Overexpression of miR-509 increases apoptosis and inhibits invasion via suppression of tumor necrosis factor-α in triple-negative breast cancer Hs578T cells

Oncology Research

Volumn 24, Issue 4, 2016, Pages 233-238

  Zhang, Guoqiang ^a   Liu, Zengyan ^a   Han, Yong ^a   Wang, Xiaohong ^a   Yang, Zhenlin ^a  

^a BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer (BC); miR 509; Triple negative breast cancer (TNBC); Tumor necrosis factor (TNF )

Indexed keywords

MICRORNA; MIRNA 509; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MIRN509 MICRORNA, HUMAN; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; TRANSIENT TRANSFECTION; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION; CELL MOTION; FEMALE; GENETICS; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; HUMANS; MICRORNAS; RNA INTERFERENCE; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84981712800     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504016X14648701447977     Document Type: Article

References (14)

1. DeSantis, C. E.; Siegel, R. L.; Sauer. A. G.; Miller, K. D.; Fedewa, S. A.; Alcaraz, K. I.; Jemal, A. Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities. CA Cancer J. Clin. 66(4):290-308; 2016.
2. Gatza, M. L.; Lucas, J. E.; Barry, W. T.; Kim, J. W.; Wang, Q.; Crawford, M. D.; Datto, M. B.; Kelley, M.; Mathey-Prevot, B.; Potti, A.; Nevins, J. R. A pathway-based classification of human breast cancer. Proc. Natl. Acad. Sci. USA 107:6994-6999; 2010.
3. Bianchini, G.; Balko, J. M.; Mayer, I. A.; Sanders, M. E.; Gianni, L. Triple-negative breast cancer: Challenges and opportunities of a heterogeneous disease. Nat. Rev. Clin. Oncol.; 2016.
4. Bauer, K. R.; Brown, M.; Cress, R. D.; Parise, C. A.; Caggiano, V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer Registry. Cancer 109:1721-1728; 2007.
5. Dent, R.; Trudeau, M.; Pritchard, K. I.; Hanna, W. M.; Kahn, H. K.; Sawka, C. A.; Lickley, L. A.; Rawlinson, E.; Sun, P.; Narod, S. A. Triple-negative breast cancer: Clinical features and patterns of recurrence. Clin. Cancer Res. 13:4429-4434; 2007.
6. O'Day, E.; Lal, A. MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res. 12:201; 2010.
7. Zhai, Q.; Zhou, L.; Zhao, C.; Wan, J.; Yu, Z.; Guo, X.; Qin, J.; Chen, J.; Lu, R. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma. Biochem. Biophys. Res. Commun. 419:621-626; 2012.
8. Ren, Z. J.; Nong, X. Y.; Lv, Y. R.; Sun, H. H.; An, P. P.; Wang, F.; Li, X.; Liu, M.; Tang, H. Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth. Cell Death Dis. 5:e1387; 2014.
9. Xing, F.; Sharma, S.; Liu, Y.; Mo, Y. Y.; Wu, K.; Zhang, Y. Y.; Pochampally, R.; Martinez, L. A.; Lo, H. W.; Watabe, K. miR-509 suppresses brain metastasis of breast cancer cells by modulating RhoC and TNF-alpha. Oncogene 34:4890-4900; 2015.
10. Griffiths, C. L.; Olin, J. L. Triple negative breast cancer: A brief review of its characteristics and treatment options. J. Pharm. Pract. 25:319-323; 2012.
11. Zhang, L.; Hao, C.; Dong, G.; Tong, Z. Analysis of clinical features and outcome of 356 triple-negative breast cancer patients in China. Breast Care (Basel) 7:13-17; 2012.
12. Brown, E. R.; Charles, K. A.; Hoare, S. A.; Rye, R. L.; Jodrell, D. I.; Aird, R. E.; Vora, R.; Prabhakar, U.; Nakada, M.; Corringham, R. E.; Dewitte, M.; Sturgeon, C.; Propper, D.; Balkwill, F. R.; Smyth, J. F. A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer. Ann. Oncol. 19:1340-1346; 2008.
13. Pileczki, V.; Braicu, C.; Gherman, C. D.; Berindan-Neagoe, I. TNF-alpha gene knockout in triple negative breast cancer cell line induces apoptosis. Int. J. Mol. Sci. 14:411-420; 2012.
14. Li, H. H.; Zhu, H.; Liu, L. S.; Huang, Y.; Guo, J.; Li, J.; Sun, X. P.; Chang, C. X.; Wang, Z. H.; Zhai, K. Tumour necrosis factor-alpha gene polymorphism is associated with metastasis in patients with triple negative breast cancer. Sci. Rep. 5:10244; 2015.