Methodological considerations in exercise endocrinology

Endocrinology of Physical Activity and Sport: Second Edition

Volumn , Issue , 2013, Pages 1-19

  Hackney, Anthony C ^a   Smith Ryan, Abbie E ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84981693673     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-62703-314-5_1     Document Type: Chapter

References (115)

1. Trembly MS, Chu SY, Mureika R. Methodological and statistical considerations for exercise-related hormone evaluations. Sports Med. 1990;20(2):90-108.
2. Kraemer WJ, Ratamess NA. Hormonal responses and adaptations to resistance exercise and training. Sports Med. 2005;35(4):339-61.
3. McMurray RG, Hackney AC. The endocrine system and exercise. In: Garrett W, editor. Sports Medicine. New York, NY: Williams & Wilkins; 2000. p. 135-62.
4. International Union of Pure and Applied Chemistry (International Union of Biochemistry and Molecular Biology): Recommendations on organic & biochemical nomenclature, symbols & terminology. www.chem.qmul.ac.uk/iupac/.
5. Warne GL, Kanumakala S. Molecular endocrinology of sex differentiation. Sem Reprod Med. 2002;20(3):169-80.
6. Webb ML, Wallace JP, Hamill C, Hodgson JL, Mashaly MM. Serum testosterone concentration during two hours of moderate intensity treadmill running in trained and untrained men and women. Endocrinol Res. 1984;10:27-38.
7. Bunt JC, Bahr JM, Bemben DA. Comparison of estradiol and testosterone levels during and immediately following prolonged exercise in moderately active males and females. Endocrinol Res. 1987;13:157-72.
8. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev. 2000;80:1055-81.
9. Foster DL, Nagatani S. Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. Biol Reprod. 1999;60(2):205-12.
10. Ruby BC, Robergs RA. Gender differences in substrate utilization during exercise. Sports Med. 1994;17:393-410.
11. Bunt JC. Metabolic actions of estradiol: signi ficance for acute and chronic exercise responses. Med Sci Sports Exerc. 1990;22(3):286-90.
12. Hackney AC, McCracken M, Ainsworth BA. Substrate metabolism responses to submaximal exercise in the mid-follicular and mid-luteal phase of the menstrual cycle. Int J Sport Nutr. 1994;4:299-308.
13. Hackney AC, McMurray RG, Judelson DA, Harrell JS. Relationship between caloric intake, body composition, and physical activity to leptin, thyroid hormones, and cortisol in adolescents. Jpn J Physiol. 2003;53(6):475-9.
14. Horswill CA, Zipf WB, Kien CL, Kahl EB. Insulin's contribution to growth in children and the potential for exercise to mediate insulin's action. Pediatr Exerc Sci. 1997;9:18-32.
15. Amile SA, Caprio S, Sherwin RS, Plewe G, Haymond MW, Tamborlane WV. Insulin resistance of puberty:a defect restricted to peripheral glucose metabolism. J Clin Endocrinol Metab. 1991;72:277-82.
16. Isurugi K, Fukutani K, Takayasu H, Wakabayashi K, Tamaoki B. Age related changes in serum LH and FSH level in normal men. J Clin Endocrinol Metab. 1974;39:955-7.
17. Purifoy EE, Koopmars LH, Tatum RW. Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females age 20-87 years. Hum Biol. 1980;52:181-91.
18. Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 1984;59:551-5.
19. Aloia JF, Feuerman M, Yeh JK. Reference range for serum parathyroid hormone. Endocr Pract. 2006;12(2):137-44.
20. Adlercreutz H, Goldin BR. Estrogen metabolism and excretion in Oriental and Caucasian women. J Natl Cancer Inst. 1994;86:1076-82.
21. Benn PA, Clive JM, Collins R. Medians for second trimester maternal serum AFP, unconjugated estriol, and hCG: differences between race or ethic groups. Clin Chem. 1997;43:333-7.
22. Mittelmark RA. Hormonal responses to exercise in pregnancy. In: Mittelmark RA, Wiswell RA, Drinkwater BL, editors. Exercise in Pregnancy. Williams & Wilkins: Baltimore, MD; 1991. p. 175-84.
23. Wang C, Christenson P, Swerdloff R. Clinical Relevance of racial and ethnic differences in sex steroids. J Clin Endocrinol Metab. 2007;92(7):2433-5.
