Opioids and social bonding: Naltrexone reduces feelings of social connection

Social Cognitive and Affective Neuroscience

Volumn 11, Issue 5, 2016, Pages 728-735

  Inagaki, Tristen K ^a   Ray, Lara A ^b   Irwin, Michael R ^b   Way, Baldwin M ^c   Eisenberger, Naomi I ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Brain opioid theory; Emotion; Social attachments; Social reward; opioid antagonist

Indexed keywords

NALTREXONE; NARCOTIC ANTAGONIST;

ADULT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN RELATION; MALE; OBJECT RELATION; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADULT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTERPERSONAL RELATIONS; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; OBJECT ATTACHMENT; YOUNG ADULT;

EID: 84981743783     PISSN: 17495016     EISSN: 17495024     Source Type: Journal    
DOI: 10.1093/scan/nsw006     Document Type: Article

References (50)

1. Anton, R. F., Moak, D. H., Waid, L. R., Latham, P. K., Malcolm, R. J., Dias, J. K. (1999). Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial. American Journal of Psychiatry, 156, 1758-64
2. Baumeister, R. F., Leary, M. R. (1995). The need to belong: desire for interpersonal attachments as a fundamental human motivation. Psychological Bulletin, 117, 497-529
3. Bond, C., LaForge, K. S., Tian, M., et al (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proceedings of the National Academy of Sciences USA, 95, 9608-13
4. Bowlby, J. (1988). A Secure Base: Parent-Child Attachment and Healthy Human Development, Basic Books, USA
5. Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., Young, L. J. (2011). Activation of mu-opioid receptors in the dorsal striatum in necessary for adult social attachment in monogamous prairie voles. Neuropsychopharmacology, 36, 2200-10
6. Chelnokova, O., Laeng, B., Eikemo, M., et al (2014). Rewards of Beauty: The Opioid System Mediates Social Motivation in Humans. Molecular Psychiatry, 19, 746-7
7. Cohen, S., Wills, T. A. (1985). Stress, social support, and the buffering hypothesis. Psychological Bulletin, 98, 310-57
8. Depue, R. A., Morrone-Strupinsky, J. V. (2005). A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation. Behavioral and Brain Sciences, 28, 350-95
9. Diener, E., Seligman, M. E. P. (2002). Very happy people. Psychological Science, 13, 81-4
10. Dlugos, A. M., Hamidovic, A., Hodgkinson, C., et al (2011). OPRM1 gene variants modulate amphetamine-induced euphoria in humans. Genes, Brain and Behavior, 10, 199-209
11. Drakenberg, K., Nikoshokov, A., Horvath, M. C., et al (2006). Mu opioid receptor A118G polymorphism is associated with striatal opioid neuropeptide gene expression in heroin abusers. Proceedings of the National Academy of Sciences U S A, 103, 7883-8
12. Durkheim, E. (1951). Suicide (J.A. Spaudling & G. Simpson, Trans. New York: Free Press. (Original work published in 1897)
13. Gunnar, M. R. (2001). Effects of early deprivation: Findings from orphanage-reared infants and children. In: C. A., Nelson, M., Luciana, editors. Handbook of Developmental Cognitive Neuroscience. Cambridge, MA: MIT Press, 617-29
14. Harlow, H. F. (1958). The nature of love. American Psychologist, 13, 673-85
15. Herman, B. H., Panksepp, J. (1981). Ascending endorphinergic inhibition of distress vocalization. Science, 211, 1060-2
16. Inagaki, T. K., Eisenberger, N. I. (2013). Shared neural mechanisms underlying "social warmth" and physical warmth. Psychological Science, 24, 2272-80
17. Kalin, N. H., Shelton, S. E., Barksdale C. M. (1988). Opiate modulation of separation-induced distress in non-human primates. Brain Res 440: 285-92
18. Kalin, N. H., Shelton, S. E., Lynn, D. E. (1995). Opiate systems in mother and infant primates coordinate intimate contact during reunion. Psychoneuroendocrinology, 20, 735-42
19. Keverne, E. B., Martensz, N. D., Tuite, B. (1989). Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships. Psychoneuroendocrinology, 14, 155-61
20. Lee, M. C., Wagner, H. N., Tanada, S., Frost, J. J., Bice, A. N., Dannals, R. F. (1988). Duration of occupancy of opiate receptors by naltrexone. Journal of Nuclear Medicine, 29, 1207-11
21. Loseth, G. E., Ellingsen, D., Leknes, S. (2014). State-dependent mu-opioid modulation of social motivation. Frontiers in Behavioral Neuroscience, 8, 430
22. Machin, A. J., Dunbar, R. (2011). The brain opioid theory of social attachment: a review of the evidence. Behaviour, 148, 985-1025
23. Martin, W. R., Jasinski, D. R., Mansky, P. A. (1973). Naltrexone, an antagonist for the treatment of heroin dependence: effects in man. Archives of General Psychiatry, 28, 784-91
