Miniaturized hairs maintain contact with the arrector pili muscle in alopecia areata but not in androgenetic alopecia: A model for reversible miniaturization and potential for hair regrowth

International Journal of Trichology

Volumn 4, Issue 3, 2012, Pages 154-157

  Yazdabadi, Anousha ^a,b   Whiting, D ^c   Rufaut, N W ^a,b   Sinclair, R ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Hair and Skin Research and Treatment Centre   (United States)

Author keywords

Arrector pili muscle; follicle; hair; regrowth

Indexed keywords

EID: 84866650348     PISSN: 09747753     EISSN: 09749241     Source Type: Journal    
DOI: 10.4103/0974-7753.100069     Document Type: Article

References (17)

1. Sinclair R, Banfield C, Dawber R. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science; 1999.
2. Van Scott EJ, Ekel TM. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp. J Invest Dermatol 1958;31:281-7.
3. Elliott K, Stephenson TJ, Messenger AG. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: Implications for the control of hair follicle size and androgen responses. J Invest Dermatol 1999;113:873-7.
4. Jahoda CA. Cellular and developmental aspects of androgenetic alopecia. Exp Dermatol 1998;7:235-48.
5. Yazdabadi A, Magee J, Harrison S, Sinclair R. The Ludwig pattern of androgenetic alopecia is due to a hierarchy of androgen sensitivity within follicular units that leads to selective miniaturization and a reduction in the number of terminal hairs per follicular unit. Br J Dermatol 2008;159:1300-2.
6. Headington JT. Transverse microscopic anatomy of the human scalp. A basis for a morphometric approach to disorders of the hair follicle. Arch Dermatol 1984;120:449-56.
7. Song WC, Hwang WJ, Shin C, Koh KS. A new model for the morphology of the arrector pili muscle in the follicular unit based on three-dimensional reconstruction. J Anat 2006;208:643-8.
8. Montagna WKA, Carlisle KS. Atlas of Normal Human Skin. Berlin: Springer-Verlag; 1992.
9. Saitoh M, Uzuka M, Sakamoto M. Human hair cycle. J Invest Dermatol 1970;54:65-81.
10. Whiting DA. Histopathologic features of alopecia areata: A new look. Arch Dermatol 2003;139:1555-9.
11. Messenger A. Alopecia Areata. In: Burns TBS, Cox N, Griffiths C, editors. Rook's textbook of Dermatology. 2004.
12. Poblet E, Jimenez F, Ortega F. The contribution of the arrector pili muscle and sebaceous glands to the follicular unit structure. J Am Acad Dermatol 2004;51:217-22.
13. Tiede S, Kloepper JE, Whiting DA, Paus R. The 'follicular trochanter': An epithelial compartment of the human hair follicle bulge region in need of further characterization. Br J Dermatol 2007;157:1013-6.
14. Cotsarelis G. Epithelial stem cells: A folliculocentric view. J Invest Dermatol 2006;126:1459-68.
15. Harrison S, Sinclair R. Telogen effluvium. Clin Exp Dermatol 2002;27: 389-5.
16. Fiala JC. Reconstruct: A free editor for serial section microscopy. J Microsc 2005;218(Pt 1):52-61.
17. Liu JY, Peng HF, Andreadis ST. Contractile smooth muscle cells derived from hair-follicle stem cells. Cardiovasc Res 2008;79:24-33.