Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection

Drug Metabolism and Disposition

Volumn 36, Issue 4, 2008, Pages 731-739

  Xu, Lin ^a,c   Adams, Bruce ^a   Jeliazkova Mecheva, Valentina V ^a   Trimble, Laird ^b   Kwei, Gloria ^a   Harsch, Andreas ^a  

^a Merck Research Laboratories Boston   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NORCOLCHICINE; 3 NORCOLCHICINE; COLCHICINE; COLCHICINE DERIVATIVE; DRUG METABOLITE; GLUTATHIONE; RADIOISOTOPE; SULFATE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; BILE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG TRANSFORMATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RADIOACTIVITY; RADIOMETRY; RAT; SCINTILLATION; SENSITIVITY AND SPECIFICITY; SULFATION; TECHNOLOGY;

ANIMALS; BILE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLCHICINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RADIOMETRY; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 41549102932     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019463     Document Type: Article

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