24. Matthes, H. W. D., Maldonado, R., Simonin, F., et al (1996). Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature, 383, 819-23
25. Moles, A., Kieffer, B. L., D'Amato, F. R. (2004). Deficit in attachment behavior in mice lacking the mu-opioid receptor gene. Science, 304, 1983-6
26. Panksepp, J. (1998). Affective Neuroscience. Oxford University Press: New York, NY
27. Panksepp, J., Bean, N. J., Bishop, P., Vilberg, T., Sahley, T. L. (1980). Opioid blockade and social comfort in chicks. Pharmacology Biochemistry and Behavior, 13, 673-83
28. Panksepp, J. (1981). Brain opioids: A neurochemical substrate for narcotic and social dependence. In S. Cooper, editor. Progress in Theory in Psychopharmacology. London: Academic Press, 149-75
29. Panksepp, J., Bishop, P. (1981). An autoradiographic map of 3H diprenorphine binding in the rat brain: Effects of social interaction. Brain Research Bulletin, 7, 405-10
30. Panksepp, J., Yovell, Y. (2014). Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): gateways to the development of new treatments for depression. Psychopathology, 47, 383-93
31. Panksepp, J., Herman, B. H., Vilberg, T., Bishop, P., DeEskinazi, F. G. (1980). Endogenous opioids and social behavior. Neuroscience and Biobehavioral Reviews, 1980, 4, 473-87
32. Panksepp, J., Herman, B., Conner, R., Bishop, P., Scott, J. P. (1987). The biology of social attachments: Opiates alleviate separation distress. Biological Psychiatry, 13, 607-18
33. Panksepp, J., Wright, J. S., Dobrossy, M. D., Schlaepfer, T. E., Coenen, V. A. (2014). Affective Neuroscience strategies for understanding and treating depression: From preclinical models to three novel therapeutics. Clinical Psychology Science, 2, 472-94
34. Petrovic, P., Pleger, B., Seymour, B., et al. (2008). Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses. Journal of Neuroscience, 28, 10509-16
35. Ray, L. A., Bujarski, S., Chin, P. F., Miotto, K. (2011). Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. Neuropsychopharmacology, 37, 445-55
36. Ray, L. A., Chin, P. F., Miotto, K. (2010). Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics. CNS & Neurological Disorders-Drug Targets, 9, 13-22
37. Ray, L. A., Hutchison, K. E. (2004). A polymorphism of the muopioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcoholism: Clinical and Experimental Research, 28, 1789-95
38. Raynor, K., Kong, H., Chen, Y., et al. (1994). Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Molecular Pharmacology, 45, 330-4
39. Roy, A., Roy, M., Deb, S., Unwin, G., Roy, A. (2014). Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review. Journal of Intellectual Disability Research, 59, 293-306
40. Schweiger, D., Stemmler, G., Burgdorf, C., Wacker, J. (2014). Opioid receptor blockade and warmth-liking: effects on interpersonal trust and frontal asymmetry. Social Cognitive and Affective Neuroscience, 9, 1608-15
41. Shayit, M., Nowak, R., Keller, M., Weller, A. (2003). Establishment of a preference by the newborn lamb for its mother: the role of opioids. Behavioral Neuroscience, 117, 446-54
42. Spitzer, R. L., Kroenke, K., Williams, J. B. W. (1999). Validation and utility of a self-report version of PRIME-MD: the PHQ Primary Care Study. The Journal of the American Medical Association, 282, 1737-44
43. Swift, R., Oslin, D. W., Alexander, M., Forman, R. (2011). Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. Journal of Studies on Alcohol and Drugs, 72, 1012-8
44. Taylor, S. E. (2010). Mechanisms linking early life stress to adult health outcomes. Proceedings of the National Academy of Sciences USA, 107, 8507-12
45. Trezza, V., Damsteegt, R., Marijke Achterberg E. J., Vanderschuren, L. J. M. J. (2011). Nucleus accumbens l-opioid receptors mediate social reward. Journal of Neuroscience, 31, 6362-70
46. Uchino, B. N. (2004). Social support and physical health: Understanding the health consequences of our relationships. Yale University Press: New Haven, CT
47. Way, B. M., Taylor, S. E., Eisenberger, N. I. (2009). Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection. Proceedings of the National Academy of Sciences U S A, 106, 15079-84
48. Weerts, E. M., Kim, Y. K., Wand, G. S., et al. (2008). Differences in delta-and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology, 33, 653-65
49. Yeomans, M. R., Gray, R. W. (1996). Selective effects of naltrexone on food pleasantness and intake. Physiology & Behavior, 60, 439-6
50. Yeomans, M. R., Gray, R. W. (1997). Effects of naltrexone on food intake and changes in subjective appetite during eating: evidence for opioid involvement in the appetizer effect. Physiology & Behavior, 62, 15-21