A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice

Journal of Clinical Periodontology

Volumn 37, Issue 6, 2010, Pages 510-517

  Orsini, Giovanna ^a   Procaccini, Maurizio ^a   Manzoli, Lamberto ^b   Giuliodori, Francesca ^a   Lorenzini, Alessandro ^a   Putignano, Angelo ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Carbonate hydroxyapatite nanocrystals; Dentifrice; Dentine hypersensitivity; Potassium nitrate; RCT

Indexed keywords

APATITE; BIOMATERIAL; CARBOAPATITE; CARBONIC ACID DERIVATIVE; DESENSITIZING AGENT; FLUORIDE; FLUORIDE SODIUM; HYDROXYAPATITE; NANOPARTICLE; NITRATE; PHOSPHATE; POTASSIUM DERIVATIVE; POTASSIUM NITRATE; TOOTHPASTE; WATER; ZINC CARBONATE; ZINC DERIVATIVE; DRUG COMBINATION; NITRIC ACID DERIVATIVE; SODIUM FLUORIDE;

ADULT; AIR; ARTICLE; CLASSIFICATION; CLINICAL TRIAL; COLD; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTIN SENSITIVITY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; FEMALE; FOLLOW UP; HUMAN; MALE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; STIMULATION; TOUCH; TREATMENT OUTCOME;

ADULT; AIR; APATITES; BIOCOMPATIBLE MATERIALS; CARBONATES; COLD TEMPERATURE; DENTIFRICES; DENTIN DESENSITIZING AGENTS; DENTIN SENSITIVITY; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; DURAPATITE; FEMALE; FLUORIDES; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NANOPARTICLES; NITRATES; PHOSPHATES; PHYSICAL STIMULATION; POTASSIUM COMPOUNDS; SODIUM FLUORIDE; TOUCH; TREATMENT OUTCOME; WATER; ZINC COMPOUNDS;

EID: 77952342802     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2010.01558.x     Document Type: Article

References (44)

