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Volumn 18, Issue 9, 2016, Pages

Evolving Immunotherapy Approaches for Renal Cell Carcinoma

Author keywords

Adoptive cell therapy; Cytokines; Immune checkpoint inhibitors; Immunotherapy; Renal cell carcinoma; Vaccine therapy

Indexed keywords

4 AMINO N (3 CHLORO 4 FLUOROPHENYL) N' HYDROXY 1,2,5 OXADIAZOLE 3 CARBOXIMIDAMIDE; AFLIBERCEPT; ALPHA INTERFERON; ATEZOLIZUMAB; AVELUMAB; AXITINIB; BEVACIZUMAB; BMS 936559; CYCLOPHOSPHAMIDE; DURVALUMAB; EVEROLIMUS; GAMMA INTERFERON; INTERLEUKIN 2; IPILIMUMAB; ITACITINIB; NIVOLUMAB; PAZOPANIB; PEGINTERFERON ALPHA2B; PEMBROLIZUMAB; PIDILIZUMAB; PLACEBO; ROCAPULDENCEL T; SUNITINIB; TG 4010; TICILIMUMAB; TUMOR VACCINE; UNINDEXED DRUG; VARLILUMAB; VITESPEN; VORINOSTAT; CYTOKINE;

EID: 84981186468     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-016-0542-9     Document Type: Review
Times cited : (24)

References (78)
  • 1
    • 84918815964 scopus 로고    scopus 로고
    • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
    • COI: 1:CAS:528:DC%2BC2cXitVyktbzI, PID: 2522084
    • Ferlay J et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.
    • (2015) Int J Cancer , vol.136 , Issue.5 , pp. E359-E386
    • Ferlay, J.1
  • 2
    • 84873085479 scopus 로고    scopus 로고
    • Current and future systemic treatments for renal cell carcinoma
    • PID: 2270528
    • Fisher R, Gore M, Larkin J. Current and future systemic treatments for renal cell carcinoma. Semin Cancer Biol. 2013;23(1):38–45.
    • (2013) Semin Cancer Biol , vol.23 , Issue.1 , pp. 38-45
    • Fisher, R.1    Gore, M.2    Larkin, J.3
  • 3
    • 42649145828 scopus 로고    scopus 로고
    • Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review
    • PID: 1831322
    • Gupta K et al. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev. 2008;34(3):193–205.
    • (2008) Cancer Treat Rev , vol.34 , Issue.3 , pp. 193-205
    • Gupta, K.1
  • 4
    • 0023115642 scopus 로고
    • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone
    • COI: 1:STN:280:DyaL2s7ksVGitA%3D%3D, PID: 349343
    • Rosenberg SA et al. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med. 1987;316(15):889–97.
    • (1987) N Engl J Med , vol.316 , Issue.15 , pp. 889-897
    • Rosenberg, S.A.1
  • 5
    • 65949115921 scopus 로고    scopus 로고
    • Sequential therapy in renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD1MXmtVOktr8%3D, PID: 1940206
    • Escudier B et al. Sequential therapy in renal cell carcinoma. Cancer. 2009;115(10 Suppl):2321–6.
    • (2009) Cancer , vol.115 , pp. 2321-2326
    • Escudier, B.1
  • 6
    • 7144255510 scopus 로고    scopus 로고
    • Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. Canadian Urologic Oncology Group
    • COI: 1:CAS:528:DyaK1cXivF2qtrc%3D, PID: 956258
    • Gleave ME et al. Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. Canadian Urologic Oncology Group. N Engl J Med. 1998;338(18):1265–71.
    • (1998) N Engl J Med , vol.338 , Issue.18 , pp. 1265-1271
    • Gleave, M.E.1
  • 7
    • 33745247366 scopus 로고    scopus 로고
    • Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients
    • COI: 1:CAS:528:DC%2BD28XltFyjurs%3D, PID: 1674073
    • Wierecky J et al. Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients. Cancer Res. 2006;66(11):5910–8.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5910-5918
    • Wierecky, J.1
  • 9
    • 0024539002 scopus 로고
    • Unexplained spontaneous regression and alpha-interferon as treatment for metastatic renal carcinoma
    • COI: 1:STN:280:DyaL1M7psVKlug%3D%3D, PID: 270239
    • Oliver RT, Nethersell AB, Bottomley JM. Unexplained spontaneous regression and alpha-interferon as treatment for metastatic renal carcinoma. Br J Urol. 1989;63(2):128–31.
