High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 35, Issue 11, 2016, Pages 1759-1766

  Aly, M M ^a   Abu Alsoud, N M ^a   Elrobh, M S ^b,d   Al Johani, S M ^a   Balkhy, H H ^a,c  

^a KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^d Ain Shams University   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GENOMIC DNA; IMIPENEM; MEROPENEM; PER 1 PROTEIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL DNA; BETA LACTAMASE; BETA-LACTAMASE PER-1; CARBAPENEM DERIVATIVE;

ACINETOBACTER BAUMANNII; ADOLESCENT; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CULTURE; BACTERIUM ISOLATE; CARBAPENEM RESISTANT ACINETOBACTER BAUMANNII; CHILD; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; SAUDI ARABIA; SEQUENCE BASED TYPING; YOUNG ADULT; ACINETOBACTER INFECTIONS; ANALYSIS; CHEMISTRY; CLASSIFICATION; CLUSTER ANALYSIS; DNA SEQUENCE; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR EPIDEMIOLOGY; PLASMID; TERTIARY CARE CENTER; VERY ELDERLY;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DNA, BACTERIAL; FEMALE; GENOTYPE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; PLASMIDS; POLYMERASE CHAIN REACTION; PREVALENCE; SAUDI ARABIA; SEQUENCE ANALYSIS, DNA; TERTIARY CARE CENTERS; YOUNG ADULT;

EID: 84982111804     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-016-2723-8     Document Type: Article

References (29)

1. Al Johani SM, Akhter J, Balkhy H et al (2010) Prevalence of antimicrobial resistance among gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia. Ann Saudi Med 30(5):364–369
2. Aly M, Balkhy HH (2012) The prevalence of antimicrobial resistance in clinical isolates from Gulf Corporation Council countries. Antimicrob Resist Infect Control 1(1):26
3. Aly M, Tayeb HT, Al Johani SM et al (2014) Genetic diversity of OXA-51-like genes among multidrug-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia. Eur J Clin Microbiol Infect Dis 33(7):1223–1228
4. Peleg AY, Seifert H, Paterson DL (2008) Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev 21(3):538–582
5. Poirel L, Marqué S, Héritier C et al (2005) OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii. Antimicrob Agents Chemother 49(1):202–208
6. Mussi MA, Limansky AS, Viale AM (2005) Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of {beta}-barrel outer membrane proteins. Antimicrob Agents Chemother 49(4):1432–1440
7. Bae IK, Jang SJ, Kim J et al (2011) Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum beta-lactamase. Antimicrob Agents Chemother 55(3):1305–1307
8. Vahaboglu H, Coskunkan F, Tansel O et al (2001) Clinical importance of extended-spectrum beta-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains. J Med Microbiol 50(7):642–645
9. Vahaboglu H, Saribaş S, Akbal H et al (1998) Activities of cefepime and five other antibiotics against nosocomial PER-1-type and/or OXA-10-type beta-lactamase-producing Pseudmonas aeruginosa and Acinetobacter spp. J Antimicrob Chemother 42(2):269–270
10. Pasterán F, Rapoport M, Petroni A et al (2006) Emergence of PER-2 and VEB-1a in Acinetobacter baumannii strains in the Americas. Antimicrob Agents Chemother 50(9):3222–3224
11. Hu WS, Yao SM, Fung CP et al (2007) An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii. Antimicrob Agents Chemother 51(11):3844–3852
12. Chen TL, Chang WC, Kuo SC et al (2010) Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in Acinetobacter genomic species 13TU. Antimicrob Agents Chemother 54(8):3107–3112
13. Vahaboglu H, Oztürk R, Aygün G et al (1997) Widespread detection of PER-1-type extended-spectrum beta-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey: a nationwide multicenter study. Antimicrob Agents Chemother 41(10):2265–2269
14. Culebras E, González-Romo F, Head J et al (2010) Outbreak of Acinetobacter baumannii producing OXA-66 in a Spanish hospital: epidemiology and study of patient movements. Microb Drug Resist 16(4):309–315
15. Giannouli M, Cuccurullo S, Crivaro V et al (2010) Molecular epidemiology of multidrug-resistant Acinetobacter baumannii in a tertiary care hospital in Naples, Italy, shows the emergence of a novel epidemic clone. J Clin Microbiol 48(4):1223–1230
16. Gogou V, Pournaras S, Giannouli M et al (2011) Evolution of multidrug-resistant Acinetobacter baumannii clonal lineages: a 10 year study in Greece (2000–09). J Antimicrob Chemother 66(12):2767–2772
17. Evans BA, Hamouda A, Towner KJ et al (2010) Novel genetic context of multiple bla OXA-58 genes in Acinetobacter genospecies 3. J Antimicrob Chemother 65(8):1586–1588
18. Rawat D, Nair D (2010) Extended-spectrum beta-lactamases in Gram negative bacteria. J Glob Infect Dis 2(3):263–274
19. Diancourt L, Passet V, Nemec A et al (2010) The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool. PLoS One 5(4):e10034
20. Bacila I, Jakab E, Ferencz B et al (2008) MLST method (Multilocus Sequence Typing). Bacteriol Virusol Parazitol Epidemiol 53(1):13–17
21. Hujer KM, Hujer AM, Hulten EA et al (2006) Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. Isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother 50(12):4114–4123
22. Mugnier PD, Bindayna KM, Poirel L et al (2009) Diversity of plasmid-mediated carbapenem-hydrolysing oxacillinases among carbapenem-resistant Acinetobacter baumannii isolates from Kingdom of Bahrain. J Antimicrob Chemother 63(5):1071–1073
23. Opazo A, Vali L, Al Obaid K et al (2014) Novel genetic structure harbouring blaPER-1 in ceftazidime-resistant Acinetobacter baumannii isolated from Kuwait. Int J Antimicrob Agents 43(4):383–384
24. Khan FY, Abukhattab M, Baager K (2012) Nosocomial postneurosurgical Acinetobacter baumannii meningitis: a retrospective study of six cases admitted to Hamad general hospital, Qatar. J Hosp Infect 80(2):176–179
25. Opazo A, Sonnevend A, Lopes B et al (2012) Plasmid-encoded PER-7 beta-lactamase responsible for ceftazidime resistance in Acinetobacter baumannii isolated in the United Arab Emirates. J Antimicrob Chemother 67(7):1619–1622
26. Lakshmana Gowda K, Marie MA, Al-Sheikh YA et al (2014) A 6-year surveillance of antimicrobial resistance patterns of Acinetobacter baumannii bacteremia isolates from a tertiary care hospital in Saudi Arabia during 2005–2010. Libyan J Med 9:24039
27. Wang H, Guo P, Sun H et al (2007) Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob Agents Chemother 51:4022–4028
28. Giordano A, Varesi P, Bertini A et al (2007) Outbreak of Acinetobacter baumannii producing the carbapenem-hydrolyzing oxacillinase OXA-58 in Rome, Italy. Microb Drug Resist 13:37–43
29. Opazo A, Sonnevend A, Lopes B et al (2012) Plasmid-encoded PER-7 β-lactamase responsible for ceftazidime resistance in Acinetobacter baumannii isolated in the United Arab Emirates. J Antimicrob Chemother 67(7):1619–1622