Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 79, Issue 21, 2016, Pages 998-1007

  dos Santos, Roger L ^a   Dellacqua, Lais O ^a   Delgado, Nathalie T B ^a   Rouver, Wender N ^a   Podratz, Priscila L ^a   Lima, Leandro C F ^b   Piccin, Mariela P C ^c   Meyrelles, Silvana S ^a   Mauad, Helder ^a   Graceli, Jones B ^a   Moyses, Margareth R ^a  

^a FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; DIPEPTIDYL CARBOXYPEPTIDASE; ETHIDIUM; POMEGRANATE EXTRACT; SUPEROXIDE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; BLOOD VESSEL WALL; CONTROLLED STUDY; CORONARY ARTERY; ENZYME ACTIVITY; FEMALE; FLUORESCENCE; HYPERTENSION; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; CHEMISTRY; DRUG EFFECTS; FRUIT; LYTHRACEAE; METABOLISM; PATHOPHYSIOLOGY; VASCULAR REMODELING;

ANIMALS; ANTIOXIDANTS; FEMALE; FRUIT; HYPERTENSION; OXIDATIVE STRESS; PEPTIDYL-DIPEPTIDASE A; PLANT EXTRACTS; PUNICACEAE; RATS; RATS, INBRED SHR; VASCULAR REMODELING;

EID: 84981736018     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2016.1213690     Document Type: Article

References (44)

