Obesity, related diseases and their relationship with vitamin D deficiency in adolescents;Obesidad, enfermedades relacionadas y su relación con la defi ciencia de vitamina D en adolescentes

Nutricion Hospitalaria

Volumn 33, Issue 4, 2016, Pages 856-864

  Silva, Jacqueline de Souza ^a   Pereira, Silvia Elaine ^a   Saboya Sobrinho, Carlos José ^b   Ramalho, Andréa ^c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Adolescents; Obesity; Obesityrelated diseases; Vitamin D deficiency

Indexed keywords

ADOLESCENT; COMPLICATION; FEMALE; HUMAN; MALE; META ANALYSIS; OBESITY; VITAMIN B DEFICIENCY;

ADOLESCENT; FEMALE; HUMANS; MALE; OBESITY; VITAMIN B DEFICIENCY;

EID: 84981169915     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.20960/nh.381     Document Type: Article

References (83)

1. Skinner AC. & Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatr 2014; 168(6):561-6.
2. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, et al. Global, regional and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(9945):766-81.
3. Rivera JA, Cossío TG, Pedraza LS, Aburto TC, Sánchez TG, Martorell R Childhood and adolescent overweight and obesity in Latin America: a systematic review. Lancet Diabetes Endocrinol 2014; 2(4):321-32.
4. Sichieri R. & Souza RA. Estratégias para prevenção da obesidade em crianças e adolescentes. Cadernos de Saúde Pública 2008; 24(2):S209-S234.
5. Ramalho, A. Fome oculta: diagnóstico, tratamento e prevenção. 1 ed. São Paulo, Editora Atheneu; 2009.
6. Peters BSE, Santos LC, Fisberg M, Wood RJ, Martini LA. Prevalence of vitamin D insufficiency in Brazilian adolescents. Ann Nutr Metab 2009;54:15-21.
7. Martini LA, Verly EJR, Marchioni DM, Fisberg RM. Prevalence and correlates of calcium and vitamin D status adequacy in adolescents, adults, and elderly from the Health Survey - São Paulo. Nutrition 2013;29(6):845-50.
8. Schoor NMV & Lips P. Worldwide vitamin D status. Best Prac Res Clin Endocrinol Metab 2011;25(2):671-80.
9. Cianferrotti L. & Marcocci C. Subclinical Vitamin D deficiency. Best Prac Res Clin Endocrinol Metab 2012; 26(4):523-37.
10. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, et al. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008;88(6):1519-27.
11. Guasch A, Bulló M, Rabassa A, Bonada A, Del Castillo D, Sabench F, et al. Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study. Cardiovasc Diabetol 2012;11;11:149.
12. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab 2007;20(7):817-23.
13. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001-2004. Pediatrics 2009;124(3):362-70.
14. Wacker M, Holick MF. Sunlight and Vitamin D: A Global Perspective for Health. Dermatoendocrinol 2013;5(1):51-108.
15. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010;20(10):1352-60.
16. Pilz S, Tomaschitz, A, März, W, Drechsler C, Ritz E, et al. Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf.) 2011;75(5):575-84.
17. Ashraf A, Alvarez J, Saenz K, Gower B, McCormick K, Franklin F. Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African-American adolescents. J Clin Endocrinol Metab 2009;94(9):3200-6.
18. Williams DM, Fraser A, Lawlor DA. Associations of vitamin D, parathyroid hormone and calcium with cardiovascular risk factors in US adolescents. Heart 2011;97:315-20.
19. Oliveira, RM, Novaes, JF, Azeredo LM, Cândido AP, Leite IC. Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents. Public Health Nutr 2014;17(4):787-94.
20. Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 2013;10(2):e1001383.
21. Turer, CB, Lin, H, Flores, G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics 2013;131(1):152-61.
22. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72(3):690-3.
23. Kull M, Kallikorm R, Lember M. Body mass index determines sunbathing habits: implications on vitamin D levels. Intern Med J 2009;39(4):256-8.
24. Harel Z, Flanagan P, Forcier M, Harel D. Low vitamin D status among obese adolescents: prevalence and response to treatment. J Adolesc Health 2011;48(5):448-52.
25. Lenders CM, Feldman, HA, Von Scheven E, Merewood A, Sweeney C, et al. Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am J Clin Nutr 2009;90:459-67.
26. Campos RMS, Lazaretti-Castro M, Mello MT, Tock L, Silva PL, et al. Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents. Arq Bras Endocrinol Metabol 2012;56(1):12-18.