24. Abbott WG, Foley JE. Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children. Metabolism. 1987;36(6):576-9.
25. Ivandic A, Prpic-Krizevac I, Sucic M. Hyperinsulinemia and sex hormone in healthy premenopausal women: relative contribution of obesity, obese type, and duration of obesity. Metabolism. 1998;47:13-9.
26. Hansen BC, Jen KL, Pek SB. Rapid oscillations on plasma insulin, glucagons, and glucose in obese and normal weight humans. J Clin Endocrinol Metab. 1982;54(4):785-92.
27. Florkowski CM, Collier GR, Zimmet PZ. Low dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol (Oxf). 1996;45:769-73.
28. Pasquali R, Vicennati V. Activity of the hypothalamic-pituitary-adrenal axis in different obese phenotypes. Int J Obes Relat Metab Disord. 2000;24 Suppl 3:S47-9.
29. McMurray RG, Hackney AC. Interactions of metabolic hormones, adipose tissue and exercise. Sports Med. 2005;35(5):393-412.
30. Hurley BF, Nemeth PM, Martin WH. Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol. 1986;60:562-7.
31. Rahkila P, Soimajarvi J, Karvinrn E. Lipid metabolism during exercise II: respiratory exchange ratio and muscle glycogen content during 4 h bicycle ergometry and two groups of health men. Eur J Appl Physiol. 1980;44(3):246-54.
32. Pasman WJ, Westertrep-Plantenga MS, Saris WHM. The effect of exercise training on leptin levels in obese males. Am J Physiol Endocrinol Metab. 1998;37:E280-6.
33. Ryan AS, Partley RE, Elahi D. Changes in leptin and insulin action with resistive training in postmenopausal women. Int J Obes Relat Metab Disord. 2000;24:27-32.
34. Hackney AC. Stress and the neuroendocrine system: the role of exercise as a stressor and modi fier of stress. Expert Rev Endocrinol Metab. 2006;1(6):783-92.
35. Dorn LD, Burgress ES, Dichek HL, Putman FW, Chrousos GP, Gold PW. Thyroid hormone concentrations in depressed and nondepressed adolescents: group difference and behavioral relations. J Am Acad Child Adolesc Psychiatry. 1996;35:299-306.
36. Vaernes R, Ursin H, Darragh A, Lambe R. Endocrine response patterns and psychological correlates. J Psychosom Res. 1982;26:123-31.
37. Hackney AC. Exercise as a stressor to the neuroendocrine system. Medicina. 2006;42(10):788-97.
38. Hammer MB, Hitri A. Plasma β-endorphin levels in post-traumatic stress disorder: a preliminary report on response to exercise-induced stress. J Neuropsychiatry Clin Neurosci. 1992;4(1):59-63.
39. Gerra G, Volpi R, Delsignore R, et al. ACTH and β-endorphin responses to physical exercise in adolescent women tested for anxiety and frustration. Pyschiatry Res. 1992;41(2):179-86.
40. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24(4):385-96.
41. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988;56(6):893-7.
42. Landgren B, Aedo A, Diczfalusy E. Hormonal changes associated with ovulation and luteal function. In: Flamigni C, Givens J, editors. The Gonadotropins: Basic Science and Clinical Aspects in Females. London: Academic; 1982. p. 200-12.
43. Hackney AC, Cyren HC, Brammeier M, Sharp RL. Effects of the menstrual cycle on insulin-glucose at rest and in response to exercise. Biol Sport. 1993;10(2):73-81.
44. Vanheest JL, Mahoney CE, Rodgers CD. Oral contraceptive use and physical performance. In: Kramer WJ, Rogol A, editors. The Endocrine System in Sports and Exercise. Oxford: Blackwell; 2005. p. 250-60.
45. Loucks AB. Physical activity, fitness and female reproductive morbidity. In: Bouchard C, Shepard RJ, Stephens T, editors. Physical activity, fitness and health: international proceedings and consensus statement. Champaign, IL: Human Kinetics; 1994. p. 943-54.
46. Matsumoto AM, Bremner WJ. Modulation of pulsatile gonadotropin secretion by testosterone in man. J Clin Endocrinol Metab. 1984;58(4):609-14.
