Fenretinide: A Potential Treatment for Endometriosis

Reproductive Sciences

Volumn 23, Issue 9, 2016, Pages 1139-1147

  Pavone, Mary Ellen ^a   Malpani, Saurabh S ^a   Dyson, Matthew ^a   Kim, J Julie ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

apoptosis; endometriosis; fenretinide; retinoic acid; retinoid; retinol; STRA6

Indexed keywords

CELLULAR RETINOL BINDING PROTEIN 1; CYCLINE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 5; FENRETINIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; CASPASE 3; KI 67 ANTIGEN; MEMBRANE PROTEIN; STRA6 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COUNT; CELL VIABILITY; CONTROLLED STUDY; ENDOMETRIOSIS; ESTROGEN METABOLISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; ADULT; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; FEMALE; METABOLISM; PATHOLOGY;

ADULT; APOPTOSIS; CASPASE 3; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; ENDOMETRIOSIS; FEMALE; FENRETINIDE; HUMANS; KI-67 ANTIGEN; MEMBRANE PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROLIFERATING CELL NUCLEAR ANTIGEN; STROMAL CELLS;

EID: 84981333050     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719116632920     Document Type: Article

References (46)

1. Bulun SE,. Endometriosis. N Engl J Med. 2009; 360 (3): 268-279.
2. Giudice LC., Clinical practice. Endometriosis. N Engl J Med. 2010; 362 (25): 2389-2398.
3. Lucidi RS, Witz CA, Chrisco M, Binkley PA, Shain SA, Schenken RS,. A novel in vitro model of the early endometriotic lesion demonstrates that attachment of endometrial cells to mesothelial cells is dependent on the source of endometrial cells. Fertil Steril. 2005; 84 (1): 16-21.
4. Giudice LC, Kao LC,. Endometriosis. Lancet. 2004; 364 (9447): 1789-1799.
5. Giudice LC, Telles TL, Lobo S, Kao L,. The molecular basis for implantation failure in endometriosis: on the road to discovery. Ann N Y Acad Sci. 2002; 955: 252-264; discussion 293-255, 396-406.
6. Bulun SE, Cheng YH, Pavone ME, et al. Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis. Semin Reprod Med. 2010; 28 (1): 36-43.
7. Pavone ME, Dyson M, Reirstad S, et al. Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action. Hum Reprod. 2011; 26 (8): 2157-2164.
8. Pavone ME, Reierstad S, Sun H, Milad M, Bulun SE, Cheng YH,. Altered retinoid uptake and action contributes to cell survival in endometriosis. J Clin Endocrinol Metab. 2010; 95 (11): 300-309.
9. Umesono K, Giguere V, Glass CK, Rosenfeld MG, Evans RM,. Retinoic acid and thyroid hormone induce gene expression through a common responsive element. Nature. 1988; 336 (6196): 262-265.
10. Jones S, Meng L, Parsons DW, et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat. 2012; 33 (1): 100-103.
11. Nasu K, Yuge A, Tsuno A, Nishida M, Narahara H,. Involvement of resistance to apoptosis in the pathogenesis of endometriosis. Histol Histopathol. 2009; 24 (9): 1181-1192.
12. Formelli F, Barua AB, Olson JA,. Bioactivities of N-(4-hydroxyphenyl) retinamide and retinoyl beta-glucuronide. Faseb J. 1996; 10 (9): 1014-1024.
13. Broaddus RR, Xie S, Hsu CJ, Wang J, Zhang S, Zou C,. The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas. Am J Obstet Gynecol. 2004; 190 (3): 686-692.
14. Ciolino HP, Dai Z, Nair V,. Retinol inhibits aromatase activity and expression in vitro. J Nutr Biochem. 2011; 22 (6): 522-526.
15. Ciolino HP, Wang TT, Sathyamoorthy N,. Inhibition of aromatase activity and expression in MCF-7 cells by the chemopreventive retinoid N-(4-hydroxy-phenyl)-retinamide. Br J Cancer. 2000; 83 (3): 333-337.
16. Pavone ME, Bulun SE,. Aromatase inhibitors for the treatment of endometriosis. Fertil Steril. 2012; 98 (6): 1370-1379.
17. Ryan IP, Schriock ED, Taylor RN,. Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. J Clin Endocrinol Metab. 1994; 78 (3): 642-649.
18. Noble LS, Takayama K, Zeitoun KM, et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab. 1997; 82 (2): 600-606.
19. Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLoS Genet. 2014; 10 (3): e1004158.
20. Bio-rad. Bio-Rad TC20 Automated Cell Counter Description. Cell Counter Description. Web site. http://www.bio-rad.com/en-us/product/tc20-automated-cell-counter?tab=Description.
