. J Adolesc Health. 2011 ; 48: 448-452
47. Whayne TF. Vitamin D: popular cardiovascular supplement but benefit must be evaluated. Int J Angiol. 2011 ; 20: 63-72
48. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci. 2009 ; 338: 40-44