    • (1989) Br J Urol , vol.63 , Issue.2 , pp. 128-131
    • Oliver, R.T.1    Nethersell, A.B.2    Bottomley, J.M.3
  • 10
    • 0034039255 scopus 로고    scopus 로고
    • Interferon in metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD3cXivFOgtbc%3D, PID: 1076859
    • Fossa SD. Interferon in metastatic renal cell carcinoma. Semin Oncol. 2000;27(2):187–93.
    • (2000) Semin Oncol , vol.27 , Issue.2 , pp. 187-193
    • Fossa, S.D.1
  • 11
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial
    • COI: 1:CAS:528:DC%2BD3MXntF2qtbw%3D, PID: 1158375
    • Mickisch GH et al. Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet. 2001;358(9286):966–70.
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 966-970
    • Mickisch, G.H.1
  • 12
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXksVGqsw%3D%3D, PID: 1721552
    • Motzer RJ et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356(2):115–24.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 115-124
    • Motzer, R.J.1
  • 13
    • 84940395868 scopus 로고    scopus 로고
    • Anticancer cytokines: biology and clinical effects of interferon-alpha2, interleukin (IL)-2, IL-15, IL-21, and IL-12
    • COI: 1:CAS:528:DC%2BC2MXhsV2murrM, PID: 2632005
    • Floros T, Tarhini AA. Anticancer cytokines: biology and clinical effects of interferon-alpha2, interleukin (IL)-2, IL-15, IL-21, and IL-12. Semin Oncol. 2015;42(4):539–48.
    • (2015) Semin Oncol , vol.42 , Issue.4 , pp. 539-548
    • Floros, T.1    Tarhini, A.A.2
  • 14
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2
    • COI: 1:STN:280:DyaK2c7ms1Wmsg%3D%3D, PID: 812095
    • Rosenberg SA et al. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA. 1994;271(12):907–13.
    • (1994) JAMA , vol.271 , Issue.12 , pp. 907-913
    • Rosenberg, S.A.1
  • 15
    • 0033847587 scopus 로고    scopus 로고
    • Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
    • PID: 1068566
    • Fisher RI, Rosenberg SA, Fyfe G. Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J Sci Am. 2000;6 Suppl 1:S55–7.
    • (2000) Cancer J Sci Am , vol.6 , pp. S55-S57
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 16
    • 84961289871 scopus 로고    scopus 로고
    • The high-dose aldesleukin “select” trial: a trial to prospectively validate predictive models of response to treatment in patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC2MXhvVegu7c%3D, PID: 2542485
    • McDermott DF et al. The high-dose aldesleukin “select” trial: a trial to prospectively validate predictive models of response to treatment in patients with metastatic renal cell carcinoma. Clin Cancer Res. 2015;21(3):561–8.
    • (2015) Clin Cancer Res , vol.21 , Issue.3 , pp. 561-568
    • McDermott, D.F.1
  • 17
    • 65249166077 scopus 로고    scopus 로고
    • Phase I trial of sunitinib malate plus interferon-alpha for patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD1MXjslKqs7k%3D, PID: 1921366
    • Motzer RJ et al. Phase I trial of sunitinib malate plus interferon-alpha for patients with metastatic renal cell carcinoma. Clin Genitourin Cancer. 2009;7(1):28–33.
    • (2009) Clin Genitourin Cancer , vol.7 , Issue.1 , pp. 28-33
    • Motzer, R.J.1
  • 18
    • 34548229506 scopus 로고    scopus 로고
    • Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: a phase II study of the Southwest Oncology Group
    • COI: 1:CAS:528:DC%2BD2sXhtVWqs7jO, PID: 1766447
    • Ryan CW et al. Sorafenib with interferon alfa-2b as first-line treatment of advanced renal carcinoma: a phase II study of the Southwest Oncology Group. J Clin Oncol. 2007;25(22):3296–301.
