The association between in-hospital hemoglobin changes, cardiovascular events, and mortality in acute decompensated heart failure: Results from the ESCAPE trial

International Journal of Cardiology

Volumn 222, Issue , 2016, Pages 531-537

  Damluji, Abdulla A ^a,b   Macon, Conrad ^c   Fox, Arieh ^c   Garcia, Grettel ^c   Al Damluji, Mohammed S ^d   Marzouka, George R ^c   Myerburg, Robert J ^c   Gilchrist, Ian C ^e   Cohen, Mauricio G ^c   Moscucci, Mauro ^a  

^a SINAI HOSPITAL OF BALTIMORE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^e PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Anemia; Heart failure; Hemoglobin; Hospitalization; Mortality; Prognosis

Indexed keywords

CREATININE; HEMOGLOBIN; SODIUM; UREA; BIOLOGICAL MARKER;

ACUTE HEART FAILURE; ADULT; AGE; AGED; ANEMIA; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; HEART GRAFT; HEART LEFT VENTRICLE EJECTION FRACTION; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITAL READMISSION; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; NEW YORK HEART ASSOCIATION CLASS; PREVALENCE; PRIORITY JOURNAL; PULMONARY ARTERY CATHETER; SODIUM BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; UREA NITROGEN BLOOD LEVEL; ACUTE DISEASE; BLOOD; CLINICAL TRIAL; HEART CATHETERIZATION; HEART FAILURE; HOSPITALIZATION; METABOLISM; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; TRENDS;

ACUTE DISEASE; AGED; BIOMARKERS; CARDIAC CATHETERIZATION; FEMALE; HEART FAILURE; HEMOGLOBINS; HOSPITALIZATION; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; MORTALITY;

EID: 84982833662     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.07.264     Document Type: Article

References (30)

