Harmful Effects of Leukocyte-Rich Platelet-Rich Plasma on Rabbit Tendon Stem Cells in Vitro

American Journal of Sports Medicine

Volumn 44, Issue 8, 2016, Pages 1941-1951

  Zhang, Lei ^a   Chen, Shuo ^a   Chang, Peng ^b   Bao, Nirong ^a   Yang, Chao ^a   Ti, Yufan ^a   Zhou, Liwu ^a   Zhao, Jianning ^a  

^a NANJING UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

differentiation; leukocyte rich PRP (L PRP); platelet rich plasma (PRP); proliferation; tendinopathy; tendon stem cells (TSCs)

Indexed keywords

COLLAGEN; INTERLEUKIN 1BETA; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A;

ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; FEMALE; HUMAN; IMMUNOLOGY; LEPORIDAE; LEUKOCYTE; MALE; METABOLISM; PATHOPHYSIOLOGY; STEM CELL; TENDINITIS; TENDON; THROMBOCYTE COUNT; THROMBOCYTE RICH PLASMA; WOUND HEALING;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN; FEMALE; HUMANS; INTERLEUKIN-1BETA; LEUKOCYTES; MALE; PLATELET COUNT; PLATELET-DERIVED GROWTH FACTOR; PLATELET-RICH PLASMA; RABBITS; STEM CELLS; TENDINOPATHY; TENDONS; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84982859479     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546516644718     Document Type: Article

References (47)