    • (2007) J Clin Oncol , vol.25 , Issue.22 , pp. 3296-3301
    • Ryan, C.W.1
  • 19
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • PID: 1815603
    • Escudier B et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet. 2007;370(9605):2103–11.
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1
  • 20
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • COI: 1:CAS:528:DC%2BD1MXhslClsA%3D%3D, PID: 1893647
    • Rini BI et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol. 2008;26(33):5422–8.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5422-5428
    • Rini, B.I.1
  • 21
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
    • COI: 1:CAS:528:DC%2BC3cXpsFSgsbo%3D, PID: 2036855
    • Escudier B et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol. 2010;28(13):2144–50.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2144-2150
    • Escudier, B.1
  • 22
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206
    • COI: 1:CAS:528:DC%2BC3cXpsFSgsbw%3D, PID: 2036855
    • Rini BI et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol. 2010;28(13):2137–43.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2137-2143
    • Rini, B.I.1
  • 23
    • 84887077587 scopus 로고    scopus 로고
    • A phase II study of bevacizumab and high-dose interleukin-2 in patients with metastatic renal cell carcinoma: a cytokine working group (CWG) study
    • COI: 1:CAS:528:DC%2BC3sXhs1Kjs77M, PID: 2414536
    • Dandamudi UB et al. A phase II study of bevacizumab and high-dose interleukin-2 in patients with metastatic renal cell carcinoma: a cytokine working group (CWG) study. J Immunother. 2013;36(9):490–5.
    • (2013) J Immunother , vol.36 , Issue.9 , pp. 490-495
    • Dandamudi, U.B.1
  • 24
    • 79954438593 scopus 로고    scopus 로고
    • Sorafenib with interleukin-2 vs sorafenib alone in metastatic renal cell carcinoma: the ROSORC trial
    • COI: 1:CAS:528:DC%2BC3MXks1ajtbc%3D, PID: 2144816
    • Procopio G et al. Sorafenib with interleukin-2 vs sorafenib alone in metastatic renal cell carcinoma: the ROSORC trial. Br J Cancer. 2011;104(8):1256–61.
    • (2011) Br J Cancer , vol.104 , Issue.8 , pp. 1256-1261
    • Procopio, G.1
  • 25
    • 84888785384 scopus 로고    scopus 로고
    • Overall survival for sorafenib plus interleukin-2 compared with sorafenib alone in metastatic renal cell carcinoma (mRCC): final results of the ROSORC trial
    • Procopio G et al. Overall survival for sorafenib plus interleukin-2 compared with sorafenib alone in metastatic renal cell carcinoma (mRCC): final results of the ROSORC trial. Annals of Oncology, 2013
    • (2013) Annals of Oncology
    • Procopio, G.1
  • 26
    • 16644401873 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BD2MXpslaktw%3D%3D, PID: 1562536
    • McDermott DF et al. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol. 2005;23(1):133–41.
    • (2005) J Clin Oncol , vol.23 , Issue.1 , pp. 133-141
    • McDermott, D.F.1
  • 27
    • 0022349817 scopus 로고
    • Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer
    • COI: 1:STN:280:DyaL28%2FktVehug%3D%3D, PID: 390350
    • Rosenberg SA et al. Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med. 1985;313(23):1485–92.
    • (1985) N Engl J Med , vol.313 , Issue.23 , pp. 1485-1492
    • Rosenberg, S.A.1
  • 28
    • 0027529476 scopus 로고
    • Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer
    • COI: 1:STN:280:DyaK3s3isFWgsA%3D%3D, PID: 846872
    • Rosenberg SA et al. Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J Natl Cancer Inst. 1993;85(8):622–32.
    • (1993) J Natl Cancer Inst , vol.85 , Issue.8 , pp. 622-632
    • Rosenberg, S.A.1
  • 29
    • 0031907142 scopus 로고    scopus 로고
    • Adoptive immunotherapy of patients with metastatic renal cell cancer using lymphokine-activated killer cells, interleukin-2 and cyclophosphamide: long-term results
    • COI: 1:STN:280:DyaK1c7psFaksQ%3D%3D, PID: 953559
    • Tomita Y et al. Adoptive immunotherapy of patients with metastatic renal cell cancer using lymphokine-activated killer cells, interleukin-2 and cyclophosphamide: long-term results. Int J Urol. 1998;5(1):16–21.