1. [1] Maggioni, A.P., Anand, I., Gottlieb, S.O., Latini, R., Tognoni, G., Cohn, J.N., et al. Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J. Am. Coll. Cardiol. 40 (2002), 1414–1421.
2. [2] Silverberg, D.S., Wexler, D., Blum, M., Keren, G., Sheps, D., Leibovitch, E., et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J. Am. Coll. Cardiol. 35 (2000), 1737–1744.
3. [3] Ezekowitz, J.A., McAlister, F.A., Armstrong, P.W., Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12,065 patients with new-onset heart failure. Circulation 107 (2003), 223–225.
4. [4] Tang, Y.D., Katz, S.D., Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation 113 (2006), 2454–2461.
5. [5] Anand, I.S., Heart failure and anemia: mechanisms and pathophysiology. Heart Fail. Rev. 13 (2008), 379–386.
6. [6] Kosiborod, M., Smith, G.L., Radford, M.J., Foody, J.M., Krumholz, H.M., The prognostic importance of anemia in patients with heart failure. Am. J. Med. 114 (2003), 112–119.
7. [7] Al-Ahmad, A., Rand, W.M., Manjunath, G., Konstam, M.A., Salem, D.N., Levey, A.S., et al. Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction. J. Am. Coll. Cardiol. 38 (2001), 955–962.
8. [8] Anand, I.S., Kuskowski, M.A., Rector, T.S., Florea, V.G., Glazer, R.D., Hester, A., et al. Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure: results from Val-HeFT. Circulation 112 (2005), 1121–1127.
9. [9] Go, A.S., Yang, J., Ackerson, L.M., Lepper, K., Robbins, S., Massie, B.M., et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: the anemia in chronic heart failure: outcomes and resource utilization (ANCHOR) study. Circulation 113 (2006), 2713–2723.
10. [10] Horwich, T.B., Fonarow, G.C., Hamilton, M.A., MacLellan, W.R., Borenstein, J., Anemia is associated with worse symptoms, greater impairment in functional capacity and a significant increase in mortality in patients with advanced heart failure. J. Am. Coll. Cardiol. 39 (2002), 1780–1786.
11. [11] Lindenfeld, J., Prevalence of anemia and effects on mortality in patients with heart failure. Am. Heart J. 149 (2005), 391–401.
12. [12] Maggioni, A.P., Opasich, C., Anand, I., Barlera, S., Carbonieri, E., Gonzini, L., et al. Anemia in patients with heart failure: prevalence and prognostic role in a controlled trial and in clinical practice. J. Card. Fail. 11 (2005), 91–98.
13. [13] Mozaffarian, D., Nye, R., Levy, W.C., Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE). J. Am. Coll. Cardiol. 41 (2003), 1933–1939.
14. [14] Newton, J.D., Squire, I.B., Glucose and haemoglobin in the assessment of prognosis after first hospitalisation for heart failure. Heart 92 (2006), 1441–1446.
15. [15] Peterson, P.N., Magid, D.J., Lyons, E.E., Clarke, C.L., Zeng, C., Fitzgerald, A., et al. Association of longitudinal measures of hemoglobin and outcomes after hospitalization for heart failure. Am. Heart J. 159 (2010), 81–89.
16. [16] Sharma, R., Francis, D.P., Pitt, B., Poole-Wilson, P.A., Coats, A.J., Anker, S.D., Haemoglobin predicts survival in patients with chronic heart failure: a substudy of the ELITE II trial. Eur. Heart J. 25 (2004), 1021–1028.
17. [17] Zairis, M.N., Patsourakos, N.G., Georgilas, A.T., Melidonis, A., Argyrakis, K.S., Prekates, A.A., et al. Anemia and early mortality in patients with decompensation of chronic heart failure. Cardiology 119 (2011), 125–130.
18. [18] Groenveld, H.F., Januzzi, J.L., Damman, K., van Wijngaarden, J., Hillege, H.L., van Veldhuisen, D.J., et al. Anemia and mortality in heart failure patients a systematic review and meta-analysis. J. Am. Coll. Cardiol. 52 (2008), 818–827.
19. [19] Binanay, C., Califf, R.M., Hasselblad, V., O'Connor, C.M., Shah, M.R., Sopko, G., et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. JAMA 294 (2005), 1625–1633.
20. [20] Young, J.B., Abraham, W.T., Albert, N.M., Gattis Stough, W., Gheorghiade, M., Greenberg, B.H., et al. Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry). Am. J. Cardiol. 101 (2008), 223–230.
21. [21] Katz, S.D., Maskin, C., Jondeau, G., Cocke, T., Berkowitz, R., LeJemtel, T., Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure. J. Appl. Physiol. 88:1985 (2000), 2138–2142.
22. [22] Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J.B., Mann, D.L., Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the studies of left ventricular dysfunction (SOLVD). J. Am. Coll. Cardiol. 27 (1996), 1201–1206.
23. [23] Konishi, M., Matsuzawa, Y., Suzuki, H., Akiyama, E., Iwahashi, N., Maejima, N., et al. Higher level at admission and subsequent decline in hemoglobin in patients with acute pulmonary edema. Circ. J. 78 (2014), 896–902.
24. [24] Testani, J.M., Brisco, M.A., Chen, J., McCauley, B.D., Parikh, C.R., Tang, W.H., Timing of hemoconcentration during treatment of acute decompensated heart failure and subsequent survival: importance of sustained decongestion. J. Am. Coll. Cardiol. 62 (2013), 516–524.
25. [25] Oh, J., Kang, S.M., Hong, N., Youn, J.C., Han, S., Jeon, E.S., et al. Hemoconcentration is a good prognostic predictor for clinical outcomes in acute heart failure: data from the Korean heart failure (KorHF) registry. Int. J. Cardiol. 168 (2013), 4739–4743.
26. [26] Androne, A.S., Katz, S.D., Lund, L., LaManca, J., Hudaihed, A., Hryniewicz, K., et al. Hemodilution is common in patients with advanced heart failure. Circulation 107 (2003), 226–229.
27. [27] Qaseem, A., Humphrey, L.L., Fitterman, N., Starkey, M., Shekelle, P., Clinical Guidelines Committee of the American College of P, Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 159 (2013), 770–779.
28. [28] American Society of Anesthesiologists Task Force on Pulmonary Artery C, Practice guidelines for pulmonary artery catheterization: an updated report by the American Society of Anesthesiologists Task Force on pulmonary artery catheterization. Anesthesiology 99 (2003), 988–1014.
29. [29] Coats, A., Shewan, L., The management of heart failure with preserved ejection fraction (HFpEF). Int. Cardiovasc. Forum J. 1 (2014), 108–112.
30. [30] Sanderson, J., Comments on “the management of heart failure with preserved ejection fraction”. Int. Cardiovasc. Forum J., 1, 2014, 166.