47. Rose R, Kreutz L, Holoday J, Sulak K, Johnson C. Diurnal variation of plasma testosterone and cortisol. J Endocrinol. 1972;54:177-8.
48. Rose SR, Nisula BC. Circadian variation of thyrotropin in childhood. J Clin Endocrinol Metab. 1989;68:1086-9.
49. Hackney AC, Viru A. Twenty-four cortisol response to multiple daily exercise sessions of moderate and high intensity. Clin Physiol. 1999;19:178-82.
50. Weitzman ED. Circadian rhythms and episodic hormone secretion. Annu Rev Med. 1976;27:225-43.
51. Goodman HM. Endocrinology concepts for medical students. Adv Physiol Educ. 2005;25(4):213-24.
52. Hackney AC, Zack E. Physiological day-to-day variability of select hormones at rest in exercisetrained men. J Endocrinol Invest. 2006;29(6):RC9-12.
53. Schulz P, Knabe R. Biological uniqueness and the definition of normality: part 2-the endocrine ' finger print' of healthy adults. Med Hypotheses. 1994;42:63-8.
54. Finberg JP, Berlyne GM. Renin and aldosterone secretion following acute environmental heat exposure. Isr J Med Sci. 1976;12:844-7.
55. Galbo H, Houston ME, Christensen NJ, Holst JJ, Nielsen B, Nygaard E, et al. The effect of water temperature on the hormonal response to prolonged swimming. Acta Physiol Scand. 1979;105(3):326-37.
56. Mordes JP, Blume FD, Boyer S, Zheng MR, Braverman LE. High altitude pituitary-thyroid dysfunction on Mount Everest. N Engl J Med. 1983;308:1135-8.
57. Rastogi GK, Malhotra MS, Srivastava MC, Shawhney RC, Dua GL, Sridharan K, et al. Study of the pituitary-thyroid function at high altitude in man. J Clin Endocrinol Metab. 1977;43:447-52.
58. Hoyt RW, Honig A. Body fluid and energy metabolism at high altitude. In: Fregley MJ, Blatteis CM, editors. Handbook of physiology, Section 4: Environmental physiology. New York: Oxford University Press; 1996. p. 1277-89.
59. Galbo H, Holst JJ, Christensen NJ. The effect of different diets and of insulin on the hormonal response to prolonged exercise. Acta Physiol Scand. 1979;107(1):19-32.
60. Phinney SD, Horton ES, Sims EA, Hanson JS, Danforth E, LaGrange BM. Capacity for moderate exercise in obese subjects after adaptation to a hypocaloric, ketogenic diet. J Clin Invest. 1980;66(5):1152-61.
61. Jezova-Repcekova D, Vigas M, Klimes I. Decreased plasma cortisol response to pharmacological stimuli after glucose load in man. Endocrinol Exp. 1980;14(2):113-20.
62. Bonen A, Belcastro AN, MacIntyre K, Gardner J. Hormonal responses during intense exercise preceded by glucose ingestion. Can J Appl Sport Sci. 1980;5(2):85-90.
63. Ivy J, Portman R. Nutrient timing system: The revolutionary new system that adds the missing dimension to sports nutrition: the dimension of time. North Bergen, NJ: Basic Health; 2004. p. 33-67.
64. Kerksick C, Harvey T, Stout J, Campbell B, Wilborn C, Kreider R, et al. International Society of Sports Nutrition position stand: nutrient timing. J Int Soc Sports Nutr. 2008;5:17-29.
65. Bishop NC, Blannin AK, Robson PJ, Walsh NP, Gleeson M. The effects of carbohydrate supplementation on immune responses to a soccer-speci fic exercise protocol. J Sports Sci. 1999;17(10):787-96.
66. Bishop NC, Gleeson M, Nicholas CW, Ali A. Influence of carbohydrate supplementation on plasma cytokine and neutrophil degranulation responses to high intensity intermittent exercise. Int J Sport Nutr Exerc Metab. 2002;12(2):145-56.
67. Lancaster GI, Jentjens RL, Moseley L, Jeukendrup AE, Gleeson M. Effect of pre-exercise carbohydrate ingestion on plasma cytokine, stress hormone, and neutrophil degranulation responses to continuous, high-intensity exercise. Int J Sport Nutr Exerc Metab. 2003;13(4):436-53.