    • (1998) Int J Urol , vol.5 , Issue.1 , pp. 16-21
    • Tomita, Y.1
  • 30
    • 0028868564 scopus 로고
    • Increased LAK and T cell activation in responding renal cell carcinoma patients after low dose cyclophosphamide, IL-2 and alpha-IFN
    • COI: 1:STN:280:DyaK287it12jtg%3D%3D, PID: 853566
    • Wersall P, Mellstedt H. Increased LAK and T cell activation in responding renal cell carcinoma patients after low dose cyclophosphamide, IL-2 and alpha-IFN. Med Oncol. 1995;12(2):69–77.
    • (1995) Med Oncol , vol.12 , Issue.2 , pp. 69-77
    • Wersall, P.1    Mellstedt, H.2
  • 31
    • 0024492341 scopus 로고
    • Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells
    • COI: 1:STN:280:DyaL1M%2FmtlagsQ%3D%3D, PID: 278324
    • Thompson JA et al. Influence of schedule of interleukin 2 administration on therapy with interleukin 2 and lymphokine activated killer cells. Cancer Res. 1989;49(1):235–40.
    • (1989) Cancer Res , vol.49 , Issue.1 , pp. 235-240
    • Thompson, J.A.1
  • 32
    • 0029090362 scopus 로고
    • Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma
    • COI: 1:CAS:528:DyaK2MXosVejsLk%3D, PID: 862518
    • Law TM et al. Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma. Cancer. 1995;76(5):824–32.
    • (1995) Cancer , vol.76 , Issue.5 , pp. 824-832
    • Law, T.M.1
  • 33
    • 0025993961 scopus 로고
    • Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma
    • COI: 1:STN:280:DyaK3MzjtVWhuw%3D%3D, PID: 186844
    • Bukowski RM et al. Clinical results and characterization of tumor-infiltrating lymphocytes with or without recombinant interleukin 2 in human metastatic renal cell carcinoma. Cancer Res. 1991;51(16):4199–205.
    • (1991) Cancer Res , vol.51 , Issue.16 , pp. 4199-4205
    • Bukowski, R.M.1
  • 34
    • 0023890160 scopus 로고
    • Treatment of patients with advanced cancer using tumor-infiltrating lymphocytes and interleukin 2
    • COI: 1:STN:280:DyaL1c3gsFGlug%3D%3D, PID: 325903
    • Kradin R et al. Treatment of patients with advanced cancer using tumor-infiltrating lymphocytes and interleukin 2. Transplant Proc. 1988;20(2):336–8.
    • (1988) Transplant Proc , vol.20 , Issue.2 , pp. 336-338
    • Kradin, R.1
  • 35
    • 0023934650 scopus 로고
    • Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study
    • COI: 1:STN:280:DyaL1c3hsVCmsA%3D%3D, PID: 325926
    • Topalian SL et al. Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study. J Clin Oncol. 1988;6(5):839–53.
    • (1988) J Clin Oncol , vol.6 , Issue.5 , pp. 839-853
    • Topalian, S.L.1
  • 36
    • 14044271554 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and interleukin-2: dose and schedules of administration in the treatment of metastatic cancer
    • COI: 1:CAS:528:DC%2BD2MXhs1Cjsr8%3D, PID: 1566562
    • Dillman R et al. Tumor-infiltrating lymphocytes and interleukin-2: dose and schedules of administration in the treatment of metastatic cancer. Cancer Biother Radiopharm. 2004;19(6):730–7.
    • (2004) Cancer Biother Radiopharm , vol.19 , Issue.6 , pp. 730-737
    • Dillman, R.1
  • 37
    • 0032784492 scopus 로고    scopus 로고
    • Multicenter, randomized, phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma
    • COI: 1:STN:280:DC%2BD3c%2FjtVSntQ%3D%3D, PID: 1056131
    • Figlin RA et al. Multicenter, randomized, phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma. J Clin Oncol. 1999;17(8):2521–9.
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2521-2529
    • Figlin, R.A.1
  • 38
    • 0029094721 scopus 로고
    • Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: a pilot study
    • COI: 1:STN:280:DyaK2MzmtlCktA%3D%3D, PID: 763653
    • Goedegebuure PS et al. Adoptive immunotherapy with tumor-infiltrating lymphocytes and interleukin-2 in patients with metastatic malignant melanoma and renal cell carcinoma: a pilot study. J Clin Oncol. 1995;13(8):1939–49.