1. Absi, E. G., Addy, M. Adams, D. (1987) Dentine hypersensitivity. A study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine. Journal of Clinical Periodontology 14, 280 284.
2. Addy, M. (1990) Etiology and clinical implications of dentine hypersensitivity. Dental Clinics of North America 34, 503 514.
3. Addy, M. (1992) Clinical aspects of dentine hypersensitivity. Proceedings of the Finnish Dental Society 88 (Suppl. 1), 407 412.
4. Addy, M., West, N. X., Barlow, A. Smith, S. (2007) Dentine hypersensitivity: is there both stimulus and placebo responses in clinical trials? International Journal of Dental Hygiene 5, 53 59.
5. Ayad, F., Ayad, N., Zhang, Y. P., DeVizio, W., Cummins, D. Mateo, L. R. (2009) Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults. Journal of Clinical Dentistry 20, 10 16.
6. Bellamy, P. G., Khera, N., Day, T. N., Barker, M. L. Mussett, A. J. (2009) A randomized clinical trial to compare plaque inhibition of a sodium fluoride/potassium nitrate dentifrice versus a stabilized stannous fluoride/sodium hexametaphosphate dentifrice. Journal of Contemporary Dental Practice 10, 1 9.
7. Brannström, M. (1963) A hydrodynamic mechanism in the transmission of pain producing stimuli through dentine. In : Anderson, D. J. (ed). Sensory Mechanisms in Dentine, pp. 73 79.
8. Coswell, S. P. A., Gazzaniga, G. Roveri, N. (2006) Biologically active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and compositions incorporating the same. EU patent no. 005146.
9. Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., DeVizio, W., Zhang, Y. P., Cummins, D., Dibart, S. Mateo, L. R. (2009) Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy. Journal of Clinical Dentistry 20, 17 22.
10. Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., DeVizio, W., Zhang, Y. P. Dibart, S. (2007) Desensitizing efficacy of a new toothpaste containing 5.5% potassium citrate: a 4-week clinical study. American Journal of Dentistry 20, 209 211.
11. Drisko, C. (2007) Oral hygiene and periodontal considerations in preventing and managing dentine hypersensitivity. International Dental Journal 57, 399 410.
12. Garattini, S. Bertele, V. (2007) Non-inferiority trials are unethical because they disregard patient's interests. Lancet 370, 1875 1877.
13. Groeneveld, A., Van, E. A. A Backer, D. O. (1990) Fluoride in caries prevention: is the effect pre- or post-eruptive? Journal of Dental Research 69, 751 755.
14. Hefferren, JJ. (1976) Radioactive dentine abrasion. Journal of Dental Research 55, 563 573.
15. Holland, G. R., Narhi, M. N., Addy, M., Gangarosa, L. Orchardson, R. (1997) Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. Journal of Clinical Periodontology 24, 808 813.
16. Hooper, S., West, N. X., Pickles, M. J., Joiner, A., Newcombe, R. G. Addy, M. (2003) Investigation of erosion and abrasion on enamel and dentine: a model in situ using toothpastes of different abrasivity. Journal of Clinical Periodontology 30, 802 808.
17. Kuroiwa, M., Kodaka, T., Kuroiwa, M. Abe, M. (1994) Dentin hypersensitivity. Occlusion of dentinal tubules by brushing with and without an abrasive dentifrice. Journal of Periodontology 65, 291 296.
18. Lee, S. Y., Kwon, H. K. Kim, B. I. (2008) Effect of dentinal tubule occlusion by dentifrice containing nano-carbonate apatite. Journal of Oral Rehabilitation 35, 847 853.
19. Liou, S. C., Chen, S. Y., Lee, H. Y. Bow, J. S. (2004) Structural characterization of nano-sized calcium deficient apatite powders. Biomaterials 25, 189 196.
20. Markowitz, K., Bilotto, G. Kim, S. (1991) Decreasing intradental nerve activity in the cat with potassium and divalent cations. Archives of Oral Biology 36, 1 7.
21. Nagata, T., Ishida, H., Shinohara, H., Nishikawa, S., Kasahara, S., Wakano, Y., Daigen, S. Troullos, E. S. (1994) Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity. Journal of Clinical Periodontology 21, 217 221.
22. Ogawa, T., Saruwatari, L., Takeuchi, K., Aita, H. Ohno, N. (2008) Ti nano-nodular structuring for bone integration and regeneration. Journal of Dental Research 87, 751 756.
23. Orchardson, R. Collins, W. J. N. (1987) Clinical features of hypersensitive teeth. British Dental Journal 162, 253 256.
24. Orchardson, R. Gillam, D. G. (2000) The efficacy of potassium salts as agents for treating dentin hypersensitivity. Journal of Orofacial Pain 14, 9 19.
25. Pashley, D. (1990) Mechanisms of dentin sensitivity. Dental Clinics of North America 34, 449 474.
26. Peacock, J. M. Orchardson, R. (1995) Effects of potassium ions on action potential conduction in A- and C-fibers of rat spinal nerves. Journal of Dental Research 74, 634 641.
27. Pearce, N. X., Addy, M. Newcombe, R. G. (1994) Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. Journal of Periodontology 65, 113 119.
28. Pereira, R. Chava, V. K. (2001) Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity. Journal of Periodontology 72, 1720 1725.
29. Poulsen, S., Errboe, M., Lescay Mevil, Y. Glenny, A. M. (2006) Potassium containing toothpastes for dentine hypersensitivity. Cochrane Database of Systematic Reviews. 3, CD001476.
30. Rees, J. S. Addy, M. (2004) A cross-sectional study of buccal cervical sensitivity in UK general dental practice and a summary review of prevalence studies. International Journal of Dental Hygiene 2, 64 69.
31. Ren, Y. F., Zhao, Q., Malmstom, H. Barnes, V. (2009) Assessing fluoride treatment and resistance of dental enamel to soft drink erosion in vitro: applications of focus variation 3D scanning microscopy and stylus profilometry. Journal of Dentistry 37, 167 176.
32. Richards, A. Banting, D. W. (1996) Fluoride toothpastes. In Fejerskov, O., Ekstrand, J. Burt, B. A. (eds). Fluoride in Dentistry, 2nd edition, pp. 328 346.
33. Rimondini, L., Palazzo, B., Iafisco, M., Canegallo, L., Demarosi, F., Merlo, M. Roveri, N. (2007) The remineralizing effect of carbonate- hydroxyapatite nanocrystals on dentine. Materials Science Forum 539-543, 602 605.
34. Roveri, N., Battistella, E., Bianchi, C. L., Foltran, I., Foresti, E., Iafasco, M., Lelli, M., Naldoni, A., Palazzo, B. Rimondini, L. (2009a) Surface enamel remineralization: biomimetic apatite nanocrystals and fluoride ions different effects. Journal of Nanomaterials 2009, 1 9.
35. Roveri, N., Battistella, E., Foltran, I., Foresti, E., Iafasco, M., Lelli, M., Palazzo, B. Rimondini, L. (2008) Synthetic biomimetic carbonate-hydroxyapatite nanocrystals for enamel remineralization. Advanced Materials Research 47-50, 821 824.
36. Roveri, N., Foresti, E., Lelli, M. Lesci, I. G. (2009b) Recent advancements in preventing teeth health hazard: the daily use of hydroxyapatite instead of fluoride. Recent Patents on Biomedical Engineering 2, 197 215.
37. Silverman, G. (1985) The sensitivity-reducing effect of brushing with a potassium nitratesodium monofluorophosphate dentifrice. Compendium of Continuing Education in Dentistry 6, 131 133.
38. Silverman, G., Berman, E., Hanna, C. B., Salvato, A., Fratarcangelo, P., Bartizek, R. D., Bollmer, B. W., Campbell, S. L., Lanzalaco, A. C., Mackay, B. J., McClanahan, S. F., Perlich, M. A. Shaffer, J. B. (1996) Assessing the efficacy of three dentifrices in the treatment of dentinal hypersensitivity. Journal of American Dental Association 127, 191 201.
39. Singal, P., Gupta, R. Pandit, N. (2005) 2% sodium fluoride-iontophoresis compared to a commercially available desensitizing agent. Journal of Periodontology 76, 351 357.
40. Sowinski, J., Ayad, F., Petrone, M., DeVizio, W., Volpe, A., Ellwood, R. Davies, R. (2001) Comparative investigations of the efficacy of a new toothpaste containing potassium nitrate and triclosan 57 desensitising efficacy of a new dentifrice. Journal of Clinical Periodontology 28, 1032 1036.
41. Tarbet, W. J., Silverman, G. Stolman, J. M. (1979) An evaluation of two methods for the quantitation of dentinal hypersensitivity. Journal of American Dental Association 98, 914 918.
42. Tarbet, W. J., Silverman, G., Stolman, J. M. Fratarcangelo, P. A. (1980) Clinical evaluation of a new treatment for dentinal hypersensitivity. Journal of Periodontology 51, 535 540.
43. Yates, R., Ferro, R., Newcombe, R. G. Addy, M. (2005) A comparison of a reformulated potassium citrate desensitising toothpaste with the original proprietary product. Journal of Dentistry 33, 19 25.
44. Young, A., Thrane, P. S., Saxegaard, E., Jonski, G. Rölla, G. (2006) Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study. European Journal of Oral Sciences 114, 180 183.