Maltitol inhibits small intestinal glucose absorption and increases insulin mediated muscle glucose uptake ex vivo but not in normal and type 2 diabetic rats

International Journal of Food Sciences and Nutrition

Volumn 68, Issue 1, 2017, Pages 73-81

  Chukwuma, Chika Ifeanyi ^a   Ibrahim, Mohammed Auwal ^a,b   Islam, Md Shahidul ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b AHMADU BELLO UNIVERSITY   (Nigeria)

Author keywords

Intestinal glucose absorption; maltitol; muscle glucose uptake; rats; type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GASTROINTESTINAL AGENT; GLUCOSE; INSULIN; MALTITOL; MALTOSE; SUGAR ALCOHOL;

ABSORPTION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; DIET THERAPY; DIETARY SUPPLEMENT; DISEASE MODEL; GASTROINTESTINAL TRANSIT; HYPERGLYCEMIA; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; JEJUNUM; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PSOAS MUSCLE; RANDOMIZATION; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; STOMACH EMPTYING;

ABSORPTION, PHYSIOLOGICAL; ANIMALS; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; GASTRIC EMPTYING; GASTROINTESTINAL AGENTS; GASTROINTESTINAL TRANSIT; GLUCOSE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; IN VITRO TECHNIQUES; INSULIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; MALE; MALTOSE; MUSCLE, SKELETAL; PSOAS MUSCLES; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; SUGAR ALCOHOLS;

EID: 84981717439     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.1080/09637486.2016.1216527     Document Type: Article

References (44)