    • (1995) J Clin Oncol , vol.13 , Issue.8 , pp. 1939-1949
    • Goedegebuure, P.S.1
  • 39
    • 0027973910 scopus 로고
    • CD4 TIL (tumor infiltrating lymphocytes) induce complete response in patients treated with IL-2 (interleukin-2). Preliminary study
    • COI: 1:STN:280:DyaK2M7ntlCksQ%3D%3
    • Thiounn N et al. CD4 TIL (tumor infiltrating lymphocytes) induce complete response in patients treated with IL-2 (interleukin-2). Preliminary study. J Urol (Paris). 1994;100(4):185–8.
    • (1994) J Urol (Paris) , vol.100 , Issue.4 , pp. 185-188
    • Thiounn, N.1
  • 40
    • 84863230396 scopus 로고    scopus 로고
    • Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma
    • COI: 1:CAS:528:DC%2BC38XktVymsrk%3D, PID: 2227550
    • Liu L et al. Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clin Cancer Res. 2012;18(6):1751–9.
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1751-1759
    • Liu, L.1
  • 41
    • 22144496809 scopus 로고    scopus 로고
    • Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes
    • COI: 1:CAS:528:DC%2BD2MXlvVWqs7k%3D, PID: 1600006
    • Engels B et al. Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes. Hum Gene Ther. 2005;16(7):799–810.
    • (2005) Hum Gene Ther , vol.16 , Issue.7 , pp. 799-810
    • Engels, B.1
  • 42
    • 33749137954 scopus 로고    scopus 로고
    • Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors
    • COI: 1:CAS:528:DC%2BD28Xps1Ggt7Y%3D, PID: 1698286
    • Jiang HR et al. Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors. J Immunol. 2006;177(7):4288–98.
    • (2006) J Immunol , vol.177 , Issue.7 , pp. 4288-4298
    • Jiang, H.R.1
  • 43
    • 77950991814 scopus 로고    scopus 로고
    • T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy
    • COI: 1:CAS:528:DC%2BC3cXkslSmu7g%3D, PID: 2037169
    • Leisegang M et al. T-cell receptor gene-modified T cells with shared renal cell carcinoma specificity for adoptive T-cell therapy. Clin Cancer Res. 2010;16(8):2333–43.
    • (2010) Clin Cancer Res , vol.16 , Issue.8 , pp. 2333-2343
    • Leisegang, M.1
  • 44
    • 84997817430 scopus 로고    scopus 로고
    • Survival with AGS-003, an autologous dendritic cell-based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): phase 2 study results
    • PID: 2590128
    • Amin A et al. Survival with AGS-003, an autologous dendritic cell-based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): phase 2 study results. J Immunother Cancer. 2015;3:14.
    • (2015) J Immunother Cancer , vol.3 , pp. 14
    • Amin, A.1
  • 45
    • 59849107093 scopus 로고    scopus 로고
    • Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response
    • COI: 1:CAS:528:DC%2BD1cXhtFCrtLzI, PID: 1877974
    • Calderhead DM et al. Cytokine maturation followed by CD40L mRNA electroporation results in a clinically relevant dendritic cell product capable of inducing a potent proinflammatory CTL response. J Immunother. 2008;31(8):731–41.
    • (2008) J Immunother , vol.31 , Issue.8 , pp. 731-741
    • Calderhead, D.M.1
  • 46
    • 54049140895 scopus 로고    scopus 로고
    • Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent
    • COI: 1:CAS:528:DC%2BD1cXhtF2hs7bM, PID: 1883268
    • DeBenedette MA et al. Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent. J Immunol. 2008;181(8):5296–305.
    • (2008) J Immunol , vol.181 , Issue.8 , pp. 5296-5305
    • DeBenedette, M.A.1
  • 47
    • 78650633859 scopus 로고    scopus 로고
    • Potency of mature CD40L RNA electroporated dendritic cells correlates with IL-12 secretion by tracking multifunctional CD8(+)/CD28(+) cytotoxic T-cell responses in vitro
    • COI: 1:CAS:528:DC%2BC3cXhsFGksr7M, PID: 2115071
    • DeBenedette MA et al. Potency of mature CD40L RNA electroporated dendritic cells correlates with IL-12 secretion by tracking multifunctional CD8(+)/CD28(+) cytotoxic T-cell responses in vitro. J Immunother. 2011;34(1):45–57.
