An in silico framework for integrating epidemiologic and genetic evidence with health care applications: Ventilation-related pneumothorax as a case illustration

Journal of the American Medical Informatics Association

Volumn 23, Issue 4, 2016, Pages 711-720

  Torosyan, Yelizaveta ^a   Hu, Yuzhi ^a,b   Hoffman, Sarah ^a,c   Luo, Qianlai ^a,c   Carleton, Bruce ^d   Marinac Dabic, Danica ^a  

^a CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^b Columbia University Mailman School of Public Health ^*  (United States)

^c IL   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

In silico evidence integration using big data approaches; Medical device safety biomarkers; Repurposing and re utilization of pre existing genetic data; Translational epidemiology

Indexed keywords

ARTICLE; ARTIFICIAL VENTILATION; CAUCASIAN; COMORBIDITY; COMPUTER MODEL; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; GENE EXPRESSION PROFILING; HEALTH CARE COST; HEALTH CARE UTILIZATION; HUMAN; IATROGENIC DISEASE; IATROGENIC PNEUMOTHORAX; ICD-9; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PNEUMOTHORAX; POSITIVE END EXPIRATORY PRESSURE; RETROSPECTIVE STUDY; SPONTANEOUS PNEUMOTHORAX; COMPUTER SIMULATION; EPIDEMIOLOGY; ETHNIC GROUP; GENETICS; PILOT STUDY;

COMPUTER SIMULATION; EPIDEMIOLOGIC METHODS; ETHNIC GROUPS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; PILOT PROJECTS; PNEUMOTHORAX; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES;

EID: 84981287150     PISSN: 10675027     EISSN: 1527974X     Source Type: Journal    
DOI: 10.1093/jamia/ocw031     Document Type: Article

References (30)