1. Academy of Nutrition and Dietetics. 2012. Position of the academy of nutrition and dietetics:use of nutritive and nonnutritive sweeteners. J Acad Nutr Diet. 112:739–758.
2. Algandaby MM, Alghamdi HA, Ashour OM, Abdel-Naim AB, Ghareib SA, Abdel-Sattar EA, Hajar AS., 2010. Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats. Food Chem Toxicol. 48:2448–2453.
3. Aronoff SL, Berkowitz K, Shreiner B, Want L., 2004. Glucose metabolism and regulation:beyond insulin and glucagon. Diabetes Spectr. 17:183–190.
4. Astrup A, Raben A, Vasilaras TH, Moller AC., 2002. Sucrose in soft drinks is fattening:a randomized 10 week study in overweight subjects. Am J Clin Nutr. 7:405S.
5. Chukwuma CI, Islam MS., 2015. Effects of xylitol on carbohydrate digesting enzymes activity, intestinal glucose absorption and muscle glucose uptake:a multi-mode study. Food Funct. 6:955–962.
6. Daum F, Cohen MI, McNamara H, Finberg L., 1978. Intestinal osmolality and carbohydrate absorption in rats treated with polymerized glucose. Pediatr Res. 12:24–26.
7. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ., 2002. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr. 76:911–922.
8. Gual P, Le Marchand-Brustel Y, Tanti J., 2003. Positive and negative regulation of glucose uptake by hyperosmotic stress. Diabetes Metab. 29:566–575.
9. Hassan Z, Yam MF, Ahmad M, Yusof AP., 2010. Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats. Molecules. 15:9008–9025.
10. Hu FB., 2003. Sedentary lifestyle and risk of obesity and type 2 diabetes. Lipids. 38:103–108.
11. International Diabetes Federation. 2015. Diabetes Atlas. 7th edition. Brussels, Belgium:International Diabetes Federation.
12. Islam MS, Indrajit M., 2012. Effects of xylitol on blood glucose, glucose tolerance, serum insulin and lipid profile in a type 2 diabetes model of rats. Ann Nutr Metab. 61:57–64.
13. Islam MS, Sakaguchi E., 2006. Sorbitol-based osmotic diarrhea:possible causes and mechanism of prevention investigated in rats. World J Gastroenterol. 12:7635–7641.
14. Izumitani A, Fujiwara T, Minami T, Suzuki S, Ooshima T, Sobue S., 1989. Non-cariogenicity of maltitol in vitro and animal experiments. Shoni Shikagaku Zasshi. 27:1018–1024.
15. Kamoi M., 1975. Study on metabolism of maltitol. Part 1. Fundamental experiment. J Jap Diab Soc. 18:243–249.
16. Kang Y, Jo S, Yoo J, Cho J, Kim E, Apostolidis E, Kwon Y., 2014. Anti-hyperglycemic effect of selected sugar alcohols. FASEB J. 28:829–832.
17. Kearsley MW, Deis RC., 2012. Maltitol powder. In:O’Donnell K, Kearsley MW, editors. Sweeteners and sugar alternatives in food technology. 2nd ed. UK:John Wiley & Sons, Ltd. p. 295–308.
18. Keukenmeester RS, Slot DE, Rosema NA, Van Loveren C, Van der Weijden GA., 2014. Effects of sugar-free chewing gum sweetened with xylitol or maltitol on the development of gingivitis and plaque:a randomized clinical trial. Int J Dent Hyg. 12:238–244.
19. Lavin RJ., 1976. Digestion and absorption of carbohydrate from embryo to adult. In:Boorman RN, Freeman BM, editors. Digestion in the fowl. Edinburgh:British Poultry Science Ltd. p. 63–116.
20. Li XJ, Zhong B, Xu HX, Yi M, Wang XP., 2010. Comparative effects of the maltitol chewing gums on reducing plaque. Hua Xi Kou Qiang Yi Xue Za Zhi. 28:502–504.
21. Lian-Loh R, Birch GG, Coates ME., 1982. The metabolism of maltitol in the rat. Br J Nutr. 48:477–481.
22. Livesey G., 2012. Glycaemic responses and toleration. In:O’Donnell K, Kearsley MW, editors. Sweeteners and sugar alternatives in food technology. UK:John Wiley & Sons, Ltd. p. 3–26.
23. Livesey G., 2003. Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 16:163–191.
24. Matsuo T., 2003. Estimation of glycemic response to maltitol and mixture of maltitol and sucrose in healthy young subjects. Tech Bull Fac Kagawa Univ. 55:57–61.
25. Mimura C, Koga T, Oshikawa K, Kido K, Sadanaga T, Jinnouchi T, Kawaguchi K., 1972. Maltitol tests with diabetics. Jap J Nutr. 30:145–152.
26. Moon S, Lee M, Huh K, Lee K., 1990. Effects of maltitol on blood glucose and insulin responses in normal and diabetic subjects. Korean J Nutr. 23:270–278.
27. Olokoba AB, Obateru OA, Olokoba LB., 2012. Type 2 diabetes mellitus:a review of current trends. Oman Med J. 27:269–273.
28. Ooshima T, Izumitani A, Minami T, Yoshida T, Sobue S, Fujiwara T, Hamada S., 1992. Noncariogenicity of maltitol in specific pathogen-free rats infected with mutants streptococci. Caries Res. 26:33–37.
29. Quílez J, Bulló M, Salas-Salvadó J., 2007. Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose cornstarch. J Food Sci. 72:407–411.
30. Ranganath L, Norris F, Morgan L, Wright J, Marks V., 1998. Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabet Med. 15:120–124.
31. 14C in rat, dog and man. J Agric Food Chem. 24:287–291.
32. Respondek F, Hilpipre C, Chauveau P, Cazaubiel M, Gendre D, Maudet C, Wagner A., 2014. Digestive tolerance and postprandial glycaemic and insulinaemic responses after consumption of dairy desserts containing maltitol and fructo-oligosaccharides in adults. Eur J Clin Nutr. 68:575–580.
33. Rider AK, Schedl HP, Nokes G, Shining S., 1967. Small intestinal glucose transport. Proximal-distal kinetic gradients. J Gen Physiol. 50:1173–1182.
34. Ruskoné-Fourmestraux A, Attar A, Chassard D, Coffin B, Bornet F, Bouhnik YA., 2003. A digestive tolerance study of maltitol after occasional and regular consumption in healthy humans. Eur J Clin Nutr. 57:26–30.
35. Salminen E, Salminen S, Porkka L, Koivistoinen P., 1984. The effects of xylitol on gastric emptying and secretion of gastric inhibitory polypeptide in the rat. J Nutr. 114:2201–2203.
36. Secchi A, Pontiroli AE, Cammelli L, Bizzi A, Cini M, Pozza G., 1986. Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man. Klin Wochenschr. 64:265–269.
37. Shafer RB, Levine AS, Marlette JM, Morley JE., 1987. Effects of xylitol on gastric emptying and food intake. Am J Clin Nutr. 45:744–747.
38. Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, et al. 2011. Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women. J Clin Endocrinol Metab. 96:E1596–E1605.
39. Thorburn AW, Storlien LH, Jenkins AB, Khouri S, Kraegen EW., 1989. Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats. Am J Clin Nutr. 49:1155–1163.
40. Van Loveren C., 2004. Sugar alcohols:what is the evidence for caries-preventive and caries-therapeutic effects? Caries Res. 38:286–293.
41. Vessby B, Karlstrom B, Skarfors E., 1990. Comparison of the effects of maltitol with those of sucrose, fructose and sorbitol on blood glucose and serum insulin concentrations in healthy and non-insulin dependent diabetic subjects:studies after an oral load and after addition to a standard breakfast meal. Diabetes Nutr Metab Clin Exp. 3:231–237.
42. Wheeler ML, Fineberg SE, Gibson R, Fineberg N., 1990. Metabolic response to oral challenge of hydrogenated starch hydrolysate versus glucose in diabetes. Diabetes Care. 13:733–740.
43. Wilson RD, Islam MS., 2012. Fructose-fed streptozotocin-injected rat:an alternative model for type 2 diabetes. Pharmacol Rep. 64:129–139.
44. Wu Y, Ding Y, Tanaka Y, Zhang W., 2014. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 11:1185–1200.