68. Rokitzki L, Logemann E, Huber G, Keck E, Keul J. Alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr. 1994;4(3):253-64.
69. Nieman DC. Influence of carbohydrate on the immune response to intensive, prolonged exercise. Exerc Immunol Rev. 1998;4:64-76.
70. Nieman DC, Davis JM, Henson DA, Walberg-Rankin J, Shute M, Dumke CL, et al. Carbohydrate ingestion in fluences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol. 2003;94(5):1917-25.
71. Tipton KD, Rasmussen BB, Miller SL, Wolf SE, Owens-Stovall SK, Petrini BE, et al. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am J Physiol Endocrinol Metab. 2001;281(2):E197-206.
72. Hsu MC, Chien KY, Hsu CC, Chung CJ, Chan KH, Su B. Effects of BCAA, arginine and carbohydrate combined drink on post-exercise biochemical response and psychological condition. Chin J Physiol. 2011;54(2):71-8.
73. Betts JA, Beelen M, Stokes KA, Saris WH, van Loon LJ. Endocrine responses during overnight recovery from exercise: impact of nutrition and relationships with muscle protein synthesis. Int J Sport Nutr Exerc Metab. 2011;21(5):398-409.
74. La Bounty PM, Campbell BI, Wilson J, Galvan E, Berardi J, Kleiner SM, et al. International Society of Sports Nutrition position stand: meal frequency. J Int Soc Sports Nutr. 2011;8:4.
75. Schwarz NA, Rigby BR, La Bounty P, Shelmadine B, Bowden RG. A review of weight control strategies and their effects on the regulation of hormonal balance. J Nutr Metab. 2011;2011:237932.
76. Støving RK, Hangaard J, Hansen-Nord M, Hagen C. A review of endocrine changes in anorexia nervosa. J Psychiatr Res. 1999;33(2):139-52.
77. Casper RC. Recognizing eating disorders in women. Psychopharmacol Bull. 1998;34(3):267-9.
78. Södersten P, Bergh C, Zandian M. Psychoneuroendocrinology of anorexia nervosa. Psychoneuroendocrinology. 2006;31(10):1149-53.
79. VanHelder T, Radomski MW. Sleep deprivation and the effect on exercise performance. Sports Med. 1989;7:235-47.
80. Aakvaag A, Bentdal O, Quigstad K, Walstad P, Ronningen H, Fonnum F. Testosterone and testosterone binding globulin (TeBG) in young men during prolonged stress. Int J Androl. 1978;1:22-31.
81. Aakvaag A, Sand T, Opstad PO, Fonnum F. Hormonal changes in serum in young men during prolonged physical strain. Eur J Appl Physiol. 1978;39:283-91.
82. Diamond P, Brisson GR, Candas B, Peronnet F. Trait anxiety, submaximal physical exercise and blood androgens. Eur J Appl Physiol. 1989;58:699-704.
83. Hackney AC, Feith S, Pozos R, Seale J. Effects of high altitude and cold exposure on resting thyroid hormone concentrations. Aviat Space Environ Med. 1995;66:325-9.
84. Viru A, Hackney AC, Valja E, Karelson K, Janson T, Viru M. Influence of prolonged continuous exercise on hormonal responses to subsequent intensive exercise. Eur J Appl Physiol. 2001;85:578-85.
85. Hackney AC. The neuro-endocrine system, overload training, and regeneration. In: Lehmann M, editor. Ulm International Conference Proceeding: performance, overload training and regeneration. London: Plenum; 1999. p. 173-86.
86. Viru A, Karelson K, Smirnova T. Stability and variability in hormonal responses to prolonged exercise. Int J Sports Med. 1992;13:230-5.
87. Hartley LH, Mason JW, Hogan RP, Jones LG, Kotchen TA, Mougey EH, et al. Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol. 1972;33(5):602-6.
88. Richter EA, Sutton JR. Hormonal adaptation to physical activity. In: Bouchard C, Shephard RJ, Stephen T, editors. Physical activity, fitness and health: international proceedings and consensus statement. Champaign, IL: Human Kintetics; 331. p. 342-1994.
89. Luger A, Deuster PA, Kyle SB, Gallucci WT, Montgomery LC, Gold PW. Acute hypothalamicpituitary- adrenal responses to the stress of treadmill exercise: physiologic adaptations to physical training. N Engl J Med. 1987;316:1309-15.