    • (2011) J Immunother , vol.34 , Issue.1 , pp. 45-57
    • DeBenedette, M.A.1
  • 48
    • 77958015499 scopus 로고    scopus 로고
    • Results of a randomized phase II study investigating multipeptide vaccination with IMA901 in advanced renal cell carcinoma (RCC)
    • Reinhardt, C., et al., Results of a randomized phase II study investigating multipeptide vaccination with IMA901 in advanced renal cell carcinoma (RCC). ASCO Meeting Abstracts, 2010. 28(15_suppl): p. 4529.
    • (2010) ASCO Meeting Abstracts , vol.28 , pp. 4529
    • Reinhardt, C.1
  • 49
    • 78349284842 scopus 로고    scopus 로고
    • Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study
    • COI: 1:CAS:528:DC%2BC3cXhsVWmsbnN, PID: 2088100
    • Amato RJ et al. Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin Cancer Res. 2010;16(22):5539–47.
    • (2010) Clin Cancer Res , vol.16 , Issue.22 , pp. 5539-5547
    • Amato, R.J.1
  • 50
    • 79959699551 scopus 로고    scopus 로고
    • MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients
    • COI: 1:CAS:528:DC%2BC3MXmsVajtLw%3D, PID: 2138710
    • Harrop R et al. MVA-5T4-induced immune responses are an early marker of efficacy in renal cancer patients. Cancer Immunol Immunother. 2011;60(6):829–37.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.6 , pp. 829-837
    • Harrop, R.1
  • 51
    • 79151471986 scopus 로고    scopus 로고
    • A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings
    • COI: 1:CAS:528:DC%2BC3MXptFeqsA%3D%3D, PID: 2106932
    • Oudard S et al. A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings. Cancer Immunol Immunother. 2011;60(2):261–71.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.2 , pp. 261-271
    • Oudard, S.1
  • 52
    • 10744230275 scopus 로고    scopus 로고
    • Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial
    • COI: 1:CAS:528:DC%2BD2cXhsVOnsLg%3D, PID: 1498788
    • Jocham D et al. Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial. Lancet. 2004;363(9409):594–9.
    • (2004) Lancet , vol.363 , Issue.9409 , pp. 594-599
    • Jocham, D.1
  • 53
    • 77950503440 scopus 로고    scopus 로고
    • Ten-year survival analysis for renal carcinoma patients treated with an autologous tumour lysate vaccine in an adjuvant setting
    • PID: 1987662
    • May M et al. Ten-year survival analysis for renal carcinoma patients treated with an autologous tumour lysate vaccine in an adjuvant setting. Cancer Immunol Immunother. 2010;59(5):687–95.
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.5 , pp. 687-695
    • May, M.1
  • 54
    • 46749085802 scopus 로고    scopus 로고
    • An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial
    • COI: 1:CAS:528:DC%2BD1cXosVynurY%3D, PID: 1860268
    • Wood C et al. An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial. Lancet. 2008;372(9633):145–54.
    • (2008) Lancet , vol.372 , Issue.9633 , pp. 145-154
    • Wood, C.1
  • 55
    • 79952269861 scopus 로고    scopus 로고
    • Ipilimumab: a promising immunotherapy for melanoma
    • Thumar JR, Kluger HM. Ipilimumab: a promising immunotherapy for melanoma. Oncology (Williston Park). 2010;24(14):1280–8.
    • (2010) Oncology (Williston Park) , vol.24 , Issue.14 , pp. 1280-1288
    • Thumar, J.R.1    Kluger, H.M.2
  • 56
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 2052599
    • Hodi FS et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–23.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1
  • 57
    • 34547161239 scopus 로고    scopus 로고
    • High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer
    • COI: 1:CAS:528:DC%2BD2sXosF2ru7s%3D, PID: 1767872
    • Cozar JM et al. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. Hum Immunol. 2007;68(8):698–704.
