Association between comorbidities and absence of chest pain in acute coronary syndrome with in-hospital outcome

International Journal of Cardiology

Volumn 217, Issue , 2016, Pages S37-S43

  Manfrini, Olivia ^a   Ricci, Beatrice ^a   Cenko, Edina ^a   Dorobantu, Maria ^b   Kalpak, Oliver ^c   Kedev, Sasko ^c   Kneževic, Božidarka ^d   Koller, Akos ^e,f   Milicic, Davor ^g   Vasiljevic, Zorana ^h   Badimon, Lina ⁱ   Bugiardini, Raffaele ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Clinical Emergency Hospital of Bucharest   (Romania)

^c SS CYRIL AND METHODIUS UNIVERSITY   (Macedonia)

^d UNIVERSITY OF MONTENEGRO   (Montenegro)

^e UNIVERSITY OF PHYSICAL EDUCATION   (Hungary)

^f NEW YORK MEDICAL COLLEGE   (United States)

^g UNIVERSITY OF ZAGREB   (Croatia)

^h UNIVERSITY OF BELGRADE   (Serbia)

ⁱ UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Acute coronary syndrome; Chest pain; Chronic kidney disease; Comorbidity; Heart failure; Stroke

Indexed keywords

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CHRONIC KIDNEY DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG UTILIZATION; FEMALE; HEART FAILURE; HOSPITAL MORTALITY; HUMAN; INVASIVE PROCEDURE; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; MORTALITY RISK; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; PROGNOSIS; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THORAX PAIN; UNSTABLE ANGINA PECTORIS; CHEST PAIN; CLINICAL TRIAL; MIDDLE AGED; ODDS RATIO; PERCUTANEOUS CORONARY INTERVENTION; REGISTER; RISK FACTOR; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

CARDIOVASCULAR AGENT;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; CARDIOVASCULAR AGENTS; CHEST PAIN; COMORBIDITY; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PERCUTANEOUS CORONARY INTERVENTION; REGISTRIES; RISK FACTORS;

EID: 84979966843     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.06.221     Document Type: Article

References (51)