1. O.Y.Althunibat, A.H.Al-Mustafa, K.Tarawneh, K.M.Khleifat, B.H.Ridzwan, and H.N.Qaralleh, 2010. Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats. Process Biochem. 45:581–585.
2. M.F.Alves, M.C.Araujo, M.A.Juliano, E.M.Oliveira, J.E.Krieger, D.E.Casarini, L.Juliano, and A.K.Carmona, 2005. A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity. Braz. J. Med. Biol. Res. 38:861–868.
3. M.Aviram, and L.Dornfeld, 2001. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158:195–198.
4. M.Aviram, and R.Rosenblat, 2012. Pomegranate protection against cardiovascular diseases. J. Evidence-Based Complement. Altern. Med. 2012:382763
5. M.Aviram, L.Dornfeld, M.Rosenblat, N.Volkova, M.Kaplan, R.Coleman, T.Hayek, D.Presser, and B.Fuhrman, 2000. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation:Studies in humans and in atherosclerotic apolipoprotein E–deficient mice. Am. J. Clin. Nutr. 71:1062–1076.
6. .∙- in vascular smooth muscle cells. Circ. Res. 77:29–36.
7. B.Bazargani-gilani, H.Tajik, and J.Aliakbarlu, 2014. Physicochemical and antioxidative characteristics of Iranian pomegranate (Punica granatum L. cv. Rabbab-e-Neyriz) juice and comparison of its antioxidative activity with Zataria multiflora Boiss essential oil. Vet. Res. Forum 5:313–318.
8. M.V.Borgo, E.R.Claudio, F.B.Silva, W.G.Romero, S.A.Gouvea, M.R.Moysés, R.L.Santos, S.A.Almeida, P.L.Podratz, J.B.Graceli, and G.R.Abreu, 2016. Hormonal therapy with estradiol and drospirenone improves endothelium-dependent vasodilation in the coronary bed of ovariectomized spontaneously hypertensive rats. Braz. J. Med. Biol. Res. 49:e4655.
9. A.K.Carmona, S.L.Schwager, M.A.Juliano, L.Juliano, and E.D.Sturrock, 2006. A continuous fluorescence resonance energy transfer angiotensin I-converting enzyme assay. Nat. Protocols 1:1971–1976.
10. L.Comini, T.Bachetti, A.Cargnoni, D.Bastianon, G.L.Gitti, C.Ceconi, and R.Ferrari, 2007. Therapeutic modulation of the nitric oxide:All ACE inhibitors are not equivalent. Pharmacol. Res. 56:42–48.
11. F.Danesi, P.A.Kroon, S.Saha, D.de Biase, L.F.D’Antuono, and A.Bordoni, 2014. Mixed pro- and anti-oxidative effects of pomegranate polyphenols in cultured cells. Int. J. Mol. Sci. 15:19458–19471.
12. E.I.Dedkov, J.K.Perloff, R.J.Tomanek, M.C.Fishbein, and D.D.Gutterman, 2006. The coronary microcirculation in cyanotic congenital heart disease. Circulation 114:196–200.
13. H.J.Forman, J.M.Fukuto, T.Miller, H.Zhang, A.Rinna, and S.Levy, 2008. The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch. Biochem. Biophys. 477:183–195.
14. C.G.Fraga, 2007. Plant polyphenols:How to translate their in vitro antioxidant actions to in vivo conditions. IUBMB Life 59:308–315.
15. L.B.Furieri, M.Galán, M.S.Avendaño, A.B.García-Redondo, A.Aguado, S.Martínez, V.Cachofeiro, M.V.Bartolomé, M.J.Alonso, D.V.Vassallo, and M.Salaices, 2011. Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species. Br. J. Pharmacol. 162:1819–1831.
16. A.J.Ghio, M.S.Carraway, and M.C.Madden, 2012. Composition of air pollution particles and oxidative stress in cells, tissues and living systems. J. Toxicol. Environ. Health B 15:1–21.
17. D.Ghosh, and A.Scheepens, 2009. Vascular action of polyphenols. Mol. Nutr. Food Res. 53:322–331.
18. M.I.Gil, F.Tomas-Barberan, B.Hess-Pierce, D.M.Holcroft, and A.A.Kader, 2000. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 48:4581–4589.
19. C.A.Hamilton, M.J.Brosnan, M.McIntyre, D.Graham, and A.F.Dominiczak, 2001. Superoxide excess in hypertension and aging:A common cause of endothelial dysfunction. Hypertension 37:529–534.
20. H.D.Intengan, and E.L.Schiffrin, 2001. Vascular remodeling in hypertension. Role of apoptosis, inflammation and fibrosis. Hypertension 38:581–587.
21. D.C.Irwin, C.V.Garat, J.T.Crossno, Jr., P.S.MacLean, T.M.Sullivan, P.F.Erickson, M.R.Jackman, J.W.Harral, J.E.Reusch, and D.J.Klemm, 2014. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulmon. Circ. 4:638–653.
22. J.Jurenka, 2008. Therapeutic applications of pomegranate (Punica granatum L.):A review. Altern. Med. Rev. 13:128–144.
23. P.M.Kearney, M.Whelton, K.Reynolds, P.Muntner, P.K.Whelton, and J.He, 2005. Global burden of hypertension:Analysis of worldwide data. Lancet 365:217–223.
24. C.Kitiyakara, and C.S.Wilcox, 1998. Antioxidants for hypertension. Curr. Opin. Nephrol. Hypertens. 7:531–538.
25. B.Lapornik, M.Prosek, and A.G.Wondra, 2005. Comparison of extracts prepared from plant by-products using different solvents and extraction time. J. Food Eng. 71:214–222.