1. Bosch G, van Schie HT, de Groot MW, et al. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: a placebo-controlled experimental study. J Orthop Res. 2010; 28 (2): 211-217.
2. Brown RL, Ormsby I, Doetschman TC, Greenhalqh DG,. Wound healing in the transforming growth factor-beta-deficient mouse. Wound Repair Regen. 1995; 3 (1): 25-36.
3. Brubaker AL, Schneider DF, Kovacs EJ,. Neutrophils and natural killer T cells as negative regulators of wound healing. Expert Rev Dermatol. 2011; 6 (1): 5-8.
4. Butler DL, Juncosa N, Dressler MR,. Functional efficacy of tendon repair processes. Ann Rev Biomed Eng. 2004; 6: 303-329.
5. Diegelmann RF, Evans MC,. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 2004; 9: 283-289.
6. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T,. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009; 27 (3): 158-167.
7. Dovi JV, He LK, DiPietro LA,. Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol. 2003; 73 (4): 448-455.
8. Dragoo JL, Braun HJ, Durham JL, et al. Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons. Am J Sports Med. 2012; 40 (6): 1274-1281.
9. Emans PJ, Spaapen F, Surtel DA, et al. A novel in vivo model to study endochondral bone formation, HIF-1alpha activation and BMP expression. Bone. 2007; 40 (2): 409-418.
10. Fan H, Liu H, Wang Y, Toh SL, Goh JC,. Development of a silk cable-reinforced gelatin/silk fibroin hybroin scaffold for ligament tissue engineering. Cell Transplant. 2008; 17 (12): 1389-1341.
11. Gosens T, Peerbooms JC, van Laar W, den Oudsten BL,. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trail with 2-year follow up. Am J Sports Med. 2011; 39 (6): 1200-1208.
12. Hoch RV, Soriano P,. Roles of PDGF in animal development. Development. 2003; 130 (20): 4769-4784.
13. Intawicha P, Ou YW, Lo NW, et al. Characterization of embryonic stem cell lines derived from New Zealand white rabbit embryos. Cloning Stem Cells. 2009; 11 (1): 27-38.
14. Jo CH, Kim JE, Yoon KS, et al. Does platelet-rich plasma accelerate recovery after rotator cuff repair? A prospective cohort study. Am J Sports Med. 2011; 39 (10): 2082-2090.
15. Koshima H, Kondo S, Mishima S, et al. Expression of interleukin-1beta, cyclooxygenase-2, and prostaglandin E2 in a rotator cuff tear in rabbits. J Orthop Res. 2007; 25 (1): 91-97.
16. Li Z, Yang G, Khan M, Stone D, Woo SL, Wang JH,. Inflammatory response of human tendon fibroblasts to cyclic mechanical stretching. Am J Sports Med. 2004; 32: 435-440.
17. Lyras DN, Kazakos K, Agrogiannis G, et al. Experimental study of tendon healing early phase: is IGF-1 expression influenced by platelet rich plasma gel? Orthop Traumatol Surg Res. 2010; 96 (4): 381-387.
18. MacLean S, Khan WS, Malik AA, Snow M, Anand S,. Tendon regeneration and repair with stem cells. Stem Cells Int. 2012; 2012: 316281.
19. Magalon J, Bausset O, Serratrice N, et al. Characterization and comparison of 5 platelet-rich plasma preparations in a single-donor model. Arthroscopy. 2014; 30 (5): 629-638.
20. Marx RE,. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001; 10 (4): 225-228.
21. Mazzocca AD, McCarthy MB, Chowaniec DM, et al. The positive effects of different platelet-rich plasma methods on human muscle, bone, and tendon cells. Am J Sports Med. 2012; 40 (8): 1742-1749.
22. McCarrel TM, Minas T, Fortier LA,. Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg Am. 2012; 94 (19): e143.
23. Mishra AK, Skrepnik NV, Edwards SG, et al. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trail of 230 patients. Am J Sports Med. 2014; 42 (2): 463-471.
24. Molloy T, Wang Y, Murrell G,. The roles of growth factors in tendon and ligament healing. Sports Med. 2003; 33 (5): 381-394.
25. Montalvan B, Goux PL, Klouche S, Borgel D, Hardy P, Breban M,. Inefficacy of ultrasound-guided local injections of autologous conditioned plasma for recent epicondylitis: results of a double-blind placebo-controlled randomized clinical trial with one-year follow-up. Rheumatology. 2016; 55 (2): 279-285.
26. Moses HL, Pietenpol JA, Munger K, Murphy CS, Yang EY,. TGF beta regulation of epithelial cell proliferation: role of tumor suppressor genes. Princess Takamatsu Symp. 1991; 22: 183-195.
27. Plachokova AS, Nikolidakis D, Mulder J, Jansen JA, Creugers NH,. Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review. Clin Oral Implants Res. 2008; 19 (6): 539-545.
28. Randelli P, Arrigoni P, Ragone V, Aliprandi A, Cabitza P,. Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up. J Shoulder Elbow Surg. 2011; 20 (4): 518-528.
29. Rodeo SA, Delos D, Williams RJ, Adler RS, Pearle A, Warren RF,. The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: a prospective, randomized clinical study. Am J Sports Med. 2012; 40 (6): 1234-1241.
30. Sanchez M, Anitua E, Azofra J, Andia I, Padilla S, Mujika I,. Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med. 2007; 35 (2): 245-251.
31. Schepull T, Kvist T, Norrman H, Trinks M, Berlin G, Aspenberg P,. Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study. Am J Sports Med. 2011; 39 (1): 38-47.
32. Schneider A, Zhang Y, Zhang M, et al. Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Kidney Int. 2004; 65 (4): 1205-1213.
33. Silva A, Sampaio R,. Anatomic ACL reconstruction: does the platelet-rich plasma accelerate tendon healing? Knee Surg Sports Traumatol Arthrosc. 2009; 17 (6): 676-682.
34. Spang JT, Tischer T, Salzmann GM, et al. Platelet concentrate vs saline in a rat patellar tendon healing model. Knee Surg Sports Traumatol Arthrosc. 2011; 19 (3): 495-502.
35. Taylor DW, Petrera M, Hendry M, Theodoropoulos JS,. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries. Clin J Sport Med. 2011; 21 (4): 344-352.
36. Trindade-Suedam IK, Leite FR, de Morais JA, Leite ER, Marcantonio EJ, Leite AA,. Avoiding leukocyte contamination and early platelet activation in platelet-rich plasma. J Oral Implantol. 2007; 33 (6): 334-339.
37. Tsuzaki M, Guyton G, Garrett W, et al. IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells. J Orthop Res. 2003; 21 (2): 256-264.
38. Wang JH, Guo Q, Li B,. Tendon biomechanics and mechanobiology: a mini-review of basic concepts and recent advancements. J Hand Ther. 2012; 25 (2): 133-140.
39. Wang JH, Jia F, Yang G, et al. Cyclic mechanical stretching of human tendon fibroblasts increases the production of prostaglandin E2 and levels of cyclooxygenase expression: a novel in vitro model study. Connect Tissue Res. 2003; 44 (3-4): 128-133.
40. Wang X, Qiu Y, Triffitt J, Carr A, Xia Z, Sabokbar A,. Proliferation and differentiation of human tenocytes in response to platelet rich plasma: an in vitro and in vivo study. J Orthop Res. 2012; 30 (6): 982-990.
41. Yang G, Im HJ, Wang JH,. Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene. 2005; 363: 166-172.
42. Yassibag-Berkman Z, Tuncer O, Subasioglu T, Kantarci A,. Combined use of platelet-rich plasma and bone grafting with or without guided tissue regeneration in the treatment of anterior interproximal defects. J Periodontol. 2007; 78 (5): 801-809.
43. Zhang J, Middleton KK, Fu FH, Im H, Wang JHC,. HGF mediates the anti-inflammatory effects of PRP on injured tendons. PLoS One. 2013; 8 (6): e67303.
44. Zhang J, Wang JH,. Characterization of differential properties of rabbit tendon stem cells and tenocytes. BMC Musculoskelet Disord. 2010; 11: 10.
45. Zhang J, Wang JH,. Moderate exercise mitigates the detrimental effects of aging on tendon stem cells. PLoS One. 2015: 10 (6): e0130454.
46. Zhao SP, Dong SZ,. Effect of tumor necrosis factor alpha on cholesterol efflux in adipocytes. Clin Chim Acta. 2008; 389 (1-2): 67-71.
47. Zimmermann R, Reske S, Metzler P, Schlegel A, Ringwald J, Eckstein R,. Preparation of highly concentrated and white cell-poor platelet-rich plasma by plateletpheresis. Vox Sang. 2008; 95 (1): 20-25.