Outbreak of Acinetobacter baumannii producing the carbapenem-hydrolyzing oxacillinase OXA-58 in Rome, Italy

Microbial Drug Resistance

Volumn 13, Issue 1, 2007, Pages 37-43

  Giordano, Alessandra ^a   Varesi, Paola ^a   Bertini, Alessia ^a   Villa, Laura ^a   Dionisi, Anna Maria ^a   Venditti, Mario ^b   Carfagna, Paolo ^c   Luzzi, Ida ^a   Mancini, Carlo ^a   Carattoli, Alessandra ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c Ospedale Madre G Vannini   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL ENZYME; CARBAPENEM; GENTAMICIN; IMIPENEM; OXACILLINASE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; EPIDEMIC; GENE CASSETTE; GENOTYPE; HOSPITAL INFECTION; INTEGRON; INTENSIVE CARE UNIT; ITALY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSED FIELD GEL ELECTROPHORESIS; RANDOM AMPLIFIED POLYMORPHIC DNA; SOUTHERN BLOTTING;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BACTERIOLOGICAL TECHNIQUES; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBAPENEMS; DISEASE OUTBREAKS; ELECTROPHORESIS, GEL, PULSED-FIELD; GENOTYPE; HUMANS; INTEGRONS; INTENSIVE CARE UNITS; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; ROME;

ACINETOBACTER BAUMANNII;

EID: 34249725158     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.2006.9995     Document Type: Article

References (37)