1. [1] Fang, J., Alderman, M.H., Keenan, N.L., Ayala, C., Acute myocardial infarction hospitalization in the United States, 1979 to 2005. Am. J. Med. 123 (2010), 259–266.
2. [2] Vaccarino, V., Badimon, L., Corti, R., et al. Presentation, management, and outcomes of ischaemic heart disease in women. Nat. Rev. Cardiol. 10 (2013), 508–518.
3. [3] Canto, J.G., Rogers, W.J., Goldberg, R.J., et al. Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA 307 (2012), 813–822.
4. [4] Canto, J.G., Shlipak, M.G., Rogers, W.J., et al. Prevalence, clinical characteristics, and mortality among patients with myocardial infarction presenting without chest pain. JAMA 283 (2000), 3223–3229.
5. [5] Ricci, B., Cenko, E., Varotti, E., Puddu, P.E., Manfrini, O., Atypical chest pain in ACS: a trap especially for women. Curr. Pharm. Des., 2016, 10.2174/1381612822666160309115125.
6. [6] El-Menyar, A., Zubaid, M., Sulaiman, K., et al. Atypical presentation of acute coronary syndrome: a significant independent predictor of in-hospital mortality. J. Cardiol. 57 (2011), 165–171.
7. [7] Canto, J.G., Fincher, C., Kiefe, C.I., et al. Atypical presentations among Medicare beneficiaries with unstable angina pectoris. Am. J. Cardiol. 90 (2002), 248–253.
8. [8] Bugiardini, R., Eskola, M., Huhtala, H. et-al, Coronary revascularisation in stable patients after an acute coronary syndrome: a propensity analysis of early invasive versus conservative management in a register-based cohort study. BMJ Open., 3, 2013 pii: e002559.
9. [9] Dorsch, M.F., Lawrance, R.A., Sapsford, R.J., et al. Poor prognosis of patients presenting with symptomatic myocardial infarction but without chest pain. Heart 86 (2001), 494–498.
10. [10] Hwang, S.Y., Park, E.H., Shin, E.S., Jeong, M.H., Comparison of factors associated with atypical symptoms in younger and older patients with acute coronary syndromes. J. Korean Med. Sci. 24 (2009), 789–794.
11. [11] Manfrini, O., Bugiardini, R., Barriers to clinical risk scores adoption. Eur. Heart J. 28 (2007), 1045–1046.
12. [12] Cenko, E., Bugiardini, R., Barriers to risk stratification accuracy in ischemic heart disease in women: the role of non-obstructive coronary artery disease. Curr. Pharm. Des., 2016, 10.2174/1381612822666160311115344.
13. [13] Bugiardini, R., Estrada, J.L., Nikus, K., Hall, A.S., Manfrini, O., Gender bias in acute coronary syndromes. Curr. Vasc. Pharmacol. 8 (2010), 276–284.
14. [14] Bugiardini, R., Women, ‘non-specific’ chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcome. Eur. Heart J. 27 (2006), 1387–1389.
15. [15] Bugiardini, R., Badimon, L., Manfrini, O., on the behalf of the ISACS-TC Investigators, Rationale and design of the ISACS-TC (International Survey of Acute Coronary Syndromes in Transitional Countries) project. Eur. Heart J. Suppl. 16:Suppl. A (2014), A1–A6.
16. [16] Manfrini, O., Dorobantu, M., Vasiljevic, Z., et al. Acute coronary syndrome in octogenarian patients: results from the international registry of acute coronary syndromes in transitional countries (ISACS-TC) registry. Eur. Heart J. Suppl. 16:Suppl. A (2014), A87–A94.
17. [17] Vasiljevic, Z., Krljanac, G., Davidovic, G., et al. Gender differences in case fatality rates of acute myocardial infarction in Serbia. Eur. Heart J. Suppl. 16:Suppl. A (2014), A48–A55.
18. [18] Dorobantu, M., Tautu, O.F., Fruntelata, A., et al. Hypertension and acute coronary syndromes in Romania: data from the ISACS-TC registry. Eur. Heart J. Suppl. 16:Suppl. A (2014), A20–A27.
19. [19] Bugiardini, R., Manfrini, O., Stakic, M.M., et al. Exploring in-hospital death from myocardial infarction in eastern Europe: from the International Registry of Acute Coronary Syndromes in Transitional Countries (ISACS-TC); on the behalf of the working group on Coronary Pathophysiology & Microcirculation of the European Society of Cardiology. Curr. Vasc. Pharmacol. 12 (2014), 903–909.
20. [20] Bugiardini, R., Dorobantu, M., Vasiljevic, Z., et al. Unfractionated heparin-clopidogrel interaction in ST-elevation myocardial infarction not receiving reperfusion therapy. Atherosclerosis 241 (2015), 151–156.
21. [21] Bugiardini, R., Cenko, E., Ricci, B., et al. Comparison of early versus delayed oral β blockers in acute coronary syndromes and effect on outcomes. Am. J. Cardiol. 117 (2016), 760–767.
22. [22] Cenko, E., Ricci, B., Kedev, S., et al. Reperfusion therapy for ST-elevation acute myocardial infarction in eastern Europe: the ISACS-TC registry. Eur. Heart J. Qual. Care Clin. Outcomes 2 (2016), 45–51.
23. [23] Thygesen, K., Alpert, J.S., Jaffe, A.S., Simoons, M.L., Chaitman, B.R., White HD; task force for the universal definition of myocardial infarction. Nat. Rev. Cardiol. 9 (2012), 620–633.
24. [24] Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg, P.G., James, S.K., Atar, D., et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur. Heart J. 33 (2012), 2569–2619.
25. [25] Hamm, C.W., Bassand, J.P., Agewall, S., et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur. Heart J. 32 (2011), 2999–3054.
26. [26] Culić, V., Eterović, D., Mirić, D., Silić, N., Symptom presentation of acute myocardial infarction: influence of sex, age, and risk factors. Am. Heart J. 144 (2002), 1012–1017.
