Voriconazole-susceptible and voriconazole-resistant aspergillus fumigatus coinfection

American Journal of Respiratory and Critical Care Medicine

Volumn 193, Issue 8, 2016, Pages 927-929

  Kolwijck, Eva ^a   Van Der Hoeven, Hans ^a   De Sévaux, Ruud G L ^a   Ten Oever, Jaap ^a   Rijstenberg, L Lucia ^a   Van Der Lee, Henrich A L ^a   Zoll, Jan ^a   Melchers, Willem J G ^a   Verweij, Paul E ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; CIPROFLOXACIN; GALACTOMANNAN; MEROPENEM; METHYLPREDNISOLONE; MYCOPHENOLATE MOFETIL; OSELTAMIVIR; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; RAPAMYCIN; THYMOCYTE ANTIBODY; VALGANCICLOVIR; VORICONAZOLE; ANTIFUNGAL AGENT; CREATININE; PYRROLE DERIVATIVE;

ADULT; ANTIFUNGAL RESISTANCE; ANTIFUNGAL THERAPY; ARTIFICIAL VENTILATION; ASPERGILLUS FUMIGATUS; CASE REPORT; CHILL; COMPUTER ASSISTED TOMOGRAPHY; DYSPNEA; FEMALE; FEVER; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFLUENZA A; INVASIVE ASPERGILLOSIS; KIDNEY GRAFT REJECTION; LARGE CELL LYMPHOMA; LETTER; LUNG INSUFFICIENCY; LUNG LAVAGE; LUNG LESION; LYMPHOCELE; MALE; MIDDLE AGED; MIXED INFECTION; MULTIPLE ORGAN FAILURE; PANCYTOPENIA; PLASMAPHERESIS; PRIORITY JOURNAL; SURGICAL DRAINAGE; THORAX RADIOGRAPHY; TRACHEOBRONCHITIS; AGED; ASPERGILLOSIS; DRUG EFFECTS; FATALITY; ACUTE GRAFT REJECTION; ANTIFUNGAL SUSCEPTIBILITY; AUTOPSY; BRAIN BIOPSY; BRONCHIAL ASPIRATION PROCEDURE; CYTOMEGALOVIRUS INFECTION; DEATH; DELIRIUM; DIABETIC NEPHROPATHY; DIFFUSE LARGE B CELL LYMPHOMA; DISEASE COURSE; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; FUNGAL COLONIZATION; FUNGUS CULTURE; FUNGUS GROWTH; FUNGUS HYPHAE; FUNGUS MUTATION; HEMODIALYSIS; HOSPITAL INFECTION; HYPERTENSION; HYPOXIA; IN VITRO STUDY; INFLUENZA A (H1N1); INTENSIVE CARE; KIDNEY FAILURE; LUNG ASPERGILLOSIS; LUNG INFILTRATE; NONHUMAN; OXYGEN SATURATION; PALLIATIVE THERAPY; PNEUMONIA; PYELONEPHRITIS; RECURRENT DISEASE; SCHIZOPHRENIA; SPUTUM CULTURE; TACHYPNEA; THROAT CULTURE;

AGED; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; COINFECTION; DRUG RESISTANCE, FUNGAL; FATAL OUTCOME; FEMALE; HUMANS; MALE; MIDDLE AGED; VORICONAZOLE;

EID: 84982215760     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201510-2104LE     Document Type: Letter

References (11)

1. van der Linden JW, Arendrup MC, Warris A, Lagrou K, Pelloux H, Hauser PM, Chryssanthou E, Mellado E, Kidd SE, Tortorano AM, et al. Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerg Infect Dis 2015;21:1041-1044.
2. Chowdhary A, Kathuria S, Xu J, Meis JF. Emergence of azole-resistant Aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health. PLoS Pathog 2013;9:e1003633.
3. Snelders E, Camps SM, Karawajczyk A, Schaftenaar G, Kema GH, van der Lee HA, Klaassen CH, Melchers WJ, Verweij PE. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PLoS One 2012;7:e31801.
4. Snelders E, van der Lee HA, Kuijpers J, Rijs AJ, Varga J, Samson RA, Mellado E, Donders AR, Melchers WJ, Verweij PE. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med 2008;5:e219.
5. van der Linden JW, Snelders E, Kampinga GA, Rijnders BJ, Mattsson E, Debets-Ossenkopp YJ, Kuijper EJ, Van Tiel FH, Melchers WJ, Verweij PE. Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009. Emerg Infect Dis 2011;17:1846-1854.
6. van der Linden JW, Camps SM, Kampinga GA, Arends JP, Debets-Ossenkopp YJ, Haas PJ, Rijnders BJ, Kuijper EJ, van Tiel FH, Varga J, et al. Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles. Clin Infect Dis 2013;57:513-520.
7. Arendrup MC, Cuenca-Estrella M, Lass-Flörl C, Hope WW. Breakpoints for antifungal agents: an update from EUCAST focussing on echinocandins against Candida spp. and triazoles against Aspergillus spp. Drug Resist Updat 2013;16:81-95.
8. de Valk HA, Meis JF, Curfs IM, Muehlethaler K, Mouton JW, Klaassen CH. Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates. J Clin Microbiol 2005;43:4112-4120.
9. de Valk HA, Meis JF, de Pauw BE, Donnelly PJ, Klaassen CH. Comparison of two highly discriminatory molecular fingerprinting assays for analysis of multiple Aspergillus fumigatus isolates from patients with invasive aspergillosis. J Clin Microbiol 2007;45: 1415-1419.
10. Chong GL, van de Sande WW, Dingemans GJ, Gaajetaan GR, Vonk AG, Hayette MP, van Tegelen DW, Simons GF, Rijnders BJ. Validation of a new Aspergillus real-time PCR assay for direct detection of Aspergillus and azole resistance of Aspergillus fumigatus on bronchoalveolar lavage fluid. J Clin Microbiol 2015;53: 868-874.
11. Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, et al. International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus. Drug Resist Updat 2015;21-22:30-40.