Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: A double-blind randomized controlled trial

Quintessence International

Volumn 45, Issue 8, 2014, Pages 703-711

  Vano, Michele ^a,b   Derchi, Giacomo ^a,b   Barone, Antonio ^a,b   Covani, Ugo ^a,b  

^a UNIVERSITY OF PISA   (Italy)

^b Tuscan Stomatologic Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYAPATITE; PLACEBO; TOOTHPASTE;

ADULT; CONTROLLED STUDY; DENTIN SENSITIVITY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; NANOTECHNOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; DENTIN SENSITIVITY; DOUBLE-BLIND METHOD; DURAPATITE; FEMALE; HUMANS; MALE; NANOTECHNOLOGY; PLACEBOS; TOOTHPASTES;

EID: 84982994782     PISSN: 00336572     EISSN: None     Source Type: Journal    
DOI: 10.3290/j.qi.a32240     Document Type: Article

References (50)

1. Addy M. Bristol. Tooth brushing, tooth wear and dentine hypersensitivity: are they related? Int Dent J 2005;55:261-267
2. Rees JS, Addy M. A cross-sectional study of dentine hypersensitivity. J Clin Periodontol 2002;29:997-1003
3. Brännström M. A hydrodynamic mechanism in the transmission of pain producing stimuli through dentine. In: Anderson DJ (ed). Sensory Mechanisms in Dentine. Oxford: Pergamon Press, 1963:73-79
4. Chung G, Jung SJ, Oh SB. Cellular and molecular mechanisms of dental nociception. J Dent Res 2013;92:948-955
5. Absi EG, Addy M, Adams D. Dentine hypersensitivity. A study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine. J Clin Periodontol 1987;14:280-284
6. Pashley D. Mechanisms of dentin sensitivity. Dent Clin North Am 1990;34: 449-474
7. Chidchuangchai W, Vongsavan N, Matthews B. Sensory transduction mechanisms responsible for pain caused by cold stimulation of dentine in man. Arch Oral Biol 2007;52:154-160
8. Han SY, Jung HI, Kwon HK, Kim BI. Combined effects of Er:YAG laser and nanocarbonate apatite dentifrice on dentinal tubule occlusion: in vitro study. Photomed Laser Surg 2013;31:342-348
9. Markowitz K, Pashley DH. Personal reflections on a sensitive subject. J Dent Res 2007;86:292-295
10. Lin PY, Cheng YW, Chu CY, Chien KL, Lin CP, Tu YK. In-office treatment for dentin hypersensitivity: a systematic review and network meta-analysis. J Clin Periodontol 2013;40:53-64
11. da Rosa WL, Lund RG, Piva E, da Silva AF. The effectiveness of current dentin desensitizing agents used to treat dental hypersensitivity: a systematic review. Quintessence Int 2013;44:535-546
12. Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nature Nanotech 2010;5:565-569
13. Najibfard K, Ramalingam K, Chedjieu I, Amaechi BT. Remineralization of early caries by a nano hydroxyapatite dentifrice. J Clin Dent 2011;22:139-143
14. Vandiver J, Dean D, Patel N, Bonfield W, Ortiz C. Nanoscale variation in surface charge of synthetic hydroxyapatite detected by chemically and spatially specific high-resolution force spectroscopy. Biomaterials 2006;26:271-283
15. Huang SB, Gao S, Cheng L, Yu H. Combined effects of nano-hydroxyapatite and Galla chinensis on remineralisation of initial enamel lesion in vitro. J Dent 2010;38:811-819
16. Huang S, Gao S, Yu H. Remineralization potential of nano-hydroxyapatite on initial enamel lesions: an in vitro study. Caries Res 2011;45:460-468
17. Lee S, Kwon H, Kim B. Effect of dentinal tubule occlusion by dentifrice containing nano-carbonate apatite. J Oral Rehabil 2008;35:847-853
18. Roveri N, Battistella E, Bianchi CL, et al. Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects. J Nanomater 2009:746383
19. Roveri N, Battistella E, Foltran I, et al. Synthetic biomimetic carbonatehydroxyapatite nanocrystals for enamel remineralization. Adv Mater Res 2008;47-50:821-824
20. Roveri, N, Foresti E, Lelli M, Lesci IG. Recent advancements in preventing teeth health hazard: the daily use of hydroxyapatite instead of fluoride. Recent Patents Biomed Eng 2009:197-215
21. Rimondini L, Palazzo B, Iafisco M, et al. The remineralizing effect of carbonatehydroxyapatite nanocrystals on dentine. Mater Sci Forum 2007;539-543; 602-605
22. Yuan P, Shen X, Liu J, et al. Effects of dentifrice containing hydroxyapatite on dentinal tubule occlusion and aqueous hexavalent chromium cations sorption: a preliminary study. PLoS One 2012;7:e45283
23. Browning WD, Cho SD, Deschepper EJ. Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity. J Esthet Restor Dent 2012;24:268-276
24. Schulz KF, Altman DG, Moher D; CONSORT Group. CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials. Trials 2010;11:32