90. Hackney AC, Sinning WE, Brout BC. Comparison of resting reproductive hormonal pro files in endurance trained and untrained men. Med Sci Sports Exerc. 1988;20(1):60-5.
91. Remes K, Kuoppasalmi K, Adlercreutz H. Effect of long-term physical training on plasma testosterone, androstenedione, luteinizing hormone and sex-hormone binding globulin capacity. Sacnd J Clin Lab Invest. 1979;39:743-9.
92. Hakkinen K, Pakarinen A. Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes. J Appl Physiol. 1993;74:882-7.
93. Westendorp RG, Roos AN, Riley LC, Walma S, Frolich M, Mienders AE. Chronic stimulation of atrial natriuretic peptide attenuates the secretory responses to postural changes. Am J Med Sci. 1993;306:371-5.
94. Fawcett JK, Wynn V. Effects of posture on plasma volume and some blood constituents. J Clin Pathol. 1960;13:304-13.
95. Chen YM, Cintron NM, Whitson PA. Long term storage of salivary cortisol samples at room temperature. Clin Chem. 1992;38:304.
96. Calam RR. Reviewing the importance of specimen collection. J Am Med Technol. 1977;38:297-300.
97. Sanntag O. Hemolysis as interference factor in clinical chemistry. J Clin Chem Biochem. 1986;24:575-7.
98. Obminski Z, Klusiewicz A, Stupnicki R. Changes in salivary and serum cortisol concentrations in junior athletes following exercises of different intensities. Biol Sport. 1994;11:49-57.
99. Caraway WT. Chemical and diagnostic speci ficity of laboratory tests. Am J Clin Pathol. 1961;37:445-64.
100. Kopchick JJ, Sackman-Sala L, Ding J. Primer: molecular tools used for the understanding of endocrinology. Nat Clin Pract Endocrinol Metab. 2007;3(4):355-68.
101. Bowers LD. Analytical advances in detection of performance enhancing compounds. Clin Chem. 1997;43:1299-304.
102. Dudley RF. Chemiluminescence immunoassay: an alternative to RIA. Lab Med. 1990;21:216-22.
103. Shah VP, Midha KK, Findlay JWA, Hill HM, Hulse JD, McGilveray IJ, et al. Bioanalytic method validation - a revisit with a decade of progress. Pharm Res. 2000;17:1551-7.
104. DeRonde W, Van Der Schouw YT, Pols HAP, Gooren LJG, Muller M, Grobbee DE, et al. Calculation of bioavailable and free testosterone in men: a comparison of 5 published algorithms. Clin Chem. 2006;52(9):1777-84.
105. Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H. Position statement: utility, limitations and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab. 2007; 92:405-13.
106. Rodbard D. Statistical quality control and routine data processing for radioimmunoassay and immunoradiometric assays. Clin Chem. 1974;20(10):1255-70.
107. Fraser CG, Harris EK. Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci. 1989;27:409-37.
108. Hackney AC, Premo MC, McMurray RG. Influence of aerobic versus anaerobic exercise on the relationship between reproductive hormones in men. J Sports Sci. 1995;13(4):305-11.
109. Veldhuis JD, Johnson ML. Deconvolution analysis of hormone data. Methods Enzymol. 1992;210:539-75.
110. Kingle RD, Johnson GF. Statistical procedures. In: Tietz NW, editor. Textbook of clinical chemistry. Philadelphia, PA: Saunders; 1986. p. 287-355.
111. Pincus SM, Hartman ML, Roelfsema F, Thorner MO, Veldhuis JD. Hormone pulsatility discrimination via course and short time sampling. Am J Physiol Endocrinol Metab. 1999;277:E948-57.
112. Matthews DR. Time series analysis in endocrinology. Acta Paediatr Scand Suppl. 1988;347:55-62.
113. Hopkins WG. Measures of reliability in sports medicine and science. Sports Med. 2000;30(1):1-15.
114. Mohammadreza H, Xu G. A visitor's guide to effect sizes-statistical signi ficance versus practical (clinical) importance of research findings. Adv Health Sci Ed. 2004;9(3):1573-7.
115. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Englewood: Lawrence Erlbaum; 1988. p. 116-73.