Effects of transplanted circulating endothelial progenitor cells and platelet microparticles in atherosclerosis development

Biology of the Cell

Volumn 108, Issue 8, 2016, Pages 219-243

  Georgescu, Adriana ^a,d   Alexandru, Nicoleta ^a,d   Andrei, Eugen ^a   Dragan, Emanuel ^a   Cochior, Daniel ^b,c   Dias, Sérgio ^d  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^b TITU MAIORESCU UNIVERSITY   (Romania)

^c General Surgery Clinic   (Romania)

^d INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

Atherosclerosis; Cell therapy; Circulating platelet microparticles (PMPs); Endothelial progenitor cells (EPCs); Vascular dysfunction

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; GLUCOSE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; MONOCYTE CHEMOTACTIC PROTEIN 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; RANTES; STROMAL CELL DERIVED FACTOR 1ALPHA; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR; TRIACYLGLYCEROL; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY WALL; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD CLOT LYSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE COURSE; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIAL PROGENITOR CELL TRANSPLANTATION; FATTY LIVER; GLUCOSE BLOOD LEVEL; HAMSTER MODEL; HEART RATE; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTENSIVE HYPERCHOLESTEROLEMIC DIET; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MOLECULAR PATHOLOGY; NONHUMAN; PARACRINE SIGNALING; PLATELET MICROPARTICLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REMISSION; STEM CELL TRANSPLANTATION; SYRIAN HAMSTER; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VASOCONSTRICTION; VASODILATATION;

EID: 84980349466     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1111/boc.201500104     Document Type: Article

References (42)

