The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis

Anatomical Science International

Volumn 92, Issue 1, 2017, Pages 151-158

  Torkamani, Niloufar ^a,b,c   Rufaut, Nicholas ^a,b   Jones, Leslie ^a,b   Sinclair, Rodney ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b EPWORTH HOSPITAL   (Australia)

^c Epworth Research Institute   (Australia)

Author keywords

Arrector pili muscle; Phalloidin; Stemcells

Indexed keywords

F ACTIN; PHALLOIDIN; ACTIN;

ALOPECIA; ANATOMY; ARRECTOR PILI MUSCLE; ARTICLE; BIOPSY; CLINICAL ARTICLE; DERMOEPIDERMAL JUNCTION; EPIDERMIS; FOLLICULAR STEM CELL NICHE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERFOLLICULAR EPIDERMIS; MALE; MUSCLE; PRIORITY JOURNAL; SCALP; STEM CELL; THREE DIMENSIONAL IMAGING; ANATOMY AND HISTOLOGY; BASEMENT MEMBRANE; CYTOLOGY; HAIR FOLLICLE; PATHOLOGY; PROCEDURES; SMOOTH MUSCLE; STAINING; STEM CELL NICHE;

ACTINS; ALOPECIA; ANATOMY; BASEMENT MEMBRANE; EPIDERMIS; HAIR FOLLICLE; HUMANS; MUSCLE, SMOOTH; PHALLOIDINE; SCALP; STAINING AND LABELING; STEM CELL NICHE;

EID: 84980025152     PISSN: 14476959     EISSN: 1447073X     Source Type: Journal    
DOI: 10.1007/s12565-016-0359-5     Document Type: Article

References (27)

1. Barcaui CB, Pineiro-Maceira J, De Avelar Alchorne MM (2002) Arrector pili muscle: evidence of proximal attachment variant in terminal follicles of the scalp. Br J Dermatol 146:657–658
2. Black J, Dykes A, Thatcher S et al (2009) FRET analysis of actin–myosin interaction in contracting rat aortic smooth muscle. Can J Physiol Pharmacol 87:327–336
3. Clifton MM, Mendelson JK, Mendelson B (2000) Immunofluorescent microscopic investigation of the distal arrector pilli: a demonstration of the spatial relationship between α5β1 integrin and fibronectin. J Am Acad Dermatol 43:19–23
4. Kim JN, Lee JY, Shin KJ et al (2014) Morphological and morphometric study of the androgenetic alopecic scalp using two- and three-dimensional analysis comparing regional differences. Br J Dermatol 170:1313–1318
5. Kobayashi K, Rochat A, Barrandon Y (1993) Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa. Proc Natl Acad Sci USA 90:7391–7395
6. Kwon O, Phillips CL, Molitoris BA (2002) Ischemia induces alterations in actin filaments in renal vascular smooth muscle cells. Am J Physiol Ren Physiol 282:1012–1019
7. Lavker RM, Sun TT (1982) Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations. Science 215:1239–1241
8. Lesson TS, Lesson CR, Paparo AA (1988) Text/atlas of histology. W.B. Saunders Co., Philadelphia, pp 125–135
9. Lunstrum GP, Sakai LY, Keene DR et al (1986) Large complex globular domains of type VII procollagen contribute to the structure of anchoring fibrils. J Biol Chem 261:9042–9048
10. Mecklenburg L, Linek M, Tobin DJ (2009) Hair loss disorders in domestic animals. Wiley–Blackwell, Ames, p 44
11. Mendelson JK, Smoller BR, Mendelson B, Horn TD (2000) The microanatomy of the distal arrector pili: possible role for α1β1 and α5β1 integrins in mediating cell-cell adhesion and anchorage to the extracellular matrix. J Cutan Pathol 27:61–66
12. Narisawa Y, Kohda H (1993) Arrector pili muscle surrounds human facial vellus hair follicles. Br J Dermatol 129:138–139
13. Narisawa Y, Hashimoto K, Kohda H (1994) Two- and three-dimensional observations of human terminal and vellus hair follicles. J Dermatol Sci 7:13–19
14. Narisawa Y, Hashimoto K, Kohda H (1996) Merkel cells participate in the induction and alignment of epidermal ends of arrector pili muscles of human fetal skin. Br J Dermatol 134:494–498
15. Ohyama M (2007) Advances in the study of stem-cell-enriched hair follicle bulge cells: a review featuring characterization and isolation of human bulge cells. Dermatology 214:342–351
16. Oshima H, Rochat A, Kedzia C et al (2001) Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104:233–245
17. Poblet E, Ortega F, Jiménez F (2002) The arrector pilli muscle and the follicular unit of the scalp: a microscopic anatomy study. Dermatol Surg 28:800–803
18. Sinclair RD (2014) Alopecia areata and suicide of children. Med J Aust 200:145
19. Song WC, Hu KS, Koh KS (2005) Multiunit arrector pili muscular structure as a variation observed by using computer-based three-dimensional reconstruction. Cell Tissue Res 322:335–337
20. Song W, Hwang WJ, Shin C, Koh KS (2006) A new model for the morphology of the arrector pilli muscle in the follicular unit based on three-dimensional reconstruction. J Anat 208:643–648
21. Tiede S, Kloepper JE, Whiting DA, Paus R (2007) The follicular trochanter: an epithelial compartment of the human hair follicle bulge region in need of further characterization. Br J Dermatol 157:1013–1016
22. Torkamani N, Rufaut NW, Jones L, Sinclair RD (2014a) Beyond goosebumps: does the arrector pili muscle have a role in hair loss? Int J Trichol 6:88–94
23. Torkamani N, Rufaut NW, Jones L, Sinclair R (2014b) Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia. Br J Dermatol 170:1291–1298
24. Torkamani N, Rufaut N, Jones L, Sinclair R (2016) Epidermal cells expressing stem cell markers in non-glabrous skin exist in direct proximity with the distal end of the arrector pili muscle. Stem Cells Int 1286315
25. Toyoshima KE, Asakawa K, Ishibashi N et al (2012) Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches. Nat Commun 3:784
26. Wang X, Shi Y, Zhou Q et al (2012) Detailed histological structure of human hair follicle bulge region at different ages: a visible niche for nesting adult stem cells. J Huazhong Univ Sci Technol Med Sci 32:648–656
27. Yazdabadi A, Whiting D, Rufaut NW, Sinclair R (2012) Arrector pili muscle and alopecia. Int J Trichol 4:154–157