21. Dyson MT, Jones JK, Kowalewski MP, et al. Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells. Biol Reprod. 2008; 78 (2): 267-277.
22. Bruner KL, Eisenberg E, Gorstein F, Osteen KG,. Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids. 1999; 64 (9): 648-653.
23. Bruner KL, Matrisian LM, Rodgers WH, Gorstein F, Osteen KG,. Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest. 1997; 99 (12): 2851-2857.
24. Eaton JL, Unno K, Caraveo M, Lu Z, Kim JJ,. Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis. J Clin Endocrinol Metab. 2013; 98 (12): e1871-e1879.
25. Formelli F, Cleris L,. Therapeutic effects of the combination of fenretinide and all-trans-retinoic acid and of the two retinoids with cisplatin in a human ovarian carcinoma xenograft and in a cisplatin-resistant sub-line. Eur J Cancer. 2000; 36 (18): 2411-2419.
26. Carrera S, Cuadrado-Castano S, Samuel J, et al. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013; 20 (7): 910-919.
27. Decensi A, Robertson C, Guerrieri-Gonzaga A, et al. Randomized double-blind 2× 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women. J Clin Oncol. 2009; 27 (23): 3749-3756.
28. Villablanca JG, London WB, Naranjo A, et al. Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group. Clin Cancer Res. 2011; 17 (21): 6858-6866.
29. Maurer BJ, Kang MH, Villablanca JG, et al. Phase I trial of fenretinide delivered orally in a novel organized lipid complex in patients with relapsed/refractory neuroblastoma: a report from the New Approaches to Neuroblastoma Therapy (NANT) consortium. Pediatr Blood Cancer. 2013; 60 (11): 1801-1808.
30. Ratko TA, Detrisac CJ, Dinger NM, Thomas CF, Kelloff GJ, Moon RC,. Chemopreventive efficacy of combined retinoid and tamoxifen treatment following surgical excision of a primary mammary cancer in female rats. Cancer Res. 1989; 49 (16): 4472-4476.
31. Mittal N, Malpani S, Dyson M, et al. Fenretinide: a novel treatment for endometrial cancer. PLoS One. 2014; 9 (10): e110410.
32. Gopal AK, Pagel JM, Hedin N, Press OW,. Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase-dependent mechanism. Blood. 2004; 103 (9): 3516-3520.
33. Mukherjee N, Reuland SN, Lu Y, et al. Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells Including melanoma initiating cells. J Invest Dermatol. 2015; 135 (3): 842-850.
34. Cheng YH, Yin P, Xue Q, Yilmaz B, Dawson MI, Bulun SE,. Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab. 2008; 93 (5): 1915-1923.
35. Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N,. Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Mol Cell Biol. 2012; 32 (15): 3164-3175.
36. Sokalska A, Anderson M, Villanueva J, et al. Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. J Clin Endocrinol Metab. 2013; 98 (3): e463-e471.
37. Veronesi U, De Palo G, Marubini E, et al. Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst. 1999; 91 (21): 1847-1856.
38. Veronesi U, Mariani L, Decensi A, et al. Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer. Ann Oncol. 2006; 17 (7): 1065-1071.
39. Torrisi R, Parodi S, Fontana V, et al. Effect of fenretinide on plasma IGF-I and IGFBP-3 in early breast cancer patients. Int J Cancer. 1998; 76 (6): 787-790.
40. Koay DC, Zerillo C, Narayan M, Harris LN, DiGiovanna MP,. Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations. Breast Cancer Res. 2010; 12 (4): r62.
41. Durante S, Orienti I, Teti G, et al. Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model. Oncotarget. 2014; 5 (13): 4811-4820.
42. Mata NL, Lichter JB, Vogel R, Han Y, Bui TV, Singerman LJ,. Investigation of oral fenretinide for treatment of geographic atrophy in age-related macular degeneration. Retina. 2013; 33 (3): 498-507.
43. Holpuch AS, Phelps MP, Desai K-GH, et al. Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention. Carcinogenesis. 2012; 33 (5): 1098-1105.
44. ® (HPR). Eur J Canc Clin Oncol. 1989; 25 (5): 805-808.
45. Camerini T, Mariani L, De Palo G, et al. Safety of the synthetic retinoid fenretinide: long-term results from a controlled clinical trial for the prevention of contralateral breast cancer. J Clin Oncol. 2001; 19 (6): 1664-1670.
46. Soprano DR, Soprano KJ,. Retinoids as teratogens. Annu Rev Nutr. 1995; 15 (1): 111-132.