Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open-labeled, Controlled Study

Phytotherapy Research

Volumn , Issue , 2016, Pages 1339-1344

  Yari, Zahra ^a   Rahimlou, Mehran ^b   Poustchi, Hossein ^c   Hekmatdoost, Azita ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

central obesity; flaxseed; insulin resistance; metabolic syndrome

Indexed keywords

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HUMAN; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LINSEED; MALE; METABOLIC SYNDROME X; OBESITY; OPEN STUDY; OUTCOME ASSESSMENT; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT RESPONSE; WAIST CIRCUMFERENCE;

EID: 84982845606     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5635     Document Type: Article

References (34)

1. Akaberi M, Hosseinzadeh H. 2016. Grapes (Vitis vinifera) as a potential candidate for the therapy of the metabolic syndrome. Phytother Res 30: 540–556.
2. Akpolat M, Kanter M, Topcu-Tarladacalisir Y, Aydogdu N. 2011. Protective effect of flaxseed oil on renal injury in hyperlipidaemic rats: the effect of flaxseed oil on hyperlipidaemia. Phytother Res 25: 796–802.
3. Alberti KG, Eckel RH, Grundy SM, et al. 2009. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120: 1640–1645.
4. Azizi F, Hadaegh F, Khalili D, et al. 2010. Appropriate definition of metabolic syndrome among Iranian adults: report of the Iranian National Committee of Obesity. Arch Iran Med 13: 426–428.
5. Bassett CM, Rodriguez-Leyva D, Pierce GN. 2009. Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed. Appl Physiol Nutr Metab 34: 965–974.
6. Brant LH, Cardozo LF, Velarde LG, Boaventura GT. 2012. Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats. Acta Cir Bras 27: 537–543.
7. Cornish SM, Chilibeck PD, Paus-Jennsen L, et al. 2009. A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults. Appl Physiol Nutr Metab 34: 89–98.
8. Eslamparast T, Zamani F, Hekmatdoost A, et al. 2014. Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study. Br J Nutr 112: 438–445.
9. Ghaffarpour M, Houshiar-Rad A, Kianfar H. 1999. The Manual for Household Measures, Cooking Yields Factors and Edible Portion of Foods. Nashre Olume Keshavarzy: Tehran; 1–40.
10. Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. 2011. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 105: 417–427.
11. Goyal A, Sharma V, Upadhyay N, Gill S, Sihag M. 2014. Flax and flaxseed oil: an ancient medicine & modern functional food. J Food Sci Tech 51: 1633–1653.
12. Grundy SM, Cleeman JI, Daniels SR, et al. 2005. Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 112: 2735–2752.
13. Hekmatdoost A, Mirmiran P, Hosseini-Esfahani F, Azizi F. 2011. Dietary fatty acid composition and metabolic syndrome in Tehranian adults. Nutrition 27: 1002–1007.
14. HosseinI A, Hosseinzadeh H. 2015. A review on the effects of Allium sativum (Garlic) in metabolic syndrome. J Endocrinol Invest 38: 1147–1157.
15. Hrebicek J, Janout VR, Malinčíková J, Horáková D, Čížek LK. 2002. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab 87: 144–144.
16. Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. 2013. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr Res 33: 367–375.
17. Izzo AA, Hoon-Kim S, Radhakrishnan R, Williamson EM. 2016. A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytother Res. doi:10.1002/ptr.5591 [Epub ahead of print]
18. Jeong HS, Hong SJ, Lee TB, et al. 2014. Effects of black raspberry on lipid profiles and vascular endothelial function in patients with metabolic syndrome. Phytother Res 28: 1492–1498.
19. Kelishadi R, Rabiei K, Khosravi A, et al. 2001. Assessment of physical activity of adolescents in Isfahan. Shahrekord Univ Med Sci J 3: 55–66.
20. Mani UV, Mani I, Biswas M, Kumar SN. 2011. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl 8: 257–265.
21. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412–419.
22. Mirmiran P, Hekmatdoost A, Azizi F. 2007. Metabolic syndrome is associated with adherence to an unhealthy diet. Diabetes Care 30e93:.
23. Morisset A-S, Lemieux S, Veilleux A, Bergeron J, John Weisnagel S, Tchernof A. 2009. Impact of a lignan-rich diet on adiposity and insulin sensitivity in post-menopausal women. Br J Nutr 102: 195–200.
24. National Institutes of Health, National Heart, Lung, and Blood Institute, NHLBI Obesity Education Initiative, North American Association for the Study of Obesity. 2000. The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults.
25. Paschos G, Magkos F, Panagiotakos D, Votteas V, Zampelas A. 2007. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 61: 1201–1206.
26. Razavi BM, Hosseinzadeh H. 2014. A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. J Endocrinol Invest 37: 1031–1040.
27. Rhee Y, Brunt A. 2011. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J 10: 44.
28. Tarpila A, Wennberg T, Tarpila S. 2005. Flaxseed as a functional food. Curr Top Nutraceut Res 3: 167–188.
29. Wong H, Chahal N, Manlhiot C, Niedra E, Mccrindle BW. 2013. Flaxseed in pediatric hyperlipidemiaA placebo-controlled, blinded, randomized clinical trial of dietary flaxseed supplementation for children and adolescents with hypercholesterolemiaflaxseed in pediatric hyperlipidemiaflaxseed in pediatric hyperlipidemia. JAMA Pediatr 167: 708–713.
30. Wu H, Pan A, Yu Z, et al. 2010. Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. J Nutr 140: 1937–1942.
31. Yang TY, Chou JI, Ueng KC, et al. 2014a. Weight reduction effect of Puerh tea in male patients with metabolic syndrome. Phytother Res 28: 1096–1101.
32. Yang YS, Su YF, Yang HW, et al. 2014b. Lipid-lowering effects of curcumin in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Phytother Res 28: 1770–1777.
33. Zhang W, Wang X, Liu Y, et al. 2008. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. Br J Nutr 99: 1301–1309.
34. Zilaee M, Kermany T, Tavalaee S, Salehi M, Ghayour-Mobarhan M, Ferns GA. 2014. Barberry treatment reduces serum anti-heat shock protein 27 and 60 antibody titres and high-sensitivity C-reactive protein in patients with metabolic syndrome: a double-blind, randomized placebo-controlled trial. Phytother Res 28: 1211–1215.