1. Terzi E, Zarogoulidis K, Kougioumtzi I, et al. Acute respiratory distress syndrome and pneumothorax. J Thorac Dis. 2014;6(Suppl 4):S435-S442.
2. Iatrogenic pneumothorax (provider-level): rate per 1,000 discharges. http://www.qualitymeasures.ahrq.gov/content.aspx?id=38515&search=pneu-mothorax. Accessed February 28, 2015. Source: AHRQ QI. Patient safety indicators #6: technical specifications. Iatrogenic pneumothorax rate [version 4.4]. Rockville, MD: Agency for Healthcare Research and Quality; 2012.
3. Downey JR, Hernandez-Boussard T, Banka G, Morton JM. Is patient safety improving? National trends in patient safety indicators: 1998-2007. Health ServRes. 2012;47(1 Pt 2):414-430.
4. Rosen AK, Zhao S, Rivard P, et al. Tracking rates of patient safety indicators over time: lessons from the Veterans Administration. Med Care. 2006;44(9): 850-861.
5. Despars JA, Sassoon CS, Light RW. Significance of iatrogenic pneumothoraces. Chest. 1994; 105(4): 1147-1150.
6. Patient Safety Indicator Comparative Data: Based on the 2009 Nationwide Inpatient Sample (NIS), Version 4.4 (August 2012). http://www.qualityindi-cators.ahrq.gov/Downloads/Modules/PSI/V44/Comparative_Data_PSI_4.4.pdf. Accessed February 28,2014.
7. Lissac J. [Spontaneous and iatrogenic pneumothorax in the adult. 217 personal cases]. Bull Acad Natl Med. 1994;178(2):213-223; discussion 223225. [Article in French]
8. Celik B, Sahin E, Nadir A, Kaptanoglu M. Iatrogenic pneumothorax: etiology, incidence and risk factors. Thorac Cardiovasc Surg. 2009; 57(5): 286-290.
9. Hsu CW, Sun SF. Iatrogenic pneumothorax related to mechanical ventilation. World J Crit Care Med. 2014; 3(1): 8-14.
10. da Silva PS, de Aguiar VE, Fonseca MC. Iatrogenic pneumothorax in mechanically ventilated children: incidence, risk factors and other outcomes. HeartLung. 2015; 44(3): 238-242.
11. Hsu CW, Sun SF, Lee DL, Chu KA, Lin HS. Clinical characteristics, hospital outcome and prognostic factors of patients with ventilator-related pneumothorax. Minerva Anestesiol. 2014; 80(1): 29-38.
12. Baumann MH. Pneumothorax. Semin Respir Crit Care Med. 2001;22(6): 647-656.
13. Vinson DR, Ballard DW, Hance LG, et al., Kaiser Permanente CREST Network Investigators. Pneumothorax is a rare complication of thoracic central venous catheterization in community EDs. Am J Emerg Med. 2015; 33(1):60-66.
14. Tsai CL, Lee WY, Delclos GL, Hanania NA, Camargo CA Jr. Comparative effectiveness of noninvasive ventilation vs invasive mechanical ventilation in chronic obstructive pulmonary disease patients with acute respiratory failure. J Hosp Med. 2013; 8(4): 165-172.
15. Chiu HT, Garcia CK. Familial spontaneous pneumothorax. Curr Opin Pulm Med. 2006; 12(4): 268-272.
16. Cabrera-Benitez NE, Laffey JG, Parotto M, et al. Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome. Anesthesiology. 2014; 121(1): 189-198.
17. Ley B, Collard HR. Epidemiology of idiopathic pulmonary fibrosis. Clin Epidemiol. 2013;5:483-492.
18. Brenner JS, Karlowicz MG. Nonfatal symptomatic spontaneous pneumothorax in neonates: association with white ethnicity and lack of association with major urinary tract malformations. Clin Pediatr (Phila). 1997;36(4): 241-243.
19. Sadikot RT, Greene T, Meadows K, Arnold AG. Recurrence of primary spontaneous pneumothorax. Thorax. 1997; 52(9): 805-809.
20. Guo Y, Xie C, Rodriguez RM, Light RW. Factors related to recurrence of spontaneous pneumothorax. Respirology. 2005; 10(3): 378-384.
21. Kawakami Y, Irie T, Kamishima K. Stature, lung height, and spontaneous pneumothorax. Respiration. 1982;43:35-40.
22. De Paepe ME, Greco D, Mao Q. Angiogenesis-related gene expression profiling in ventilated preterm human lungs. Exp Lung Res. 2010;36(7): 399-410.
23. Li LF, Liu YY, Kao KC, et al. Mechanical ventilation augments bleomycin-induced epithelial-mesenchymal transition through the Src pathway. Lab Invest. 2014; 94(9): 1017-1029.
24. Shoemaker CT, Reiser KM, Goetzman BW, Last JA. Elevated ratios of type I/ III collagen in the lungs of chronically ventilated neonates with respiratory distress. Pediatr Res. 1984; 18(11): 1176-1180.
25. Bhargava M, Becker TL, Viken KJ, et al. Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors. PLoS One. 2014; 9(10): e109713.
26. International consensus conferences in intensive care medicine. Ventilator-associated lung injury in ARDS. American Thoracic Society, European Society of Intensive Care Medicine, Societe de Réanimation Langue Franchise. [No authors listed] Intensive Care Med. 1999;25(12):1444-1452. Review.
27. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproli-ferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014; 43(1): 276-285.
28. Preumont V, Hermans MP, Lebecque P, Buysschaert M. Glucose homeostasis and genotype-phenotype interplay in cystic fibrosis patients with CFTR gene deltaF508 mutation. Diabetes Care. 2007; 30(5): 1187-1192.
29. Dahl M, Tybjaerg-Hansen A, Lange P, Nordestgaard BG. Asthma and COPD in cystic fibrosis intron-8 5T carriers. A population-based study. Respir Res. 2005;6:113.
30. Cohen JC, Lundblad LK, Bates JH, Levitzky M, Larson JE. The "Goldilocks effect" in cystic fibrosis: identification of a lung phenotype in the CFTR knockout and heterozygous mouse. BMC Genet. 2004; 27(5): 21.