    • (2007) Hum Immunol , vol.68 , Issue.8 , pp. 698-704
    • Cozar, J.M.1
  • 58
    • 37349072460 scopus 로고    scopus 로고
    • Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
    • COI: 1:CAS:528:DC%2BD2sXhtlGqs7fO, PID: 1804933
    • Yang JC et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother. 2007;30(8):825–30.
    • (2007) J Immunother , vol.30 , Issue.8 , pp. 825-830
    • Yang, J.C.1
  • 59
    • 79551717184 scopus 로고    scopus 로고
    • Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
    • COI: 1:CAS:528:DC%2BC3MXislensr4%3D, PID: 2092278
    • Rini BI et al. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer. 2011;117(4):758–67.
    • (2011) Cancer , vol.117 , Issue.4 , pp. 758-767
    • Rini, B.I.1
  • 60
    • 84967293088 scopus 로고    scopus 로고
    • Reversing T-cell dysfunction and exhaustion in cancer
    • COI: 1:CAS:528:DC%2BC28XmsFeqs78%3D, PID: 2708473
    • Zarour HM. Reversing T-cell dysfunction and exhaustion in cancer. Clin Cancer Res. 2016;22(8):1856–64.
    • (2016) Clin Cancer Res , vol.22 , Issue.8 , pp. 1856-1864
    • Zarour, H.M.1
  • 61
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • COI: 1:CAS:528:DC%2BC3cXpslajtLw%3D, PID: 2051644
    • Brahmer JR et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(19):3167–75.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1
  • 62
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 2265812
    • Topalian SL et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1
  • 63
    • 84929361060 scopus 로고    scopus 로고
    • Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab
    • COI: 1:CAS:528:DC%2BC2MXhsFKmt7vK, PID: 25800770, In treatment refractory advanced stage renal cell carcinoma nivolumab can produce durable responses with a manageable toxicity profile. This response can continue in some patients even after drug treatment is stopped
    • McDermott DF. Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab. J Clin Oncol. 2015;33(18):2013–20. In treatment refractory advanced stage renal cell carcinoma nivolumab can produce durable responses with a manageable toxicity profile. This response can continue in some patients even after drug treatment is stopped.
    • (2015) J Clin Oncol , vol.33 , Issue.18 , pp. 2013-2020
    • McDermott, D.F.1
  • 64
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
    • COI: 1:CAS:528:DC%2BC2MXpvFahsbY%3D, PID: 2545245
    • Motzer RJ et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J Clin Oncol. 2015;33(13):1430–7.
    • (2015) J Clin Oncol , vol.33 , Issue.13 , pp. 1430-1437
    • Motzer, R.J.1
  • 65
    • 84946607195 scopus 로고    scopus 로고
    • Nivolumab versus everolimus in advanced renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BC28XjsFyhsrg%3D, PID: 26406148, Nivolumab is superior to everolimus in second- or third-line treatment of advanced clear cell renal cell carcinoma. Nivolumab is associated with higher rates of response and improved overall survival while producing fever grade 3 and 4 adverse events
    • Motzer RJ. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373(19):1803–13. Nivolumab is superior to everolimus in second- or third-line treatment of advanced clear cell renal cell carcinoma. Nivolumab is associated with higher rates of response and improved overall survival while producing fever grade 3 and 4 adverse events.
    • (2015) N Engl J Med , vol.373 , Issue.19 , pp. 1803-1813
    • Motzer, R.J.1
  • 66
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rsbnJ, PID: 2265812
    • Brahmer JR et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–65.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1
  • 67
    • 84962497081 scopus 로고    scopus 로고
    • Anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study
    • et al. Atezolizumab, an . Atezolizumab, an anti PDL-1 antibody, shows antitumor activity in clear cell and non clear cell advanced renal cell carcinoma with an acceptable toxicity profile. Tumors with both positive and negative PDL-1 expression demonstrate response, though response rate is superior in PDL-1 expressing tumors
    • McDermott, DF et al. Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: long-term safety, clinical activity, and immune correlates from a phase Ia study. J Clin Oncol. 2016. Atezolizumab, an anti PDL-1 antibody, shows antitumor activity in clear cell and non clear cell advanced renal cell carcinoma with an acceptable toxicity profile. Tumors with both positive and negative PDL-1 expression demonstrate response, though response rate is superior in PDL-1 expressing tumors.