27. [27] Brieger, D., Eagle, K.A., Goodman, S.G., et al. Acute coronary syndromes without chest pain, an underdiagnosed and undertreated high-risk group: insights from the Global Registry of Acute Coronary Events. Chest 126 (2004), 461–469.
28. [28] Stern, S., Behar, S., Leor, J., et al. Presenting symptoms, admission electrocardiogram, management, and prognosis in acute coronary syndromes: differences by age. Am. J. Geriatr. Cardiol. 13 (2004), 188–196.
29. [29] Rosengren, A., Wallentin, L., Simoons, M., et al. Age, clinical presentation, and outcome of acute coronary syndromes in the Euroheart acute coronary syndrome survey. Eur. Heart J. 27 (2006), 789–795.
30. [30] Grosmaitre, P., Le Vavasseur, O., Yachouh, E., et al. Significance of atypical symptoms for the diagnosis and management of myocardial infarction in elderly patients admitted to emergency departments. Arch. Cardiovasc. Dis. 106 (2013), 586–592.
31. [31] Di Pasquale, G., Andreoli, A., Pinelli, G., et al. Cerebral ischemia and asymptomatic coronary artery disease: a prospective study of 83 patients. Stroke 17 (1986), 1098–1101.
32. [32] Rokey, R., Rolak, L.A., Harati, Y., Kutka, N., Verani, M.S., Coronary artery disease in patients with cerebrovascular disease: a prospective study. Ann. Neurol. 16 (1984), 50–53.
33. [33] Hasdai, D., Haim, M., Behar, S., Boyko, V., Battler, A., Acute coronary syndromes in patients with prior cerebrovascular events: lessons from the Euro-Heart Survey of acute coronary syndromes. Am. Heart J. 146 (2003), 832–838.
34. [34] Bansal, N., Clinically silent myocardial infarctions in the CKD community. Nephrol. Dial. Transplant. 27 (2012), 3387–3391.
35. [35] Sosnov, J., Lessard, D., Goldberg, R.J., Yarzebski, J., Gore, J.M., Differential symptoms of acute myocardial infarction in patients with kidney disease: a community-wide perspective. Am. J. Kidney Dis. 47 (2006), 378–384.
36. [36] Choi, J.S., Kim, C.S., Park, J.W., et al. Renal dysfunction as a risk factor for painless myocardial infarction: results from Korea Acute Myocardial Infarction Registry. Clin. Res. Cardiol. 101 (2012), 795–803.
37. [37] Rizk, D.V., Gutierrez, O., Levitan, E.B., et al. Prevalence and prognosis of unrecognized myocardial infarctions in chronic kidney disease. Nephrol. Dial. Transplant. 27 (2012), 3482–3488.
38. [38] Tatu-Chitoiu, G., Cinteza, M., Dorobantu, M., et al. In-hospital case fatality rates for acute myocardial infarction in Romania. CMAJ 180 (2009), 1207–1213.
39. [39] Manfrini, O., Morrell, C., Das, R., et al. Effects of angiotensin-converting enzyme inhibitors and beta blockers on clinical outcomes in patients with and without coronary artery obstructions at angiography (from a register-based cohort study on acute coronary syndromes). Am. J. Cardiol. 113 (2014), 1628–1633.
40. [40] Maseri, A., Crea, F., Kaski, J.C., Crake, T., Mechanisms of angina pectoris in syndrome X. J. Am. Coll. Cardiol. 17 (1991), 499–506.
41. [41] Bugiardini, R., Galvani, M., Ferrini, D., et al. Myocardial ischemia induced by prostacyclin and iloprost. Clin. Pharmacol. Ther. 38 (1985), 101–108.
42. [42] Bugiardini, R., Galvani, M., Ferrini, D., et al. Myocardial ischemia during intravenous prostacyclin administration: hemodynamic findings and precautionary measures. Am. Heart J. 113:2 Pt 1 (1987), 234–240.
43. [43] Manfrini, O., Morgagni, G., Pizzi, C., Fontana, F., Bugiardini, R., Changes in autonomic nervous system activity: spontaneous versus balloon-induced myocardial ischaemia. Eur. Heart J. 25 (2004), 1502–1508.
44. [44] Penninx, B.W., Milaneschi, Y., Lamers, F., Vogelzangs, N., Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med., 11, 2013, 129.
45. [45] Manfrini, O., Pizzi, C., Morgagni, G., Fontana, F., Bugiardini, R., Effect of pravastatin on myocardial perfusion after percutaneous transluminal coronary angioplasty. Am. J. Cardiol. 93 (2004), 1391–1393 (A6).
46. [46] Manfrini, O., Slucca, M., Pizzi, C., Colombo, A., Viecca, M., Bugiardini, R., Effect of percutaneous coronary intervention on coronary blood flow at rest in myocardial sites remote from the intervention site in patients with stable angina pectoris. Am. J. Cardiol. 101 (2008), 776–779.
47. [47] Weissler-Snir, A., Kornowski, R., Sagie, A., et al. Gender differences in left ventricular function following percutaneous coronary intervention for first anterior wall ST-segment elevation myocardial infarction. Am. J. Cardiol. 114 (2014), 1473–1478.
48. [48] Manfrini, O., Bazzocchi, G., Luati, A., Borghi, A., Monari, P., Bugiardini, R., Coronary spasm reflects inputs from adjacent esophageal system. Am. J. Physiol. Heart Circ. Physiol. 290 (2006), H2085–H2091.
49. [49] Pozzati, A., Bugiardini, R., Borghi, A., et al. Transient ischaemia refractory to conventional medical treatment in unstable angina: angiographic correlates and prognostic implications. Eur. Heart J. 13 (1992), 360–365.
50. [50] Alfonso, F., Timmis, A., Pinto, F.J., et al. Conflict of interest policies and disclosure requirements among European Society of Cardiology National Cardiovascular Journals. Eur. Heart J. 33 (2012), 587–594.
51. [51] Shewan, L.G., Rosano, G.M.C., Henein, M.Y., Coats, A.J.S., A statement on ethical standards in publishing scientific articles in the international journal of cardiology family of journals. Int. J. Cardiol. 170 (2014), 253–254.