Thyroid hormone synthesis: A potential target of a Chinese herbal formula Haizao Yuhu Decoction acting on iodine-deficient goiter

Oncotarget

Volumn 7, Issue 32, 2016, Pages 51699-51712

  Zhang, Yanqiong ^a   Li, Yuting ^a   Mao, Xia ^a   Yan, Chen ^a   Guo, Xiaodong ^b   Guo, Qiuyan ^a   Liu, Zhenli ^a   Song, Zhiqian ^a   Lin, Na ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING 302 HOSPITAL   (China)

Author keywords

Chinese herbal formula; Experimental validation; Genome wide microarray; Goiter; Network pharmacology

Indexed keywords

CHINESE DRUG; HAIZAO YUHU DECOCTION; HERBACEOUS AGENT; THYROID HORMONE; UNCLASSIFIED DRUG; HAIZAO YUHU; IODINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE EXPRESSION PROFILING; GLYCYRRHIZA; GOITER; HISTOPATHOLOGY; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; IODINE DEFICIENT GOITER; MALE; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; THALLUS; THALLUS SARGASSI PALLIDI; THYROID GLAND TISSUE; THYROID HORMONE SYNTHESIS; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CHINESE MEDICINE; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; METABOLISM; MICROARRAY ANALYSIS; WISTAR RAT;

ANIMALS; DRUGS, CHINESE HERBAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GOITER; IODINE; MALE; MEDICINE, CHINESE TRADITIONAL; METABOLIC NETWORKS AND PATHWAYS; MICROARRAY ANALYSIS; RATS; RATS, WISTAR; THYROID HORMONES;

EID: 84982279670     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10329     Document Type: Article

References (41)