27. Griz LH, Bandeira F, Gabbay MA, Dib SA, Carvalho EF. Vitamin D and diabetes mellitus: an update 2013. Arq Bras Endocrinol Metabol 2014;58(1):1-8.
28. Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr 2013;32(3):375-81.
29. Institute of Medicine. Standing Committee to review dietary reference intakes for vitamin D and calcium. Institute of Medicine November 2010 Dietary reference intakes for calcium and vitamin D. www.iom.edu/vitamind, Accessed December 10, 2014.
30. Putman MS, Pitts, SA, Milliren CE, Feldman HA, Reinold K, Gordon CM. A randomized clinical trial of vitamin D supplementation in healthy adolescents. J Adolesc Health 2013;52(5):592-98.
31. Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, et al. Vitamin D in the healthy European paediatric population. Journal of Pediatric Gastroenterology and Nutrition 2013;56(6):692-701.
32. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Clinical Practice Guideline: Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96(7):1911-30.
33. The Society for Adolescent Health and Medicine. Recommended Vitamin D Intake and Management of Low Vitamin D Status in Adolescents: A Position Statement of the Society for Adolescent Health and Medicine. J Adolesc Health 2013; (52):801-03.
34. Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab 2004;(89):5387e91.
35. Heaney RP, Recker RR, Grote J, Horst RL, Armas LA. Vitamin D3 is more potent than vitamin D2 in humans. J Clin Endocrinol Metab 2011;(96):447e52.
36. Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, et al. Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 2008;(93):677e81.
37. Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, et al. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab 2008;(93):2716e21.
38. Castaneda RA, Nader N, Weaver A. Response to Vitamin D3 Supplementation in Obese and Non-obese Caucasian Adolescents. Horm Res Paediatr 2012;(78):226-31.
39. Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2003;77:204-10.
40. Belenchia AM, Tosh AK, Hillman LS, Peterson CA. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013;97(4):774-81.
41. O’Mahony L, Stepien M, Gibney MJ, Nugent AP, Brennan L. The potential role of vitamin D enhanced foods in improving vitamin D status. Nutrients 2011;3(12):1023-41.
42. Lagunova Z, Porojnicu AC, Aksnes L, Holick MF, Iani V, Bruland OS, et al. Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial. Br J Dermatol 2013;169(2):434-40.
43. Dong Y, Pollock N, Satllmann-Jorgensen IS, Gutin B, Lan L, et al. Low 25-hydroxyvitamin D levels in adolescents: race, season, adiposity, physical activity, and fitness. Pediatrics 2010;125(6):1104-11.
44. Santos BR, Mascarenhas LP, Satler F, Boguszewski MC, Spritzer PM. Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants. BMC Pediatrics 2012; 8(12):62.
45. Mann JP, Goonetilleke R, Mckiernan P. Paediatric non-alcoholic fatty liver disease: a practical overview for non-specialists. Arch Dis Child 2015;100(7):673-7.
46. Schwimmer JB, Pardee PE, Lavine JE, Blumkin AK, Cook S. Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 2008;118(3):277-83.
47. Kelly AS, Barlow SE, Rao G, Inge, TH, Hayman LL, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association. Circulation 2013;128(15):1689-712.
48. Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge TH. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatology 2006;(4):226-32.
49. Neuschwander-Tetri BA & Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003;37(5):1202-09.
50. Schwimmer JB, Deustsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics 2006;118(4): 1388-93.
51. Alavian SM, Mohammad-Alizadeh AH, Esna-Ashari F, Ardalan G, Hajarizadeh B. Non-alcoholic fatty liver disease prevalence among school-aged children and adolescents in Iran and its association with biochemical and anthropometric measures. Liver Int 2009;29(2):159-63.
52. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002;277(28): 25125-32.
53. Kitson MT, Roberts SK. D-livering the message: the importance of vitamin D status in chronic liver disease. J Hepatol 2012;57(4):897-909.
54. Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999–2004. Gastroenterology 2007;133(6):1814-20.
55. Manco M, Ciampalini P, Nobili V. Low levels of 25- hydroxyvitamin D(3) in children with biopsy-proven nonalcoholic fatty liver disease. Hepatology 2010;51(6):2229-30.
