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Volumn 9, Issue 4, 2016, Pages 221-227

Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ARACHIDONIC ACID; VORAPAXAR;

EID: 84982239073     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/cts.12405     Document Type: Article
Times cited : (10)

References (10)
  • 1
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    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow, D.A. et al. Vorapaxar in the secondary prevention of atherothrombotic events. N. Engl. J. Med. 366, 1404–1413 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 1404-1413
    • Morrow, D.A.1
  • 2
    • 85016499293 scopus 로고    scopus 로고
    • Efficacy and safety of vorapaxar as approved for clinical use in the United States
    • Magnani, G. et al. Efficacy and safety of vorapaxar as approved for clinical use in the United States. J. Am. Heart Assoc. 4, e001505 (2015).
    • (2015) J. Am. Heart Assoc , vol.4
    • Magnani, G.1
  • 3
    • 0015525988 scopus 로고
    • The bleeding time as a screening test for evaluation of platelet function
    • Harker, L.A. & Slichter, S.J. The bleeding time as a screening test for evaluation of platelet function. N. Engl. J. Med. 287, 155–159 (1972).
    • (1972) N. Engl. J. Med , vol.287 , pp. 155-159
    • Harker, L.A.1    Slichter, S.J.2
  • 4
    • 0022625892 scopus 로고
    • Surgicutt: a device for modified template bleeding times
    • Smith, C. Surgicutt: a device for modified template bleeding times. J. Med. Technol. 3, 29–31 (1986).
    • (1986) J. Med. Technol , vol.3 , pp. 29-31
    • Smith, C.1
  • 5
    • 84857047314 scopus 로고    scopus 로고
    • No differences in the pharmacodynamics and pharmacokinetics of the thrombin receptor antagonist vorapaxar between healthy Japanese and Caucasian subjects
    • Kosoglou, T. et al. No differences in the pharmacodynamics and pharmacokinetics of the thrombin receptor antagonist vorapaxar between healthy Japanese and Caucasian subjects. Eur. J. Clin. Pharmacol. 68, 291–300 (2012).
    • (2012) Eur. J. Clin. Pharmacol , vol.68 , pp. 291-300
    • Kosoglou, T.1
  • 6
    • 84927158455 scopus 로고    scopus 로고
    • Pharmacokinetics of vorapaxar and its metabolite following oral administration in healthy Chinese and American subjects
    • Chen, X. et al. Pharmacokinetics of vorapaxar and its metabolite following oral administration in healthy Chinese and American subjects. Int. J. Clin. Pharmacol. Ther. 52, 889–899 (2014).
    • (2014) Int. J. Clin. Pharmacol. Ther , vol.52 , pp. 889-899
    • Chen, X.1
  • 7
    • 0022181586 scopus 로고
    • Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction
    • De Caterina, R. et al. Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction. Thromb. Haemost. 54, 528–532 (1985).
    • (1985) Thromb. Haemost , vol.54 , pp. 528-532
    • De Caterina, R.1
  • 8
    • 0036598117 scopus 로고    scopus 로고
    • Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action
    • Payne, D.A., Hayes, P.D., Jones, C.I., Belham, P., Naylor, A.R. & Goodall, A.H. Combined therapy with clopidogrel and aspirin significantly increases the bleeding time through a synergistic antiplatelet action. J. Vasc. Surg. 35, 1204–1209 (2002).
    • (2002) J. Vasc. Surg , vol.35 , pp. 1204-1209
    • Payne, D.A.1    Hayes, P.D.2    Jones, C.I.3    Belham, P.4    Naylor, A.R.5    Goodall, A.H.6
  • 9
    • 84911996318 scopus 로고    scopus 로고
    • The effects of laropiprant on the antiplatelet activity of co-administered clopidogrel and aspirin
    • De Kam, P.J. et al. The effects of laropiprant on the antiplatelet activity of co-administered clopidogrel and aspirin. Platelets 25, 480–487 (2014).
    • (2014) Platelets , vol.25 , pp. 480-487
    • De Kam, P.J.1
  • 10
    • 84857041061 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of the novel PAR-1 antagonist vorapaxar (formerly SCH 530348) in healthy subjects
    • Kosoglou, T. et al. Pharmacodynamics and pharmacokinetics of the novel PAR-1 antagonist vorapaxar (formerly SCH 530348) in healthy subjects. Eur. J. Clin. Pharmacol. 68, 249–258 (2012).
    • (2012) Eur. J. Clin. Pharmacol , vol.68 , pp. 249-258
    • Kosoglou, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.