1. Bertini, A., A. Giordano, P. Varesi, L. Villa, C. Mancini, and A. Carattoli. 2006. First report of the plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter baumannii isolates in Italy. Antimicrob. Agents Chemother. 50: 2268-2269.
2. Bogaerts, P., T. Naas, I. Wybo, C. Bauraing, O. Soetens, D. Pierard, P. Nordmann, and Y. Glupczynski. 2006. Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-58 in Belgium. J. Clin. Microbiol. 44:4189-4192.
3. Carr, E., H. Eason, S. Feng, A. Hoogenraad, R. Croome, J. Soddell, K. Lindrea, and R. Seviour. 2001. RAPD-PCR typing of Acinetobacter isolates from activated sludge systems designed to remove phosphorus microbiologically. J. Appl. Microbiol. 90:309-319.
4. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; Fifteenth supplement Institute. January 2005 25 (1), Replaces M100-S14, Vol. 24, No 1. Clinical and Laboratory Standards, Wayne, PA.
5. Coelho, J., N. Woodford, M. Afzal-Shah, and D. Livermore. 2006. Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents. Antimicrob. Agents Chemother. 50:756-758.
6. Corbella, X., A. Montero, M. Pujol, M.A. Domínguez, J. Ayats, M.J. Argerich, F. Garrigosa, J. Ariza, and F. Gudiol. 2000. Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii. J. Clin. Microbiol. 38:4086-4095.
7. del Mar Tomas, M., M. Cartelle, S. Pertega, A. Beceiro, P. Llinares, D. Canle, F. Molina, R. Villanueva, J.M. Cisneros, and G. Bou. 2005. Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection. Clin. Microbiol. Infect. 11:540-546.
8. Docquier, J.D., M.L. Riccio, C. Mugnaioli, F. Luzzaro, A. Endimiani, A. Toniolo, G. Amicosante, and G.M. Rossolini. 2003. IMP-12, a new plasmid-encoded metallo-β-lactamase from a Pseudomonas putida clinical isolate. Antimicrob. Agents Chemother. 47:1522-1528.
9. Fournier, P.E., D. Vallenet, V. Barbe, S. Audic, H. Ogata, L. Poirel, H. Richet, C. Robert, S. Mangenot, C. Abergel, P. Nordmann, J. Weissenbach, D. Raoult, and J.M. Claverie. 2006. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet. 2:e7.
10. Gales, A.C., R.N. Jones, K.R. Forward, J. Linares, H.S. Sader, and J. Verhoef. 2001. Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients:geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999). Clin. Infect. Dis. 32:S104-S113.
11. Gallego, L., and K.J. Towner. 2001. Carriage of class 1 integrons and antibiotic resistance in clinical isolates of Acinetobacter baumannii from Northern Spain. J. Med. Microbiol. 50:71-77.
12. Garner, J.S., W.R. Jarvis, T.G. Emori, T.C. Horan, and J.M. Hughes. 1996. CDC definitions for nosocomial infections. In: R.N. Olmsted (ed). APIC infection control and applied epidemiology: principles and practice. St. Louis, MO: Mosby, pp. A1-A20.
13. Gombac, F., M.L. Riccio, G.M. Rossolini, C. Lagatolla, E. Tonin, C. Monti-Bragadin, A. Lavenia, and L. Dolzani. 2002. Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays. Antimicrob. Agents Chemother. 46:3665-3668.
14. Héritier, C., A. Dubouix, L. Poirel, N. Marty, and P. Nordmann. 2005. A nosocomial outbreak of Acinetobacter baumannii isolates expressing the carbapenem-hydrolyzing oxacillinase OXA-58. J. Antimicrob. Chemother. 55:115-118.
15. Héritier, C., L. Poirel, T. Lambert, and P. Nordmann. 2005. Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:3198-3202.
16. Jeon, B.C., S.H. Jeong, I.K. Bae, S.B. Kwon, K. Lee, D. Young, J.H. Lee, J.S. Song, and S.H. Lee. 2005. Investigation of a nosocomial outbreak of imipenem-resistant Acinetobacter baumannii producing the OXA-23 beta-lactamase in Korea. J. Clin. Microbiol. 43:2241-2245.
17. Kallel, H., M. Bahloul, L. Hergafi, M. Akrout, W. Ketata, H. Chelly, C.B. Hamida, N. Rekik, A. Hammami, and M. Bouaziz. 2006. Colistin as a salvage therapy for nosocomial infections caused by multidrug-resistant bacteria in the ICU. Int. J. Antimicrob. Agents. 28:366-369.
18. Koeleman, J.G., J.J. Stoof, M.W. van der Bijl, C.M.J.E. Vanderbroucke-Grauls, and P.H.M. Savelkou. 2001. Identification of epidemic strains of Acinetobacter baumanni by integrase gene PCR. J. Clin. Microbiol. 39:8-13.
19. Levesque, C., L. Piche, C. Larose, and P.H. Roy. 1995. PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob. Agents Chemother. 39:185-191.
20. Marqué, S., L. Poirel, C. Héritier, S. Brisse, M.D. Blasco, R. Filip, G. Coman, T. Naas, and P. Nordmann. 2005. Regional occurrence of plasmid-mediated carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter spp. In Europe. J. Clin. Microbiol. 43:4885-4888.
21. Navon-Venezia, S., R. Ben-Ami, and Y. Carmeli. 2005. Update on Pseudomonas aeruginosa and Acinetobacter baumannii infections in the healthcare setting. Curr. Opin. Infect. Dis. 18:306-313.
22. Perilli, M., A. Felici, A. Oratore, G. Cornaglia, G. Bonfiglio, G.M. Rossolini, and G. Amicosante. 1996. Characterization of the chromosomal cephalosporinascs produced by Acinetobacter Iwoffii and Acinetobacter baumannii clinical isolates. Antimicrob. Agents Chemother. 40:715-719.
23. Petrosillo, N., P. Petrosillo, M. Chinello, F. Proietti, L. Cecchini, M. Masala, C. Franchi, M. Venditti, S. Esposito, and E. Nicastri. 2005. Combined colistin and rifampicin therapy for carbapenem-resistant Acinetobacter baumannii infections: clinical outcome and adverse events. Clin. Microbiol. Infect. 11:682-683.
24. Poirel, L., and P. Nordmann. 2002. Acquired carbapenem-hydrolyzing β-lactamases and their genetic support. Curr. Pharm. Biotechnol. 3:117-127.
25. Poirel, L., S. Marque, C. Heritier, C. Segonds, G. Chabanon, and P. Nordmann. 2005. OXA-58. a novel class D {beta}-lactamase involved in resisiance to curbapenems in Acinetobacter baumannii. Antimicrob. Agents Chemother. 49:202-208.
26. Pournaras, S., A. Ikonomidis, A. Markogiannakis, A.N. Maniatis, and A. Tsakris. 2005. Heteroresistance to carbapenems in Acinetobacter baumannii J. Antimicrob. Chemother. 55:1055-1056.
27. Pournaras, S., A. Markogiannakis, A. Ikonomidis, L. Kondyli, K. Bethimouti, A.N. Maniatis, N.J. Legakis and A. Tsakris. 2006. Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit. J. Antimicrob. Chemother. 57:557-561.
28. Riccio, M.L., N. Franceschini, L. Boschi, B. Caravelli, G. Cornaglia, R. Fontana, G. Amicosante, and G.M. Rossolini. 2000. Characterization of the metallo-β-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of blaIMP allelic variants carried by gene cassettes of different phylogeny. Antimicrob. Agents Chemother. 44:1229-1235.
29. Struelens, M.J., V. Schwam, A. Deplano, and D. Baran. 1993. Genome macrorestriction analysis of diversity and variability of P. aeruginosa strains infecting Cystic Fibrosis patients. J. Clin. Microb. 31:2320-2326.
30. Theaker, C., B. Azadian, and N. Soni. 2003. The impact of Acinetobacter baumannii in the intensive care unit. Anaesthesia. 58:271-274.
31. Turton, J.F., M.E. Kaufmann, J. Glover, J.M. Coelho, M. Warner, R. Pike, and T.L. Pitt. 2005. Detection and typing of integrons in epidemic strains of Acinetobacter baumannii found in the United Kingdom. J. Clin. Microb. 43:3074-3082.
32. Tysall, L., M.W. Stockdale, P.R. Chadwick, M.F. Palepou, K.J. Towner, D.M. Livermore, and N. Woodford. 2002. IMP-1 carbapenemase detected in an Acinetobacter clinical isolate from the UK. J Antimicrob. Chemother. 49:217-218.
33. Van Looveren, M., H. Goossens. and the ARPAC Steering Group. 2004. Antimicrobial resistance of Acinetobacter spp. in Europe. Clin. Microbiol. Infect. 10:684-704.
34. Villari P., L. Iacuzio, E.A. Vozzella, and U. Bosco. 1999. Unusual genetic heterogeneity of Acinetobacter baumannii isolates in university hospital in Italy. American J. Infect. Control. 27:247-253.
35. Walsh, T.R., A. Bolmström, A. Qwärnström, and A. Gales. 2002. Evaluation of a new Etest for detecting metallo-β- lactamases in routine clinical testing. J. Clin. Microbiol. 40:2755-2759.
36. Walsh, T.R., M.A. Toleman, L. Poirel, and P. Nordmann. 2005. Metallo-β-lactamases: the quiet before the storm? Clin. Microbiol. Rev. 18:306-325.
37. Zarrilli, R., M. Crispino, M. Bagattini, E. Barretta, A. Di Popolo, M. Triassi, and P. Villari. 2004. Molecular epidemiology of sequential outbreaks of Acinetobacter baumannii in an intensive care unit shows the emergence of carbapenem resistance. J. Clin. Microb. 42:946-953.