56. Holterman MJ, Le Holterman AX, Browne AF. Pediatric obesity. Surg Clin North Am 2012;92(3):559-82.
57. Zhao G, Ford ES, Li C. Associations of serum concentrations of 25 hydroxyvitamin D and parathyroid hormone with surrogate markers of insulin resistance among U.S. adults without physician-diagnosed diabetes: NHANES, 2003–2006. Diabetes Care 2010;33(2):344-47.
58. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, et al. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study the Australian diabetes, obesity and lifestyle study. Diabetes Care 2011;34(5):1133-38.
59. Bhandari, SK, Pashayan S, Liu IL, Rasgon SA, Kujubu DA, et al. 25-hydroxyvitamin D levels and hypertension rates. J Clin Hypertens (Greenwich). 2011;13(3):170-77.
60. Karhapaa P, Pihlajamaki J, Porsti I, Kastarinen M, Mustonen J, et al. Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias. J Intern Med 2010;268(6):604-10.
61. Reddy Vanga S, Good M., Howard PA, Vacek JL. Role of vitamin D in cardiovascular health. Am J Cardiol 2010;10(6):798-805.
62. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 2008;4(2):80-90.
63. Brewer LC, Michos ED, Reis JP. Vitamin D in atherosclerosis, vascular disease, and endothelial function. Curr Drug Targets 2011;12(1):54-60.
64. Dong Y, Stallmann-Jorgensen IS, Pollock NK, Harris RA, Keeton D, et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab 2010;95(10):4584-91.
65. Atabek ME, Eklioglu BS, Akyurek N, Alp H. Association between vitamin D level and cardiovascular risk in obese children and adolescents. J Pediatr Endocrinol Metab 2014; 27(7-8):661-66.
66. Alemzadeh R, Kichler J. Parathyroid hormone is associated with biomarkers of insulin resistance and inflammation, independent of vitamin D status, in obese adolescents. Metab Syndr Relat Disord 2012; 10(6):422-29.
67. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004; 89-90 (1-5):121-5.
68. Chiu, KC, Chu, A, Go, VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004;79(5):820-25.
69. Oliveira CL, Mello MT, Cintra IP, Fisberg, M. Obesidade e síndrome metabólica na infância e adolescência. Revista de Nutrição 2004;17(2):237-45.
70. Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol 2012;2012(ID 634195):1-11.
71. George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med 2012;29(8):142-50.
72. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr 2011;94(2):486-94.
73. Javed A, Vella A, Balagopal PB, Fischer PR, Weaver AL, et al. Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial. J Nutr 2015;145(2):284-90.
74. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, et al. Systematic review: Vitamin D and cardiometabolic outcomes. Ann Intern Med 2010;152:307-14.
75. Kunutsor SK, Apekey TA, Steur M. Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants. Eur J Epidemiol 2013; 28(3):205-21.
76. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am J Clin Nutr 2001;94:225-33.
77. Parikh S, Guo DH, Pollock NK, Petty K, Bhagatwala J, et al. Circulating 25-hydroxyvitamin D concentrations are correlated with cardiometabolic risk among American black and white adolescents living in a year-round sunny climate. Diabetes Care 2012;35:1133-38.
78. Kao KT, Abidi N, Ranasinha S, Brown J, Rodda C, et al. Low vitamin D is associated with hypertension in paediatric obesity. J Paediatr Child Health 2015;51(12):1207-13.
79. Snijder MB, Lips P, Seidell, JC, Visser M, Deeg DJ, et al. Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women. J Intern Med 2007;261(6):558-65.
80. Carbone LD, Rosenberg EW, Tolley EA, Holick MF, Hughes TA, et al. 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism 2008;57(6):741-48.
81. De Courten B, Mousa A, Naderpoor N, Teede H, De Courten MP, Scragg R. Vitamin D supplementation for the prevention of type 2 diabetes in overweight adults: study protocol for a randomized controlled trial. Trials 2015;16:335.
82. Valle M, Gascón F, Martos R, Ruz FJ, Bermudo F, et al. Metabolic cardiovascular syndrome in obese prepubertal children: the role of high fasting insulin levels. Metabolism 2002;51(4):423-28.
83. Stokić E, Kupusinac A, Tomić-Naglić D, Zavišić BK, Mitrović M, et al. Obesity and vitamin D deficiency: trends to promote a more proatherogenic cardiometabolic risk profile. Angiology 2015;66(3):237-43.