Is bursting more effective than spiking in evoking pituitary hormone secretion? A spatiotemporal simulation study of calcium and granule dynamics

American Journal of Physiology - Endocrinology and Metabolism

Volumn 310, Issue 7, 2016, Pages E515-E525

  Tagliavini, Alessia ^a   Tabak, Joël ^b,c   Bertram, Richard ^b   Pedersen, Morten Gram ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b FLORIDA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

Author keywords

Ca2+ oscillations; Dynamic clamp; Electrical activity; Exocytosis; Mathematical modeling

Indexed keywords

CALCIUM ION; GONADORELIN; HYPOPHYSIS HORMONE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LUTEINIZING HORMONE; CALCIUM; CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CELL ACTIVITY; CELL GRANULE; CLINICAL EFFECTIVENESS; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTRIC ACTIVITY; EXOCYTOSIS; FEMALE; GONADOTROPIN SECRETING CELL; HORMONE RELEASE; HYPOPHYSIS CELL; HYPOPHYSIS FUNCTION; MATHEMATICAL MODEL; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; SECRETORY GRANULE; SPATIOTEMPORAL ANALYSIS; ANIMAL; GROWTH HORMONE SECRETING CELL; METABOLISM; PATCH CLAMP TECHNIQUE; PROLACTIN SECRETING CELL; SECRETION (PROCESS); SECRETORY VESICLE; THEORETICAL MODEL;

ANIMALS; CALCIUM; CALCIUM CHANNELS; COMPUTER SIMULATION; EXOCYTOSIS; GONADOTROPHS; LACTOTROPHS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, THEORETICAL; PATCH-CLAMP TECHNIQUES; PITUITARY HORMONES; RATS; SECRETORY VESICLES; SOMATOTROPHS;

EID: 84982842093     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00500.2015     Document Type: Article

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