25. Holland GR, Narhi MN, Addy M, Gangarosa L, Orchardson, R. Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontol 1997;24:808-813
26. Plagmann HC, König J, Bernimoulin JP, Rudhart AC, Deschner J. A clinical study comparing two high-fluoride dentifrices for the treatment of dentinal hypersensitivity. Quintessence Int 1997;28:403-408
27. Schiff T, Dotson M, Cohen S, De Vizio W, McCool J, Volpe A. Efficacy of a dentifrice containing potassium nitrate, soluble pyrophosphate, PVM/MA copolymer, and sodium fluoride on dentinal hypersensitivity: a twelve-week clinical study. J Clin Dent 1994;5:87-92
28. Sowinski J, Ayad F, Petrone M, et al. Comparative investigations of the efficacy of a new toothpaste containing potassium nitrate and triclosan 57 desensitising efficacy of a new dentifrice. J Clin Periodontol 2001;28:1032-1036
29. Pereira R, Chava V. Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity. J Periodontol 2001;72:1720-1725
30. Singal P, Gupta R, Pandit N. 2% sodium fluoride-iontophoresis compared to a commercially available desensitizing agent. J Periodontol 2005;76:351-357
31. Orsini G, Procaccini M, Manzoli L, Giuliodori F, Lorenzini A, Putignano A. A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. J Clin Periodontol 2010;37:510-517
32. Earl J, Leary R, Muller K, Langford R, Greenspan D. Physical and chemical characterization of dentin surface following treatment with NovaMin technology. J Clin Dent 2011;22:62-67
33. Mason S, Hughes N, Sufi F, et al. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentine hypersensitivity. J Clin Dent 2010;21:42-48
34. Hughes N, Mason S, Jeffery P, et al. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. J Clin Dent 2010;21:49-55
35. Seong J, Macdonald E, Newcombe RG, et al. In situ randomised trial to investigate the occluding properties of two desensitising toothpastes on dentine after subsequent acid challenge. Clin Oral Investig 2013;17:195-203
36. Peacock JM, Orchardson R. Effects of potassium ions on action potential conduction in A-and C-fibers of rat spinal nerves. J Dent Res 1995;74:634-641
37. Waraaswapati N, Krongnawakul D, Jiraviboon D, Adulyanon S, Karimbux N, Pitiphat W. The effect of a new toothpaste containing potassium nitrate and triclosan on gingival health, plaque formation and dentine hypersensitivity. J Clin Periodontol 2005;32:53-58
38. Kim SY, Kim EJ, Kim DS, Lee IB. The evaluation of dentinal tubule occlusion by desensitizing agents: a real-time measurement of dentinal fluid flow rate and scanning electron microscopy. Oper Dent 2013;38:419-428
39. Frechoso C, Menendez M, Guisasola C, Arregui I, Tejerina J, Sieilsa A. Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentinal hypersensitivity: A randomized clinical trial. J Clin Periodontol 2003;30:315-320
40. Tschoppe P, Zandim DL, Martus P, Kielbassa AM. Enamel and dentine remineralization by nano-hydroxyapatite toothpastes. J Dent 2011;39:430-437
41. Sgolastra F, Petrucci A, Gatto R, Monaco A. Effectiveness of laser in dentinal hypersensitivity treatment: a systematic review. J Endod 2011;37:297-303
42. Sgolastra F, Petrucci A, Severino M, Gatto R, Monaco A. Lasers for the treatment of dentin hypersensitivity: a meta-analysis. J Dent Res 2013;92:492-429
43. Gillam D, Newman H, Davies E, Bulman J. Clinical efficacy of a low abrasive dentifrice for the relief of cervical dentinal hypersensitivity. J Clin Periodontol 1992;19:197-201
44. Walsh T, Worthington HV, Glenny AM, Appelbe P, Marinho VC, Shi X. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2010;20:CD007868
45. Itota T, Nakabo S, Torii Y, Narukami T, Doi J, Yoshiyama M. Effect of fluoridereleasing liner on demineralized dentin. Quintessence Int 2006;37:297-303
46. Sharma D, McGuire JA, Amini P. Randomized trial of the clinical efficacy of a potassium oxalate-containing mouthrinse in rapid relief of dentin sensitivity. J Clin Dent 2013;24:62-67
47. Kielbassa AM, Tschoppe P, Hellwig E, Wrbas KT. Effects of regular and whitening dentifrices on remineralization of bovine enamel in vitro. Quintessence Int 2009;40:103-112
48. Colloca L, Benedetti F. Placebos and painkillers: is mind as real as matter? Nat Rev Neurosci 2005;6:545-552
49. Di Blasi Z, Harkness E, Ernst E, Georgiu A, Kleijnen J. Influence of context effect on health outcomes. A systemic review. Lancet 2001;375:757-762
50. Barrett B, Muller D, Rakel D, Rabago D, Marchand L, Scheder JC. Placebo, meaning, and health. Perspect Biol Med 2006;49:178-198