1. Qureshi IA, Khabaz MN, Baig M, Begum B, Abdelrehaman AS, Hussain MB. Histopathological findings in goiter: A review of 624 thyroidectomies. Neuro Endocrinol Lett. 2015; 36:48-52.
2. Knobel M. Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters. J Endocrinol Invest. 2016; 39:357-373. doi: 10.1007/s40618-015-0391-7.
3. Anees M, Anis RA, Yousaf S, Murtaza I, Sultan A, Arslan M, Shahab M. Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. Curr Med Res Opin. 2015; 31:667-74.
4. Zhao W, Han C, Shi X, Xiong C, Sun J, Shan Z, Teng W. Prevalence of goiter and thyroid nodules before and after implementation of the universal salt iodization program in mainland China from 1985 to 2014: a systematic review and meta-analysis. PLoS One. 2014; 9:e109549.
5. Han Y, Gao L, Sun N, Zhang J, Zhang W, Zhou X, Zhang H, Zhao J. Effects of Kang-Jia-Wan, a Chinese medicinal herb officinal, on apoptosis induction in goiter of rats. J Ethnopharmacol. 2009; 122:533-40.
6. Medeiros-Neto G, Camargo RY, Tomimori EK. Approach to and treatment of goiters. Med Clin North Am. 2012; 96:351-68.
7. Dralle H, Lorenz K, Machens A. State of the art: surgery for endemic goiter-a plea for individualizing the extent of resection instead of heading for routine total thyroidectomy. Langenbecks Arch Surg. 2011; 396:1137-43.
8. Bonnema SJ, Fast S, Hegedüs L. Non-surgical approach to the benign nodular goiter: new opportunities by recombinant human TSH-stimulated 131I-therapy. Endocrine. 2011; 40:344-53.
9. Thomusch O, Machens A, Sekulla C, Ukkat J, Lippert H, Gastinger I, Dralle H. Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany. World J Surg. 2000; 24:1335-41.
10. Hegedüs L, Bonnema SJ, Bennedbaek FN. Management of simple nodular goiter: current status and future perspectives. Endocr Rev. 2003; 24:102-32.
11. Liu SM, Luo MM, Li YJ. The law of thyromegaly treated with TCM in ancient literature. [Article In Chinese]. Information on Traditional Chinese Medicine. 2003; 20: 61-62.
12. Liu YX, Zhong GS, Liu HY, Li YW, Ou LN, Zhao T, Liu M. Therapeutic effect of Haizao Yuhu decoction with/without seaweed and liquorice anti-drug combination on goiter rats in preferred dosage conditions. [Article In Chinese]. Science and technology review. 2015; 33: 87-91.
13. Qi TC, Gao TS. Comparative Study on Intervention Mechanisms of Iodine and Haizao Yuhu Decoction for Goiter Caused by Iodine Deficiency. [Article In Chinese]. Chinese archives of traditional Chinese medicine. 2012; 30: 1211-1214.
14. Lin L, Chen YH. Clinical observation of the combination of Haizao Yuhu decoction and tapazole in the treatment of "Yin syndrome" (Phlegm and Blood Stasis Syndrome) in 42 cases. [Article In Chinese]. Journal of Qiannan Medical College for Nationalities. 2015; 28: 34-35, 8.
15. Poncin S, Gérard AC, Boucquey M, Senou M, Calderon PB, Knoops B, Lengelé B, Many MC, Colin IM. Oxidative stress in the thyroid gland: from harmlessness to hazard depending on the iodine content. Endocrinology. 2008; 149:424-33.
16. Qi TC, Gao TS. Comparative Study on intervention mechanisms of iodine and Haizao Yuhu Decoction for goiter caused by iodine deficiency. [Article In Chinese]. Chinese Archives of Traditional Chinese Medicine. 2012; 30: 1211-1214.
17. Hopkins AL. Network pharmacology. Nat Biotechnol. 2007; 25:1110-1.
18. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol. 2008; 4:682-90.
19. Li S. Network target: a starting point for traditional Chinese medicine network pharmacology. [Article In Chinese]. Zhongguo Zhong Yao Za Zhi. 2011; 36:2017-2020.
20. Zhang Y, Bai M, Zhang B, Liu C, Guo Q, Sun Y, Wang D, Wang C, Jiang Y, Lin N, Li S. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation. Sci Rep. 2015; 5: 9463.
21. Guo Q, Zhong M, Xu H, Mao X, Zhang Y, Lin N. A Systems Biology Perspective on the Molecular Mechanisms Underlying the Therapeutic Effects of Buyang Huanwu Decoction on Ischemic Stroke. Rejuvenation Res. 2015; 18: 313-25.
22. Zhang Y, Guo X, Wang D, Li R, Li X, Xu Y, Liu Z, Song Z, Lin Y, Li Z, Lin N. A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma. Sci Rep. 2014; 4: 4154.
23. Guo QY, Mao X, Zhang YQ, Meng SQ, Xi Y, Ding Y, Zhang XC, Dai YT, Liu X, Wang C, Li YT, Lin N. Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance. J Transl Med. 2016; 14:165
24. Li S, Zhang ZQ, Wu LJ, Zhang XG, Li YD, Wang YY. Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Syst Biol. 2007; 1:51-60
25. Zhang Y, Wang D, Tan S, Xu H, Liu C, Lin N. A systems biology-based investigation into the pharmacological mechanisms of wu tou tang acting on rheumatoid arthritis by integrating network analysis. Evid Based Complement Alternat Med. 2013; 2013: 548498.
26. Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE. Thyroid hormone receptors and resistance to thyroid hormone disorders. Nat Rev Endocrinol. 2014; 10: 582-91.
27. LaFranchi S. Thyroid hormone in hypopituitarism, Graves' disease, congenital hypothyroidism, and maternal thyroid disease during pregnancy. Growth Horm IGF Res. 2006; 16 Suppl A: S20-4.
28. Gillam MP, Kopp P. Genetic defects in thyroid hormone synthesis.Curr Opin Pediatr. 2001; 13: 364-72.
29. Miot F, Dupuy C, Dumont J, Rousset B. Chapter 2 Thyroid Hormone Synthesis And Secretion. In: De Groot LJ, Beck-Peccoz P, Chrousos G, Dungan K, Grossman A, Hershman JM, Koch C, McLachlan R, New M, Rebar R, Singer F, Vinik A, Weickert MO, editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000; 2000-2015.
30. Brix K, Führer D, Biebermann H. Molecules important for thyroid hormone synthesis and action-known facts and future perspectives. Thyroid Res. 2011; 4 Suppl 1: S9.
31. Saxena P, Charpin-El Hamri G, Folcher M, Zulewski H, Fussenegger M. Synthetic gene network restoring endogenous pituitary-thyroid feedback control in experimental Graves' disease. Proc Natl Acad Sci U S A. 2016; 113:1244-9. doi: 10.1073/pnas.1514383113.
32. Medici M, Visser WE, Visser TJ, Peeters RP. Genetic determination of the hypothalamic-pituitary-thyroid axis: where do we stand? Endocr Rev. 2015; 36: 214-44.
33. Romarís-Hortas V, Moreda-Piñeiro A, Bermejo-Barrera P. Microwave assisted extraction of iodine and bromine from edible seaweed for inductively coupled plasma-mass spectrometry determination. Talanta. 2009; 79:947-52.
34. Miyai K, Tokushige T, Kondo M; Iodine Research Group. Suppression of thyroid function during ingestion of seaweed "Kombu" (Laminaria japonoca) in normal Japanese adults. Endocr J. 2008; 55:1103-8.
35. Sun XW, Weng HX, Qin YC. Release of bioactive active iodine in kelp. J Environ Sci (China). 2005; 17:241-4.
36. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008; 36:D901-6.
37. Chen CY. TCM Database-Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One. 2011; 6:e15939
38. Wixon J, Kell D. The Kyoto encyclopedia of genes and genomes-KEGG. Yeast. 2000; 17:48-55.
39. Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, Kuhn M, Bork P, Jensen LJ, von Mering C. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015; 43:D447-52.
40. Ballester M, Castelló A, Ibáñez E, Sánchez A, Folch JM. Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals. Biotechniques. 2004; 37: 610-3.
41. Zhang Y, Bai M, Zhang B, Liu C, Guo Q, Sun Y, Wang D, Wang C, Jiang Y, Lin N, Li S. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation. Sci Rep. 2015; 5: 9463.