Lactated Ringer Is Associated with Reduced Mortality and Less Acute Kidney Injury in Critically Ill Patients: A Retrospective Cohort Analysis∗

Critical Care Medicine

Volumn 44, Issue 12, 2016, Pages 2163-2170

  Zampieri, Fernando G ^a,b   Ranzani, Otavio T ^a   Azevedo, Luciano Cesar Pontes ^a,c   Martins, Izanio D S ^d   Kellum, John A ^e   Libório, Alexandre B ^d  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL ALEMÃO OSWALDO CRUZ   (Brazil)

^c HOSPITAL SÍRIO LIBANÊS   (Brazil)

^d School of Medicine of Juazeiro do Norte   (Brazil)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

acute kidney injury; balanced solutions; critically ill; Lactated Ringer

Indexed keywords

CREATININE; RINGER LACTATE SOLUTION; SODIUM CHLORIDE; ISOTONIC SOLUTION; RINGER'S LACTATE;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; CLINICAL OUTCOME; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; FEMALE; HOSPITAL ADMISSION; HOSPITAL MORTALITY; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURVIVAL ANALYSIS; ACUTE KIDNEY INJURY; AGED; CRITICAL ILLNESS; FLUID THERAPY; MORTALITY; PROCEDURES;

ACUTE KIDNEY INJURY; AGED; CRITICAL ILLNESS; FEMALE; FLUID THERAPY; HOSPITAL MORTALITY; HUMANS; ISOTONIC SOLUTIONS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 84982813813     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001948     Document Type: Article

References (39)

1. Cecconi M, Hofer C, Teboul JL, et al; FENICE Investigators; ESICM Trial Group: Fluid challenges in intensive care: The FENICE study: A global inception cohort study. Intensive Care Med 2015; 41:1529-1537
2. Boyd JH, Forbes J, Nakada TA, et al: Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med 2011; 39:259-265
3. Lee SJ, Ramar K, Park JG, et al: Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: A retrospective cohort study. Chest 2014; 146:908-915
4. Lee J, de Louw E, Niemi M, et al: Association between fluid balance and survival in critically ill patients. J Intern Med 2015; 277:468-477
5. Finfer S, Liu B, Taylor C, et al; SAFE TRIPS Investigators: Resuscitation fluid use in critically ill adults: An international cross-sectional study in 391 intensive care units. Crit Care 2010; 14:R185
6. Shaw AD, Raghunathan K, Peyerl FW, et al: Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. Intensive Care Med 2014; 40:1897-1905
7. Raghunathan K, Shaw A, Nathanson B, et al: Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis. Crit Care Med 2014; 42:1585-1591
8. Yunos NM, Bellomo R, Hegarty C, et al: Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012; 308:1566-1572
9. Young P, Bailey M, Beasley R, et al: Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit. JAMA 2015; 314:1701-1710
10. Severs D, Hoorn EJ, Rookmaaker MB: A critical appraisal of intravenous fluids: From the physiological basis to clinical evidence. Nephrol Dial Transplant 2015; 30:178-187
11. Zampieri FG, Kellum JA, Park M, et al: Relationship between acidbase status and inflammation in the critically ill. Crit Care 2014; 18:R154
12. Yunos NM, Kim IB, Bellomo R, et al: The biochemical effects of restricting chloride-rich fluids in intensive care. Crit Care Med 2011; 39:2419-2424
13. Neyra JA, Canepa-Escaro F, Li X, et al; Acute Kidney Injury in Critical Illness Study Group: Association of hyperchloremia with hospital mortality in critically ill septic patients. Crit Care Med 2015; 43:1938-1944
14. Young JB, Utter GH, Schermer CR, et al: Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: A randomized trial. Ann Surg 2014; 259:255-262
15. Todd SR, Malinoski D, Muller PJ, et al: Lactated Ringer's is superior to normal saline in the resuscitation of uncontrolled hemorrhagic shock. J Trauma 2007; 62:636-639
16. Shaw AD, Schermer CR, Lobo DN, et al: Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care 2015; 19:334
17. O'Malley CM, Frumento RJ, Hardy MA, et al: A randomized, doubleblind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation. Anesth Analg 2005; 100:1518-1524
18. Burdett E, Dushianthan A, Bennett-Guerrero E, et al: Perioperative buffered versus non-buffered fluid administration for surgery in adults. Cochrane Database Syst Rev 2012; 12:CD004089
19. Kellum JA, Shaw AD: Assessing toxicity of intravenous crystalloids in critically ill patients. JAMA 2015; 314:1695-1697
20. Saeed M, Villarroel M, Reisner AT, et al: Multiparameter intelligent monitoring in intensive care II: A public-access intensive care unit database. Crit Care Med 2011; 39:952-960
21. Froissart M, Rossert J, Jacquot C, et al: Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 2005; 16:763-773
22. Le Gall JR, Loirat P, Alperovitch A, et al: A simplified acute physiology score for ICU patients. Crit Care Med 1984; 12:975-977
23. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
24. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
25. Kellum JA, Lameire N; KDiGO AKI Guideline Work Group: Diagnosis, evaluation, and management of acute kidney injury: A KDiGO summary (part 1). Crit Care 2013; 17:204
26. Desquilbet L, Mariotti F: Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 2010; 29:1037-1057
27. Wood SN: Generalized Additive Models: An Introduction With R. United Kingdom, Chapman and Hall/CRC, 2006
28. Harrell FE: Regression Modeling Strategies. New York, NY, Springer, 2001
29. Bartlett MS: The use of transformations. Biometrics 1947; 3:39-52
30. Lachin JM, McGee PL, Greenbaum CJ, et al; Type 1 Diabetes Trial Network: Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes. PLoS One 2011; 6:e26471
31. Peres-Neto PR, Jackson DA, Somers KM: Giving meaningful interpretation to ordination axes: Assessing loading significance in principal component analysis. Ecology 2003; 84:2347-2363
32. Richman MB: A cautionary note concerning a commonly applied eigenanalysis procedure Tellus B. 1988; 40B:50-58
33. Honaker J, King G, Blackwell M: {Amelia II}: A program for missing. Data J Stat Softw 2011; 45:1-47
34. Hastings C, Mosteller F, Tukey JW, et al: Low moments for small samples: A comparative study of order statistics Ann Math Stat 1947; 18:413-426
35. R Core Team: R: A Language and Environment for Statistical Computing. 2015. Available at: http://www.r-project.org/
36. Harrell EH Jr: rms: Regression Modeling Strategies. 2015. Available at: http://cran.r-project.org/package=rms. Accessed March 25, 2016
37. Wickham H: ggplot2: Elegant Graphics for Data Analysis. New York, Springer, 2009. Available at: http://had.co.nz/ggplot2/book. Accessed March 25, 2016
38. von Elm E, Altman DG, Egger M, et al; STROBE Initiative: Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. BMJ 2007; 335:806-808
39. Virgilio RW, Smith DE, Zarins CK: Balanced electrolyte solutions: Experimental and clinical studies. Crit Care Med 1979; 7:98-106