    • (2016) J Clin Oncol
    • McDermott, D.F.1
  • 69
    • 85015309834 scopus 로고    scopus 로고
    • Phase Ib study of pembrolizumab in combination with bevacizumab for the treatment of metastatic renal cell carcinoma: Big Ten Cancer Research Consortium BTCRC-GU14-003
    • Dudek AZ. Phase Ib study of pembrolizumab in combination with bevacizumab for the treatment of metastatic renal cell carcinoma: Big Ten Cancer Research Consortium BTCRC-GU14-003. ASCO Meeting Abstracts. 2016;34(2_suppl):559.
    • (2016) ASCO Meeting Abstracts , vol.34 , pp. 559
    • Dudek, A.Z.1
  • 70
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXht1ektbrF, PID: 2372486
    • Wolchok JD et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369(2):122–33.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1
  • 71
    • 84939150439 scopus 로고    scopus 로고
    • Expanded cohort results from CheckMate 016: a phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
    • Hammers HJ et al. Expanded cohort results from CheckMate 016: a phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts. 2015;33(15_suppl):4516.
    • (2015) ASCO Meeting Abstracts , vol.33 , pp. 4516
    • Hammers, H.J.1
  • 72
    • 84914148032 scopus 로고    scopus 로고
    • Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
    • Hammers HJ. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). ASCO Meeting Abstracts. 2014;32(15_suppl):4504.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 4504
    • Hammers, H.J.1
  • 73
    • 84958771685 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) plus low-dose ipilimumab (IPI) in patients (pts) with advanced melanoma (MEL) or renal cell carcinoma (RCC): data from the KEYNOTE-029 phase 1 study
    • Atkins MB. Pembrolizumab (MK-3475) plus low-dose ipilimumab (IPI) in patients (pts) with advanced melanoma (MEL) or renal cell carcinoma (RCC): data from the KEYNOTE-029 phase 1 study. ASCO Meeting Abstracts. 2015;33(15_suppl):3009.
    • (2015) ASCO Meeting Abstracts , vol.33 , pp. 3009
    • Atkins, M.B.1
  • 74
    • 84936821509 scopus 로고    scopus 로고
    • Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): association of biomarkers with clinical outcomes
    • Choueiri TK. Immunomodulatory activity of nivolumab in metastatic renal cell carcinoma (mRCC): association of biomarkers with clinical outcomes. ASCO Meeting Abstracts. 2015;33(15_suppl):4500.
    • (2015) ASCO Meeting Abstracts , vol.33 , pp. 4500
    • Choueiri, T.K.1
  • 75
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • COI: 1:CAS:528:DC%2BC2cXitFanurbM, PID: 2542850
    • Herbst RS et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515(7528):563–7.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 563-567
    • Herbst, R.S.1
  • 76
    • 84896974949 scopus 로고    scopus 로고
    • PD-L1 expression in clear cell renal cell carcinoma: an analysis of nephrectomy and sites of metastases
    • COI: 1:CAS:528:DC%2BC2cXhtlOht7nJ, PID: 2456367
    • Jilaveanu LB et al. PD-L1 expression in clear cell renal cell carcinoma: an analysis of nephrectomy and sites of metastases. J Cancer. 2014;5(3):166–72.
    • (2014) J Cancer , vol.5 , Issue.3 , pp. 166-172
    • Jilaveanu, L.B.1
  • 77
    • 84905107303 scopus 로고    scopus 로고
    • PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases
    • Callea M. PD-L1 expression in primary clear cell renal cell carcinomas (ccRCCs) and their metastases. ASCO Meeting Abstracts. 2014;32(15_suppl):4585.
    • (2014) ASCO Meeting Abstracts , vol.32 , pp. 4585
    • Callea, M.1
  • 78
    • 84944460024 scopus 로고    scopus 로고
    • Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens
    • PID: 2631790
    • Baine MK et al. Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens. Oncotarget. 2015;6(28):24990–5002.
    • (2015) Oncotarget , vol.6 , Issue.28 , pp. 24990-25002
    • Baine, M.K.1


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