26. S.S.Lim, T.Vos, A.D.Flaxman, G.Danaei, K.Shibuya, H.Adair-Rohani, M.Amann, H.R.Anderson, K.G.Andrews, M.Aryee, C.Atkinson, L.J.Bacchus, A.N.Bahalim, K.Balakrishnan, J.Balmes, S.Barker-Collo, A.Baxter, M.L.Bell, J.D.Blore, F.Blyth, C.Bonner, G.Borges, R.Bourne, M.Boussinesq, M.Brauer, P.Brooks, N.G.Bruce, B.Brunekreef, C.Bryan-Hancock, C.Bucello, R.Buchbinder, F.Bull, R.T.Burnett, T.E.Byers, B.Calabria, J.Carapetis, E.Carnahan, Z.Chafe, F.Charlson, H.Chen, J.S.Chen, A.T.Cheng, J.C.Child, A.Cohen, K.E.Colson, B.C.Cowie, S.Darby, S.Darling, A.Davis, L.Degenhardt, F.Dentener, D.C.Des Jarlais, K.Devries, M.Dherani, E.L.Ding, E.R.Dorsey, T.Driscoll, K.Edmond, S.E.Ali, R.E.Engell, P.J.Erwin, S.Fahimi, G.Falder, F.Farzadfar, A.Ferrari, M.M.Finucane, S.Flaxman, F.G.Fowkes, G.Freedman, M.K.Freeman, E.Gakidou, S.Ghosh, E.Giovannucci, G.Gmel, K.Graham, R.Grainger, B.Grant, D.Gunnell, H.R.Gutierrez, W.Hall, H.W.Hoek, A.Hogan, H.D.Hosgood, 3rd., D.Hoy, H.Hu, B.J.Hubbell, S.J.Hutchings, S.E.Ibeanusi, G.L.Jacklyn, R.Jasrasaria, J.B.Jonas, H.Kan, J.A.Kanis, N.Kassebaum, N.Kawakami, Y.H.Khang, S.Khatibzadeh, J.P.Khoo, C.Kok, F.Laden, R.Lalloo, Q.Lan, T.Lathlean, J.L.Leasher, J.Leigh, Y.Li, J.K.Lin, S.E.Lipshultz, S.London, R.Lozano, Y.Lu, J.Mak, R.Malekzadeh, L.Mallinger, W.Marcenes, L.March, R.Marks, R.Martin, P.McGale, J.McGrath, S.Mehta, G.A.Mensah, T.R.Merriman, R.Micha, C.Michaud, V.Mishra, K.Mohd Hanafiah, A.A.Mokdad, L.Morawska, D.Mozaffarian, T.Murphy, M.Naghavi, B.Neal, P.K.Nelson, J.M.Nolla, R.Norman, C.Olives, S.B.Omer, J.Orchard, R.Osborne, B.Ostro, A.Page, K.D.Pandey, C.D.Parry, E.Passmore, J.Patra, N.Pearce, P.M.Pelizzari, M.Petzold, M.R.Phillips, D.Pope, C.A.Pope, 3rd, J.Powles, M.Rao, H.Razavi, E.A.Rehfuess, J.T.Rehm, B.Ritz, F.P.Rivara, T.Roberts, C.Robinson, J.A.Rodriguez-Portales, I.Romieu, R.Room, L.C.Rosenfeld, A.Roy, L.Rushton, J.A.Salomon, U.Sampson, L.Sanchez-Riera, E.Sanman, A.Sapkota, S.Seedat, P.Shi, K.Shield, R.Shivakoti, G.M.Singh, D.A.Sleet, E.Smith, K.R.Smith, N.J.Stapelberg, K.Steenland, H.Stöckl, L.J.Stovner, K.Straif, L.Straney, G.D.Thurston, J.H.Tran, R.Van Dingenen, A.van Donkelaar, J.L.Veerman, L.Vijayakumar, R.Weintraub, M.M.Weissman, R.A.White, H.Whiteford, S.T.Wiersma, J.D.Wilkinson, H.C.Williams, W.Williams, N.Wilson, A.D.Woolf, P.Yip, J.M.Zielinski, A.D.Lopez, C.J.Murray, M.Ezzati, M.A.AlMazroa, and Z.A.Memish, 2012. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010:A systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2224–2260
27. L.C.F.Lima, M.L.Porto, B.P.Campagnaro, C.L.Tonini, B.V.Nogueira, T.M.Pereira, E.C.Vasquez, and S.S.Meyrelles, 2012. Mononuclear cell therapy reverts cuff-induced thrombosis in apolipoprotein E-deficient mice. Lipids Health Dis. 11:96.
28. K.M.Lounsbury, Q.Hu, and R.C.Ziegelstein, 2000. Calcium signaling and oxidant stress in the vasculature. Free Radical Biol. Med. 28:1362–1369.
29. O.H.Lowry, N.J.Rosebrough, A.L.Farr, and R.J.Randall, 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265–275.
30. F.K.Marcondes, F.J.Bianchi, and A.P.Tanno, 2002. Determination of the estrous cycle phases of rats:Some helpful considerations. Braz. J. Biol. 62:609–614.
31. M.Mohan, H.Waghulde, and S.Kasture, 2010. Effect of pomegranate juice on angiotensin II-induced hypertension in diabetic Wistar rats. Phytother. Res. 24:196–203.
32. K.Nakazono, N.Watanabe, K.Matsuno, J.Sasaki, T.Sato, and M.Inoue, 1991. Does superoxide underlie the pathogenesis of hypertension? Proc. Natl. Acad. Sci. USA 88:10045–10048.
33. G.Nickenig, and D.G.Harrison, 2002. The AT1-type angiotensin receptor in oxidative stress and atherogenesis:Part II:AT1 receptor regulation. Circulation 105:530–536.
34. J.L.Probstfield, and K.D.O’Brien, 2010. Progression of cardiovascular damage:The role of renin-angiotensin system blockade. Am. J. Cardiol. 105:10–20.
35. E.Prodel, T.Barbosa, A.Machado, D.Mansur, A.C.Nobrega, and L.Vianna 2015. Arterial stiffening in human hypertension:Is there a contribution of the sympathetic nervous system? FASEB J. 29(1 Suppl):649–613.
36. A.Púzserová, J.Kopincová, and I.Bernátová, 2010. Endothelial (dys)function in the experimental model of primary hypertension. Cesk. Fysiol. 59:4–14.
37. J.F.Reckelhoff, and J.C.Romero, 2003. Role of oxidative stress in angiotensin induced hypertension. Am. J. Physiol. Reg. Integr. Comp. Physiol. 284:893–912.
38. A.Romanowskia, J.R.Murray, and M.J.Huston, 1960. Effects of hydrogen peroxide on normal and hypertensive rats. Pharm. Acta Helv. 35:354–357.
39. W.Rosamond, K.Flegal, G.Friday, K.Furie, A.Go, K.Greenlund, N.Haase, M.Ho, V.Howard, B.Kissela, S.Kittner, D.Lloyd-Jones, M.McDermott, J.Meigs, C.Moy, G.Nichol, C.J.O’Donnell, V.Roger, J.Rumsfeld, P.Sorlie, J.Steinberger, T.Thom, S.Wasserthiel-Smoller, and Y.Hong, 2007. Heart disease and stroke statistics:2007 Update:A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 115:69–171.
40. R.M.Touyz, and E.L.Schiffrin, 2000. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol. Rev. 52:639–672.
41. R.M.Touyz, F.Tabet, and E.L.Schiffrin, 2003. Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension. Clin. Exp. Pharmacol. Physiol. 30:860–866.
42. M.Ushio-Fukai, A.M.Zafari, T.Fukui, N.Ishizaka, and K.K.Griendling, 1996. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J. Biol. Chem. 271:23317–23321.
43. S.Wind, K.Beuerlein, M.E.Armitage, A.Taye, A.H.S.Kumar, D.Janowitz, C.Neff, A.M.Shah, K.Wingler, and H.H.Schmidt, 2010. Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension 56:490–497.
44. G.Zalba, F.J.Beaumont, G.San José, A.Fortuño, M.A.Fortuño, J.C.Etayo, and J.Díez, 2000. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 35:1055–1061.