Interstitial fluid glucose is not just a shifted-in-time but a distorted mirror of blood glucose: Insight from an in Silico study

Diabetes Technology and Therapeutics

Volumn 18, Issue 8, 2016, Pages 505-511

  Cobelli, Claudio ^a   Schiavon, Michele ^a   Dalla Man, Chiara ^a   Basu, Ananda ^b   Basu, Rita ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BLOOD INTERSTITIAL FLUID GLUCOSE KINETICS; COMPUTER MODEL; EXERCISE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN DEPENDENT DIABETES MELLITUS; INTERSTITIAL FLUID; INTERSTITIAL FLUID GLUCOSE; LINEAR SYSTEM; MEAL; NORMAL HUMAN; PRIORITY JOURNAL; STEADY STATE; ANALYSIS; CHEMISTRY; COMPUTER SIMULATION; EXTRACELLULAR FLUID;

BLOOD GLUCOSE; COMPUTER SIMULATION; EXTRACELLULAR FLUID; GLUCOSE; HUMANS;

EID: 84983043937     PISSN: 15209156     EISSN: 15578593     Source Type: Journal    
DOI: 10.1089/dia.2016.0112     Document Type: Article

References (10)

1. Schiavon M, Dalla Man C, Dube S, et al. Modeling plasma-To-interstitium glucose kinetics from multitracer plasma and microdialysis data. Diabetes Technol Ther 2015; 17: 825-831.
2. Basu A, Dube S, Slama M, et al. Time lag of glucose from intravascular to interstitial compartment in humans. Diabetes 2013; 62: 4083-4087.
3. Basu A, Dube S, Veettil S et al.: Time lag of glucose from intravascular to interstitial compartment in type 1 diabetes J Diabetes Sci Technol 2015 9 63-68.
4. Schiavon M, Hinshaw L, Mallad A, et al. Postprandial glucose fluxes and insulin sensitivity during exercise: a study in healthy individuals. Am J Physiol Endocrinol Metab 2013; 305: E557-E566.
5. Bolinder J, Ungerstedt U, Arner P. Microdialysis measurement of the absolute glucose concentration in subcutaneous adipose tissue allowing glucose monitoring in diabetic patients. Diabetologia 1992; 35: 1177-1180.
6. Bolinder J, Ungerstedt U, Arner P. Long-Term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. Lancet 1993; 342: 1080-1085.
7. Rebrin K, Sheppard NF Jr, Steil GM. Use of subcutaneous interstitial fluid glucose to estimate blood glucose: revisiting delay and sensor offset. J Diabetes Sci Technol 2010; 4: 1087-1098.
8. Regittnig W, Ellmerer M, Fauler G, et al. Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab 2003; 285: E241-E251.
9. Wilinska ME, Bodenlenz M, Chassin LJ, et al. Interstitial glucose kinetics in subjects with type 1 diabetes under physiologic conditions. Metabolism 2004; 53: 1484-1491.
10. Steil GM, Rebrin K, Hariri F, et al. Interstitial fluid glucose dynamics during insulin-induced hypoglycaemia. Diabetologia 2005; 48: 1833-1840.