Nanoparticle-mediated siRNA delivery assessed in a 3D co-culture model simulating prostate cancer bone metastasis

International Journal of Pharmaceutics

Volumn 511, Issue 2, 2016, Pages 1058-1069

  Fitzgerald, Kathleen A ^a   Guo, Jianfeng ^a   Raftery, Rosanne M ^b,c   Castaño, Irene Mencía ^b,c   Curtin, Caroline M ^b,c   Gooding, Matt ^a   Darcy, Raphael ^a   O’ Brien, Fergal J ^b,c   O’ Driscoll, Caitriona M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

3D co culture; Collagen based scaffolds; Gene delivery; Modified cyclodextrin; Osteoblasts; Prostate cancer cells

Indexed keywords

CYCLODEXTRIN; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOFECTAMINE; NANOPARTICLE; SMALL INTERFERING RNA;

ARTICLE; BONE METASTASIS; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENZYME RELEASE; GENE DELIVERY SYSTEM; GENE SILENCING; GENE VECTOR; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LNCAP CELL LINE; MALE; MONOCULTURE; OSTEOBLAST; PRIORITY JOURNAL; PROSTATE CANCER; TISSUE CULTURE; TUMOR MICROENVIRONMENT; BONE NEOPLASMS; CELL SURVIVAL; DRUG EFFECTS; GENE TRANSFER; METABOLISM; PHYSIOLOGY; PROCEDURES; PROSTATIC NEOPLASMS; SECONDARY; TUMOR CELL CULTURE;

BONE NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; COCULTURE TECHNIQUES; GENE TRANSFER TECHNIQUES; HUMANS; MALE; NANOPARTICLES; PROSTATIC NEOPLASMS; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 84982104849     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.07.079     Document Type: Article

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