1. Alexandru, N., Popov, D., Dragan, E., Andrei, E. and Georgescu, A. (2011) Platelet activation in hypertension associated with hypercholesterolemia; effects of irbersartan. J. Thromb. Haemost. 9, 173–184
2. Alexandru, N., Popov, D., Dragan, E., Andrei, E. and Georgescu A. (2013) Circulating endothelial progenitor cell and platelet microparticle impact on platelet activation in hypertension associated with hypercholesterolemia. PloS One 8, e52058–e52068
3. Bagley, R.G., Walter-Yohrling, J., Cao, X., Weber, W., Simons, B., Cook, B.P., Chartrand, S.D., Wang, C., Madden, S.L. and Teicher, B.A. (2003) Endothelial precursor cells as a model of tumor endothelium: characterization and comparison with mature endothelial cells. Cancer Res. 63, 5866–5873
4. Brill, A., Dashevsky, O., Rivo, J., Gozal, Y. and Varon, D. (2005) Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovasc. Res. 67, 30–38
5. Caiado, F., Reall, C., Carvalho, T. and Dias, S. (2008) Notch pathway modulation on bone marrow-derived vascular precursor cells regulates their angiogenic and wound healing potential. PLoS One 3, e3752
6. Chironi, G.N., Boulanger, C.M., Simon, A., Dignat-George, F., Freyssinet, J.-M. and Tedgui, A. (2009) Endothelial microparticles in diseases. Cell Tissue Res. 335, 143–151
7. Dernbach, E., Urbich, C., Brandes, R.P., Hofmann, W.K., Zeiher, A.M. and Dimmeler, S. (2004) Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Blood 104, 3591–3597
8. Dileepan, K.N., Simpson, K.M., Lynch, S.R. and Stechschulte, D.J. (1989) Dismutation of eosinophil superoxide by mast cell granule superoxide dismutase. Biochem. Arch. 5, 153–160
9. Dimmeler, S. and Zeiher, A.M. (2004) Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J. Mol. Med. 82, 671–677
10. Fan, Y., Shen, F., Frenzel, T., Zhu, W., Ye, J., Liu, J., Chen, Y., Su, H., Young, W.L. and Yang, G.Y. (2010) Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann. Neurol. 67, 488–497
11. Galkina, E. and Ley, K. (2009) Immune and inflammatory mechanisms of atherosclerosis. Annu. Rev. Immunol. 27, 165–197
12. Georgescu, A., Alexandru, N., Andrei, E., Titorencu, I., Dragan, E., Tarziu, C., Ghiorghe, S., Badila, E., Bartos, D. and Popov, D. (2012) Circulating microparticles and endothelial progenitor cells in atherosclerosis; pharmacological effects of irbesartan. J. Thromb. Haemost. 10, 680–691
13. Georgescu, A., Alexandru, N., Nemecz, M., Titorencu, I. and Popov, D. (2013) Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines. Eur. J. Pharmacol. 711, 27–35
14. Georgescu, A., Alexandru, N., Popov, D., Amuzescu, M., Andrei, E., Zamfir, C., Maniu, H. and Badila, E. (2009) Chronic venous insufficiency is associated with elevated level of circulating microparticles. J. Thromb. Haemost. 7, 1566–1575
15. 2 – adrenoceptor. Pharmacology 81, 110–117
16. Georgescu, A., Popov, D., Dragan, E., Dragomir, E. and Badila, E. (2007) Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. Eur. J. Pharmacol. 570, 149–158
17. Giannotti, G. and Landmesser, U. (2007) Endothelial dysfunction as an early sign of atherosclerosis. Herz 32, 568–572
18. He, T., Peterson, T.E. Holmuhamedov E.L., Terzic, A., Caplice, N.M., Oberley, L.W. and Katusic, Z.S. (2004a) Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase. Arterioscler. Thromb. Vasc. Biol. 24, 2021–2027
19. He, T., Smith, L.A., Harrington, S., Nath, K.A., Caplice, N.M. and Katusic, Z.S. (2004b) Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 35, 2378–2384
20. Hristov, M. and Weber, C. (2008) Ambivalence of progenitor cells in vascular repair and plaque stability. Curr. Opin. Lipidol. 19, 491–497
21. Hristov, M. and Weber, C. (2009) Progenitor cell trafficking in the vascular wall. J. Thromb. Haemost. 7, 31–34
22. Kim, J.Y., Song, S.H., Kim, K.L., Maeng, Y.S., Im, J.E., Yie, S.W., Ahn, Y.K., Kim, D.K. and Suh, W. (2010) Human cord blood-derived endothelial progenitor cells and their conditioned media exhibit therapeutic equivalence for diabetic wound healing. Cell Transplant. 19, 1635–1644
23. Leroyer, A.S., Ebrahimian, T.G., Cochain, C., Récalde, A., Blanc-Brude, O., Mees, B., Vilar, J., Tedgui, A., Levy, B.I., Chimini, G., Boulanger, C.M. and Silvestre, J.S. (2009) Microparticles from ischemic muscle promotes postnatal vasculogenesis. Circulation 119, 2808–2817
24. Leroyer, A.S., Tedgui, A. and Boulanger, C.M. (2008) Role of microparticles in atherothrombosis. J. Intern. Med. 263, 528–537
25. Li, M., Kuo, L. and Stallone, J.N. (2008) Estrogen potentiates constrictor prostanoid function in female rat aorta by upregulation of cyclooxygenase-2 and thromboxane pathway expression. Am. J. Physiol. Heart Circ. Physiol. 294, H2444–H2455
26. Mallat, Z., Benamer, H., Hugel, B., Benessiano, J., Steg, P.G., Freyssinet, J.M and Tedgui, A. (2000) Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 101, 841–843
27. Martinez, M.C. and Ramaroson, A. (2011) Microparticles in angiogenesis therapeutic potential. Circ. Res. 109, 110–119
28. Mause, S.F, Ritzel, E., Liehn, E.A., Hristov, M., Bidzhekov, K., Muller-Newen, G., Soehnlein, O. and Weber, C. (2010) Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 122, 494–506
29. Morel, O., Toti, F., Bakouboula, B., Grunebaum, L. and Freyssinet, J.-M. (2006) Procoagulant microparticles: “criminal partners” in atherothrombosis and deleterious cellular exchanges. J. Path. Haemost. Thromb. 21, 15–22
30. Morel, O., Toti, F., Morel, N. and Freyssinet. J.-M. (2009) Microparticles in endothelial cell and vascular homeostasis: are they really noxious? Haematologica 94, 313–317
31. Mulvany, M.J. and Halpern, W. (1977) Contractile properties of small arteriolar resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 41, 19–26
32. Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D.M., Leri, A. and Anversa, P. (2001) Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U.S.A. 98, 10344–10349
33. Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the1990s. Nature 362, 801–809
34. Sata, M., Saiura, A., Kunisato, A., Tojo, A., Okada, S., Tokuhisa, T., Hirai, H., Makuuchi, M., Hirata, Y. and Nagai, R. (2002) Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat. Med. 8, 403–409
35. Smith, D.D., Tan, X., Tawfik, O., Milne, G., Stechschulte, D.J. and Dileepan, K.N. (2010) Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production. J. Physiol. Pharmacol. 61, 309–316
36. Spinetti, G., Kraenkel, N., Emanueli, C. and Madeddu, P. (2008) Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies. Cardiovasc. Res. 78, 265–284
37. Sun, J., Sukhova, G.K., Wolters, P.J., Yang, M., Kitamoto, S., Libby, P., MacFarlane, L.A., Mallen-St Clair, J. and Shi, G.P. (2007) Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat. Med. 13, 719–724
38. Targher, G., Day, C.P. and Bonora, E. (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N. Engl. J. Med. 363, 1341–1350
39. Urbich, C. and Dimmeler, S. (2004) Endothelial progenitor cells: characterization and role in vascular biology. Circ. Res. 95, 343–353
40. Vasa, M., Fichtlscherer, S., Aicher, A., Adler, K., Urbich, C., Martin, H., Zeiher, A.M. and Dimmeler, S. (2001) Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ. Res. 89, 1–7
41. Woywodt, A., Bahlmann, F.H., De Groot, K., Haller, H. and Haubitz, M. (2002) Circulating endothelial cells: life, death, detachment and repair of the endothelial cell layer. Nephrol. Dial. Transplant. 17, 1728–1730
42. Xu, Q. (2004) Mouse models of arteriosclerosis: from arterial injuries to vascular grafts. Am. J. Pathol. 165, 1–10